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| Number | Title | Issue Date |
| 7622551 | Leukocyte stimulating peptides The present application describes peptides that stimulate arachidonic acid release in target cells. The application also discloses peptides that cause intracellular calcium release. The application also discloses methods of using the disclosed peptides. ... | 11/24/2009 |
| 7544774 | Mimotopes and anti-mimotopes of human platelet glycoprotein Ib/IX The present invention is directed to an isolated peptide that functionally mimics a binding site for a monoclonal antibody, the monoclonal antibody recognizing an epitope within the human platelet glycoprotein Ib/IX complex. This peptide is called a mimotope. The in... | 06/09/2009 |
| 7544773 | Antimicrobials against pathogenic bacteria and method for screening them The present invention provides antimicrobials for efficient therapy of infections caused by bacterial pathogens. The antimicrobials include peptides corresponding to the active site of N-terminal extension of subunits composing specific adhesive organelles of virule... | 06/09/2009 |
| 7538188 | Method for fabricating an olfactory receptor-based biosensor A biosensor, a method of making a biosensor, and a method of using a biosensor are described. A biosensor includes a transducer and a peptide encoding the most probable binding domain of an olfactory receptor protein. In embodiments, the transducer is a piezoelectri... | 05/26/2009 |
| 7531624 | Nuclear targeting sequence The present provides nuclear localization signaling (NLS) sequences derived from titin, comprised of amino acids 181-220: SVGRATSTAE LLVQGEEEVP AKKTKTIVST AQISESRQTR and fragments thereof, such as amino acids 193-208: VQGEEEVP AKKTKTIV; amino acids 199-208: VPAKKTKT... | 05/12/2009 |
| 7521530 | Peptides and peptidomimetics useful for inhibiting the activity of prostaglandin Freceptor The invention relates to compositions which are useful for inhibiting prostaglandin F2αreceptor. The compositions include, but are not limited to, linear peptides, peptide analogs, and peptidomimetics. Methods of using the compositions of the invention t... | 04/21/2009 |
| 7442763 | Compositions for treating abnormalities in glomerular filtration, patent ductus arteriosus and osteoporosis The present invention relates to a composition of matter comprising novel prostaglandin E2 receptor antagonists, and their use in treatments for regulating the fluid filtration in the kidney, preventing bone mineral loss in osteoporosis and dental disease and additi... | 10/28/2008 |
| 7439319 | Selective substrates for matrix metalloproteinases The invention provides isolated MMP-2, MMP-9 and MT1-MMP selective substrate polypeptides or functional peptidomimetics. The selective substrate polypeptides contain the following sequences: MMP-2 selective substrate polypeptides contain SEQ ID NOS:1-27, MMP-9 selec... | 10/21/2008 |
| 7439345 | Supramolecular pairing system, its preparation and use The invention relates to conjugates including at least one linker, a biomolecule coupled to the linker, and cyclohexane derivatives of the following formula: and oligomers thereof. ... | 10/21/2008 |
| 7425608 | Method of making metallopeptides Method of making metallopeptides is provided, for use in biological, pharmaceutical and related applications. The metallopeptides are made of peptides, peptidomimetics and peptide-like constructs, and include a metal ion-binding region thereof which includes at leas... | 09/16/2008 |
| 7425541 | Enzyme-cleavable prodrug compounds The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the enzyme Thimet oligopeptidase, or TOP. Also disclosed are m... | 09/16/2008 |
| 7423021 | Peptidic thrombin inhibitors The invention relates to biologically active molecules, which interact with and inhibit thrombin. The invention particularly relates to molecules of general formula (I): Y1—(NH—X1—CO)—(NH—X2—C═O)—(NH—X3... | 09/09/2008 |
| 7423116 | Pentapeptide compounds and uses related thereto Pentapeptide compounds are disclosed. The compounds have biological activity, e.g., cytotoxicity. Prodrugs having targeting groups and pentapeptide moieties, as well as precursors thereof are also disclosed. For example, precursors having a reactive linker that can ... | 09/09/2008 |
