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| Number | Title | Issue Date |
| 7473760 | Cyclic peptide compositions for treatment of sexual dysfunction A cyclic peptide of the structural formula: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, R6, m, n and p are as defined. Further provided are c... | 01/06/2009 |
| 7345144 | Cyclic peptides for treatment of cachexia A highly selective melanocortin-4 receptor antagonist cyclic hexapeptide of the formula where R1, R2, R3a, R3b, R4, R5, x, y and z are as defined in the spec... | 03/18/2008 |
| 7342089 | Cyclic peptides for treatment for cachexia A highly selective melanocortin-4 receptor antagonist cyclic peptide of the formula where R1, R2, R3, R4a, R4b, R5, R6, R7, x, y and z ... | 03/11/2008 |
| 7276251 | Sustained-release composition of drugs encapsulated in microparticles of hyaluronic acid A sustained-release drug composition consisting essentially of microparticles of hyaluronic acid having a high molecular weight or an inorganic salt thereof and a protein or peptide drug encased in said microparticles, wherein the average size of said microparticles... | 10/02/2007 |
| 7258850 | Methods and compositions for treating erectile dysfunction Methods are provided for increasing libido and/or treating erectile dysfunction in a man. The methods include the administration of a formulation testosterone alone, another fast-acting drug to treat erectile dysfunction or a combination of the testosterone and the ... | 08/21/2007 |
| 7235625 | Multiple agent therapy for sexual dysfunction Multiple agent therapy for treatment of sexual dysfunction, including male erectile dysfunction, with sequential administration a type V phosphodiesterase inhibitor (PDE-5), such as sildenafil, preferably wherein the PDE-5 inhibitor is administered by oral dose mean... | 06/26/2007 |
| 7176279 | Cyclic peptide compositions and methods for treatment of sexual dysfunction A cyclic peptide with a C-terminus —OH group. Further provided are compositions and methods for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction, by administration of a cycli... | 02/13/2007 |
| 7135548 | Modified α-MSH peptides and derivatives thereof Novel peptides with antimicrobial activity are disclosed. The novel peptides are octomeric peptides modified from α-MSH. The modified α-MSH antimicrobial peptides disclosed herein may have enhanced activity against microbes over α-MSH due to modifications in pept... | 11/14/2006 |
| 7052833 | Absorptive hypercalciuria locus on human chromosome 1 Disclosed is a region on human chromosome 1 that provides a genetic basis for absorptive hypercalciuria. The genes, proteins, and other biological materials provided are envisioned for use in diagnostic and therapeutic methods related to absorptive hypercalciuria an... | 05/30/2006 |
| 7049398 | Melanocortin metallopeptide constructs, combinatorial libraries and applications Metallopeptides and metallopeptide combinatorial libraries specific for melanocortin receptors are provided, for use in biological, pharmaceutical and related applications. The metallopeptides and combinatorial libraries are made of peptides, peptidomimetics and pep... | 05/23/2006 |
| 6794489 | Compositions and methods for treatment of sexual dysfunction Compositions and methods are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. In one embodiment, a peptide-based composition including the peptide sequence Ac-Nle... | 09/21/2004 |
| 6716810 | Composition and method for regulation of body weight and associated conditions Described are methods and compositions for regulating body weight and/or regulating the rate of weight gain or loss, and particularly, for treating or preventing obesity. Specifically, methods of administering varying levels of circulating proopiomelanocortin peptid... | 04/06/2004 |
| 6607709 | Melanotropin analogs for potential radiopharmaceuticals for diagnosis and treatment of melonoma A compound for use as a diagnostic or therapeutic pharmaceutical and method of using the same where the compound consists essentially of an alpha-melanotropin stimulating hormone analog which has integrally located a radionuclide. The radionuclide is admi... | 08/19/2003 |
| 6579968 | Compositions and methods for treatment of sexual dysfunction Compositions and methods are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. In one embodiment, a peptide-based composition including the peptide sequ... | 06/17/2003 |
| 6500934 | Bivalent agonists for G-protein coupled receptors Bivalent agonists having affinity for one or more G-protein coupled receptors, comprising two agonist or two antagonist ligand domains, wherein the distance between the ligand domains can range from about 40 to about 250 Å, and further comprising a backb... | 12/31/2002 |
| 6448032 | Human melanocyte stimulating hormone receptor polypeptide and DNA Novel DNA fragments encoding novel polypeptides having properties of melanotropic hormone receptors, especially DNA molecules encoding melanocyte stimulating hormone receptors (MSH receptors), as well as polypeptides which are MSH receptors, are disclosed... | 09/10/2002 |
| 6350430 | Melanocortin receptor ligands and methods of using same The invention provides ligands for melanocortin receptors. For example, the invention provides the melanocortin receptor peptide ligand Ac-Nlc-Gln-His-(p(I)-D-Phe)-Arg-(D-Trp)-Cly-NH2, (SEQ ID NO: 1), where the iodo group is unlabeled or radioa... | 02/26/2002 |
| 6338834 | Melanotropin analogs for potential radiopharmaceuticals for diagnosis and treatment of melanoma A compound for use as a diagnostic or therapeutic pharmaceutical and method of using the same where the compound consists essentially of an alpha-melanotropin stimulating hormone analog which has integrally located a radionuclide. The radionuclide is admi... | 01/15/2002 |
| 6278038 | Mammalian melanocortin receptors and uses This invention provides methods and reagents for developing naturally-occurring and synthetic agonists and antagonists specific for a mammalian melanocortin receptor, and the use of such agonists and antagonists for treatment and alleviation of dysfunctio... | 08/21/2001 |
