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| Number | Title | Issue Date |
| 6762166 | Synthetic complementary peptides and ophthalmologic uses thereof The present invention is directed to a series of complementary peptides for the pro-gly-pro sequence as antagonists of polymorphonuclear leukocyte chemoattractants. Also provided are applications of such peptides for treating alkali-injuried eyes and other types of ... | 07/13/2004 |
| 6759510 | Peptides for use in culture media The present invention provides peptides libraries which are useful for rapid identification of biologically active compounds. The invention further provides peptides which include cell-growth affecting peptides and peptides which enhance or inhibit production of cel... | 07/06/2004 |
| 6759509 | Branched peptide linkers Conjugates containing a targeting ligand, such as an antibody, a therapeutically active drug and a branched peptide linker. The branched peptide linker contains two or more amino acid moieties that provide an enzyme cleavage site. The number of drugs capable of bein... | 07/06/2004 |
| 6756356 | Compounds and methods for modulating claudin-mediated functions Methods for using modulating agents to enhance or inhibit claudin-mediated cell adhesion in a variety of in vivo and in vitro contexts are provided. Within certain embodiments, the modulating agents may be used to increase blood/brain barrier permeability. The modul... | 06/29/2004 |
| 6756041 | Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this process A process for preparing a protein-polysaccharide conjugate includes reacting a protein with a polysaccharide to produce a mixture including a protein-polysaccharide conjugate and free protein. At least one unreacted reagent or low molecular weight component is remov... | 06/29/2004 |
| 6753410 | Investigational compounds The present invention is directed to compounds and pharmaceutical compositions comprising the compounds which are inhibitors of the enzyme gamma secretase and which are useful in the treatment or prevention of diseases in which the beta-amyloid peptide is involved, ... | 06/22/2004 |
| 6753316 | Acryloyl derivatives analogous to distamycin, process for preparing them, and their use as antitumor agents Compounds which are acryloyl substituted distamycin derivatives of formula (I) wherein: n is 2, 3 or 4; m is 1 or 2; X and Y are the same or different and are selected, independently for each heterocyclic ring of the polyetherocyclic chain, from N and CH; R1 | 06/22/2004 |
| 6750058 | Transfecting peptide vector, composition containing same and applications The invention concerns transfecting peptide vector, a composition containing said vector and their applications for treating and preventing diseases in human beings and animals. Said vector for transfecting a chemical substance selected in the group consisting of nu... | 06/15/2004 |
| 6743769 | Antimicrobial peptides and derived metapeptides The peptides and derivative metapeptides based upon natural antimicrobial peptides have potent and broad spectrum activity against pathogens exhibiting multiple antibiotic resistance. In addition, they exhibit lower inherent mammalian cell toxicities than convention... | 06/01/2004 |
| 6740639 | Inclusion complees of a high potent opioid peptide, pharmaceutical compositions and method of treatment The invention provides novel inclusion complexes of highly potent opioid peptide of L-Tyrosyl-D-alanyl-glycyl-N-methylphenylalanyl-glycyl-isopropylamide with cyclodextrin, pharmaceutical preparations containing these inclusion complexes of L-Tyrosyl-D-alanyl-glycyl-... | 05/25/2004 |
| 6737409 | Dolastatin 10 derivatives Novel anti-tumor compounds of formula, are disclosed. Also disclosed are pharmaceutical compositions comprising compounds of formula (I), the use of compounds of formula (I) for the treatment of cancer, and processes for... | 05/18/2004 |
| 6727227 | Tetrapetide revealing geroprotective effect, pharmacological substance on its basis, and the method of its application Tetrapeptide L-alanyl-L-glutamyl-L-aspartyl-glycine (SEQ ID NO: 1) of the general formula L-Ala-L-Glu-L-Asp-Gly (SEQ ID NO: 1) is proposed as a biologically active compound with a geroprotective effect. The use of L-Ala-L-Glu-L-Asp-Gly (SEQ ID NO: 1) tetrapeptide in... | 04/27/2004 |
