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| Number | Title | Issue Date |
| 7364889 | Catalytically active peptides A catalytically active peptide comprising an imidazole function in position i flanked by at least one functional group to be amidated in position i+3+4k, where k is an integer equal to or higher than ā1 or in position iā4ā4n, wherein n is an integer equal to o... | 04/29/2008 |
| 7229835 | Amine detection method and materials A compound linked to a solid support (R) through a divalent linker moiety (X) and which is represented by the following formula: is disclosed. In particular, the 1-hydroxybenzotriazole-6-carboxylic acid is direct... | 06/12/2007 |
| 6750312 | Process for the preparation of supports for solid phase synthesis A method for preparing a solid support material for carrying out a chemical reaction, said method comprising the following steps: (i) reacting an amino functionalised solid material with a carboxylic acid having at least two similarly protected amino groups t... | 06/15/2004 |
| 6204361 | Method of peptide synthesis The present invention relates to a process for forming an N--amino protected amino acid fluoride in situ by reacting an N--amino protected amino acid with an ionic fluoride salt in the presence of a peptide coupling agent. It is also directe... | 03/20/2001 |
| 5807748 | N-terminal protein sequencing reagents and methods which form amino acid detectable by a variety of techniques Novel alkoxythiocarbonylimidazoles provide new reagents for the N-terminal sequencing of small polypeptide samples. These reagents form an alkoxy thiourea derivative which is cleaved with acid to remove the N-terminal amino acid as a stable thiazolinone w... | 09/15/1998 |
| 5773575 | Process for peptide segment condensation The present invention is drawn to a process for forming an amide bond linkage comprising reacting a carboxylic acid and an amine in a two-phase mixture of water and an organic solvent selected from an oxygenated organic solvent or an aromatic solvent in t... | 06/30/1998 |
| 5750649 | Process for producing amides using catalytic amounts of an N-hydroxy compound A process is disclosed for the manufacture of amides, including peptides, in which a carboxylic acid is reacted with a primary or secondary amine in the presence of a carbodiimide and a catalytic amount of N-hydroxy compound.... | 05/12/1998 |
| 5644028 | Process for producing peptide derivatives and salts therefor A process for producing peptide derivatives of formula (1) or salts thereof: ##STR1## which comprises condensation of peptide derivative of formula (2): ##STR2## with carboxylic acid of formula (3): ##STR3## or condensation of a peptid... | 07/01/1997 |
| 5644029 | Reagents for peptide couplings This invention relates to a process for forming an amide or an ester from a reaction between an amine or an alcohol, respectively and an acylating derivative of a carboxylic acid, in the presence of an effective amount of a compound having the formula: ... | 07/01/1997 |
| 5536816 | Process for producing amides using catalytic amounts of an N-hydroxy compound A process for the manufacture of amides, including peptides, by reacting a carboxylic acid with a primary or secondary amine in the presence of a carbodiimide and a catalytic amount of a N-hydroxy compound.... | 07/16/1996 |
| 5516891 | Liquid phase synthesis of peptides and peptide derivatives A liquid phase peptide synthetic method which uses (1) Fmoc as the protecting group for the non-side chain amino functionality, (2) ammonia, a primary or secondary amine to remove the Fmoc protecting group, and (3) substituted carbodiimide as the coupling... | 05/14/1996 |
| 5502165 | Process for peptide segment condensation The present invention is drawn to a process for forming an amide bond linkage comprising reacting a carboxylic acid and an amine in a two-phase mixture of water and an organic solvent selected from an oxygenated organic solvent or an aromatic solvent in t... | 03/26/1996 |
| 5306781 | Carboxylic acid modified polyethylene membrane activated by a linker coupled amide Activated carboxylic acid modified polyethylene membranes useful in the C-terminal sequencing of a peptide are disclosed. The membranes comprise activated carboxylic acid modified polyethylene having a linker coupled to an amide linkage to the surface car... | 04/26/1994 |