| 7423010 | Nonporous microparticle-prodrug conjugates for treatment of infection This invention provides novel methods and reagents for specifically delivering biologically active compounds to phagocytic mammalian cells. The invention also relates to specific uptake of such biologically active compounds by phagocytic cells and delivery of such c... | 09/09/2008 |
| 7420030 | Aminopeptidase A (APA) targeting peptides for the treatment of cancer The present invention concerns compositions and methods for the treatment of cancer. More specifically, the present invention relates to identification of aminopeptidase A (APA) as a functional target in neo-vasculature, e.g., tumor vasculature; the present inventio... | 09/02/2008 |
| 7417027 | Linear and cyclic melanocortin receptor-specific peptides Linear and cyclic peptides are provided specific to one or melanocortin receptors, and which exhibit agonist, antagonist, or mixed agonist-antagonist activity. In one embodiment, a linear peptide of the following general formula is provided: | 08/26/2008 |
| 7413537 | Directed evolution of disulfide-bonded micro-proteins The invention relates, in part, to a library of chimeric proteins, each chimeric protein including a mini-protein between about eight and about forty amino acids long, wherein the mini-protein has a single disulfide bond formed by a pair of invariant cysteines and h... | 08/19/2008 |
| 7410945 | Treatment of inflammatory bowel disease This invention relates to methods of treatment of inflammatory bowel disease, and especially to treatment of this condition with cyclic peptidic and peptidomimetic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compound... | 08/12/2008 |
| 7407939 | Protein kinase inhibitors comprising ATP mimetics conjugated to peptides or peptidomimetics The present invention provides small molecules having high affinity to the ATP binding site of protein kinases, which are conjugated to apeptide or peptidomimetic moiety which mimics the substrate of PKB. The chimeric compounds according to the present invention pre... | 08/05/2008 |
| 7408028 | Peptides, antibodies thereto, and their use in treatment of central nervous system, damage The application provides peptides that interact with the inhibitory domains of the myelin proteins Nogo, TNR, and MAG. These may be used in the treatment of CNS damage, and for the development of further treatments. Also provided are methods and materials for immuni... | 08/05/2008 |
| 7408030 | Purification of immunoglobulins using affinity chromatography and peptide ligands An immunoglobulin binding peptide having the general formula, from amino terminus to carboxy terminus, of Z-R1—R2—R3—R4—R5—R6—X, is described, wherein: R1 is H or Y; R2 | 08/05/2008 |
| 7408031 | Peptide epitopes recognized by disease promoting CD4+ T lymphocytes The invention provides methods for identifying peptide epitopes that activate CD4+ T cells involved in the pathogenesis of diseases, e.g., autoimmune diseases, susceptibility to which is determined by expression of particular class II MHC genes. The invention includ... | 08/05/2008 |
| 7407940 | Antimicrobial hexapeptides The invention encompasses hexapeptides consisting of alternating hydrophobic residues (B) at positions 2, 4, and 6, hydrophilic, charged residues (X) at positions 1 and 3, and a naphthylalanine (Nal), an aliphatic or aromatic residue (O) at position five, represente... | 08/05/2008 |
| 7405200 | Use of oxytocin for the preparation of a pharmaceutical composition against cancer in situ and cervicitis A method of treating cancer in situ and cervicitis is disclosed. A pharmaceutical composition comprising at least one substance with oxytocin activity against cancer in situ and cervicitis and compound of the formula SEQ ID NO:2 is also disclosed. ... | 07/29/2008 |
| 7404948 | Peptidic conjugates for alopecia prevention and treatment The invention relates to novel peptidic conjugates containing a Gly-His-Lys sequence and used for dermatology or cosmetology for stimulating hair growth or stopping hair fall. ... | 07/29/2008 |
| 7402556 | Prodrugs activated by plasmin and their use in cancer chemotherapy The product of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide having a plasmin peptide substrate of 2-4 amino acids and mono- or di-peptide linkage, a stabilizing group and, optionally, a linker group. The ... | 07/22/2008 |
