Quotables
"The production of too many useful things results in too many useless people."
Karl Marx
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8153762 | Composition for palladium-mediated cleavage of peptides containing CXC, CXH or CHM sequences The invention provides a process for amidating a desired peptide comprising cleaving a substrate polypeptide at a X1-cysteine sequence, wherein X1 is the amino acid at the peptide carboxyl-terminus and cysteine is the first amino acid of a pall... | 04/10/2012 |
| 8143375 | Aziridine aldehydes, aziridine-conjugated amino derivatives, aziridine-conjugated biomolecules and processes for their preparation The present invention relates to unprotected amino aldehydes and applications for same. More particularly, the present invention relates to novel aziridine aldehydes and processes for preparing these novel compounds. The invention also relates to aziridine-conjugate... | 03/27/2012 |
| 8080519 | Compositions and methods for enhanced pharmacological activity of compositions comprising peptide drug substances Pharmaceutical agents, compositions containing the same and methods for their use for enhancing the bioavailability and pharmacological efficacy of therapeutic peptides. The pharmaceutical agents have the formula Carrier-Linker-Peptide Wherein Pe... | 12/20/2011 |
| 8071718 | Selective radiolabeling of biomolecules Provided herein are methods for introducing fluorine atom onto a biomolecule comprising: (i) providing a linker comprising a thiol-reactive terminus and an azido/alkyne-reactive terminus; (ii) reacting the thiol-reactive terminus of the linker with a biomolecule com... | 12/06/2011 |
| 8008435 | Polymer stabilized neuropeptides A substantially hydrophilic conjugate is provided having a peptide that is capable of passing the blood-brain barrier covalently linked to a water-soluble nonpeptidic polymer such as polyethylene glycol. The conjugate exhibits improved solubility and in vivo stabili... | 08/30/2011 |
| 7939630 | Conjugated biological molecules and their preparation Novel biologically active compounds of the general formula (I) in which one of X and X′ represents a polymer, and the other represents a hydrogen atom; each Q independently represents a linking group; W represents an electron-withdrawing moiety or a moiety prepara... | 05/10/2011 |
| 7902332 | Fluorine-labeled compounds Methods for introducing fluorine atom onto a polypeptide are provided. Also provided are linkers, bioconjugates, and bifunctional compound agents made using the methods, linkers, and bioconjugates. The methods comprise: (i) providing a linker comprising a thiol-reac... | 03/08/2011 |
| 7572884 | Method for making acylated polypeptides The present invention related to a method of producing polypeptides in transformed host cells by expressing a precursor molecule of the desired polypeptide which are to be acylated in a subsequent in vitro step. The invention is also related to DNA-sequences, vector... | 08/11/2009 |
| 7563866 | Modular antigen transporter molecules (MAT molecules) for modulating immune reactions, associated constructs, methods and uses Modular antigen transporter molecules (MAT molecules), which are used as vaccines and for the treatment of allergies, include three modules: a translocation module which brings about transport of the MAT molecule into the interior of the cell; a targeting module whi... | 07/21/2009 |
| 7521531 | Methods for the purification of stable radioiodine conjugates The present invention is directed toward a method for preparing and purifying a conjugate of a radioiodinated aminopolycarboxylate-appended peptide and a targeting agent. The method involves (A) providing a solution comp rising (i) unbound radioiodine (ii) a radioio... | 04/21/2009 |
| 7498406 | Substantially cell membrane impermeable compound and use thereof The present invention relates to a compound according to Formula (I): A-(L-Y)p, wherein A comprises at least one substantially cell- membrane impermeable pendant group; L comprises any suitable linker and/or spacer group; Y comprises at least one arsenoxi... | 03/03/2009 |
| 7462690 | Peptide amidation process The invention provides a process for amidating a desired peptide comprising cleaving a substrate polypeptide at a X1-cysteine sequence, wherein X1 is the amino acid at the peptide carboxyl-terminus and cysteine is the first amino acid of a palladium cleav... | 12/09/2008 |
