Did You Know...
...that Robert Adler has the dubious distinction of being the Father of the Couch Potato? Back in 1955 Adler was employed by what was then Zenith Radio Corp., where he was charged to invent something that would allow viewers to turn down the TV volume without leaving their chairs. After a series of flops (such as a wired contraption that people tripped over), Adler hit on the idea of using sound waves. Thus the Remote Control was born...
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| Number | Title | Issue Date |
| 7208285 | Fret protease assays for botulinum serotype A/E toxins The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor ... | 04/24/2007 |
| 7208572 | Leptin-related peptides The present invention relates to methods and compositions containing novel leptin peptides, preferably for the modulation of body mass (i.e., weight), more specifically for novel diagnostic and therapeutic applications in homeostasis of body weight and adipose tissu... | 04/24/2007 |
| 7208591 | G protein-coupled receptor-like receptors and modulators thereof The invention provides neuropeptide ligands, G protein-coupled receptors and methods of screening for modulators of receptor activity. Identified modulators, including neuropeptide ligand mimetics, are useful as biostatic and biocidal agents of varying scope, rangin... | 04/24/2007 |
| 7205435 | Type B botulism toxin inhibitors Novel compounds of general formula (I), are provided with inhibitory properties for the type B botulism toxin activity, along with methods for preparation thereof and corresponding pharmaceutical compositions. ... | 04/17/2007 |
| 7199099 | Methanobactin: a copper binding compound having antibiotic and antioxidant activity isolated from methanotrophic bacteria A means and method for treating bacterial infection, providing antioxidant activity, and chelating copper using a copper binding compound produced by methanotrophic bacteria is described. The compound, known as methanobactin, is the first of a new class of antibioti... | 04/03/2007 |
| 7195766 | Product and process for liquefaction of mucus or sputum Disclosed are compositions and methods for decreasing the viscosity and/or cohesiveness of and/or increasing the liquefaction of excessively or abnormally viscous or cohesive mucus or sputum. The composition contains a protein or peptide containing a thioredoxin act... | 03/27/2007 |
| 7192921 | Peptides that home to tumor lymphatic vasculature and methods of using same The present invention provides a conjugate containing a moiety linked to a homing molecule that selectively homes to tumor lymphatic vasculature. The invention also provides a method of directing a moiety to tumor lymphatic vasculature in a subject by administering ... | 03/20/2007 |
| 7193038 | Extraction and utilization of cell growth-promoting peptides from silk protein Peptides are provided having an excellent safety, stability due to relatively low molecular weights thereof, and cell growth promotion, which are different from cell growth factors produced by abnormal cells such as tumor cells. Peptide compositions which are excell... | 03/20/2007 |
| 7192735 | Phosphopantetheinyl transferases and uses thereof The invention pertains to isolated phosphopantetheinyl transferases, such as the E. coli acyl carrier protein synthase, which transfer a phosphopantetheinyl group onto a substrate. The enzyme can be purified from a natural source, produced recombinantly, or s... | 03/20/2007 |
| 7193043 | Tropoelastin derivatives The disclosure relates to derivatives of tropoelastin and variants of those derivatives. The disclosure further provides expression products and hybrid molecules of the derivatives and variants of the invention. Methods for the production of the derivatives, variant... | 03/20/2007 |
| 7192928 | T cell antigen receptor peptides The present invention provides peptides which affect T-cells, presumably by action on the T-cell antigen receptor. The present invention further relates to the therapy of various inflammatory and autoimmune disease states involving the use of these peptides. Specifi... | 03/20/2007 |
| 7189694 | Inhibitors of autophosphorylation protein kinases The subject invention concerns peptide molecules that specifically inhibit the enzymatic function of tyrosine kinases, including the JAK and EGF receptor (EGFR) family of kinases, to autophosphorylate, i.e., to transfer a phosphate group from ATP to an amino acid in... | 03/13/2007 |