| 7402559 | Composition and method of treatment for urogenital conditions The present invention is directed to a composition and method for treating uro-genital conditions. One embodiment disclosed is a pharmaceutical composition for use in the treatment of uro-genital conditions wherein said composition comprises a KPV dimer, a first pre... | 07/22/2008 |
| 7402664 | Nucleic acids and expression vectors comprising carotenoid binding peptides The present application relates to peptides which bind to a target stain, phenol oxidizing enzyme-binding peptide complexes wherein the binding peptide is attached to the C-terminus of the phenol oxidizing enzyme or is inserted or substituted into the phenol oxidizi... | 07/22/2008 |
| 7396814 | Metallopeptide compositions for treatment of sexual dysfunction Metallopeptide compositions are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. The metallopeptides include at least one, and preferably two, aromatic amino acid... | 07/08/2008 |
| 7396817 | Biologically active peptides comprising Isoleucyl-valyl-threonyl-asparaginyl-threonyl-threonine (IVTNTT) The peptide Isoleucyl-valyl-threonyl-asparaginyl-threonyl-threonine (SEQ ID NO.1) is disclosed with its use as a pharmaceutical composition in reducing symptoms of viral disease and stimulating properties of immune system in a subject. A method is also disclosed for... | 07/08/2008 |
| 7387879 | Diagnosis of tauopathies The present invention provides a method for the diagnosis of tauopathies in an individual and/or for the differential diagnosis of a tauopathy versus a non-tauopathy based on the detection of the ratio of phospho-tau (181)/total tau in said individual. The present i... | 06/17/2008 |
| 7388072 | MAGE peptides presented by HLA class II molecules The invention describes HLA class II binding peptides encoded by the MAGE tumor associated genes, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes.... | 06/17/2008 |
| 7385025 | Metallopeptide compounds Metallopeptides with a sequence of a biologically active alpha-melanocyte stimulating hormone (α-MSH), gamma-melanocyte stimulating hormone (γ-MSH), or bombesin sequence of length n residues, wherein a residue including a nitrogen atom and sulfur atom each availab... | 06/10/2008 |
| 7378396 | Therapeutic agents and methods for cardiovascular disease The present invention provides methods and agents for treating subjects who have or are at risk of developing or having cardiovascular disease. Such agents inhibit binding of myeloperoxidase (MPO) to a molecule comprising the MPO binding site of apolipoprotein A-1 (... | 05/27/2008 |
| 7378397 | TRH-degrading ectoenzyme inhibitors Peptide derivatives useful as inhibitors of activity of thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE) are of formula Ia: wherein: R1 is an optionally su... | 05/27/2008 |
| 7371724 | KAPREKY peptidomimetics and analogues thereof Analogues of the amino acid sequence KAPREKY and their use in screening for compounds which interacts with FcεRIα. ... | 05/13/2008 |
| 7368119 | Compositions and methods for WT1 specific immunotherapy Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that sp... | 05/06/2008 |
| 7368421 | Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis The present invention provides a new use of DP IV-inhibitors. The compounds of the present invention, and their corresponding pharmaceutically acceptable acid addition salt forms, are useful in treating conditions mediated by DP IV or DP IV-like enzymes, such as imm... | 05/06/2008 |
| 7368528 | Antineoplastic peptides The present invention provides antineoplastic peptides of formula I, R1R2N—CHX—CO-A-B-D-E-(G)s-K I wherein R1, R2, X, A, B, D, E, G, K, and s have the meanings stated in the description. ... | 05/06/2008 |
| 7361638 | Pharmaceutical combination for the treatment of tissue damage owing to an arterial irrigation defect This invention relates to a medicine for humans, and particularly to a pharmaceutical combination comprising Epidermal Growth Factor (EGF) and Growth Hormone secretagogue hexapeptide (GHRP) for use in preventing tissue damage due to blood flow suppression by enhanci... | 04/22/2008 |