| 7462689 | Hydrazine-based and carbonyl-based bifunctional crosslinking reagents Reagents and methods are provided for crosslinking and immobilizing biomolecules, drugs and synthetic polymers. The reagents possess (i) a thiol or amino reactive group; and (ii) a hydrazino or oxyamino moiety. Conjugates and immobilized biomolecules are also provid... | 12/09/2008 |
| 7442764 | Reversible modification of amine-containing compounds An process for the reversible modification of an amine-containing compound is described. Modification of the compound can be used to facilitate delivery of molecules to cells in vitro and in vivo or to alter interactions or activities the compounds. The described mo... | 10/28/2008 |
| 7435716 | Compounds pharmaceutical compositions and methods for treatment of bacteremia and/or septicemia Novel conjugates of bacterial outer membrane binding peptides, preferably having bacterial sensitization activity, and immune cells chemotactic peptides, and pharmaceutical compositions containing same useful in the treatment of bacteremia and/or septicemia followin... | 10/14/2008 |
| 7432246 | Sir2 products and activities A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2′-O-acetyl-ADP-ribose, which is the newly discovered product of the reaction of S... | 10/07/2008 |
| 7432240 | Fumaric acid amides Fumaric acid amides of the general formula (I) wherein R1 represents OR3 or a D- or L-amino acid radical —NH—CHR4—COOH bonded via an amide bond, wherein R3 is hydrogen, a st... | 10/07/2008 |
| 7432239 | Polyoxyalkylene compound and method for making A process for forming a conjugate of a polyoxyalkylene polymer, such as polyethylene glycol, with a compound containing an amine group(s) and/or a sulfide group(s) by reacting the compound with an acrylate terminated polyoxyalkylene, such as polyethylene glycol term... | 10/07/2008 |
| 7425541 | Enzyme-cleavable prodrug compounds The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the enzyme Thimet oligopeptidase, or TOP. Also disclosed are m... | 09/16/2008 |
| 7420035 | Purification of polypeptides This invention relates to a process for purifying a polypeptide, a capture tag useful for purifying a polypeptide and a periodate-cleavable amino acid derivative useful for purifying a polypeptide. The polypeptide to be purified comprises a vicinal-amino-thiol, vici... | 09/02/2008 |
| 7408024 | Somatostatin antagonists The present invention is directed to a somatostatin antagonist according to formula (I): A1-cyclo {D-Cys-A2-D-Trp-A3-A4-Cys}-A5Y1, wherein A1 is an optionally substituted aromatic a-amino a... | 08/05/2008 |
| 7408023 | Peptoids incorporating chemoselective functionalities Molecules having potential biological activity, particularly peptoids, that are conjugated to solid phase supports, spacer groups, and/or ligation moieties, and methods of their preparation, are described. In some instances, the molecules of the invention are made e... | 08/05/2008 |
| 7402556 | Prodrugs activated by plasmin and their use in cancer chemotherapy The product of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide having a plasmin peptide substrate of 2-4 amino acids and mono- or di-peptide linkage, a stabilizing group and, optionally, a linker group. The ... | 07/22/2008 |
| 7402652 | Baclofen conjugate and a pharmaceutical composition for treatment of neuronal disorders A compound is provided that has the formula NH2CH2CH2CHR1C(O)N—R (I) where R1 is p-chlorophenyl, R is a moiety capable of crossing the blood brain barrier and is as a free compound se... | 07/22/2008 |
| 7399860 | Manufacture of polyglutamate-therapeutic agent conjugates The invention provides new processes for preparing polyglutamic acid-therapeutic agent conjugates for clinical development and pharmaceutical use, and polyglutamic acid-therapeutic agent conjugates prepared by these processes. ... | 07/15/2008 |
| 7390875 | Method for binding, in solution, a peptide and a lipophilic vector and uses thereof The invention concerns a method for binding, in solution, at least a peptide composition and at least a lipophilic vector bearing an aldehyde function, the coupling comprising a step which consists in producing a hydrazone bond between the peptide compound and the l... | 06/24/2008 |
| 7378489 | Angiotensin derivatives An angiotensin derivative comprising at least one angiotensin peptide moiety coupled to a peptide carrier-binding moiety which can be used for therapy and prophylaxis of conditions associated with the renin activated angiotensin system. ... | 05/27/2008 |