| 7186694 | Leptin-related peptides The present invention relates to methods and compositions containing novel leptin peptides, preferably for the modulation of body mass (i.e., weight), more specifically for novel diagnostic and therapeutic applications in homeostasis of body weight and adipose tissu... | 03/06/2007 |
| 7186799 | Peptide and amine examination method using the same A peptide for detecting amine, and a method and apparatus for detecting amines using the peptide. The method comprises the application of a sensor to examine a sample, wherein the sensor is coated with the peptide. The result collected from the sensor is compared wi... | 03/06/2007 |
| 7183066 | Cell-based fluorescence resonance energy transfer (FRET) assays for clostridial toxins The present invention provides a method of determining clostridial toxin activity by (a) contacting with a sample a cell containing a clostridial toxin substrate that includes a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission sp... | 02/27/2007 |
| 7183373 | MNTF peptides and compositions and methods of use The present invention is directed to novel peptides and compositions capable of modulating viability and growth in neuronal cells, and to methods of modulating neuronal cell viability and growth employing the novel peptides and compositions of the invention. In one ... | 02/27/2007 |
| 7176279 | Cyclic peptide compositions and methods for treatment of sexual dysfunction A cyclic peptide with a C-terminus —OH group. Further provided are compositions and methods for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction, by administration of a cycli... | 02/13/2007 |
| 7176185 | Short peptide carrier system for cellular delivery of agent A dipeptide or tripeptide carrier system for active agent delivery to cells has an N-terminus natural amino acid and an active agent covalently bonded to a side chain of one of the remaining amino acid bases. The system is amenable to formulation as an oral administ... | 02/13/2007 |
| 7176183 | Methods for treating and preventing damage to mucosal tissue The present invention provides improved methods, kits, and pharmaceutical compositions for treating and preventing damage to mucosal tissue by administering an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof,... | 02/13/2007 |
| 7173011 | Radiation therapy methods The present invention provides methods and kits for mitigating radiation induced tissue damage, improving the effectiveness of radiation therapy, to support bone marrow transplantation, and promoting megakaryocyte production and mobilization and platelet production,... | 02/06/2007 |
| 7169752 | Compounds and compositions for prevention of overdose of oxycodone The invention relates to pharmaceutical compounds and compositions comprised of a chemical moiety attached to an opioid such as oxycodone in a manner that substantially decreases the potential of the opioid to cause overdose. When delivered at the proper dosage the ... | 01/30/2007 |
| 7169574 | Fluorescence detection of proteases or peptidases The invention concerns the use of a PyA-(Z)x-pNF group in a substrate for detecting, identifying and/or analyzing by fluorometry peptidases or proteases capable of cleaving the or a bond between a PyA and pNF and/or compounds with inhibiting or activating... | 01/30/2007 |
| 7166475 | Compositions and methods for monitoring the modification state of a pair of polypeptides This invention relates to a method for analyzing a sample comprising: immobilising a polypeptide to a physical support; contacting the immobilised polypeptide with a test sample which may contain an agent capable of modifying the immobilised polypeptide; contacting ... | 01/23/2007 |
| 7166695 | Affinity markers for human serum albumin Methods and compositions are provided for identifying compounds having affinity or complementarity to a target molecule. Compounds according to the invention may be described by the formula E-Ca—R—Cb-A, wherein E is a therapeutic or diagnos... | 01/23/2007 |
| 7166436 | Differential labeling for quantitative analysis of complex protein mixtures The present invention relates to a method of simultaneously identifying and determining the levels of expression of cysteine-containing proteins in normal and perturbed cells, a method for proteomic analysis, a process for preparing fusion proteins, and compounds an... | 01/23/2007 |
| 7163920 | Peptide with osteogenic activity The present invention provides a composition including an isolated or recombinant peptide component that has osteogenic cell proliferative activity. The peptide, which promotes proliferation of osteoblasts, is useful for treatment of fractures, as a filler in defici... | 01/16/2007 |
