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| Number | Title | Issue Date |
| 4143134 | Halo-phosphonopeptides The present disclosure relates to halo-phosphonopeptides. The subject compounds are antibacterial agents and also potentiate the activity of antibiotics.... | 03/06/1979 |
| 4128542 | Peptide derivatives There is provided peptide derivatives of the general formula ##STR1## wherein R1, R2 and R3 each represent the characterizing group of an -amino acid of the type normally found in proteins; R4 repres... | 12/05/1978 |
| 4126606 | Physiologically active peptides and a process for preparation thereof The present invention relates to new physiologically active peptides, derivatives thereof and a process for preparation thereof. In particular, it relates to new tetrapeptides designated amastatins A1, A2, A3, B1 | 11/21/1978 |
| 4124578 | Antiovulatory polypeptides Peptides of the formula: wherein: X is Trp or D-Trp, and Y is Pro-NHEt or the peptide segment --Gly--X1 --X2 --Arg--Pro--Z, wherein: X1 is Ala, D-Ala, or MeAla; X2 is Leu or D-Leu; and Z is --NH2 or --NHEt, Or ... | 11/07/1978 |
| 4116949 | Water-soluble, physiologically active, synthetic copolypeptides Water-soluble copolypeptides having high physiological activity for prolonged periods of time comprise water-soluble, linear copolypeptides having attached to their polymeric backbone at least one substituent having the structure: ##STR1## where... | 09/26/1978 |
| 4115374 | Substrates for angiotensin converting enzyme The novel compounds Iodo-p-hydroxyphenyl-glycylglycylglycine and Benzoylprolylphenylalanylarginine are disclosed, together with radioisotope labeled forms thereof, wherein the radioisotope is incorporated in the Iodo-p-hydroxyphenyl moiety or the Benzoyl ... | 09/19/1978 |
| 4113858 | Novel compounds, compositions and methods of their use Synthetic compounds of the formula: ##STR1## are disclosed wherein X is an integer of at least 0 and A and B each represent a divalent moiety of the formula: ##STR2## WHEREIN R1 and R5 are each selected from the residue of ... | 09/12/1978 |
| 4107158 | Process for making an octapeptide useful for the treatment of diabetes Process for the preparation of the compound consisting of the peptide chain: leucyl -- seryl -- arginyl -- leucyl -- phenylalanyl -- aspartyl -- asparaginyl -- alanine (I), characterized in that the synthesis is carried out from constituent amino-acids of... | 08/15/1978 |
| 4107298 | Antigenically active polypeptide and a process for its preparation The invention provides for a synthetic antigenically active polypeptide containing an immunologically inert portion and as an active immunological determinant group the amino acid sequence A-3 -A-2 -A-1 -A0 -A | 08/15/1978 |
| 4105602 | Synthesis of peptides with parathyroid hormone activity Resin peptides useful in the preparation of peptides having biological activity, and particularly such resin peptides containing R--CH2 --O--Phe--Asn at one end of an amino acid chain, R being the resin and Phe and Asn being the residues of the... | 08/08/1978 |
| 4105652 | Synthesis of human ଲ-endorphin Human ଲ-endorphin (ଲh -endorphin) is prepared by solution phase peptide synthesis. Synthesis proceeded via the protected ଲ-endorphin fragments 1-9, 10-18, 19-21 and 22-31.... | 08/08/1978 |
| 4086136 | Process for producing a peptide using a serine or thiol proteinase A peptide having the formula X--A--B--Y-- wherein A and B are the same or different and each represents an amino acid residue or a peptide residue, X represents an amino protective group, Y represents a carboxyl protective group selected from the group consist... | 04/25/1978 |
| 4073890 | Novel polypeptides Novel polypeptides of the formula R1 --Arg--R2 --Phe--Phe--R3 wherein R1 is hydrogen, or a basic or neutral amino acid residue, R2 is a neutral amino acid residue and R3 is NH2, Tyr--... | 02/14/1978 |