| 7375085 | Melanocyte-stimulating hormone inhibitors In the present specification is disclosed a melanocyte-stimulating hormone inhibitory composition which comprises, as the active ingredient, a di- or tripeptide derivative having a certain naphthyl group or the salts thereof, or a melanocyte-stimulating hormone inhi... | 05/20/2008 |
| 7368425 | Cyclic peptides for modulating growth of neo-vessels and their use in therapeutic angiogenesis The present disclosure teaches analogs of human chemokines and methods of using them in the prevention, treatment, and ameliorization of diseases that can benefit from therapeutic angiogenesis. The teachings are generally directed to compositions comprising SDF-1 mi... | 05/06/2008 |
| 7368431 | Polypeptide, the conjugate thereof with doxorubicine and a pharmaceutical composition based thereon The inventive polypeptide is embodied in the form of a similar fragment of the epidermal growth factor of aminoacid ranging from 21 to 31 and capable of efficiently binding with the receptor of the epidermal growth factor as a vector for the directed supply of antic... | 05/06/2008 |
| 7364889 | Catalytically active peptides A catalytically active peptide comprising an imidazole function in position i flanked by at least one functional group to be amidated in position i+3+4k, where k is an integer equal to or higher than −1 or in position i−4−4n, wherein n is an integer equal to o... | 04/29/2008 |
| 7364849 | Treatment of substrates for immobilizing biomolecules A method of treating a substrate for immobilizing a biomolecule and substrates produced by the method are disclosed. The method includes contacting at least a portion of a substrate with a reducing agent such as a hydride. Treatment with an appropriate reducing agen... | 04/29/2008 |
| 7361731 | Peptide derivatives, and their use for the synthesis of silicon-based composite materials Methods for forming peptide derivatives using functional moieties and peptide derivatives are provided. Further, methods for using peptide derivatives to form silicon-based composite materials and silicon-based composite materials formed thereby are provided. The si... | 04/22/2008 |
| 7358379 | Steroid conjugates, preparation thereof and the use thereof Conjugates comprising one or more steroids conjugated with one or more mammalian proteins are disclosed. The conjugates are useful for diagnosis or treatment of solid cancer and hematological malignancies. Further the conjugates exhibit a synergistic action together... | 04/15/2008 |
| 7351855 | Chemically defined non-polymeric valency platform molecules and conjugates thereof Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide duplexes of at least 20 base pairs that have significant binding activi... | 04/01/2008 |
| 7351797 | Labeled peptides, and processes and intermediates useful for their preparation The invention provides intermediates and methods that allow for site-specific modification of peptides after synthesis. Accordingly, functional molecules can be selectively linked to a peptide to provide a peptide conjugate having altered biological, chemical, or ph... | 04/01/2008 |
| 7351787 | Process for the preparation of activated polyethylene glycols A process for preparing activated polyethylene glycols is disclosed. In some embodiments, the process includes reacting a molten polyethylene glycol with an activator. In other embodiments, the process includes reacting a polyethylene glycol with an activator in the... | 04/01/2008 |
| 7348310 | Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them The invention relates to aplidine derivatives of the general formula: which are useful for the treatment of tumors. ... | 03/25/2008 |
| 7348399 | Nanofabricated polypeptide multilayer films, coatings, and microcapsules Disclosed herein are films, coatings and microcapsules comprising polypeptides. A thin film, for example, comprises a plurality of layers of polypeptides, the layers comprising alternating oppositely charged polypeptides. A first layer comprises a first layer polype... | 03/25/2008 |
| 7344721 | Polypeptide for the treatment of cancer and a method for preparation thereof This invention characterizes the specific peptide fragment derived from specially prepared zinc charged fetuin and a method of preparation thereof, wherein the fragment was found to contain an apoptosis-inducing activity. Specifically, the amino acid sequence of thi... | 03/18/2008 |
