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Pizza Pie With Concentric Rings of Crust
A pizza mold for forming a plurality of concentric raised ridges of dough (i.e., crust) on the surface of a pizza pie.
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| Number | Title | Issue Date |
| 7449547 | Process for the synthesis of distamycin and derivatives thereof using 1-methyl-4-formylamino-2-pyrrolecarbonyl chloride iteratively as an intermediate A process for the total synthesis of Distamycin, and synthetic poly-(4 aminopyrrole-2-carboxamide) congeners thereof, using 1-methyl-4-forinylamino-2-pyrrolecarbonyl chloride iteratively as an intermediate, is provided. The process finds application for both in solu... | 11/11/2008 |
| 7435791 | Process for rapid solution synthesis of peptides The present invention relates to a process for rapid solution synthesis of a peptide, the process comprising repetitive cycles of steps (a)-(d): (a) a coupling step, using an excess of an activated carboxylic component to acylate an amino component, | 10/14/2008 |
| 7427678 | Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method This invention discloses a novel method for immobilizing molecules to a support. Specifically, this invention discloses a method of immobilizing derivatized biomolecules, such as oligonucleotides, using cycloaddition reactions, such as the Diels-Alder reaction. Incl... | 09/23/2008 |
| 7396903 | Process for preparing insulin compounds A preferred way of converting insulin precursors into insulin compounds is to perform an enzymatic peptide cleavage in an aqueous medium and, thereafter, without removal of the intermediate product formed, to add an amino acid ester or a peptide ester and an organic... | 07/08/2008 |
| 7381408 | Methods for chemically synthesizing immunoglobulin chimeric proteins The invention provides methods of chemically synthesizing chimeric proteins comprising at least a portion of an immunoglobulin constant region and a biologically active molecule. ... | 06/03/2008 |
| 7329727 | Methods and compositions for controlled polypeptide synthesis Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for initiating the polymerization of aminoacid-N-carboxyanhydride (NCA) monomer by combining the monomer with an amido-containin... | 02/12/2008 |
| 7294456 | Mass labels Provided herein are sets of mass labels. Each mass label in a set includes 1) a mass marker moiety; 2) a mass normalisation moiety; and 3) a cleavable linker connecting the mass marker moiety to the mass normalisation moiety. Each mass marker moiety is characterised... | 11/13/2007 |
| 7268210 | PEG-LHRH analog conjugates PEG-LHRH analog conjugates, where a PEG moiety is covalently bound to a serine residue of a LHRH analog, and methods for producing these conjugates are provided in the present invention. Also provided are a pharmaceutical composition and a method for treating pathol... | 09/11/2007 |
| 7214768 | Echinocandin process This invention relates to an improved process for the minimization of acid-catalyzed reactions of certain echinocandins of the kind disclosed in U.S. Pat. No. 5,378,804. The process involves the use of a boronic acid. ... | 05/08/2007 |
| 7192713 | Stabilized compounds having secondary structure motifs The present invention provides novel stabilized crosslinked compounds having secondary structure motifs, libraries of these novel compounds, and methods for the synthesis of these compounds libraries thereof. The synthesis of these novel stabilized compounds involve... | 03/20/2007 |
| 7102023 | Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present invention ... | 09/05/2006 |
| 7084250 | Process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalaninamides The present invention relates to a process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalaninamides of the formula I, in which the anions X are physiologically acceptable anions, ... | 08/01/2006 |
| 7053055 | Compounds of unstable DP IV-inhibitors Novel compounds of unstable inhibitors of the serine peptidase dipeptidyl peptidase IV, are used in the treatment of various disorders, especially of metabolic disorders. The compounds can be used in the treatment of impaired glucose tolerance, glucosuria, hyperlipi... | 05/30/2006 |