| 5250664 | Process for tanning protein substances, in particular vegetable protein substances such as the proteins of oil seeds and tanned protein substances obtained using this process Process for tanning a protein substance, in particular one of vegetable oin, such as oil seed proteins, characterized in that it includes treating the said protein substance with a dithiocarbamate type compound, partially degraded by a strong acid.... | 10/05/1993 |
| 4888415 | Gelonin immunotoxin Immunotoxins having improved toxic activity have the composition ##STR1## wherein Toxin-NH is a ribosome-inactivating protein containing no accessible sulfhydryl groups, n is an integer from 1 to 5, m is an integer from 1 to 5, and NH-Antibody is a m... | 12/19/1989 |
| 4442029 | Process for the preparation of acid amides and application of the process A process for the preparation of acid amides, comprising reacting a carboxylic acid and an amine in the presence of an isonitrile, wherein the isonitrile has at least one hetero-atom in the substituent present in the above-mentioned isonitrile group. The ... | 04/10/1984 |
| 4371515 | Method for forming an isolated lectin-immunological conjugate A lectin is covalently bonded to an immunological conjugate such as an antibody-antigen or its equivalent. Then, the lectin-conjugate is isolated from the reaction product mixture by one of a number of alternative techniques involving one or more of the f... | 02/01/1983 |
| 4341707 | Imido carbonate compound, production thereof and uses thereof as reagent for forming active ester of amino acids A new carbonate compound which is N,N'-di-succinimidyl carbonate, N,N'-diphthalimidyl carbonate or N,N'-bis(5-norbornene-2,3-dicarboxyimidyl) carbonate is produced by reacting an N-hydroxy compound of the formula wherein R is succinimido, phthalimido or 5... | 07/27/1982 |
| 4336188 | Method for the preparation of macromolecularized adenine derivatives A method is disclosed for preparing functionalized adenine derivatives, said method comprising the step of reacting a compound which contains an adenine nucleus which has been halogen substituted in the 8-position, with a compound having the general formu... | 06/22/1982 |
| 4250086 | Method and composition for preparation of H-SAR-LYS-SAR-GLN-NH2 A method for solution synthesis of H-SAR-LYS-SAR-GLN-NH2 in good yield and compositions useful therein are disclosed.... | 02/10/1981 |
| 4242507 | Sulfonic acid esters A novel process for the amidation or esterification which comprises reacting a compound having a carboxy group with a compound having an amino or imino group which can be acylated or with a compound having a hydroxy group in the presence of a sulfonic aci... | 12/30/1980 |
| 4215037 | Partially protected human insulin-A-chain and process for its manufacture Partially protected human insulin-A-chain suitable as intermediate for insulin synthesis and process for its manufacture by reacting the partially protected peptide fragment 6 to 26 of the insulin-A-chain with the peptide fragment 1 to 5 containing an N-t... | 07/29/1980 |
| 4093609 | Somatostatin synthesis A mixed solid phase-solution phase synthesis for somatostatin which combines the speed of conventional solid phase synthesis with the advantage of solution phase isolation and purification techniques.... | 06/06/1978 |
| 3960829 | Process for acylation of amino, imino and hydroxyl groups using pyrimidine derivatives Pyrimidine derivatives represented by the formula, ##SPC1## Wherein R1 and R2 are individually a hydrogen atom or a methyl group, and R3 is a group formed by removing the carboxyl group from a carboxylic acid, are quite us... | 06/01/1976 |
| 3933783 | Formation of peptide bonds in the presence of isonitriles Amino acids having masked amino groups react with amino acids having masked carboxyl groups to form peptide derivatives in good yields if the reaction medium contains an isonitrile. Isonitriles also are effective in causing condensation of amino acids hav... | 01/20/1976 |
| 3931138 | N-carbobenzoxy-pyroglutamyl-histidine A method for making N-carbobenzoxy-pGlu-His which is an important intermediate for the manufacture of several releasing hormones. The new product is made by a rapid method which produces good yields and good quality dipeptide material.... | 01/06/1976 |