| 6723830 | Short peptides which selectively modulate the activity of protein kinases Peptides which are peptide derivatives of the αD region of a protein kinase can modulate the activity of protein kinases. The activity of a protein kinase in a subject can be modulated by administering one or more of these peptides. ... | 04/20/2004 |
| 6723700 | Compounds and methods for modulating claudin-mediated functions Method for using modulating agents to enhance or inhibit claudin-mediated cell adhesion in a variety of in vivo and in vitro contexts are provided. Within certain embodiments, the modulating agents may be used to increase blood/brain barrier permeability. The modula... | 04/20/2004 |
| 6720306 | Tetrapartate prodrugs A compound of Formula I, providing tetrapartate prodrugs is provided wherein: L1 is a bifunctional linking moiety; D is a moiety that is a leaving group, or a residue of a compound to be delivere... | 04/13/2004 |
| 6716810 | Composition and method for regulation of body weight and associated conditions Described are methods and compositions for regulating body weight and/or regulating the rate of weight gain or loss, and particularly, for treating or preventing obesity. Specifically, methods of administering varying levels of circulating proopiomelanocortin peptid... | 04/06/2004 |
| 6716809 | Mage-A3 peptides presented by HLA class molecules The invention describes HLA class II binding peptides encoded by the MAGE-A3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocyte... | 04/06/2004 |
| 6713445 | Peptides for treatment of HIV infection The HIV-1 envelope protein gp120 is toxic to rodent and human neurons by indirect mechanisms requiring accessory glial cells. Chemokines are known to block gp120 interactions with chemokine receptors on T cells, macrophanges, and microglia, thereby preventing viral ... | 03/30/2004 |
| 6706487 | Monoclonal antibody and the method of using the antibody Chimeric, humanized and other IL-18 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided. ... | 03/16/2004 |
| 6703483 | Compounds useful in pain management Compounds of the formula I ##STR1## are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, particular in the management... | 03/09/2004 |
| 6699838 | Antiangiogenic peptides Mammalian kringle 5 fragments and kringle 5 fusion proteins are disclosed as a compounds for treating angiogenic diseases. Methods and compositions for inhibiting angiogenic diseases are also disclosed.... | 03/02/2004 |
| 6693167 | Peptide-based gemini compounds New peptide-based Gemini compounds comprising two linked chains (a) each having: (1) a positively charged hydrophilic head, Q1 or Q2 formed from one or more amino acids and/or amines, (2) a central portion, P1 or P2, having a polypep... | 02/17/2004 |
| 6693072 | Elastase inhibitors This invention relates to compounds which are inhibitors of elastase, particularly human neutrophil elastase. The inhibitors are short, synthetic peptides in which the P2 moiety is substituted with various nitrogen-containing heterocyclic group... | 02/17/2004 |
| 6693165 | Cyclic peptides as potent and selective melanocortin-4 receptor antagonists Cyclic peptides of formula I are potent and selective antagonists of melanocortin-4 receptors, and as such are useful research tool for the determination of the physiological roles of the MC-4 receptor, as well as for the diagnosis, treatment or preventio... | 02/17/2004 |
| 6689752 | Modulators of ଲ-amyloid peptide aggregation comprising D-amino acids Compounds that modulate natural ଲ amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a ଲ amyloid peptide, that is comprised entirely of D-amino acids. Preferably, the peptide compr... | 02/10/2004 |
| 6689753 | ଲ sheet breaker peptide analogs that inhibit ଲ pleated sheet formation in amyloid ଲ-peptide The present invention provides peptide analogs and peptide mimetics that inhibit pleated sheet formation in amyloid ଲ-peptide, pharmaceutical compositions thereof and their therapeutic use. The inhibitory peptides possess activity as inhibitors in t... | 02/10/2004 |
| 6686445 | Synthetic antineoplastic agents derived from dolastatin 15 and methods of making same A composition of matter, denominated herein as 12a-r, having the structural formula set forth below: ##STR1## wherein R is selected from the group consisting of: a) R=NHPh; b) R=NHCH2 Ph; c) R=NH(CH2)2 Ph; d) R=NH(CH2 | 02/03/2004 |
