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| Number | Title | Issue Date |
| 7163918 | Iodothyronine compositions The present invention relates to compositions comprising thyroxine (T4) and triiodothyronine (T3). More specifically, the invention relates to thyroxine (T4) and triiodothyronine (T3) compositions that include a peptide carrier and thyroxine (T4) and triiodothyronin... | 01/16/2007 |
| 7060708 | Active agent delivery systems and methods for protecting and administering active agents The present invention relates to active agent delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to active agents and methods for administering conjugated active agent compositions... | 06/13/2006 |
| 6916642 | Vertebrate telomerase genes and proteins and uses thereof Nucleic acid molecules encoding vertebrate telomerase are provided. Gene products, expression vectors and host cells suitable for expressing telomerase are also provided. Methods for identifying inhibitors of telomerase activity and inhibitor compositions are disclo... | 07/12/2005 |
| 6448378 | Compound delivery using rapidly dissolving collagen film Disclosed herein are collagen films which rapidly dissolve at 35° C. Also disclosed are methods for the preparation of the collagen films and their use as a vehicle for delivering a dose of therapeutic compound to a specific tissue site.... | 09/10/2002 |
| 6376649 | Methods for the synthesis of - hydroxy-ଲ-amino acid and amide derivatives Methods for the synthesis of -hydroxy-ଲ-amino acid and amide derivatives and -ketoamide derivatives and novel derivatives made by these methods are provided. These methods involve reacting a N-terminally blocked (protected) aminoaldehy... | 04/23/2002 |
| 6254986 | Peracylated protein-based sutures and fabrics and process for making the same A method for modifying a protein or polypeptide is disclosed which includes the steps of dispersing a protein or polypeptide in an essentially non-aqueous medium and peracylating the protein or polypeptide with a cyclic anhydride having a carbon chain sub... | 07/03/2001 |
| 6162895 | Peracylated insulin compositions and process for making the same A method for modifying a protein or polypeptide is disclosed which includes the steps of dispersing a protein or polypeptide in an essentially non-aqueous medium and peracylating the protein or polypeptide with a cyclic anhydride having a carbon chain sub... | 12/19/2000 |
| 5986050 | Peracylated proteins and synthetic polypeptides and process for making the same A method for modifying a protein or polypeptide is disclosed which includes the steps of dispersing a protein or polypeptide in an essentially non-aqueous medium and peracylating the protein or polypeptide with a cyclic anhydride having a carbon chain sub... | 11/16/1999 |
| 5962502 | Polyamidic acid derivatives with antigastrin activity, a method for their preparation, and their pharmaceutical use Derivatives of glutamic and aspartic of formula (I) are described ##STR1## where the compounds are potent receptor antagonists of gastrin at the peripheral level and of cholecystokinin at the level of the central nervous system.... | 10/05/1999 |
| 5786447 | Opioid peptide analogs Compounds of the formula I as well as methods for their preparation, their pharmaceutical preparations and their use as analgesics. ##STR1##... | 07/28/1998 |
| 5652336 | Polymer-bound mixed carboxylic anhydrides as a stable form of activated carboxylic acids Polymer-bound mixed carboxylic anhydrides can be prepared under mild conditions by the condensation of carboxylic acids (including N-protected amino acids) with polymer-bound acid chlorides. These mixed anhydrides function as polymeric reagents in the sen... | 07/29/1997 |
| 5521097 | Method of determining amino acid sequence of protein or peptide from carboxy-terminal A protein or peptide is treated by a vapor containing an organic acid represented by the following general formula CF3 --(CF2)n--COOH (n is zero or more integer). The resulting reaction mixture is processed by a mass spectrometer to ... | 05/28/1996 |
| 5516892 | Polymer-bound mixed carboxylic anhdrides as a stable form of activated carboxylic acids Polymer-bound mixed carboxylic anhydrides can be prepared under mild conditions by the condensation of carboxylic acids (including N-protected amino acids) with polymer-bound acid chlorides. These mixed anhydrides function as polymeric reagents in the sen... | 05/14/1996 |
