Bizarre Patents
Mouthguard made at least partially from an edible candy
A mouthguard includes a U-shaped upper bite plate which removably fits over upper teeth of a person, with the entire upper bite plate being made from a soft, deformable and edible gummi candy.
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| Number | Title | Issue Date |
| 7674881 | Convergent synthesis of proteins by kinetically controlled ligation The present invention concerns methods and compositions for synthesizing a polypeptide using kinetically controlled reactions involving fragments of the polypeptide for a fully convergent process. In more specific embodiments, a ligation involves reacting a first pe... | 03/09/2010 |
| 7622552 | Ligation method A method of ligating two or more molecules, for example, peptides to peptides or peptides to labels is provided. The method may comprise the steps: a) providing a first oligopeptide having a reactive moiety, which is a hydrazine moiety, a hydrazide moiety or an amin... | 11/24/2009 |
| 7408026 | Synthesis of proteins by native chemical ligation Proteins of moderate size having native peptide backbones are produced by a method of native chemical ligation. Native chemical ligation employs a chemoselective reaction of two unprotected peptide segments to produce a transient thioester-linked intermediate. The t... | 08/05/2008 |
| 7262275 | Polypeptide and process for producing the same The invention provides for a polypeptide, which is useful as a biomaterial and free from infection. The polypeptide comprises a peptide unit of formula (1), and optionally one or more units of formulae (2) to (3): (1) [—(OC—(CH2)m—CO) | 08/28/2007 |
| 7256259 | Methods for ligation of molecules to surfaces The present invention is a method for a covalent ligation of one or more molecules to one or more surfaces, that is site-specific and both rapid and high yielding. The covalent ligation to the surface is based on the reaction of an azide and a phosphinothioester to ... | 08/14/2007 |
| 7247614 | Composition and method for modulating somatolactogenic function A human prolactin-binding protein and compositions and methods using this protein are provided. ... | 07/24/2007 |
| 7214768 | Echinocandin process This invention relates to an improved process for the minimization of acid-catalyzed reactions of certain echinocandins of the kind disclosed in U.S. Pat. No. 5,378,804. The process involves the use of a boronic acid. ... | 05/08/2007 |
| 7129327 | Polypeptide and protein derivatives and process for their preparation Protein and polypeptid derivatives and their salts are claimed characterized in that a protein or polypeptide is conjugated via an intermediate grouping containing at least one radical of the formula —C(R)═N— (or —N═C(R)—) or —CH(R)—NH— (or —NH... | 10/31/2006 |
| 7094871 | Solid phase native chemical ligation of unprotected or N-terminal cysteine protected peptides in aqueous solution The present invention provides methods, apparatus and kits for synthesizing assembled peptides and proteins on a solid phase with sequential ligation of three or more unprotected peptide segments using chemoselective and mild ligation chemistries in aqueous solution... | 08/22/2006 |
| 7084110 | Dolastatin 15 derivatives Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L, (I) and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and ... | 08/01/2006 |
| 7045592 | Processes for coupling amino acids using bis-(trichloromethyl) carbonate A process is disclosed for using bis-(trichloromethyl)carbonate (triphosgene), diphosgene or phosgene as efficient and effective coupling reagents during coupling of carbohydrates to peptide chains. This process is particularly useful for the coupling to sterically ... | 05/16/2006 |
| 7029846 | Site-specific protein modification Site-specific modified proteins and method for producing site-specific modified proteins using amino acid analogs are disclosed. Methods for labeling proteins at a desired site in the presence of nucleophilic side chains, including lysine and cysteine side chains, a... | 04/18/2006 |
| 7030217 | Solid phase native chemical ligation of unprotected or N-terminal cysteine protected peptides in aqueous solution The present invention provides methods, apparatus and kits for synthesizing assembled peptides and proteins on a solid phase with sequential ligation of three or more unprotected peptide segments using chemoselective and mild ligation chemistries in aqueous solution... | 04/18/2006 |