| 4066635 | L-Pyroglutamyl-L-histidyl-L-prolyl-beta-alaninamide and salts This disclosure relates to L-pyroglutamyl-L-histidyl-L-prolyl-beta-alaninamide and acid addition salts thereof as anti-depressant agents.... | 01/03/1978 |
| 4062835 | Pentapeptides and methods for their production New pentapeptides having the formula X-R-Tyr(methyl)-Ser(benzyl)-R1 -Y wherein X is t-butoxycarbonyl or benzyloxycarbonyl, R is a single amino acid fragment, a dipeptide fragment or tripeptide fragment utilizing amino acids selected from the gr... | 12/13/1977 |
| 4058513 | Pentapeptides and methods for their production New pentapeptides having the formula X-R-His(benzyl)-His(benzyl)-R1 -Trp-R2 -Y wherein X is t-butoxycarbonyl or benzyloxycarbonyl, R is a single bond or Pro; R1 is Ser(benzyl) or Tyr(benzyl), R2 is a single bond... | 11/15/1977 |
| 4043994 | New pentapeptides and methods for their production New pentapeptides having the formula X-R-Ser-(benzyl)-Tyr(benzyl)-R1 -Y wherein X is t-butoxycarbonyl or benzyloxycarbonyl, R is a single amino acid fragment or a dipeptide fragment utilizing amino acids selected from the group consisting of Az... | 08/23/1977 |
| 4043993 | New pentapeptides and methods for their production New pentapeptides having the formula X-R-Tyr-(benzyl)-Ser(benzyl)-R1 -Y wherein X is t-butoxycarbonyl or benzyloxycarbonyl, R is a single amino acid fragment, a dipeptide fragment or tripeptide fragment utilizing amino acids selected from the g... | 08/23/1977 |
| 4039519 | Broad spectrum antibiotics and method The present invention relates to the new antibiotic polymyxine methyl tetracycline wide spectrum salts of the general formula in which m and n represent positive integers of less than 6, A= and B- represent mineral or organic anions, T re... | 08/02/1977 |
| 4038282 | Pyridyl-4-methyl-succinimidocarbonate and process for its preparation The disclosed invention relates to &3xb5;-N-pyridyl-4-methyloxycarbonyllysine valuable in the synthesis of lysine containing peptides to the process of preparing this compound starting with 4-pyridyl-carbinol and succinimido-chloroformate and to the ... | 07/26/1977 |
| 4035348 | Tetrapeptides and methods for their production New tetrapeptides having the formula A-R1 -Tyr(benzyl)-Ser(benzyl)-D-Ala-R2 wherein A is t-butoxycarbonyl, cyclohexylcarbonyl, benzyloxycarbonyl and p-nitrobenzyloxycarbonyl; R1 is L-His(benzyl), D-Pro, or L-Trp; Tyr(benzy... | 07/12/1977 |
| 4031072 | Tetrapeptides New tetrapeptides having the formula A-Pro-Pro-Tyr(benzyl)-Ser(benzyl)-R1 wherein A is t-butoxycarbonyl, cyclohexylcarbonyl, benzyloxycarbonyl and p-nitrobenzyloxycarbonyl; Pro is D-Pro or L-Pro; Tyr(benzyl) is D-Tyr(benzyl) or L-Tyr(benzyl); S... | 06/21/1977 |
| 4031069 | Tetrapeptides New tetrapeptides having the formula A-R1 -Ser(benzyl)-Tyr(benzyl)-R2 -R3 wherein A is t-butoxycarbonyl, cyclohexylcarbonyl, benzyloxycarbonyl and p-nitrobenzyloxycarbonyl; R1 is L-Trp, L-Thr(benzyl), L-Met or G... | 06/21/1977 |
| 4031070 | Tetrapeptides New tetrapeptides having the formula A-R1 -R2 -Ser(benzyl)-Tyr(benzyl)-R3 wherein A is t-butoxycarbonyl, cyclohexylcarbonyl, benzyloxycarbonyl and p-nitrobenzyloxycarbonyl; R1 is L-Trp or L-His(benzyl); R2 | 06/21/1977 |
| 4031071 | Tetrapeptides New tetrapeptides having the formula A-Ser(benzyl)-Try(benzyl)-D-Ala-Leu-R1 wherein A is t-butoxycarbonyl, cyclohexylcarbonyl, benzyloxycarbonyl and p-nitrobenzyloxycarbonyl; Ser(benzyl) is D-Ser(benzyl) or L-Ser(benzyl); Tyr(benzyl) is D-... | 06/21/1977 |
| 4028318 | Chromogenic enzyme substrates Chromogenic substrates for serine proteases, represented by the formula: or its salts, where R1 is hydrogen or alkanoyl having from 1 to 12 carbon atoms or cyclohexylcarbonyl or benzoyl or benzoyl substituted with one or two halogen atoms, methylami... | 06/07/1977 |
