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Class 530/315 - Oxytocin; vasopressin; related peptides


Subclass of Class 530 - Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
Definition: Peptides containing at least half the amino acid residues
No. of patents: 96
Last issue date: 06/14/2011


1      
NumberTitleIssue Date
7960336Composition for long-acting peptide analogs
The invention describes compositions of peptide analogs exemplified by peptides derived from vasopressin, terlipressin, and GLP1 and others that are active in blood or cleavable in blood to release an active peptide. The peptide analogs have a general formula: A-(Cm...
06/14/2011
7439225Substances K01-B0171 and process for producing the same
The present invention is comprised of culturing a microorganism having ability to produce K01-B0171-B substance and/or K01-B0171-C substance in a medium, accumulating K01-B0171-B substance and/or K01-B0171-C substance in a culture fluid and isolating K01-B0171-B sub...
10/21/2008
7326700Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
The present invention provides tricyclic carboxamide compounds and methods and pharmaceutical compositions for their use in treatment, prevention, or suppression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including prevention a...
02/05/2008
7276251Sustained-release composition of drugs encapsulated in microparticles of hyaluronic acid
A sustained-release drug composition consisting essentially of microparticles of hyaluronic acid having a high molecular weight or an inorganic salt thereof and a protein or peptide drug encased in said microparticles, wherein the average size of said microparticles...
10/02/2007
72652001-desamino-8-D-arginyl vasopressin analogs
Analogs of 1-desamino-8-D-arginyl vasopressin having the formula: wherein, X and Y are amino acids as defined herein, useful as an anti-diuretic or as an inhibitor of metastasis and cancer cell migration. ...
09/04/2007
7202239Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
The present invention provides novel tricyclic benzodiazepine carboxamides compounds and methods and pharmaceutical compositions utilizing them for the treatment and/or prevention and/or suppression of disorders which may be remedied or alleviated by oxytocin antago...
04/10/2007
7160853Protocol for paracentesis
The present invention relates to an improved method for the treatment of hypovolaemia or hypotension associated with therapeutic paracentesis, which method is characterised by the use of a peptide according to general formulae (I) or a salt thereof, wherin Asn, Cys,...
01/09/2007
7109193Tricyclic diazepines tocolytic oxytocin receptor antagonists
This invention provides novel tricyclic diazepine compounds as well as methods and pharmaceutical compositions utilizing these compounds for the treatment and/or prevention and/or suppression of disorders which may be remedied or alleviated by oxytocin antagonist ac...
09/19/2006
7064120Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
This invention provides novel substituted tricyclic pyridyl carboxamides which act as oxytocin receptor competitive antagonists, as well as methods of their manufacture, pharmaceutical compositions and methods of their use in treatment, inhibition, suppression or pr...
06/20/2006
7045497Use of peptide
The present invention relates to use of peptide to which G-protein coupled receptor protein recognizes as a ligand. Since the ligand polypeptide of the present invention has a stimulating action on oxytocin secretion, it is useful as a drug for ameliorating, preserv...
05/16/2006
7022699Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
The present invention provides novel tricyclic diazepine compounds and methods and pharmaceutical compositions utilizing them for the treating or preventing disorders including diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, bleeding and coag...
04/04/2006
6995236Sphingomyelin detecting probe
An object of the present invention is to provide a protein useful as a sphingomyelin detecting probe, which specifically recognizes sphingomyelin and has low cytotoxicity. The present invention provides a protein which has an amino acid sequence having, as the amino...
02/07/2006
6858210Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same
The present invention provides domain 1 β2GPI polypeptides, polynucleotides encoding these polypeptides, mimetics of these polypeptides, and methods using domain 1 β2GPI polypeptides and mimetics. Domain 1 of β2GPI has been shown ...
02/22/2005
6673769Lanthionine bridged peptides
Disclosed are lanthionine bridged peptides having the structure ##STR1## methods of their preparation and their use as pharmacologically active agents....
01/06/2004
6380155Use of vasopressin receptor antagonist for regulation of ACTH release
A method for normalising abnormally elevated ACTH release in mammals, such as humans, which method comprises the administration of an effective, non-toxic amount of a compound which regulates the biological activity of the arginine vasopressin V1b recepto...
04/30/2002
6268339Lanthionine bridged peptides
Disclosed are lanthionine bridged peptides having the structure ##STR1## methods of their preparation and their use as pharmacologically active agents....
07/31/2001
6262021Use of substances having oxytocin activity for preparation of medicaments for wound healing
Substances having oxytocin activity can be used for the preparation of a pharmaceutical composition for the curative or prophylactic treatment of wounds, such as chronic wounds. The wound healing effect can be strengthened or prolonged by combining oxytoc...
07/17/2001
6228836Permucous preparation
A composition for permucosal administration characterized by containing Antago-3 or a physiologically acceptable salt thereof, and a sucrose fatty acid ester. With the composition for permucosal administration of the invention there is provided a long-ter...
05/08/2001
6143722Heptapeptide oxytocin analogues
Heptapeptide analogues or pharmaceutically acceptable salts thereof consist of a hexapeptide moiety S and a C-terminal ଲ-aminoalcohol residue Z bound to the moiety S by an amide bond, wherein the ଲ-aminoalcohol Z is --NR--CH(Q)--CH2...
11/07/2000
6093692Method and compositions for lipidization of hydrophilic molecules
Fatty acid derivatives of disulfide-containing compounds (for example, disulfide-containing peptides or proteins) comprising fatty acid-conjugated products with a disulfide linkage are employed for delivery of the compounds to mammalian cells. This modifi...
