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| Number | Title | Issue Date |
| 8138306 | Separation method The present invention relates to a method of separating a compound from a liquid, which method comprises providing a separation matrix comprising at least one uncharged ligand; providing a liquid wherein the compound to be separated is present in a positively charge... | 03/20/2012 |
| 8124727 | Use of modified metal oxides for enrichment of phosphopeptides Use of modified metal oxides for the purification and enrichment of negatively charged biomolecules such as peptides, proteins, DNA, RNA, Lipids, carbohydrates, glyco molecules. These metal oxides are modified in such a way that the density of the Lewis acid group i... | 02/28/2012 |
| 7951913 | Method of polymyxin B recovery from fermentation broth The invention is related to the method of polymyxine B recovery from fermentation broth for the purpose of pure substance recovery. The invention mentioned above is obtained by using the method of polymyxine B recovery from fermentation broth according invention, wh... | 05/31/2011 |
| 7928191 | Method for purifying bioactive substances A method for purifying bioactive substances includes the steps of: causing a bioactive substance having histidine units to contact media, each constituted by a substrate, ligands which are physically attached to the surface of the substrate, and Cu(II) or Fe(II) met... | 04/19/2011 |
| 7884187 | Analysis of amino acid copolymer compositions Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate prese... | 02/08/2011 |
| 7879976 | Method for stabilizing a protein The invention relates to a method for stabilizing an aqueous protein solution against exogenous stress and to the use of a container for stabilizing an aqueous protein solution. ... | 02/01/2011 |
| 7696313 | Prodrug compounds with isoleucine The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide having an isoleucine residue, a stabilizing group and, optionally, a linker group. The prodrug is clea... | 04/13/2010 |
| 7612166 | Fluorous capping reagents and methods for peptide purification Aspects of the present invention relate to compounds for preparing fluorocarbon compounds, methods for preparing fluorocarbon compounds, and methods for purifying a mixture of compounds. One aspect of the present invention relates to a trivalent iodonium fluorocarbo... | 11/03/2009 |
| 7438917 | Peptide sequences specific for the hepatic stages of bearing epitopes capable of stimulating the T lymphocytes The present invention relates to an in vitro diagnostic method for malaria in an individual comprising placing a tissue or a biological fluid taken from an individual in contact with a molecule or polypeptide composition, wherein said molecule or polypeptide composi... | 10/21/2008 |
| 7427659 | Process for purifying proteins in a hydrophobic interaction chromatography flow-through fraction The present invention is a process for separating a target protein (such as a recombinant protein produced in a cell culture) from a mixture containing the target protein and contaminants (such as cell culture contaminants), by contacting the mixture with a hydropho... | 09/23/2008 |
| 7420035 | Purification of polypeptides This invention relates to a process for purifying a polypeptide, a capture tag useful for purifying a polypeptide and a periodate-cleavable amino acid derivative useful for purifying a polypeptide. The polypeptide to be purified comprises a vicinal-amino-thiol, vici... | 09/02/2008 |
| 7414106 | Synthesis of peptide α-thioesters Disclosed herein is a new method for the solid phase peptide synthesis (SPPS) of C-terminal peptide α thioesters using Fmoc/t-Bu chemistry. This method is based on the use of an aryl hydrazine linker, which is totally stable to conditions required for Fmoc-SPPS. Wh... | 08/19/2008 |
| 7405267 | Method for purifying teicoplanin A Disclosed is a method for purifying teicoplanin A2 comprising: (i) a primary pre-purification step of purifying a filtrate of fermentation broth of a strain using a synthetic adsorbent; (ii) a secondary pre-purification step of purifying the primary pre-p... | 07/29/2008 |
| 7385029 | Method of making tetrapeptide derivative TZT-1027 crystal The invention provides crystals of N2-(N,N-dimethyl-L-valyl)-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl]-1-pyrrolidinyl]-1-[(S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide or salts thereof which p... | 06/10/2008 |
