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| Number | Title | Issue Date |
| 7196059 | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith Pharmaceutical compositions that include insulin, an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component or a bile salt component without a fatty acid component are described. The insulin drug is covalently coupled to an oligomeric moi... | 03/27/2007 |
| 7195766 | Product and process for liquefaction of mucus or sputum Disclosed are compositions and methods for decreasing the viscosity and/or cohesiveness of and/or increasing the liquefaction of excessively or abnormally viscous or cohesive mucus or sputum. The composition contains a protein or peptide containing a thioredoxin act... | 03/27/2007 |
| 7192928 | T cell antigen receptor peptides The present invention provides peptides which affect T-cells, presumably by action on the T-cell antigen receptor. The present invention further relates to the therapy of various inflammatory and autoimmune disease states involving the use of these peptides. Specifi... | 03/20/2007 |
| 7189701 | Tetrapeptide stimulating functional activity of neurons pharmacological agent based thereon and method of use thereof Tetrapeptide L-alanyl-L-glutamyl-L-asparagyl-L-proline of the general formula L-Ala-L-Glu-Asp-L-Pro is proposed as a biologically active compound stimulating the functional activity of neurones. The application of L-Ala-L-Glu-L-Asp-L-Pro tetrapeptide in medicine is ... | 03/13/2007 |
| 7189692 | Synthetic peptides and pseudopeptides having osteogenic activity and pharmaceutical compositions containing the same Cyclic to Synthetic pseudopeptide derivatives of osteogenic growth polypeptide (OGP) and OGP(10-14) which are capable of enhancing bone cell proliferation and bone formation. Pharmaceutical composition comprising as active ingredient at least one pseudopeptide deriv... | 03/13/2007 |
| 7189700 | Anti-chrondrosarcoma compounds The invention provides inhibitors of chondrosarcoma cell growth that are useful as anti-cancer and anti-tumor agents. The inhibitors are peptides having sequences related to cleavage regions of the proenzyme forms of matrix metalloproteinases and that can inhibit th... | 03/13/2007 |
| 7186693 | Metalloproteinase inhibitors for wound healing The invention provides inhibitors of matrix metalloproteinases that are useful for treating wounds. The inhibitors are peptides having sequences related to cleavage regions of the proenzyme forms of matrix metalloproteinases. The peptide inhibitors of the invention ... | 03/06/2007 |
| 7183252 | Indole peptidomimetics as thrombin receptor antagonists The invention is directed to novel indole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosc... | 02/27/2007 |
| 7183258 | Two synthetic peptides for treatment and prevention of cancers Two synthetic peptides, Atroporin (AT) and Kaotree (KT), each consisting of ten amino acids and their use for the treatment and/or prevention of various types of cancers is disclosed. The amino acid sequence from the N-terminal for AT is Phe-Cys-Arg-Phe-Leu-Leu-Cys-... | 02/27/2007 |
| 7183059 | Synthesis of compounds and libraries of compounds A method of generating a compound having at least one biological activity of a peptide. The method includes identifying a biologically active peptide, providing a first monomer which contains terminal reactive moieties and at least one functionalizable group, provid... | 02/27/2007 |
| 7179635 | Peptides for use in culture media The present invention provides peptides libraries which are useful for rapid identification of biologically active compounds. The invention further provides peptides which include cell-growth affecting peptides and peptides which enhance or inhibit production of cel... | 02/20/2007 |
| 7179792 | Combination product of a 1,4-benzothiepine 1,1-dioxide compound with at least one other active ingredient and the use of the product The present invention is directed to a 1,4-benzothiepine 1,1-dioxide compound of formula I in which the radicals have the meanings defined herein, or a pharmaceutically acceptable salt or physiologically function... | 02/20/2007 |