| 7030218 | Pseudo native chemical ligation The present invention concerns methods and compositions for extending the technique of native chemical ligation of a wider range of peptides, polypeptides, other polymers and other molecules via an amide bond (see FIG. 1). The invention further provides metho... | 04/18/2006 |
| 7001745 | Intein mediated peptide ligation The present invention provides methods that utilize compositions containing colostrinin, an constituent peptide thereof, an active analog thereof, and combinations thereof, as an oxidative stress regulator. ... | 02/21/2006 |
| 6972320 | Ligation method and reagents to form an amide bond Methods and reagents for the formation of amide bonds between an activated carboxylic acid derivative and an azide useful in the synthesis of peptides, proteins and derivatized or labeled amino acids, peptide or proteins. The method involves the formation of a phosp... | 12/06/2005 |
| 6939946 | Ring modified cyclic peptide analogs A method for modifying the cyclic peptide ring system of Echinocandin-type compounds to produce new analogs having antifungal activity is provided. The inventive process comprises opening the cyclic peptide ring, cleaving the terminal ornithine unit, inserting at le... | 09/06/2005 |
| 6849710 | Method for the synthesis of analogs of parathyroid hormone and parathyroid hormone related peptide A fragment condensation process for the synthesis of analogs of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP), in which amino acid residues (22-31) form a synthetic amphipathic α-helix, is provided. ... | 02/01/2005 |
| 6822074 | Process for the preparation of cyclo(Asp-DPhe-NMeVal-Arg-Gly) Process for the preparation of the cyclic pentapeptide cyclo(Arg-Gly-Asp-DPhe-NMeVal) by cyclization of a linear pentapeptide selected from the group consisting of H-Arg(Pbf)-Gly-Asp(OBzl)-DPhe-NMeVal-OH... | 11/23/2004 |
| 6528324 | Apparatus for pre-determined mass sorting of positional-encoded solid phase synthesis supports A system for producing a library of oligomer comprising at least two monomers in a positionally determined array comprise a plurality of synthesis supports, a first plurality of support carriers wherein each carrier has a uniform array of distinct support... | 03/04/2003 |
| 6476190 | Process for preparing modified proteins Processes for the preparation of modified proteins comprising the coupling of a first peptide segment having a haloacyl group at the N-terminus thereof with a second peptide sequent having a carbonylthiol group at the C-terminus thereof are disclosed. Nov... | 11/05/2002 |
| 6380156 | Total synthesis of the amino hip analogue of didemnin A Disclosed is a synthetic method for the preparation of analogs of Didemnin A (1), particularly the Amino-Hip analog of Didemnin A, also known as "AipDidemnin A" (8). These compounds have the following structures: ##STR1##... | 04/30/2002 |
| 6326468 | Solid phase native chemical ligation of unprotected or n-terminal cysteine protected peptides in aqueous solution The present invention provides methods, apparatus and kits for synthesizing assembled peptides and proteins on a solid phase with sequential ligation of three or more unprotected peptide segments using chemoselective and mild ligation chemistries in aqueo... | 12/04/2001 |
| 6316593 | Synthesis of VIP analog This invention relates to a novel process for the synthesis of vasoactive intestinal peptide analog Ac(1-31)-NH2 from four protected peptide fragments.... | 11/13/2001 |
| 6310180 | Method for synthesis of proteins A method for peptide synthesis is disclosed that requires neither protecting groups nor activation of the C- carboxyl groups. The method comprises ligating a first molecule to a second molecule by promoting the orthogonal coupling of the molecules ... | 10/30/2001 |
| 6307018 | General chemical ligation Disclosed herein is a process whereby oligopeptides are ligated to form ligation peptide products. In the first step, two starting oligopeptides are ligated to form an intermediate having an amino-thioester linkage. In the second step, the aminothioester ... | 10/23/2001 |