| 6982315 | Process for the preparation of carboxamides The invention relates to a process for the preparation of carboxamides, in particular peptides, from an acid component in the form of a compound containing at least one carboxyl group and an amine component in the form of a compound containing at least one primary o... | 01/03/2006 |
| 6972320 | Ligation method and reagents to form an amide bond Methods and reagents for the formation of amide bonds between an activated carboxylic acid derivative and an azide useful in the synthesis of peptides, proteins and derivatized or labeled amino acids, peptide or proteins. The method involves the formation of a phosp... | 12/06/2005 |
| 6962902 | Compounds for control of appetite, blood pressure, cardiovascular response, libido, and circadian rhythm This invention relates generally to dipeptides and tripeptides and to methods for pharmaceutical treatment of mammals using analogs of such dipeptides and tripeptides. More specifically, the invention relates to tripeptides and their analogs, to pharmaceutical compo... | 11/08/2005 |
| 6939946 | Ring modified cyclic peptide analogs A method for modifying the cyclic peptide ring system of Echinocandin-type compounds to produce new analogs having antifungal activity is provided. The inventive process comprises opening the cyclic peptide ring, cleaving the terminal ornithine unit, inserting at le... | 09/06/2005 |
| 6932943 | Nucleic acid synthesizers The present invention relates to nucleic acid synthesizers and methods of using and modifying nucleic acid synthesizers. For example, the present invention provides highly efficient, reliable, and safe synthesizers that find use, for example, in high throughput and ... | 08/23/2005 |
| 6914121 | PEG-LHRH analog conjugates PEG-LHRH analog conjugates, where a PEG moiety is covalently bound to a serine residue of a LHRH analog either directly or via a bifunctional linker molecule, such as an amino acid, and methods for producing these conjugates are provided in the present invention. Al... | 07/05/2005 |
| 6897289 | Peptide synthesis procedure in solid phase A procedure for the solid phase peptide synthesis (SPPS), following a linear or convergent strategy, wherein the peptides contain the sequence of general formula (I), wherein n, Y, X and A1 to An have the meanings indicated in the specification... | 05/24/2005 |
| 6878557 | Logically ordered arrays of compounds and methods of making and using the same A method for constructing an array of synthetic molecular constructs, by forming a plurality of molecular constructs having a scaffold backbone of a chemical molecule comprising a linear, branched or cyclic organic compound having at least atoms of carbon, nitrogen,... | 04/12/2005 |
| 6864357 | Process for the preparation of peptides The present invention relates to a process for the preparation of peptides using an excess of an activated carboxylic component to acylate an amino component, wherein after the acylation an amine comprising a free anion or a latent anion is used as a scavenger of re... | 03/08/2005 |
| 6849710 | Method for the synthesis of analogs of parathyroid hormone and parathyroid hormone related peptide A fragment condensation process for the synthesis of analogs of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP), in which amino acid residues (22-31) form a synthetic amphipathic α-helix, is provided. ... | 02/01/2005 |
| 6822074 | Process for the preparation of cyclo(Asp-DPhe-NMeVal-Arg-Gly) Process for the preparation of the cyclic pentapeptide cyclo(Arg-Gly-Asp-DPhe-NMeVal) by cyclization of a linear pentapeptide selected from the group consisting of H-Arg(Pbf)-Gly-Asp(OBzl)-DPhe-NMeVal-OH... | 11/23/2004 |
| 6762281 | Process for preparing peptide derivatized oligomeric compounds Methods of preparing peptide linked oligomeric compounds are provided. The method is useful for preparing larger scale amounts of peptide linked oligomeric compounds. More particularly, the synthesis of peptide linked oligomeric compounds is performed without the pr... | 07/13/2004 |
| 6750312 | Process for the preparation of supports for solid phase synthesis A method for preparing a solid support material for carrying out a chemical reaction, said method comprising the following steps: (i) reacting an amino functionalised solid material with a carboxylic acid having at least two similarly protected amino groups t... | 06/15/2004 |
