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| Number | Title | Issue Date |
| 6569993 | Process for the preparation of resin-bound cyclic peptides This invention is directed to a process for the solid phase, fragment-based synthesis of resin-bound cyclic peptide analogs of parathyroid hormones and analogs of parathyroid hormone-related proteins, which analogs contain at least one bridge between the ... | 05/27/2003 |
| 6566336 | Compounds alkylating specific base sequence of DNA and method for synthesizing the same The invention provides a compound recognizing the minor group of hydrogen bonds between base pairs and being capable of forming a covalent bond with bases. The inventive compound can recognize a specific nucleotide sequence and can strongly bind to adjace... | 05/20/2003 |
| 6566327 | Histogranin peptides and their analgesic use The invention relates to linear and cyclic peptide and pseudopeptide compounds useful as analgesics, pharmaceutical compositions comprising such compounds, the use of the compounds and the compositions in the treatment of pain, and commercial packages con... | 05/20/2003 |
| 6566330 | Positively charged non-natural amino acids, methods of making and using thereof in peptides This invention relates to positively charged non-natural amino acids, methods of making thereof, and utilization thereof in peptides.... | 05/20/2003 |
| 6559280 | Controlling protein levels in eucaryotic organisms The invention relates to novel compounds comprising a ubiquitination recognition element and a protein binding element. The invention also relates to the use of said compounds for modulating the level and/or activity of a target protein. The compounds are... | 05/06/2003 |
| 6551574 | Tuftsin metallopeptide analogs and uses thereof Tuftsin receptor-specific peptides, peptidomimetics and peptide-like constructs are provided, particularly for use in biological, pharmaceutical and radiopharmaceutical applications, in which the peptide, peptidomimetic or construct is conformationally fi... | 04/22/2003 |
| 6551994 | Compounds and methods for inhibiting the interaction between -catenin and ଲ-catenin Modulating agents for inhibiting an interaction between -catenin and ଲ-catenin are provided. The modulating agents comprise one or more of: (a) a ଲ-catenin HAV motif; (b) a peptide analogue or mimetic of a ଲ-catenin HAV motif; or ... | 04/22/2003 |
| 6551998 | Antimicrobial agents Antimicrobial compounds of formula I are disclosed: R1 --X--R2 wherein X is a group comprising of from about 4 to about 10 amino acids, wherein at least one of the amide (--CONH--) linkages is replaced by --CRa Ra R | 04/22/2003 |
| 6552168 | Gamma-ketoacid tetrapeptides as inhibitors of caspase-3 The invention encompasses the novel class of compounds represented by formula I, which are caspase-3 inhibitors. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of caspase-3 mediated diseases comprising compounds ... | 04/22/2003 |
| 6548479 | Therapeutic uses of depsipeptides and congeners thereof Depsipeptides and congeners thereof are disclosed having the following structure: ##STR1## wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, ... | 04/15/2003 |
| 6534283 | Method for treatment and prevention of physiological shock Shock is a life threatening complication in situations associated with trauma including burns, surgery, ischemia, sepsis, and other critical care applications. Shock is induced by pancreatic proteases when they are released into the small intestine when t... | 03/18/2003 |
| 6534478 | Cyclic azapeptides with angiogenic effect Compounds of the formula I cyclo-(aArg-aGly-aAsp-aX-aY) I in which aArg, aGly, aAsp, aX and aY have the meanings indicated in claim 1, and their salts, can be used as integrin inhibitors, in particular for the prophylaxis and treatment of diseases of the circ... | 03/18/2003 |
| 6531578 | Immunoassay method employing monoclonal antibody reactive to human iNOS A panel of monoclonal antibodies recognizing and binding to human inducible nitric oxide synthase (iNOS or type II iNOS) enzyme have been developed. The monoclonal antibodies may also be employed in an assay to detect the presence and/or quantitate the am... | 03/11/2003 |
