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| Number | Title | Issue Date |
| 7834141 | Non-mammalian GnRH analogs and uses thereof in tumor cell growth regulation and cancer therapy Specially designed non-mammalian GnRH analogs resistant to degradation by the tumor tissue enzymes, post-proline peptidases as well as endopeptidases, are disclosed. The GnRH analogs are further defined as analogs of chicken II GnRH, salmon GnRH, or herring GnRH, bu... | 11/16/2010 |
| 7381706 | Gonadotropin-releasing hormone, precursor peptides thereof and genes encoding the same A novel peptide found as gonadotropin-releasing hormone (GnRH) in octopuses, a member of mollusks. The structure and the activities of the peptide have been unraveled. The peptide finds use as a reagent used in the studies of correlations between the structure and t... | 06/03/2008 |
| 7364910 | Methods of inducing ovulation The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific admini... | 04/29/2008 |
| 7341989 | Use of LH in controlled ovarian hyperstimulation The invention provides a new use for LH, and analogues having LH-activity for aiding folliculogenesis in controlled ovarian hyperstimulation (COH), in which the LH or an analogue thereof is administered during a priming period lasting from day 1 to about day 4 of th... | 03/11/2008 |
| 7312304 | Somatostatin agonists Claimed are a series of somatostatin agonists and uses thereof, according to formula (I), A1-cyclo[Cys-A2-D-Trp-A3-A4-Cys]-A5-Y1, (I) wherein A1, A2, A | 12/25/2007 |
| 7282352 | Homogeneity and secretion of recombinant proteins in mammalian systems The present invention relates to a method for improving homogeneity and/or secretion of a recombinant protein of interest expressed in mammalian cells by replacing the endogenous signal peptide sequence of the DNA encoding the protein of interest with that of human ... | 10/16/2007 |
| 7276251 | Sustained-release composition of drugs encapsulated in microparticles of hyaluronic acid A sustained-release drug composition consisting essentially of microparticles of hyaluronic acid having a high molecular weight or an inorganic salt thereof and a protein or peptide drug encased in said microparticles, wherein the average size of said microparticles... | 10/02/2007 |
| 7268210 | PEG-LHRH analog conjugates PEG-LHRH analog conjugates, where a PEG moiety is covalently bound to a serine residue of a LHRH analog, and methods for producing these conjugates are provided in the present invention. Also provided are a pharmaceutical composition and a method for treating pathol... | 09/11/2007 |
| 7267963 | Modified plant viruses and methods of use thereof The present invention relates to modulating the nature and/or level of an immune response to a molecule. In particular, the invention relates to effecting an increase in the TH1 immune response to molecules such as, but not limited to, antigens or immunogens. The in... | 09/11/2007 |
| 7235524 | Medicaments for initiating ovulation The invention relates to medicaments for initiating ovulation comprising LH in an administrable form which ensures an increase in LH plasma levels for a period of some 40 to 60 hours. ... | 06/26/2007 |
| 7214662 | Injectable solution of an LHRH antagonist An aqueous injectable soution of an LHRH antagonist, such as Cetrorelix, in an organic, pharmaceutically acceptable acid, such as gluconic acid. ... | 05/08/2007 |
| 7122553 | Liposomal formulation of irinotecan The present invention is for novel compositions and methods for treating cancer, particularly, for treating cancer in mammals and more particularly in humans. The therapeutic compositions of the present invention include liposome entrapped irinotecan in which the li... | 10/17/2006 |
| 7109171 | Methods for treating FSH related conditions with GnRH antagonists Methods for treating FSH related conditions, such as prostatic intraepithelial neoplasia, pedophilia, infertility, or vaginal bleeding, with GnRH antagonists are disclosed. The methods of the invention generally feature administering to a subject a GnRH antagonist s... | 09/19/2006 |
| 7105487 | Method for inducing onset of the reproductive cycle of female breeding animals A method for inducing the onset of the reproductive cycle of female breeding animals is provided. To this end, the animals are injected with an agent that contains synthetically produced FSH releasing hormones as the active substance which comprise known sequences, ... | 09/12/2006 |