| 6686445 | Synthetic antineoplastic agents derived from dolastatin 15 and methods of making same A composition of matter, denominated herein as 12a-r, having the structural formula set forth below: ##STR1## wherein R is selected from the group consisting of: a) R=NHPh; b) R=NHCH2 Ph; c) R=NH(CH2)2 Ph; d) R=NH(CH2 | 02/03/2004 |
| 6686446 | Methods and compositions for controlled polypeptide synthesis Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for initiating the polymerization of aminoacid-N-carboxyanhydride (NCA) monomer by combining the monomer with an amid... | 02/03/2004 |
| 6680365 | Methods and compositions for controlled polypeptide synthesis Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for making block copolypeptides and related protocols for adding aminoacid-N-carboxyanhydrides (NCAs) to polyaminoaci... | 01/20/2004 |
| 6664372 | Azatide peptidomimetics Peptidomimetic azatides and combinatorial oligoazitide libraries are produced by means of a stepwise synthesis. Combinatorial library construction of this new biomimetic polymer provides a means to fabricate global peptidomimetic libraries.... | 12/16/2003 |
| 6653281 | Ring modified cyclic peptide analogs A method for modifying the cyclic peptide ring system of Echinocandin-type compounds to produce new analogs having antifungal activity is provided. The inventive process comprises opening the cyclic peptide ring, cleaving the terminal omithine unit, inser... | 11/25/2003 |
| 6632922 | Methods and compositions for controlled polypeptide synthesis Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for making self assembling amphiphilic block copolypeptides and related protocols adding oligo(ethyleneglycol) functi... | 10/14/2003 |
| 6610655 | Pentapeptide with specific conformation, its production and use Cyclic pentapeptides are disclosed having the following formula (I)-Cyclo(-A1 -A2 -A3 -A4 -A5 -)-wherein A1, A2, A3, A4 and A5 are amino acid residues... | 08/26/2003 |
| 6608175 | Serine protease inhibitors Certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases, are prepared in various embodiments using Grignard reagents and alkyllithium reagents and various aldehydes to make oxadiazole, thiadiazo... | 08/19/2003 |
| 6596867 | Tartrate salt of a substituted dipeptide as growth hormone secretagogue This application relates to processes for making compounds of formula I, and processes for making intermediates useful in the processes for making compounds of formula I. ##STR1##... | 07/22/2003 |
| 6566329 | Freeze-dried preparation of human growth hormone A readily-soluble freeze-dried solid preparation of hGH with a minimal content of degradation products in terms of deamidation, dimers, polymers, and sulphoxide forms, obtainable by a method comprising a single lyophilization of an aqueous slurry of an am... | 05/20/2003 |
| 6562944 | Amide library formation using a "by-product-free" activation/coupling sequence Disclosed is an improved method for preparing an activated carboxylic acid in the form of a pentafluorophenyl ester, an improved method for making a carboxamide from a pentaflourophenyl ester, and a carboxamide and carboxamide library prepared using both ... | 05/13/2003 |
| 6559279 | Process for preparing peptide derivatized oligomeric compounds Methods of preparing peptide linked oligomeric compounds are provided. The method is useful for preparing larger scale amounts of peptide linked oligomeric compounds. More particularly, the synthesis of peptide linked oligomeric compounds is performed wit... | 05/06/2003 |
| 6552166 | Process for the preparation of conjugates useful in the treatment of prostate cancer The present invention is directed to the improved synthesis of compounds of formula I: ##STR1## which may be useful in the treatment of prostate cancer. Such compounds are synthesized in the presence of a carboxyl activating agent, an additive and a ... | 04/22/2003 |
| 6534627 | Synthesis and use of amino acid fluorides as peptide coupling reagents The present invention is directed to the process of preparing a peptide comprising reacting a first amino acid or peptide with an amino acid fluoride of the formula: ##STR1## or the acid fluoride salts thereof wherein BLK is an N-amino protecting group; A... | 03/18/2003 |