| 6686336 | N-terminal D(-)-penicillamine peptides as aldehyde sequestration agents The invention provides a compound of formula I: ##STR1## wherein R1 -R3 have any of the values described in the specification; or a salt thereof. The compounds are useful as aldehyde sequestration agents (e.g., in the treatment of al... | 02/03/2004 |
| 6682740 | Peptides derived fram complement peptide C3a sequence and antiallergic compositions comprising them Peptides corresponding partially or entirely to positions 50-77 of the sequence of the complement-derived peptide C3a and analogs thereof are capable of inhibiting IgE-mediated triggering and/or the Fc&3xb5;RI-induced secretory response of mucosal mast ce... | 01/27/2004 |
| 6683048 | Compounds and methods for stimulating gene expression and cellular differentiation Modulating agents for inhibiting an interaction between -catenin and ଲ-catenin are provided. The modulating agents comprise one or more of: (a) a ଲ-catenin HAV motif; (b) a peptide analogue or mimetic of a ଲ-catenin HAV motif; or ... | 01/27/2004 |
| 6683154 | Antimicrobial compositions containing ଲ-amino acid oligomers Disclosed are antimicrobial compositions containing ଲ-peptides and methods of inhibiting microbial growth in mammals using the compositions. The ଲ-peptides present in the compositions contain ring structures in the peptide backbone which limit... | 01/27/2004 |
| 6670326 | Depsipeptide compound This invention relates to a novel compound which has a cytotoxic activity and TGF-ଲ like activity for human cancer cells and is useful as an antitumor agent and to a pharmaceutical composition which contains the same.... | 12/30/2003 |
| 6664368 | Inhibition of nuclear import by backbone cyclic peptide analogs The design and the synthesis of backbone cyclic peptide analogs which functionally mimic the nuclear localization signal (NLS) region of macromolecules is disclosed. The principles of the invention are exemplified for the NLS sequences of the human immuno... | 12/16/2003 |
| 6664371 | Mimetic insect allatostatin analogs for insect control Novel pseudopeptide analogs of the insect allatostain neuropeptide family which possess biological activity mimicking that of the naturally ocurring neuropepetides are disclosed. By addition of a hydrophobic moiety to an active portion of the allatostatin... | 12/16/2003 |
| 6664372 | Azatide peptidomimetics Peptidomimetic azatides and combinatorial oligoazitide libraries are produced by means of a stepwise synthesis. Combinatorial library construction of this new biomimetic polymer provides a means to fabricate global peptidomimetic libraries.... | 12/16/2003 |
| 6656905 | Cyclic tetrapeptide compound and use thereof A cyclic tetrapeptide compound and use thereof. Especially, a compound WF27082, a process for production of the compound by culturing, in a nutrient medium, a WF27082-producing strain belonging to Acremonium and recovering the compound from a culture brot... | 12/02/2003 |
| 6649395 | Tyrosine-containing cyclophilin and related methods The present invention relates to the use of these cyclophilins, hereinafter referred to as `tyrosine-containing` cyclophilins, in a method for identifying compounds capable of binding to and/or inhibiting the enzymatic activity of these proteins. Such com... | 11/18/2003 |
| 6649746 | Biological production of stable glutamine, poly-glutamine derivatives in transgenic organisms and their use for therapeutic purposes The invention provides a bioproduction of glutamine rich peptides. These peptides are used for rehydration and nutrition therapy in patients and for enhanced nutrition in animals. The peptides may be used as individual peptides or combined with other pept... | 11/18/2003 |
| 6638941 | Conformationallly constrained peptidomimetics as ଲ-turn templates and modulators of SH3 domains Spirolactam compounds useful as inhibitors of protein-protein interactions modulated by SH3 domains are disclosed. Compounds of the invention are also useful as ଲ-turn mimetics. Also disclosed are libraries of compounds of the invention, pharmaceuti... | 10/28/2003 |
| 6638912 | Peptide compositions mimicking TGF-ଲ activity Compositions suitable for pharmaceutical administration are provided in which one compound is a small peptide mimic of TGF-ଲ. More preferably, pharmaceutical compositions of the present invention are formulated as combinations of two components, whe... | 10/28/2003 |