| 7160983 | Echinocandin derivatives, their method of preparation and their application as anti-fungal agents Compound of the formula wherein R2 is —CH2—CH2—NH2, R3 is —CH3, R4 is —OH, R is ... | 01/09/2007 |
| 7160982 | Peptide substrate identified by type BoNT/B botulinus toxin and use thereof for assaying and/or detecting said toxin or corresponding inhibitors A peptide substrate is identified by type BoNT/B botulinus toxin, characterized in that it incorporates in its structure a fragment of formula PYA-(Z)-pNF, wherein Z represents one or several amino acids, said fragment being cleavable by said toxin. ... | 01/09/2007 |
| 7160864 | Methods for production of growth-promoting proteins and peptides for kidney epithelial cells Novel growth peptides derived from protein factors having molecular weights of about 22 and 45 kDa stimulate mitogenic activity of epithelial, but not fibroblastic cells, in particular, kidney epithelial cells. A source of the factors is scrape-wounded kidney epithe... | 01/09/2007 |
| 7160554 | Enhanced circulation effector composition and method A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the bloodstream. The effector molecules are attached to the distal ends of the ... | 01/09/2007 |
| 7157422 | Glycogen synthase kinase-3 inhibitors Peptide inhibitors of glycogen synthase kinase-3 (GSK-3) having an amino acid sequence motif of XZXXXS(p)X, wherein S(p)=phosphorylated serine or phosphorylated threonine, X=any amino acid, and Z=any amino acid except serine or threonine. These inhibitors, which are... | 01/02/2007 |
| 7153933 | Solid phase method for synthesis peptide-spacer-lipid conjugates, conjugates synthesized thereby and targeted liposomes containing the same A solid phase synthesis method for preparing peptide-spacer-lipid conjugates, the peptide-spacer-lipid conjugates synthesized by the method, and liposomes containing the peptide-spacer-lipid conjugates. The present invention provides a convenient solid phase synthes... | 12/26/2006 |
| 7153931 | Transport vectors The invention relates to modified and truncated forms of the membrane transport vector penetratin. Such truncated forms include 7-mer peptides that may in themselves include further variation. ... | 12/26/2006 |
| 7153822 | Compositions and methods for modulating connexin hemichannels Disclosed are compositions and methods for modulating hemichannel function in a cell, tissue or organ. The invention also relates to useful screens for detecting such compounds, particularly those capable of modulating connexin phosphorylation. Further provided are ... | 12/26/2006 |
| 7144569 | Diagnosis of coeliac disease using a gliadin epitope A method of diagnosing coeliac disease, or susceptibility to coeliac disease, in an individual comprising: (a) contacting a sample from the host with an agent selected from (i) the epitope comprising sequence which is: SEQ ID NO: 1 or 2, or an equivalent sequence fr... | 12/05/2006 |
| 7144854 | Long lasting anti-angiogenic peptides Modified anti-angiogenic peptides are disclosed. The modified peptides are capable of forming a peptidase stabilized anti-angiogenic peptide. The modified anti-angiogenic peptides, particularly modified kringle 5 peptides are capable of forming a conjugate with a bl... | 12/05/2006 |
| 7141593 | Pharmaceutical formulations Improved pharmaceutical compositions are provided comprising one or more solubilized HIV protease inhibiting compounds having improved solubility properties in a medium and/or long chain fatty acid, or mixtures thereof, a pharmaceutically acceptable alcohol, and wat... | 11/28/2006 |
| 7138370 | Specific binding agents of human angiopoietin-2 Disclosed are peptides that bind to Ang-2. Also disclosed are peptibodies comprising the peptides, methods of making such peptides and peptibodies, and methods of treatment using such peptides and peptibodies. ... | 11/21/2006 |
| 7138503 | Synthetic molecules that specifically react with target sequences The present invention features biarsenical molecules. Target sequences that specifically react with the biarsenical molecules are also included. The present invention also features kits that include biarsenical molecules and target sequences. Tetraarsenical molecule... | 11/21/2006 |
| 7135453 | Reagents and methods for smooth muscle therapies The present invention provides novel polypeptides comprising heat shock protein 20 (HSP20)-derived polypeptides to treat or inhibit smooth muscle vasospasm, as well to treat and inhibit smooth muscle cell proliferation and migration. ... | 11/14/2006 |