| 7358332 | Bioactive peptides, uses thereof and process for the production of same Novel bioactive peptide compositions and process for producing the same and the use of such compositions for enhancing the growth of warm blooded animals and fish is disclosed. ... | 04/15/2008 |
| 7354996 | Method and kit for quantitative analysis of protein The present invention provides a method for global quantitative analysis of protein that is effectively applied also for unpurified samples such as biological samples, and achieves better detection sensitivity and quantitativeness than the conventional NBS method. A... | 04/08/2008 |
| 7335347 | Methods for purifying radiolabelled compounds One aspect of the present invention relates to a method of purifying radiolabelled compounds comprising a) loading onto a fluorous polymer a radiolabelled compound precursor comprising a fluoroalkyl tin moiety; b) reacting the radiolabelled compound precursor with a... | 02/26/2008 |
| 7335644 | Anti-hypertensive molecules and process for preparation thereof The present invention relates to novel anti-hypertensive molecules. The present invention also provides a process for the preparation of novel antihypertensive molecules. The present invention particularly relates to the preparation of novel Angiotensin Converting E... | 02/26/2008 |
| 7332613 | Capture and release based isotope tagged peptides and methods for using the same The invention provides non-affinity based isotope tagged peptides, chemistries for making these peptides, and methods for using these peptides. In one aspect, tags comprise a reactive site (RS) for reacting with a molecule on a protein to form a stable association w... | 02/19/2008 |
| 7326769 | Method for isolating and purifying grass pollen allergens The invention relates to a method for quickly and effectively isolating and purifying five, namely the group 1, 2, 3, 10 and 13 allergens from grass pollen. The purification of said grass pollen is based on the inventive combination of hydrophobic interaction chroma... | 02/05/2008 |
| 7326682 | Conotoxin peptides The invention relates to an isolated, synthetic or recombinant χ-conotoxin peptide having the ability to inhibit a neuronal amine transporter, nucleic acid molecules encoding all or part of such peptides, antibodies to such peptides and uses and methods of treatmen... | 02/05/2008 |
| 7319002 | Method for purification of viral vectors having proteins which bind sialic acid A method for isolating, from a mixture, a virus having a surface protein with a binding site for sialic acid is provided. The method involves contacting the mixture with mucin which has been linked to a solid support and washing the solid support to remove material ... | 01/15/2008 |
| 7317002 | Site-specific preparation of polyethylene glycol-GRF conjugates A method is described for the site-specific preparation of hGRF-PEG conjugates containing one or more PEG units (per mole of hGRF) covalently bound to Lys12 and/or Lys21 and/or Nα, characterized in that the conjugation reaction betw... | 01/08/2008 |
| 7312195 | Cyclised conotoxin peptides This invention relates to cyclised conotoxin peptides, processes for their preparation and their pharmaceutical use. ... | 12/25/2007 |
| 7294352 | Matrix protein composition for treating inflammation Active enamel substances may be used for the preparation of a pharmaceutical or cosmetic composition for healing of a wound, improving healing of a wound, soft tissue regeneration or repair, or for preventing or treating infection or inflammation. ... | 11/13/2007 |
| 7294614 | Phosphoprotein affinity resins and methods for making and using the same Phosphorylated protein (i.e., phosphoprotein) affinity resins and methods for making and using the same are provided. The subject resins include a substrate bonded to aspartate-based tetradentate ligand/metal ion complexes, where the tetradentate ligand/metal ion co... | 11/13/2007 |
| 7273846 | Selective melanin-concentrating hormone type-1 receptor agonists The present invention features truncated hMCH analogs selectively active at MCH-1R over MCH-2R. Using amino acid numbering provided in hMCH, the featured analogs contain an X6 which is either a D-amino acid, 5-guanidinopropionic acid or its lower or highe... | 09/25/2007 |