07/25/2000
6028168Lanthionine bridged peptides
Disclosed are lanthionine peptides having the structure ##STR1## methods of their preparation and use as pharmacologically active agents....
02/22/2000
5990273Synthesis of cyclic peptides
A process for preparing and purifying cyclic peptides having disulfide moieties in a two step processing operation including reverse phase chromatography which simplifies synthesis and reduces production costs, yet produces high, quality yield. The improv...
11/23/1999
5939381Compounds and compositions for delivering active agents
Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well....
08/17/1999
5922680Stabilized composition for oral administration of peptides
A solid pharmaceutical composition for oral administration of small and medium size peptides, particularly vasopressin, oxytocin, and their analogues, comprises said peptide, an enteric coat and a pharmaceutically acceptable carrier containing a buffering...
07/13/1999
5849261Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
This invention relates to radiotherapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic and radiotherapeutic agents. Specifically, the invention relates to VIP receptor binding peptides, d...
12/15/1998
5843903Targeted cytotoxic anthracycline analogs
This invention is in the field of the chemistry of targeting anticancer anthracycline derivatives. More particularly, it concerns doxorubicin (DOX) or its daunosamine modified derivatives (DM-DOX) linked covalently to analogs of peptide hormones such as L...
12/01/1998
5827893Mechanical and pharmacological therapies to treat cardiac arrest
A pharmaceutical composition is provided which comprises vasopressin and an adrenergic agent in combination with a pharmaceutically acceptable carrier. The pharmaceutical composition is effective to increase arterial blood pressure so as to enhance arteri...
10/27/1998
5763405Stabilized composition for oral administration of peptides
A solid pharmaceutical composition for oral administration of small and medium size peptides, particularly vasopressin, oxytocin, and their analogues, comprises said peptide, an enteric coat and a pharmaceutically acceptable carrier containing a buffering...
06/09/1998
5756344DNA coding for a human vasoconstrictive peptide and use thereof
Disclosed are (1) a DNA containing a cDNA segment coding for human endothelin-2 (SEQ ID NO:1), (2) a precursor of human endothelin-2 (SEQ ID NO:2), (3) a transformant carrying a DNA containing a cDNA segment coding for human endothelin-2, and (4) a method...
05/26/1998
5726287Synthesis of cyclic peptides
A process for preparing and purifying cyclic peptides having disulfide moieties in a single processing operation which simplifies synthesis and reduces production costs, yet produces high, quality yield. Higher yields are obtained by isolating the desired...
03/10/1998
5698516Biologically active vasopressin analogues
Vasopressin analogues of formula (I) ##STR1## wherein X is (S)-2-amino-2-methyl-butanoic acid (CaMeAbu) or Valine (Val), Y is Thienylalanine (Thi) or Methionine (Met), Z is D-Phenylalanine (D-Phe) or D-Thienylalanine (Thi) or D-Tyrosine (D-Tyr), are ...
12/16/1997
5627268Hemoglobin comprising globin fusion proteins
The present invention relates to a novel method for making a predetermined, desired peptide in transgenic animals and can be advantageously used for the production of large quantities of the desired peptide. More particularly, the invention concerns the e...
05/06/1997
5618791Memory enhancing peptides
The invention is a class of memory enhancing peptides having the general formula: R1 --Asn--X1 --X2 --X3 --R2 where R1 =pyroglutamyl, acetyl, H, peptidyl X1 =Ala, Ile, Leu, Tyr, Phe, Val, ...
04/08/1997
5596078Synthesis of cyclic peptides
A process for preparing and purifying cyclic peptides having disulfide moieties in a single processing operation which simplifies synthesis and reduces production costs, yet produces high, quality yield. Higher yields are obtained by isolating the desired...
01/21/1997
5500413Process for manufacture of 1-deamino-8-D-arginine vasopressin
A process for the manufacture of 1-deamino-8-D-arginine vasopressin (DDAVP) comprising, condensing a preparation of Mpa(R1)-Tyr-Phe-Gln-Asn-Cys(R2)-Pro-OH (SEQ ID NO: 1), where R1 and R2 are sulfhydryl-protectin...
03/19/1996
5486596Analogues of 8-D-homoarginine vasopressin
Analogues of 8-D-homoarginine vasopressin were prepared with the general formula ##STR1## where X is L-O-methyltyrosine, L-p-ethylphenylalanine, D-p-ethylphenylalanine, L-p-methylphenylalanine or D-methylphenylalanine and R is cysteine or ³...
01/23/1996
5482931Stabilized pharmaceutical peptide compositions
Disclosed is a stabilized aqueous composition for administration to a patient comprising a biologically active peptide, a buffer, a quaternary amine-type preservative or disinfectant, and an osmotic pressure-controlling agent, which composition can be sto...
01/09/1996
5470948Vasopressin and vasotocin derivatives
This invention relates to new vasopressin and vasotocin derivatives of general formula I ##STR1## in which A stands for the radical Mca (=3-mercapto-3,3-cyclpentamethylenepropionyl radical) or for the radical Mpa (=3-mercaptopropionyl radical), ...
11/28/1995
5459236Vasoactive vasotocin derivatives
The present invention relates to new vasotocin derivatives with prolonged activity compared to previous vasotocin derivatives. In particular, the vasotocin derivatives of the present invention are of the formula (I) ##STR1## wherein Hmp is a 2-hydrox...
10/17/1995
5459077Methods for modelling tertiary structures of biologically active ligands and for modelling agonists and antagonists thereto
Disclosed are methods for modelling the three-dimensional structure (tertiary structure) of a ligand having one or more active sites employing a charge-transfer interaction. Also disclosed is a model for Angiotensin II derived from such method....
10/17/1995
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