| 7179784 | Surfactant peptide nanostructures, and uses thereof This work describes a new class of short polypeptides that can self-assemble to form regular nanotubes with an average diameters of about 50 nm. These peptides (7 to 8 amino acids) have a structure very similar to those observed in surfactant molecules with a define... | 02/20/2007 |
| 7176183 | Methods for treating and preventing damage to mucosal tissue The present invention provides improved methods, kits, and pharmaceutical compositions for treating and preventing damage to mucosal tissue by administering an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof,... | 02/13/2007 |
| 7176184 | Treatment for inflammatory bowel disease with a fibronectin polypeptide A method for the treatment of inflammatory bowel disease (IBD) is disclosed. The method comprises administration of an antibody, polypeptide or other molecule recognizing VLA-4, a surface molecule expressed on most types of white blood cells and involved in leukocyt... | 02/13/2007 |
| 7175828 | Modulators of β-amyloid peptide aggregation comprising D-amino acids Compounds that modulate natural β amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a β amyloid peptide, that is comprised entirely of D-amino acids. Preferably, the peptide comprises 3–5 D-amino ac... | 02/13/2007 |
| 7173005 | Insulin and IGF-1 receptor agonists and antagonists Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, w... | 02/06/2007 |
| 7173012 | Hypoglycaemic peptides and methods of use thereof A peptide of the formula (Xaa)n1-Xaa1-His-Thr-Asp-(Xaa)n2, wherein Xaa is any amino acid; Xaa1 is a hydrophobic amino acid, preferably Gly or Val; n1 is 0–10; and n2 is 0–10; and use thereof in regulating in vivo blood... | 02/06/2007 |
| 7169752 | Compounds and compositions for prevention of overdose of oxycodone The invention relates to pharmaceutical compounds and compositions comprised of a chemical moiety attached to an opioid such as oxycodone in a manner that substantially decreases the potential of the opioid to cause overdose. When delivered at the proper dosage the ... | 01/30/2007 |
| 7169889 | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin The present invention relates generally to hydrolyzable drug-oligomer conjugates, pharmaceutical compositions comprising such conjugates, and to methods for making and using such conjugates and pharmaceutical compositions. For example, a conjugate of insulin, PEG, a... | 01/30/2007 |
| 7166579 | Prodrugs of DP IV-inhibitors Prodrug compounds of unstable inhibitors of the serine peptidase dipeptidyl peptidase IV, are used in the treatment of various disorders, especially of metabolic disorders. The Prodrug compounds can be used in the treatment of impaired glucose tolerance, glucosuria,... | 01/23/2007 |
| 7166695 | Affinity markers for human serum albumin Methods and compositions are provided for identifying compounds having affinity or complementarity to a target molecule. Compounds according to the invention may be described by the formula E-Ca—R—Cb-A, wherein E is a therapeutic or diagnos... | 01/23/2007 |
| 7166475 | Compositions and methods for monitoring the modification state of a pair of polypeptides This invention relates to a method for analyzing a sample comprising: immobilising a polypeptide to a physical support; contacting the immobilised polypeptide with a test sample which may contain an agent capable of modifying the immobilised polypeptide; contacting ... | 01/23/2007 |
| 7163923 | Peptide deformylase activated prodrugs This invention provides a method for inhibiting the growth of a microorganism that expresses Peptide Deformylase by contacting the microorganism with an effective amount of the compound described herein. This method inhibits the growth of gram-positive and gram-nega... | 01/16/2007 |
| 7163921 | Peptide derivatives and medicinal compositions The present invention to novel nociceptin receptor agonists which are peptide derivatives represented by the following general formula (1): (in which A is alkylene, —CH2) | 01/16/2007 |
| 7160554 | Enhanced circulation effector composition and method A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the bloodstream. The effector molecules are attached to the distal ends of the ... | 01/09/2007 |
| 7157419 | Growth factor binding molecules Growth factor binding molecules having a plurality of peptide loops attached to a non-peptide organic scaffold, preferably having pseudo-six amino acid peptide loops with four amino acid sidechains. The growth factor binding molecules specifically bind various growt... | 01/02/2007 |
