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| Number | Title | Issue Date |
| 7932228 | Method of treating bone or prostate cancer with selective bradykinin B1 receptor antagonists Provided is a method for the use of a bradykinin B1 receptor antagonist of formula I: X-CO-Aaa0-Aaa1-Aaa2-Aaa3-Gly-α(Me)Phe-Ser-D-βNal-Aaa8-OH (I) or a pharmaceutically acceptable salt or hydrate thereof where... | 04/26/2011 |
| 7427496 | Anti-cancer compounds The invention provides bradykinin antagonists and pharmaceutically acceptable salts thereof having anti-cancer activity. These anti-cancer compounds are particularly useful for inhibiting the growth of lung and prostate cancers. ... | 09/23/2008 |
| 7371810 | Tachykinin peptides, precursor peptides thereof and genes encoding the same Tachykinin peptide isolated and purified from the posterior salivary gland of the mollusk Octopus vulgaris. The tachykinin peptide provides a new approach for developing medicaments and pesticides through studies on the structural activity correlation at the ... | 05/13/2008 |
| 7276251 | Sustained-release composition of drugs encapsulated in microparticles of hyaluronic acid A sustained-release drug composition consisting essentially of microparticles of hyaluronic acid having a high molecular weight or an inorganic salt thereof and a protein or peptide drug encased in said microparticles, wherein the average size of said microparticles... | 10/02/2007 |
| 7235531 | Tachykinin-like polypeptides and use thereof The present invention relates to amino acid sequences for novel tachykinin polypeptides and base sequences encoding them, agonists and antagonists of such polypeptides, pharmaceutical compositions comprising them, and the like. ... | 06/26/2007 |
| 7157429 | Method of regulating glucose metabolism, and reagents related thereto The present invention provides methods and compositions for modification and regulation of glucose and lipid metabolism, generally to reduce insulin resistance, hyperglycemia, hyperinsulinemia, obesity, hyperlipidemia, hyperlipoproteinemia (such as chylomicrons, VLD... | 01/02/2007 |
| 7153835 | Anti-inflammatory peptides Methods for inhibiting an inflammatory reaction in a mammal and pharmaceutical compositions are provided. The methods comprise administering to the mammal an effective amount of a peptide of the formula: X1-X2... | 12/26/2006 |
| 7115664 | Peptidomimetic ligands for cellular receptors and ion channels One aspect of the present invention relates to novel peptidomimetic compounds. A second aspect of the present invention relates to the use of the novel peptidomimetic compounds as ligands—agonists or antagonists—for various cellular receptors, e.g., G-protein-co... | 10/03/2006 |
| 7078381 | Method of regulating glucose metabolism, and reagents related thereto The present invention provides methods and compositions for modifying glucose metabolism and treating Type II diabetes in an animal, along with modifying metabolism of a peptide hormone in an animal. Compositions disclosed herein comprise one or more peptides and/or... | 07/18/2006 |
| 7074765 | Synthetic peptide analogs of Arg-Pro-Pro-Gly-Phe as selective inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4 The invention relates to compounds and methods for inhibiting human platelet aggregation, thrombosis and cell activation mediated by PAR1 and PAR4 using peptide analogs of Arg-Pro-Pro-Gly-Phe that contain one or more amino acid substitutions. The invention also incl... | 07/11/2006 |
| 7071168 | Anti-cancer compounds and methods related thereto The present invention provides compounds useful to inhibit tumor growth and to induce apoptosis. In general, the anti-cancer agents (ACA) are described by the formula: [ACA]n-X[Formula I] wherein X is a linker group having 2–5 functi... | 07/04/2006 |
| 7041785 | B-bradykinin receptor antagonists and use thereof The present invention relates to novel antagonists to a B1-bradykinin (B1-BK) receptor which have a good affinity and selectivity therefor, some of which being at least partially resistant to enzymatic degradation. The synthesis of the B1 ... | 05/09/2006 |