| 7268210 | PEG-LHRH analog conjugates PEG-LHRH analog conjugates, where a PEG moiety is covalently bound to a serine residue of a LHRH analog, and methods for producing these conjugates are provided in the present invention. Also provided are a pharmaceutical composition and a method for treating pathol... | 09/11/2007 |
| 7241735 | Pharmacologically active polypeptide glycoconjugates The invention relates to glycopeptidic glycoconjugates, in which the polysaccharide is obtained from Candida utilis cells and the peptides are obtained from Ricinus communis seeds. The glycoconjugates are used in the preparation of immunomodulating dru... | 07/10/2007 |
| 7238671 | Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions The present invention provides novel human glucagon-like peptide-1 (GLP-1) peptide mimics that mimic the biological activity of the native GLP-1 peptide and thus are useful for the treatment or prevention of diseases or disorders associated with GLP activity. Furthe... | 07/03/2007 |
| 7238779 | Acyl CoA:cholesterol acyltransferase (ACAT-2) Nucleic acid compositions encoding novel ACAT proteins, as well as the novel ACAT-2 proteins, (ACAT-2) are provided. Also provided are methods of producing the subject nucleic acid and protein compositions. The subject polypeptide and nucleic acid compositions find ... | 07/03/2007 |
| 7238658 | Crystallization of IGF-1 Crystalline IGF-1 is provided along with a method for production thereof. Crystallizing IGF-1 comprises the steps of mixing an aqueous solution comprising IGF-1 with a reservoir solution comprising a precipitant to form a mixture; and crystallizing the mixture, opti... | 07/03/2007 |
| 7238670 | Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions The present invention provides novel human glucagon-like peptide-1 (GLP-1) peptide mimics that mimic the biological activity of the native GLP-1 peptide and thus are useful for the treatment or prevention of diseases or disorders associated with GLP activity. Furthe... | 07/03/2007 |
| 7235376 | Gastrin hormone immunoassays The invention provides assay methods for the detection and quantitation of gastrin hormones, including total and free gastrin hormone in a sample. ELISA-type heterogeneous phase assays suitable for use with biological fluid samples such as blood, plasma or other bod... | 06/26/2007 |
| 7232796 | Medicament containing a tissue inhibitor of metalloproteinases-2 (TIMP-2) as an osteoanabolically active substance The invention relates to tissue inhibitor of metalloproteinase-2 (TIMP-2) as an osteoanabolically active peptide for use as a medicament for treating bone defects, bone diseases and for improving bone regeneration. ... | 06/19/2007 |
| 7229500 | Methods and devices for high throughput crystallization Crystallization Photoresist (PR) apparatus and methods which allow for fast screening and determination of protein crystallization conditions with small protein quantities and rapid crystallization. The apparatus comprise a first region comprising a first nucleation... | 06/12/2007 |
| 7223845 | Synthetic glycosulfopeptides and methods of synthesis thereof A new class of synthetic glycosulfopeptides (GSPs) which have one or more sulfated tyrosine residues and a glycan linked to the peptide, the glycan preferably including a sialyl Lewisx group or a sialyl Lewisa group. In a preferred version the ... | 05/29/2007 |
| 7220720 | Melanin-concentrating hormone analogs The present invention features truncated MCH analogs active at the MCH receptor. The truncated MCH analogs are optionally modified peptide derivatives of mammalian MCH. The analogs can bind to the MCH receptor and, preferably, bring about signal transduction. MCH an... | 05/22/2007 |
| 7217784 | VP1 of foot-and-mouth disease virus A pure, water-soluble polypeptide containing one or more monomers of a VP1 protein of a foot-and-mouth disease virus; or a pure, water-insoluble polypeptide comprising two or more monomers of a VP1 protein of a foot-and-mouth disease virus. Also disclosed are a vacc... | 05/15/2007 |
| 7211663 | Synthesis of oligosaccharides, reagents and methods related thereto One aspect of the present invention relates to differentially protected glycosyl phosphates. Another aspect of the present invention relates to the preparation of glycosyl phosphates from glycal precursors. In another aspect of the present invention, glycosyl phosph... | 05/01/2007 |