| 7157275 | Peptides for enhanced cell attachment and growth The present invention relates to cell adhesion promoting (“CAP”) peptide combinations that promote cell attachment or cell adhesion to culture surfaces that are otherwise cell adhesion resistant “CAR”. The invention provides combination of peptides that, whe... | 01/02/2007 |
| 7153835 | Anti-inflammatory peptides Methods for inhibiting an inflammatory reaction in a mammal and pharmaceutical compositions are provided. The methods comprise administering to the mammal an effective amount of a peptide of the formula: X1-X2... | 12/26/2006 |
| 7153833 | Therapeutic uses of SMR1 peptides A method for treating or reducing the severity of a disease or disorder mediated by a membrane metallopeptidase by administering to a mammal a SMR1-peptide or a pharmaceutically active amount of a SMR1-peptide. ... | 12/26/2006 |
| 7153822 | Compositions and methods for modulating connexin hemichannels Disclosed are compositions and methods for modulating hemichannel function in a cell, tissue or organ. The invention also relates to useful screens for detecting such compounds, particularly those capable of modulating connexin phosphorylation. Further provided are ... | 12/26/2006 |
| 7148197 | Orally administered small peptides synergize statin activity This invention provides novel peptides for the treatment of atherosclerosis. In certain embodiments the peptide is X1-X2-X3-X4 where X1 and X4 are independently selected from the group consisting of a... | 12/12/2006 |
| 7148196 | Anticancer compounds and methods The testing of tumor cells, including human tumors capable of metastases, in assays employing fibronectin-depleted substrates is described. Ex vivo induction of cells, including biopsied human cells, is performed with invasion-inducing agents. Additionally, anti-can... | 12/12/2006 |
| 7138370 | Specific binding agents of human angiopoietin-2 Disclosed are peptides that bind to Ang-2. Also disclosed are peptibodies comprising the peptides, methods of making such peptides and peptibodies, and methods of treatment using such peptides and peptibodies. ... | 11/21/2006 |
| 7138103 | Use of bi-specific antibodies for pre-targeting diagnosis and therapy The present invention relates to targetable constructs which may be bound by a bi-specific antibody or antibody fragment having at least one arm that specifically binds construct. The targetable construct comprises a carrier portion which comprises or bears at least... | 11/21/2006 |
| 7138104 | Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent The present invention describes a method of concurrent imaging in a mammal comprising: a) administering to said mammal a vitronectin receptor targeted imaging agent and a perfusion imaging agent; and b) concurrentl... | 11/21/2006 |
| 7132511 | Modified anti-EGFR antibodies with reduced immunogenicity The present invention relates to antibodies which are directed to the EGF receptor (HER1) to be administered especially to humans and in particular for therapeutic use in tumors. The antibodies are modified whereby the modification results in a reduced propensity fo... | 11/07/2006 |
| 7132392 | Inhibition of cell motility and angiogenesis by inhibitors of Grb2-SH2-domain Disclosed are methods of inhibiting cell motility, for example, by inhibiting the binding between an intracellular transducer and a receptor protein tyrosine kinase, and more particularly by inhibiting hepatocyte growth factor (HGF) induced cell motility. The presen... | 11/07/2006 |
| 7129215 | Tripeptide and tetrapeptide thioethers Tripeptide and tetrapeptide thioethers, pharmaceutical compositions containing them, their pharmaceutical use, and their preparation. The compounds are useful in potentiating the cytotoxic effects of chemotherapeutic agents in tumor cells, selectively exerting toxic... | 10/31/2006 |
| 7129052 | Peptides and their utility in modulation of behavior of cells expressing α3β1 integrins The present invention relates to a peptide comprising the sequence R1-X1-X2-X3-X4-R2, wherein X1 is selected from the group consisting of N, Q, D and S; X2 is selected from the g... | 10/31/2006 |