| 6277958 | Method for preparing peptide thiol ester The present invention provides a method for producing a peptide thiol ester using fluoren-9-ylmethoxycarbonylamino acid (Fmoc-amino acid). The method is for peptide synthesis and involves (1) using and removing the Fmoc group bound as the protective group... | 08/21/2001 |
| 6277957 | Method for production of acylthio derivatives A method is provided which facilitates and enables the production of a wide range of complex conjugates composed of similar or dissimilar units linked together by amide bonds. Said method for the production of acylthio derivatives, R'--CO--SA, involves re... | 08/21/2001 |
| 6242565 | Method for preparing a peptide derivative, and intermediates for the preparation of the peptide derivative, and method for preparing the intermediates A method for preparing a peptide derivative of formula (I) or a salt thereof: ##STR1## which method comprises the steps of removing two MBzl groups from a compound of formula (II) or a salt thereof: ##STR2## wherein MBzl represents a 4-methoxybenzyl ... | 06/05/2001 |
| 6231850 | Canine interleukin 12 Canine interleukin 12 and a method for producing it by genetic engineering are disclosed. The canine interleukin 12 includes a protein having an amino acid sequence substantially the same as SEQ ID NO:1 or SEQ ID NO:11 or corresponds to part of either of ... | 05/15/2001 |
| 6204361 | Method of peptide synthesis The present invention relates to a process for forming an N--amino protected amino acid fluoride in situ by reacting an N--amino protected amino acid with an ionic fluoride salt in the presence of a peptide coupling agent. It is also directe... | 03/20/2001 |
| 6184344 | Synthesis of proteins by native chemical ligation Proteins of moderate size having native peptide backbones are produced by a method of native chemical ligation. Native chemical ligation employs a chemoselective reaction of two unprotected peptide segments to produce a transient thioester-linked intermed... | 02/06/2001 |
| 6015881 | Methods and compositions for peptide synthesis The present invention relates, first, to methods for the synthesis of peptides, in particular T-20 (also referred to as "DP-178"; SEQ ID NO:1) and T-20-like peptides. Such methods utilize solid and liquid phase synthesis procedures to synthesize and combi... | 01/18/2000 |
| 6013764 | Liquid phase peptide synthesis of KL-4 pulmonary surfactant The invention relates to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu4)4 -Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process... | 01/11/2000 |
| 5977302 | Liquid phase process for the preparation of GnRH peptides A liquid phase process for preparing GnRH peptide analogs of the formula: G-AA1 -(A)D-Phe-AA3 -AA4 -(R2)-AA5 -AA6 AA7 -AA8 -Pro-AA10 -NH2 Formula 1 which c... | 11/02/1999 |
| 5958702 | Receptor-assisted combinatorial chemistry This invention provides a method for preparing molecules that bind to a preselected receptor, whereby the receptor itself acts as an agent for either joining two ligand fragments to form a composite, tight binding ligand, or selects a composite ligand fro... | 09/28/1999 |
| 5948754 | Cyclic hexapeptides, their production and use A cyclic hexapeptide represented by the formula: cycloA--Asp(R1)--Y--NH--CHR2 --CO--C--D--Trp(Nin --R3)--! (I) wherein A is a D-acidic--amino acid residue; Y is an ... | 09/07/1999 |
| 5891993 | Template assembled synthetic protein Disclosed herein are template assembled synthetic protein (TASP) molecules that contain dendritic linkage units having the structure .psi. (CO--S--CH2 --CO--NH). Also disclosed are methods of preparing the template assembled synthetic proteins.... | 04/06/1999 |
| 5830985 | Preparation of polyaspartic acid A process for preparing polyaspartic acid by polycondensation of fine-particle aspartic acid at temperatures above 150° C. in the presence of acidic catalysts, wherein first contact between the acidic catalysts and the fine-particle aspartic acid takes p... | 11/03/1998 |
| 5817749 | Processes and intermediate compounds for the preparation of platelet glycoprotein IIb/IIIa inhibitors This invention provides processes for the synthesis of platelet glycoprotein IIb/IIIa inhibitors and intermediate compounds useful in said processes. The compounds afforded by this invention have the formula: ##STR1##... | 10/06/1998 |