| 4021387 | Eosinophilotactic tetrapeptides Two eosinophilotactic tetrapeptides of amino acid sequence Val-Gly-Ser-Glu and Ala-Gly-Ser-Glu have been isolated from extracts of human lung fragments. These tetrapeptides have been synthesized by solid phase peptide synthesis procedures and the syntheti... | 05/03/1977 |
| 4016148 | Peptide derivatives of phosphonic and phosphinic acids and intermediates therefor The present disclosure relates to peptide derivatives. More particularly, the disclosure is concerned with peptide derivatives of phosphonic and phosphinic acids, a process for the manufacture thereof and pharmaceutical preparations containing same.... | 04/05/1977 |
| 4016259 | Contraceptive polypeptides Polypeptides containing at least four amino acids are useful as mammalian contraceptives.... | 04/05/1977 |
| 4012367 | Anti-ulcer polypeptides containing L-aspartic acid and intermediates thereto This invention encompasses novel tetrapeptide amides and their intermediates containing an L-aspartic acid residue. These peptides are inhibitors of gastric acid secretion and therefore useful in the treatment of ulcers.... | 03/15/1977 |
| 4001199 | Novel polypeptides useful for treating diabetes and hypercholesteremia Novel polypeptides of the formula wherein R1 is hydrogen, or a basic or neutral amino acid residue, R2 is a neutral amino acid residue and R3 is NH2, Tyr--NH2, a residue of tyrosyl peptides consisting of 1... | 01/04/1977 |
| 3998799 | Novel, transient pro-drug forms of L-DOPA There is provided, novel, transient pro-drug forms of L-DOPA (3,4-dihydroxy-L-phenylalanine), having the formula: ##STR1## wherein n represents an integer of from 2 to 50 with respect to formula (V-A), and wherein n represents an integer of from 1 to... | 12/21/1976 |
| 3997516 | Method for protecting guanidino group and restoring the same A guanidino group in an amino acid or a peptide can be protected with a specific protective group, i.e. lower alkoxybenzenesulfonyl group or tri-lower alkylbenzenesulfonyl group, and the protective group may easily be removed without affecting the amino a... | 12/14/1976 |
| 3995051 | Methods and compositions for inducing resistance to bacterial infections A variety of substances are reported which alter host resistance to cocci and bacilli bacterial infections. Nevertheless, because of the extreme difficulty of total eradication, and the frequent reappearance of the same strains, even after their apparentl... | 11/30/1976 |
| 3978035 | 13-Norleucine-14-desamido motilin, a method for preparing it and an agent containing it The specification describes the total synthesis of L-norleucine-13-motilin ased on the replacement of the L-methionine radical located in the 13-position by an L-norleucine radical. In accordance with the present day development of peptide synthesis the ce... | 08/31/1976 |
| 3975366 | Process for the production of new pepstatins having anti-pepsin activity A process for producing new pepstatins having anti-pepsin activity by cultivating a pepstatin producing strain in a nutrient medium containing assimilable carbon sources and nitrogen sources, and extracting the new pepstatins from the cultivated broth or ... | 08/17/1976 |
| 3960828 | Catalytic hydrogenolysis of protected sulfur containing peptides The use of catalytic hydrogenolysis to selectively deblock protected moieties in sulfur containing compounds has not been a practical process due to poisoning of the catalyst by the sulfur compound. It has now been found that catalytic hydrogenolysis of s... | 06/01/1976 |
| 3943119 | Tuberculin active proteins and peptides from the cells of tubercle bacilli Tuberculin active simple proteins and peptides which have the following peptide linkage as a tuberculin active functional group, and a process for preparing the same from the cells of tubercle bacilli.... | 03/09/1976 |