| 6531446 | Peptides having biological activity The present invention relates to peptides that are more potent than or equally potent as the conventional antimicrobial peptides and has strong antimicrobial activities at high salt concentration.... | 03/11/2003 |
| 6528489 | Mycotoxin derivatives as antimitotic agents The present invention provides a treatment for mammalian diseases characterized by aberrant cell proliferation. The treatment consists of administering therapeutically active dosages of antibiotic inhibitors such as efrapeptin oligopeptides or mycotoxin d... | 03/04/2003 |
| 6528487 | Peptide inhibitors of inflammation mediated by selectins Peptides derived from three regions of the lectin domain of GMP-140 and the related selectins, ELAM-1 and the lymphocyte homing receptor, have seen found to inhibit neutrophil adhesion to GMP-140. These and additional peptides have been synthesized, havin... | 03/04/2003 |
| 6514759 | Plant growth factor The present invention relates to a peptide of the formula: ##STR1## wherein R1 and R2 are the same or different and each represents SO3 H or H; X represents an -amino acid or a single bond; Z1 and Z2... | 02/04/2003 |
| 6511963 | Allosteric modulators of the NMDA receptor and their use in the treatment of CNS disorders and enhancement of CNS function Novel compounds and compositions for modulating NMDA receptor function comprising Conantokin-G and derivatives thereof; methods for modulating NMDA receptor function and methods for treating neuropsychopharmacological disorders, using the novel compounds ... | 01/28/2003 |
| 6509444 | Serum amyloid a isoform from colostrum A novel Serum Amyloid A (SAA), isolated and purified from mammalian colostrum, is disclosed. The SAA has been isolated from colostrum of several mammalian species, including horse, cow and sheep. Nucleic acid molecules encoding the colostrum SAA, and anti... | 01/21/2003 |
| 6506876 | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use The present invention provides compounds of the formula Ar1 --Q--Ar2 --Y--R--Z and pharmaceutically acceptable salts thereof wherein Ar1 and Ar2 are optionally substituted aryl moieties, Z is an optionally subst... | 01/14/2003 |
| 6503881 | Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics Compositions and methods for treating infections, especially bacterial infections, are provided. Indolicidin peptide analogues containing at least two basic amino acids are prepared. The analogues are administered as modified peptides, preferably containi... | 01/07/2003 |
| 6500802 | Peptidyl-2-amino-1-hydroxyalkanesulfonic acid cysteine protease inhibitors The present invention is directed to novel peptidyl-2-amino-1-hydroxyalkanesulfonic acid inhibitors of cysteine proteases. Methods for the use of the protease inhibitors are also described.... | 12/31/2002 |
| 6498027 | Targeted delivery through a cationic amino acid transporter The invention relates to the targeted delivery of substances to cells. The invention provides a virus-like particle or gene delivery vehicle provided with a ligand capable of binding to a human amino acid transporter. Provided are, for example, ligands th... | 12/24/2002 |
| 6492489 | Synthetic hypusine peptides The invention relates to novel peptides synthesized according a method utilizing the hypusine reagent: ##STR1## wherein: Q1 Q2 and Q3 may be the same or different and are amino protective groups, provided that Q3 | 12/10/2002 |
| 6492490 | Liquid phase peptide syntheses of KL-4 pulmonary surfactant The invention realtes to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu4)4 -Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process... | 12/10/2002 |
| 6489446 | Self-aligning peptides modeled on human elastin and other fibrous proteins A polypeptide is provided that has a secondary structure characterized by at least three beta-sheet/beta-turn structures, and that is not a naturally occurring fibrous protein. Such polypeptides, illustrated by one modeled on elastin, are useful in prosth... | 12/03/2002 |
| 6485935 | Structure of the ankyrin binding domain of a -Na, K-ATPase The present invention provides a polypeptide of 26 amino acid residues that comprises the minimal ankyrin binding (MAB) domain. The MAB domain is responsible for the interactions between a Na,K-ATPase and ankyrin. The present invention also provides the t... | 11/26/2002 |