| 6995236 | Sphingomyelin detecting probe An object of the present invention is to provide a protein useful as a sphingomyelin detecting probe, which specifically recognizes sphingomyelin and has low cytotoxicity. The present invention provides a protein which has an amino acid sequence having, as the amino... | 02/07/2006 |
| 6770741 | Brandykinin antagonist peptides The substitution of the L-Pro at the 7-position of the peptide hormone bradykinin or other substituted analogs of bradykinin with a D-configuration hydroxyproline ether or thioether converts bradykinin agonists into bradykinin antagonists. The invention further incl... | 08/03/2004 |
| 6458923 | Modified position (7) bradykinin antagonist peptides The substitution of the L-Pro at the 7-position of the peptide hormone bradykinin or other substituted analogs of bradykinin with an isoquinoline derivative which converts bradykinin agonists into bradykinin antagonists. The invention further includes the... | 10/01/2002 |
| 6388054 | Anti-cancer compounds The present invention provides compounds useful to inhibit tumor growth and to induce apoptosis. In general, the anti-cancer agents (ACA) are described by the formula: [ACA]n -X [Formula I] wherein X is a linker group having 2-5 functional groups o... | 05/14/2002 |
| 6288036 | Bradykinin type peptides The substitution of the L-Pro at the 7-position with D-Phe or D-Tic and substitution of the L-Phe at the 8-position with hydroxyproline ethers and thioethers of the peptide hormone bradykinin and other additional substituted analogs of bradykinin converts... | 09/11/2001 |
| 6245736 | Use of peptidic bradykinin antagonists for the treatment and prevention of Alzheimer's disease The invention relates to the use of bradykinin antagonists for the production of pharmaceuticals for the treatment and prevention of Alzheimer's disease. Suitable bradykinin antagonists are peptides which inhibit the effects of the Alzheimer's protein amy... | 06/12/2001 |
| 6242573 | Method of producing water-insolubilized regenerated collagen fiber A regenerated collagen fiber is subjected to water-insolubilizing treatment with a monofunctional epoxy compound to produce a water-insolubilized regenerated collagen fiber which can substantially maintain the color and the high knot tenacity, inherent in... | 06/05/2001 |
| 6075120 | Bradykinin antagonist A bradykinin antagonist of the formula: (BKAn)(X)(Y) where BKAn is a bradykinin antagonist peptide; Y is a pharmacore; and X is a bridging link chemically joining the BKAn and Y components.... | 06/13/2000 |
| 5935932 | Bradykinin antagonists containing pentafluorophenylalanine The present invention provides bradykin antagonists containing pentafluorophenylalanine which are therapeutically useful. Moreover, the present invention provides methods to antagonize bradykinin receptors in a mammal in need of such antagonism, comprisin... | 08/10/1999 |
| 5874529 | Conformationally constrained backbone cyclized peptide analogs Novel backbone cyclized peptide analogs are formed by means of bridging groups attached via the alpha nitrogens of amino acid derivatives to provide novel non-peptidic linkages. Novel building units disclosed are N (ω-functionalized)ami... | 02/23/1999 |
| 5863899 | Bradykinin antagonists A bradykinin antagonist of the formula: (BKAn) (X) (Y) where BKAn is a bradykinin antagonist peptide; Y is a Pharmacophore; and X is a bridging link chemically joining the BKAn and Y components.... | 01/26/1999 |
| 5863901 | Use of bradykinin antagonists for the production of pharmaceuticals for the treatment of chronic fibrogenetic liver disorders and acute liver disorders This invention relates to a method of treating a chronic fibrogenetic liver disorder and/or an acute liver disorder and/or complications associated therewith, comprising administering to a patient a therapeutically effective amount of a bradykinin antagon... | 01/26/1999 |
| 5849863 | Cytolytic bradykinin antagonists The present invention provides bradykinin antagonists effective to inhibit cancer cell growth. Also provided are methods of inhibiting lung cancer cell growth by administering a therapeutically effective amount of a dimerized bradykinin antagonist.... | 12/15/1998 |
| 5843903 | Targeted cytotoxic anthracycline analogs This invention is in the field of the chemistry of targeting anticancer anthracycline derivatives. More particularly, it concerns doxorubicin (DOX) or its daunosamine modified derivatives (DM-DOX) linked covalently to analogs of peptide hormones such as L... | 12/01/1998 |
| 5843900 | Bradykinin antagonists The present invention relates to pharmaceutically effective heterodimers comprising a bradykinin antagonist component covalently linked to a mu-opioid agonist component.... | 12/01/1998 |
| 5834431 | Des-Arg9 -BK antagonists The present invention provides des-Arg9 bradykinin analogs which are selective B1 receptor antagonists.... | 11/10/1998 |
| 5811392 | Conformationally constrained backbone cyclized peptide analogs Novel backbone cyclized peptide analogs are formed by means of bridging groups attached via the alpha nitrogens of amino acid derivatives to provide novel non-peptidic linkages. Novel building units disclosed are N (ω-functionalized) am... | 09/22/1998 |
| 5789383 | Bradykinin antagonists for the prophylaxis or treatment of virus diseases Bradykinin antagonists and their physiologically tolerated salts are suitable for the treatment or prophylaxis of virus diseases.... | 08/04/1998 |
| 5750506 | Bradykinin antagonists with extended hydrophobic side chains Bradykinin antagonists, particularly Cys6 analogs, which have an extended hydrophobic side chain.... | 05/12/1998 |
| 5750646 | Bradykinin analogs with non-peptide bond A linear peptide which is an analog of a naturally occurring, biologically active peptide having an active site and a binding site responsible for the binding of the peptide to a receptor on a target cell, cleavage of a peptide bond in the active site to ... | 05/12/1998 |
| 5700779 | Bradykinin antagonist peptides incorporating N-substituted glycines The present invention provides bradykinin type peptides containing N-substituted glycines, particularly bradykinin antagonist peptides useful for the treatment of conditions mediated by bradykinin including pain and inflammation.... | 12/23/1997 |
| 5686416 | Increasing blood-brain barrier permeability with permeabilizer peptides Peptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood-brain barrier to molecules such as therapeutic agents or diagnostic agents. The permeabilizer A-7 or conformational analogues can be intravenously co-administere... | 11/11/1997 |
| 5670619 | Bradykinin-antagonists for the treatment of acute pancreatitis The invention relates to the use of bradykinin-antagonists of the formula R1 -A-B-C-E-F-G-J-K-R2 wherein R1 represents hydrogen, C1 -C4 -alkanoyl which can be substituted by mercapto, hydroxyphenyl, (4-benzoyl)... | 09/23/1997 |
| 5648333 | Peptides having bradykinin antagonist action Peptides of the formula I A-B-C-E-F-K-P-G-M-F'-I (I), wherein the terms A, B, C, E, F, K, P, G, M, F', and I are defined in the specification, have bradykinin antagonist action. Their therapeutic utility includes all patholo... | 07/15/1997 |
| 5648336 | Bradykinin antagonist peptides containing indane-substituted amino acids The present invention pertains to modified bradykinin antagonist peptides of the formula X-A0 -B1 -C2 -D3 -E4 -F5 -G6 -H7 -J8 -K9, where at least one ... | 07/15/1997 |
| 5635593 | Bradykinin antagonists A brandykinin antagonist of the formula: X(BKA)n wherein BKA is the peptide chain of a bradykinin antagonist peptide, X is a linking group and n is a whole number greater than 1. The BKA substituents may be the same or different. Monomeric antagonis... | 06/03/1997 |
| 5620958 | Bradykinin antagonists A bradykinin antagonist of the formula: X(BKA)n wherein BKA is the peptide chain of a bradykinin antagonist peptide, X is a linking group and n is a whole number greater than 1. The BKA substituents may be the same or different. Monomeric antagonist... | 04/15/1997 |
| 5610140 | Bradykinin receptor antagonists with neurokinin receptor blocking activity The present invention provides a heterodimeric compound possessing bradykinin and neurokinin receptor antagonist activities useful in the treatment of asthma and other inflammatory diseases especially those involving the airway or pulmonary system. The pr... | 03/11/1997 |