| 6147195 | Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them Conjugates of chlorophyll (Chl) and bacteriochlorophyll (Bchl) derivatives with amino acids, peptides and proteins are provided by the invention. The amino acid, peptide or protein residue is linked to the 17-propionic acid group of a Chl or Bchl residue ... | 11/14/2000 |
| 6100048 | Methods and reagents for discovering and using mammalian melanocortin receptor agonists and antagonists to modulate feeding behavior in animals The present invention provides recombinant expression constructs comprising nucleic acid encoding mammalian melanocortin receptors, and mammalian cells into which said recombinant expression constructs have been introduced that express functional mammalia... | 08/08/2000 |
| 6054556 | Melanocortin receptor antagonists and agonists Cyclic lactam peptides are disclosed which inhibit at various levels of antagonism the melanocortin 1 receptor (MC1R), melanocortin 3 receptor (MC3R), melanocortin 4 receptor (MC4R), and Melanocortin 4 receptor (MC5R).... | 04/25/2000 |
| 5891847 | Treatment of degenerative eye disorders Retinal dystrophies are treated by melanotropin peptides or analogs.... | 04/06/1999 |
| 5849871 | -melanocyte stimulating hormone receptor The present invention relates to a mammalian alpha-melanocyte stimulating hormone receptor. The invention is directed toward the isolation, characterization and pharmacological use of mammalian melanocyte stimulating hormone receptor, the gene correspondi... | 12/15/1998 |
| 5739106 | Appetite regulating compositions Compositions and methods for reducing food intake, suppressing appetite and controlling body weight are provided. Such compositions may include an amylin agonist and a CCK agonist or a hybrid peptide.... | 04/14/1998 |
| 5731408 | Peptides having potent antagonist and agonist bioactivities at melanocortin receptors Cyclic lactam peptides, seven amino acids in length, having D-2'-naphthylalanine (D-2'-Nal) or D-para-iodo-phenylalanine D-(p-I)Phe at position 4 of the peptide provided potent and specific antagonists of the two neural melanocortin receptors and of the p... | 03/24/1998 |
| 5714576 | Linear analogs of alpha-msh fragments Linear and Cyclic Alpha-MSH fragment analogues of Ac-Nle4 -Glu5 -His6 -D-Phe7 -Arg8 -Try9 -Gly10 -NH2. The method of stimulating melanocytes by the transdermal application ... | 02/03/1998 |
| 5683981 | Cyclic bridged analogs of -MSH and methods thereof A novel class of cyclic bridged analogs of -MSH are described herein. With the described analogs, when administered in pharmaceutical compositions, it is now possible to achieve normalization of hypopigmentation dysfunctions and to achieve darkenin... | 11/04/1997 |
| 5576290 | Compositions and methods for the diagnosis and treatment of psychogenic erectile dysfunction The present invention is directed to a group of linear and cyclic peptides having the structures: ##STR1## These peptides, when systemically administered to animals will bring about a sexual response and are thus useful for the diagnosis and treatmen... | 11/19/1996 |
| 5552520 | Therapeutic peptide derivatives Peptide derivatives containing one or more substituents separately linked by an amide, amino or sulfonamide bond to an amino group on either the N-terminal end or side chain of a biologically active peptide moiety. The peptide derivatives have relatively ... | 09/03/1996 |
| 5532347 | DNA encoding melanocyte stimulating hormone receptor The present invention relates to a mammalian melanocyte stimulating hormone receptor. The invention is directed toward the isolation, characterization and pharmacological use of mammalian melanocyte stimulating hormone receptor, the gene corresponding to ... | 07/02/1996 |
| 5364851 | Conformationally restricted biologically active peptides, methods for their production and uses thereof Electrochemical methods, preferably the Kolbe coupling reaction, are utilized to create intramolecularly bridged peptides, segments or peptide isosteres which are conformationally restricted and preferably, biologically active. Preferably, the peptide ana... | 11/15/1994 |
| 4950651 | Nitroso-N-(ଲ-chloro ethyl)-carbamoyl peptides The invention relates to new peptide derivatives of the general Formula I ##STR1## wherein R is a group derived from any oligopeptide by removing a terminal amino group, or--if the oligopeptide comprises a diamino carboxylic acid--the amino group in ... | 08/21/1990 |
| 4820811 | Amine reacted therapeutic agents A complex of a therapeutic agent is disclosed in which the therapeutic agent is complexed to an ammonium ion selected from the group consisting of ##STR1## where R1 and R2 are the same or different and are alkyl or hydroxy ... | 04/11/1989 |
| 4485039 | Synthetic analogues of -melanotropin Cyclic analogues of the tridecapeptide hormone, -melanotropin. (-melanocyte stimulating hormone, -MSH), wherein a physiologically stable intramolecular interaction exists (1) between the amino acid residue at position 4 and an amino a... | 11/27/1984 |
| 4469631 | Fusion peptides comprising an expressible bacterial gene and ଲ-endorphin DNA comprising the naturally occurring nucleotide sequence coding for amino acids 44-90 of ଲ-lipotropin and including the entire coding region for ଲ-endorphin with the exception of the C-terminal glutamine was modified, transferred to an expre... | 09/04/1984 |
| 4457864 | Synthetic analogues of -melanotropin Analogues of the tridecapeptide hormone, -melanotropin (a-melanocyte stimulating hormone, -MSH) of the formula: wherein X and Y are amino acid residues and X is in a D-isomeric configuration. Preferred analogues, e.g. [Nle4, D-Phe... | 07/03/1984 |
| 4278595 | Orally active MIF analogs with an effect on the central nervous system Tripeptide MIF analogs represented by the formula X--D--Leu--Gly--NR1 R2 wherein X is Pro or pGlu, and each of R1 and R2, when taken separately, is hydrogen or lower alkyl, are useful in the treatment of disorde... | 07/14/1981 |