| 6482797 | N-terminal site selective inhibitors of human angiotensin conversion enzyme (ACE) The invention relates to peptide derivatives that can be used as selective inhibitors of the N-terminal site of human angiotensin-converting enzyme. The derivatives comprise the amino acid sequence with the following formula: -Asp-Phe-.PSI.(PO2 CH | 11/19/2002 |
| 6482920 | Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents The present invention relates to acrylol substituted distamycin derivatives, to pharmaceutical compositions comprising such derivatives as well as their use in methods of treating humans and animals, particularly as anti-tumor agents.... | 11/19/2002 |
| 6482919 | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell The present invention provides novel soluble CTLA4Ig molecules having modified Ig domains.... | 11/19/2002 |
| 6482921 | Uridyl peptide antibiotic (UPA) derivatives, their synthesis and use The present invention relates to dihydro derivatives of the uridyl peptide antibiotics mureidomycin, pacidimycin and napsamycin which have antibiotic activity against a number of bacterial strains including strains resistant to current therapeutic antibio... | 11/19/2002 |
| 6479460 | Synthetic peptides and pseudopeptides having osteogenic activity and pharmaceutical compositions containing the same The invention relates to synthetic pseudopeptide derivatives of osteogenic grog polypeptide (OGP) and OGP(10-14) which may be linear or cyclic, and which are capable of enhancing bone cell proliferation and bone formation. Further, the present invention r... | 11/12/2002 |
| 6475727 | Primers and methods for the detection of disseminated tumor cells The present invention relates to primers that specifically hybridize to nucleic acid molecules complementary to the messenger RNA transcribed from genes encoding MAGE tumor-specific antigens or a part thereof or to a complementary strand thereof encoding ... | 11/05/2002 |
| 6475775 | PARG, a GTPase activating protein which interacts with PTPL1 The invention describes nucleic acids encoding the PARG protein, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by such nucleic acids, and antibodies relating thereto. Methods... | 11/05/2002 |
| 6476189 | Antibacterial peptides and antibacterial agents containing such peptides as an effective ingredient An object of the present invention is to provide antibacterial peptides of high safety, improved antibacterial activity, wide antibacterial spectrum and lower molecular weight, and antibacterial agents containing such peptides as an effective ingredient, ... | 11/05/2002 |
| 6475988 | Methods to increase white blood cell survival after chemotherapy The present invention provides improved methods, kits, and pharmaceutical compositions for increasing white blood cell survival following chemotherapy, and mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the ad... | 11/05/2002 |
| 6472369 | Anticancer compounds and methods The testing of tumor cells, including human tumors capable of metastases, in assays employing fibronectin-depleted substrates is described. Ex vivo induction of cells, including biopsied human cells, is performed with invasion-inducing agents. Additionall... | 10/29/2002 |
| 6469137 | Myelopeptides and their therapeutic use The present invention pertains to peptides comprising 4 to 10 amino acids including X1 -Pro, Pro-X2 or X1 -Pro-X2, wherein X1 and X2 are independently selected from Lys, Arg, His, Asp, Glu,... | 10/22/2002 |
| 6469138 | Thrombospondin receptor binding peptides Novel short peptides are described that bind to the thrombospondin 1 receptor, which preferably have five amino acid residues which share the tetrapeptide Arg-Val-Ala-Val and have the following sequences: Ile-Arg-Val-Ala-Val [SEQ ID NO:13] and Val-Arg-Val-Ala-... | 10/22/2002 |
| 6465253 | Vectors and methods for gene transfer to cells The present invention provides a chimeric adenovirus coat protein, which differs from the wild-type coat protein by the introduction of a nonnative amino acid sequence. Such a chimeric adenovirus coat protein according to the invention is able to direct e... | 10/15/2002 |