| 5306781 | Carboxylic acid modified polyethylene membrane activated by a linker coupled amide Activated carboxylic acid modified polyethylene membranes useful in the C-terminal sequencing of a peptide are disclosed. The membranes comprise activated carboxylic acid modified polyethylene having a linker coupled to an amide linkage to the surface car... | 04/26/1994 |
| 5087616 | Cytotoxic drug conjugates and their delivery to tumor cells A therapeutic composition comprising a chemical conjugatge including a first moiety, other than an immunoglobulin or fragment thereof, such as epidermal growth factor, which preferentially binds to a tumor cell, and is internalized by the cell, and a seco... | 02/11/1992 |
| 5068351 | Process for the preparation of n octahydropenta (6) pyrrole carboxylates The invention relates to a process for the preparation of compounds of the formula I ##STR1## in which n is 1 or 2, R denotes hydrogen or an organic radical, R1 denotes an organic radical, R2 and R3 are identical or d... | 11/26/1991 |
| 5055591 | Process for the preparation of octahydropenta(b)pyrrole carboxylates The invention relates to a process for the preparation of compounds of the formula I ##STR1## in which n is 1 or 2, R denotes hydrogen or an organic radical, R1 denotes an organic radical, R2 and R3 are identical or d... | 10/08/1991 |
| 4510083 | Process for preparing polypeptides A process for producing polypeptides is disclosed wherein potassium, rubidium, or cesium serves as the counterion for both the carbonate buffer system and the amino acid or peptide salts employed.... | 04/09/1985 |
| 4487715 | Method of conjugating oligopeptides Novel methods are provided for preparing peptide compounds involving functionalizing an available amino group with a carboxy group, esterifying the carboxy group with an hydroxylic compound which forms an ester which is stable under the conditions of clea... | 12/11/1984 |
| 4363759 | Chemiluminescent-labeled haptens and antigens Chemiluminescent-labeled conjugates of the formula: ##STR1## wherein one of R1 and R2 is hydrogen and the other is -NR3 R4 ; R3 is hydrogen or straight chain alkyl containing 1-4 carbon atoms and... | 12/14/1982 |
| 4351762 | Rapid, quantitative peptide synthesis using mixed anhydrides In the synthesis of a polypeptide chain wherein an N -urethane-protected amino acid mixed anhydride is coupled with an amino-unprotected second amino acid, the improvement comprising conducting said coupling at room temperature or above.... | 09/28/1982 |
| 4331592 | Process for the preparation of carboxylic acid amides and peptides What is disclosed is a method of making a carboxylic acid amide, including a peptide, by reacting a compound having a free amino group with a compound having a free carboxy group in the presence of an anhydride of an alkane-phosphonic acid.... | 05/25/1982 |
| 4267344 | N-Substituted N-carboxyanhydrides of -amino acids and their application in the preparation of peptides N-Substituted N-carboxyanhydrides of -amino acids, useful in peptide syntheses, and peptide synthesis process using such compounds, are disclosed. The N-substituent is penta(lower alkoxy)benzyl, or optionally substituted 9-xanthyl, 9-thioxanthyl or... | 05/12/1981 |
| 4126628 | Acylation of amino acids N-mono-substituted derivatives of diamino acids are prepared by the reaction of succinimidyl esters of carboxylic acids or substituted carbonic acids with the unprotected diamino acid. The acylation preferentially occurs at the side chain or terminal amin... | 11/21/1978 |
| 3985722 | Process for preparing N-higher aliphatic acyl derivatives of amino acids, peptides or proteins A mixed acid anhydride consisting of higher fatty acid having 6 to 22 carbon atoms and sulfuric anhydride is reacted with amino acids, peptides or proteins in the presence of a base to form N-higher aliphatic acyl derivatives of amino acids, peptides or p... | 10/12/1976 |
| 3951741 | Process and apparatus for the synthesis of peptides by use of n-carboxyanhydrides Method and apparatus are provided for preparing polypeptides by conjugating arginine as an end group to a polyethyleneimine water soluble polymer, stepwise addition of amino acids as their N-carboxyanhydrides to prepare the desired polypeptide, enzymatic ... | 04/20/1976 |
| 3941823 | Method for producing isonitrosomalonic esters Isonitrosomalonic acid esters, which are useful as a starting material for synthesizing sweet peptides and other chemicals, are prepared by allowing a nitrosating agent to act on a corresponding alkyl alkoxycarbonyl acetoimidate.... | 03/02/1976 |