| 7078236 | Methods of inducing ovulation The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific admini... | 07/18/2006 |
| 7074758 | Two gonadotropin releasing hormones and a method to isolate the same The present invention relates to two novel Gonadotropin releasing hormones muGnRH I and muGnRH II of amino acid SEQ ID 1 as QHWSAWRLPG, and SEQ ID 2 QHWSWGILPG respectively, useful for induced breeding in fish both in combination and alone, by activating production ... | 07/11/2006 |
| 7071165 | LHRH antagonist peptides Novel LHRH antagonist peptides, pharmaceutical compositions thereof, and methods of use thereof, are disclosed. The LHRH antagonist comprise a peptide compound, wherein a residue of the peptide compound corresponding to the amino acid at position 6 of natural mammal... | 07/04/2006 |
| 7048947 | Sustained-release preparation A sustained-release preparation which comprises a physiologically active peptide of general formula wherein X represents an acyl group; R1, R2 and R4 each represents ... | 05/23/2006 |
| 7037889 | Pharmaceutical compositions for sustained drug delivery Sustained delivery formulations comprising a water-insoluble complex of a peptide and a plurality of ligands are disclosed. The formulations of the invention allow for loading of high concentrations of peptide in a small volume and for delivery of a pharmaceutically... | 05/02/2006 |
| 7030214 | Ureins derived from α, ω, diamino acids and process for their preparation Ureins are obtained by reaction, in basic medium, between an Nω-(aryloxycarbonyl)diamino acid and a compound containing a free amino group. The chirality of the compounds is outstandingly well preserved. ... | 04/18/2006 |
| RE39048 | Peptide, immunogenic composition and vaccine or medical preparation, a method to immunise animals against the hormone LHRH, and analogs of the LHRH tandem repeat peptide and their use as vaccine The invention relates to a modified tandem LHRH-peptide vaccine preparation in which the amino acid glycine at position (6) of one or both LHRH decapeptides that constitute the tandem unit is substituted by a dextrorotatory amino acid that contains a side chain to w... | 03/28/2006 |
| 6977242 | Two gonadotropin releasing hormones and a method to isolate the same The present invention relates to two novel Gonadotropin releasing hormones muGnRH I and muGnRH II of amino acid SEQ ID 1 as QHWSAWRLPG, and SEQ ID 2 QHWSWGILPG respectively, useful for induced breeding in fish both in combination and alone, by activating production ... | 12/20/2005 |
| 6933271 | Chimeric toxins for targeted therapy The present invention relates particularly to neoplastic cells targeted chimeric toxins comprising of cell targeting moieties and cell killing moieties for recognizing and for destroying the neoplastic cells, wherein the cell targeting moieties consist of gonadotrop... | 08/23/2005 |
| 6924268 | Method for inactivating gonadotrophs Certain toxic compounds (T) such as, for example, compounds based upon diphtheria toxin, ricin toxin, pseudomonas exotoxin, α-amanitin, pokeweed antiviral protein (PAP), ribosome inhibiting proteins, especially the ribosome inhibiting proteins of barley, wheat, cor... | 08/02/2005 |
| 6913767 | Compositions for microencapsulation of antigens for use as vaccines Methods and compositions are provided for the encapsulation of antigens in PLGA microspheres for use as vaccines. Such microspheres can also contain adjuvants. Mixtures of microspheres are provided which release antigen at desired intervals to provide boosts with an... | 07/05/2005 |
| 6914121 | PEG-LHRH analog conjugates PEG-LHRH analog conjugates, where a PEG moiety is covalently bound to a serine residue of a LHRH analog either directly or via a bifunctional linker molecule, such as an amino acid, and methods for producing these conjugates are provided in the present invention. Al... | 07/05/2005 |
| 6878689 | Preventives or remedies for heart failure Preparations for preventing or treating acute heart failure, chronic heart failure at a phase of acute exacerbation or heart failure at a phase of transition to chronic heart failure, which contain D-alanyl-3-(naphthalen-2-yl)-D-alanyl-L-alanyl-L-tryptophyl-D-phenyl... | 04/12/2005 |
