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| Number | Title | Issue Date |
| 8093230 | Supersaturated aqueous ifosfamide compositions The invention concerns the use of mercaptoethane sulfonate-sodium (Mesna) to increase the solubility of Ifosfamide in storage-stable, concentrated and/or highly-concentrated (supersaturated) aqueous pharmaceutical preparations, storage-stable, concentrated and/or hi... | 01/10/2012 |
| 8017597 | Analgesic agent comprising cyclic phosphatidic acid derivative An object of the present invention is to elucidate an analgesic effect as one of new cPA bioactivities and thus to provide a novel analgesic agent. The present invention provides an analgesic agent which comprises a cyclic phosphatidic acid derivative that is one ty... | 09/13/2011 |
| 8017596 | Phosphonates useful as modulators of T-γ-9-δ-2 activity The invention concerns novel phosphonate derivatives, preparation method, use thereof as ligands modulating T γ9δ2 lymphocyte activity and pharmaceutical compositions comprising them. ... | 09/13/2011 |
| 7323100 | Combination of amorphous materials for hydrocracking catalysts An amorphous support, methods for making the same and methods of using, particularly in hydrocracking. A method of making may comprise mixing a first amorphous material and a second amorphous material of different acidities to form a mixture, and treating by either ... | 01/29/2008 |
| 7208481 | Aminodiphosphonate apolipoprotein E modulators The present invention relates to methods of use of aminodiphosphonate to modulate apolipoprotein E levels and the use of such compounds in therapy, including cardiovascular and neurological disease states. ... | 04/24/2007 |
| 7198487 | Whitening tip for dental flossing device A power flosser tip incorporating a tooth-whitening coating. The coating is typically abrasive, and whitens teeth by scraping or wearing down hardened plaque or other tooth discolorations. The coating may also whiten teeth through a chemical reaction. The coating ma... | 04/03/2007 |
| 7144867 | Anticancer glycoside compounds The present invention relates to new classes of anti-cancer compounds. In particular, the present invention provides glycoside compounds as anti-cancer agent, alone, or in combination with other anti-cancer agents or therapies. ... | 12/05/2006 |
| 7094571 | Combinatorial protein library screening by periplasmic expression The invention overcomes the deficiencies of the prior art by providing a rapid approach for isolating binding proteins capable of binding small molecules and peptides. In the technique, libraries of candidate binding proteins, such as antibody sequences, are express... | 08/22/2006 |
| 7083945 | Isolation of binding proteins with high affinity to ligands The invention overcomes the deficiencies of the prior art by providing a rapid approach for isolating binding proteins capable of binding small molecules and peptides via “display-less” library screening. In the technique, libraries of candidate binding proteins... | 08/01/2006 |
| 7038039 | Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside A desired isomer is selectively prepared by phosphorolyzing and isomerizing an anomer mixture of a 1-phosphorylated saccharide derivative while crystallizing one of the isomers to displace the equilibrium. Furthermore, using the action of a nucleoside phosphorylase,... | 05/02/2006 |
| 7030103 | Sulfonamidomethyl phosphonate inhibitors of β-lactamase The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and... | 04/18/2006 |
| 7019024 | Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof. ... | 03/28/2006 |
| 6998423 | Prevention of loss and restoration of bone mass by certain prostaglandin agonists Prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatment of bone disorders includ... | 02/14/2006 |
| 6919322 | Phenyl Phosphonate Fructose-1,6-Bisphosphatase Inhibitors Novel FBPase inhibitors of the formula I are useful in the treatment of diabetes and other conditions associated with elevated blood glucose. ... | 07/19/2005 |
| 6900315 | 2-amino-9H-purin-9-yl compounds and methods for inhibiting/treating HIV infections and AIDS related symptoms The present invention relates to novel compounds, compositions and methods for inhibiting the growth, elaboration and/or replication of HIV in human patients and to the prevention and treatment of human acquired immunodeficiency syndrome (AIDS) and other diseases ca... | 05/31/2005 |
| 6831105 | Compositions comprising ether compounds and pharmaceutical uses therefor The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a compo... | 12/14/2004 |
| 6737416 | Phosphonic acid derivative having inhibitory activity against carboxypeptidase B A compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof: wherein R1 represents hydrogen atom, an alkyl group, a substituted alkyl group and the like; R2... | 05/18/2004 |
| 6608045 | Streptomyces sp producing tautomycetin and immunosuppressant comprising tautomycetin as active ingredient The present invention relates to Streptomyces sp. producing tautomycetin which possesses an immunosuppressive or antibacterial activities, a process for preparing tautomycetin from the said microorganism, and an immunosuppressant or immunosuppressive phar... | 08/19/2003 |
| 6566304 | Biogenic control and limitation of the reproduction of parasitic earth nematodes in stock culture The invention relates to use of (a) compounds of phosphorus containing at least partly lipophilic organic radicals together with (b) urea and/or urea derivatives in selected quantity ratios of (a) to (b) as a soil additive for biologically controlling pla... | 05/20/2003 |
| 6559137 | Sulphonamide derivatives as prodrugs of aspartyl protease inhibitors The present invention relates to prodrugs of a class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of prodrugs of HIV aspartyl protease inhibitors characterized by favorable aqueous solu... | 05/06/2003 |
| 6514953 | Calcium (3S) tetrahydro-3-furanyl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1 -benzyl-2-(phosphonooxy)propylcarbamate The invention relates to calcium (3S) tetrahydro-3-furanyl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1 -benzyl-2-(phosphonooxy)propylcarbamate, to processes for its preparation, and to its use in the treatment of diseases caused by retroviruses. ... | 02/04/2003 |
| 6506737 | Antimicrobial phosphonium and sulfonium polyhalide compositions An oxidizing species is described herein as a reaction product through an in situ preparation combining a protonizable phosphorus or sulfur compound, and a halide source at controlled proportions in an aqueous, non-aqueous, gel, aerosol, solid-phase or po... | 01/14/2003 |
| 6506799 | