Bizarre Patents
Process For Propelling Foodstuffs or the Like into a Crowd
A method of launching foodstuffs into a crowd for promotional and entertainment purposes.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 6534627 | Synthesis and use of amino acid fluorides as peptide coupling reagents The present invention is directed to the process of preparing a peptide comprising reacting a first amino acid or peptide with an amino acid fluoride of the formula: ##STR1## or the acid fluoride salts thereof wherein BLK is an N-amino protecting group; A... | 03/18/2003 |
| 6528485 | Site-specific preparation of polyethylene glycol-grf conjugates Described are various human growth hormone releasing factor-PEG conjugates as well as their pharmaceutical use.... | 03/04/2003 |
| 6521744 | 2- or 3-dimensional geometric structures Nucleic acid analogs provide a particularly useful tool for the preparation of complex polymeric structures of defined geometry because they are relatively stable to reaction conditions for the preparation of such structures and provide the opportunity to... | 02/18/2003 |
| 6506577 | Synthesis and crosslinking of catechol containing copolypeptides The synthesis of moisture-resistant adhesive polypeptides, conditions for their use, and conditions for controlling characteristics of the crosslinked matrix are disclosed. By specifically manipulating the conditions under which these networks are formed,... | 01/14/2003 |
| 6492491 | Method of making hypusine peptides The invention relates to novel peptides synthesized according a method utilizing the hypusine reagent: ##STR1## wherein: Q1 Q2 and Q3 may be the same or different and are amino protective groups, provided that Q3 | 12/10/2002 |
| 6451972 | Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors Compounds of formula (I) ##STR1## where n is the number 0, 1 or 2, processes for the preparation together with methods for treating pathologies related to an altered vଲ.sub.3 integrin-mediated cell attachment, in particular wh... | 09/17/2002 |
| 6433135 | PEG-LHRH analog conjugates PEG-LHRH analog conjugates, where a PEG moiety is covalently bound to a serine residue of a LHRH analog either directly or via a bifunctional linker molecule, such as an amino acid, and methods for producing these conjugates are provided in the present in... | 08/13/2002 |
| 6380156 | Total synthesis of the amino hip analogue of didemnin A Disclosed is a synthetic method for the preparation of analogs of Didemnin A (1), particularly the Amino-Hip analog of Didemnin A, also known as "AipDidemnin A" (8). These compounds have the following structures: ##STR1##... | 04/30/2002 |
| 6380358 | Guanidinylation reagents Trisubstituted N-protected guanidines and methods for use as guanidinylating reagents to yield N-protected guanidine derivatives.... | 04/30/2002 |
| 6369194 | Vicinyl tricarbonyl compounds and combinatorial libraries containing same The invention relates to compounds of formula ##STR1## where R is a structural diversity element selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, peptidyl, heteroatom-substituted alkyl, cycloalkyl, and amines; and Nu is a st... | 04/09/2002 |
| 6346601 | Procedure for obtaining the somatostatin analog, octreotide A procedure for obtaining the somatostatin analog, octreotide by means of solid phase synthesis on polymer supports and by intervention of protector groups of the Fmoc/tBu type. It includes construction of the seven amino acid, Boc-D-Phe-Cys(Trt)-Phe-D-Tr... | 02/12/2002 |
| 6342582 | Reaction and dissolving medium for peptides and synthesis method using this medium The present invention relates to a reaction and dissolving medium for the synthesis of peptides. This reaction and dissolving medium for peptide synthesis and/or purification comprises a diluent A chosen from a group of water-immiscible solvents and a phe... | 01/29/2002 |
| 6316595 | PNA synthesis using a base-labile amino protecting group The invention provides compounds and processes for synthesis of peptide nucleic acids (PNA). The compounds include temporary amino protecting groups that are base-labile, and protection groups for the exocyclic amino function of the nucleotide base that i... | 11/13/2001 |
| 6316593 | Synthesis of VIP analog This invention relates to a novel process for the synthesis of vasoactive intestinal peptide analog Ac(1-31)-NH2 from four protected peptide fragments.... | 11/13/2001 |
| 6310179 | 2-or 3-dimensional geometric structures Nucleic acid analogues provide a particularly useful tool for the preparation of complex polymeric structures of defined geometry because they are relatively stable to reaction conditions for the preparation of such structures and provide the opportunity ... | 10/30/2001 |
| 6307018 | General chemical ligation Disclosed herein is a process whereby oligopeptides are ligated to form ligation peptide products. In the first step, two starting oligopeptides are ligated to form an intermediate having an amino-thioester linkage. In the second step, the aminothioester ... | 10/23/2001 |
| 6277957 | Method for production of acylthio derivatives A method is provided which facilitates and enables the production of a wide range of complex conjugates composed of similar or dissimilar units linked together by amide bonds. Said method for the production of acylthio derivatives, R'--CO--SA, involves re... | 08/21/2001 |
| 6262251 | Method for solution phase synthesis of oligonucleotides This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture of oligonucleotides with high efficiency.... | 07/17/2001 |
| 6242565 | Method for preparing a peptide derivative, and intermediates for the preparation of the peptide derivative, and method for preparing the intermediates A method for preparing a peptide derivative of formula (I) or a salt thereof: ##STR1## which method comprises the steps of removing two MBzl groups from a compound of formula (II) or a salt thereof: ##STR2## wherein MBzl represents a 4-methoxybenzyl ... | 06/05/2001 |
| 6222013 | Process for esterification of amino A process is disclosed for the esterification of an amino acid or peptide in which the amino acid or peptide is converted into the corresponding ester in the presence of a hydrosulphate have the general formula ROSO3 H, where R represents an al... | 04/24/2001 |
| 6210936 | Enzyme-catalyzed modifications of macromolecules in organic solvents Protease enzyme from Bacillus subtilis and Bacillus sp. Catalyzes the acylation of organic solvent-insoluble macromolecules in isooctane solution containing vinyl esters of fatty acids, lactones or lactides as acyl donors. The reaction occurs only when th... | 04/03/2001 |
| 6204361 | Method of peptide synthesis The present invention relates to a process for forming an N--amino protected amino acid fluoride in situ by reacting an N--amino protected amino acid with an ionic fluoride salt in the presence of a peptide coupling agent. It is also directe... | 03/20/2001 |
| 6180759 | Process for the preparation of azacycloalkylakanoyl pseudotetrapeptides This invention is directed to a process for preparing a pseudotetrapeptide of formula I ##STR1## or a salt or prodrug thereof wherein ##STR2## is optionally nitrogen protected azaheterocyclyl; ##STR3## is a single or double bond; q is 1-5; B is alkyl... | 01/30/2001 |
| 6132953 | Combinatorial synthesis on soluble polyvalent supports having a discrete architecture The present invention is directed to the use of a soluble polyvalent support for the preparation of combinatorial libraries of compounds. The resultant combinatorial libraries are useful in screening for biologically active moieties in the drug discovery ... | 10/17/2000 |
| 6130315 | Peptidase inhibitors This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide... | 10/10/2000 |
| 6126916 | Radiometal-binding peptide analogues Novel metal binding ligands are disclosed that may be coupled to peptides for use in methods of diagnosis and therapy. Peptides containing the ligands are produced using a method wherein ligand introduction or cyclization can be conducted at any point dur... | 10/03/2000 |
| 6121417 | Inhibitors of retroviral protease Novel inhibitors of retroviral protease, e.g., HIV protease, are provided which are peptides having from about 4 to about 8 amino acid residues and which are substrates for said protease derived from known cleavage sites and modified to contain an interna... | 09/19/2000 |
| 6090913 | Transesterification and other conversion reactions of acid derivatives, using an amidine base A process employs amidine or amidine base and a metal compound in the presence of an alcohol or water to transesterify, or saponify esters or amides. Since the process employs relatively mild conditions, it is especially suitable for the production of opt... | 07/18/2000 |
| 6080837 | Synthesis of VIP analog This invention relates to a novel process for the synthesis of vasoactive intestinal peptide analog Ac(1-31)--NH2 from four protected peptide fragments.... | 06/27/2000 |
| 6075141 | N -, -dimethyl-3,5-dialkoxybenzylcarbonyl amino acid 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazin-3-yl and pentafluorophenyl esters This invention provides Ddz-amino acid pentafluorophenyl esters and Ddz-amino acid 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine (ODhbt) esters and their side-chain protected derivatives. Preferred esters and derivatives are crystalline solids. The inve... | 06/13/2000 |
| 6028172 | Reactor and method for solid phase peptide synthesis A solid phase peptide synthesis reactor system and method of operating the reactor are provided. The reactor system includes a basket rotatable about an axis within a housing and a receiver which delivers fluid to, and collects fluid from, the housing. Th... | 02/22/2000 |
| 6015881 | Methods and compositions for peptide synthesis The present invention relates, first, to methods for the synthesis of peptides, in particular T-20 (also referred to as "DP-178"; SEQ ID NO:1) and T-20-like peptides. Such methods utilize solid and liquid phase synthesis procedures to synthesize and combi... | 01/18/2000 |
| 6013764 | Liquid phase peptide synthesis of KL-4 pulmonary surfactant The invention relates to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu4)4 -Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process... | 01/11/2000 |
| 6001966 | Method for solution phase synthesis of oligonucleotides and peptides This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides and peptides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.... | 12/14/1999 |
| 6001961 | Cyclic adhesion inhibitors The invention relates to novel cyclopeptides of the formula I cyclo-(nArg-nGly-nAsp-nD-nE) I, in which D and E in each case independently of one another are Gly, Ala, ଲ-Ala, Asn, Asp, Asp(OR), Arg, Cha, Cys, Gln, Glu, His, Ile, L... | 12/14/1999 |
| 5998580 | Photosensitive caged macromolecules Disclosed is a method for preparing a photosensitive peptide which is capable of being activated or deactivated in a biological system, including the steps of: (a) providing an amino acid including a photolabile molecule; and (b) incorporating the amino a... | 12/07/1999 |
| 5990273 | Synthesis of cyclic peptides A process for preparing and purifying cyclic peptides having disulfide moieties in a two step processing operation including reverse phase chromatography which simplifies synthesis and reduces production costs, yet produces high, quality yield. The improv... | 11/23/1999 |
| 5985837 | Dolastatin 15 derivatives Compounds of the present invention include cell growth inhibitors which are peptides of Formula I A--B--D--E--F--G (I) and acid salts thereof, wherein A, D, and E are -amino acid residues, B is an -amino ... | 11/16/1999 |
| 5965700 | Preparation of active peptides A process for preparing pentapeptides of the formula I ##STR1## where A and R1 -R3 have the stated meanings, comprises assembling the pentapeptide stepwise starting from a prolinamide of the formula II ##STR2## where R... | 10/12/1999 |
| 5958885 | Peptide and formulations thereof inhibiting elevations of triglyceride levels in blood The present invention relates to a peptide having an amino acid sequence of Val-Val-Tyr-Pro as well as an agent for inhibiting elevation of triglyceride levels in blood, a food for specified health use (the so-called physiologically functional food) and a... | 09/28/1999 |