| 6875843 | Prevention of diabetes and prolongation of the honeymoon phase of diabetes by administration of GnRH antagonists A method for reducing the incidence or delaying the onset of diabetes in diabetes-susceptible mammals (e.g., mice, rats, humans) is provided wherein the mammals are treated with a gonadotropin-releasing hormone (GnRH) antagonist. Additionally, the present invention ... | 04/05/2005 |
| 6867191 | Preparation and use of oligopeptide lyophilisate for gonad protection A lyophilizate, method of preparation, and use of the lyophilizate for gonad protection is described. The lyophilizate comprises cetrorelix dissolved in 30% (v/v) acetic acid, transferred to water, and freeze-dried. ... | 03/15/2005 |
| 6863891 | Oligopeptide lyophilisate, their preparation and use A novel lyophilizate and method of preparation as well as the use of the lyophilizate to treat female infertility and for gonad protection. Cetrorelix is dissolved in acetic acid 30% v/v, the solution is transferred to water and freeze dried. ... | 03/08/2005 |
| 6828415 | Oligopeptide lyophilisate, their preparation and use A novel lyophilizate and method of preparation as well as the use of the lyophilizate to treat female infertility and for gonad protection. Cetrorelix is dissolved in acetic acid 30% v/v, the solution is transferred to water and freeze dried. ... | 12/07/2004 |
| 6783761 | Chimeric peptide immunogens Chimeric peptide epitopes can serve as effective immunogens against hormones and other small peptides or proteins. Thus, immunogenic peptides are selected from promiscuous Th epitopes and synthesized together with self antigenic peptide sequences fused with or witho... | 08/31/2004 |
| 6780969 | Synthetic peptide composition as immunogens for prevention of urinary tract infection The invention provides a peptide immunogen comprising a FAFSD target peptide or an anlogue thereof, covalently linked to a helper T cell epitope and optionally to an invasin immunostimulatory domain. The present invention also provides for the use of such peptide im... | 08/24/2004 |
| 6747125 | Peptides intermediates for making GnRH antagonists Peptides which include unnatural amino acids and which either promote or inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads. Administration of an effective amount of such peptides that are GnRH antagonists... | 06/08/2004 |
| 6740634 | Sustained release compositions, process for producing the same and utilization thereof A sustained-release composition containing a hydroxynaphthoic acid salt of a biologically active substance and a biodegradable polymer, a method of its production, and a pharmaceutical composition containing said sustained-release composition. ... | 05/25/2004 |
| 6737039 | Methods for detecting lesions in dense breast tissue using LHRH antagonists Improved methods for detecting lesions in dense breast tissue are disclosed. The methods of the invention generally feature administration to a subject of an LHRH antagonist in an amount and for a period of time sufficient to reduce the density of breast tissue prio... | 05/18/2004 |
| 6716817 | Method of treatment of female infertility A method of treating female infertility using a novel cetrorelix acetate lyophilizate is disclosed. ... | 04/06/2004 |
| 6703367 | Methods for treating hot flashes and gynaecomastia Methods to inhibit hot flashes or gynaecomastia in a subject are provided. In the methods of the invention, an LHRH antagonist is administered to a subject in need of treatment for hot flashes or gynaecomastia such that hot flashes or gynaecomastia are in... | 03/09/2004 |
| 6699833 | Pharmaceutical formulations for sustained drug delivery Sustained delivery formulations comprising a water-insoluble complex of a peptide and a carrier macromolecule are disclosed. The formulations of the invention allow for loading of high concentrations of peptide in a small volume and for delivery of a phar... | 03/02/2004 |
| 6635739 | Non-mammalian GnRH analogs and uses thereof in regulation of fertility and pregnancy Specially designed non-mammalian GnRH analog decapeptides resistant to degradation by the placental enzyme, C-ase-1, or a post-proline peptidase, are disclosed. The GnRH analogs are further defined as analogs of chicken II GnRH or salmon GnRH. These non-m... | 10/21/2003 |
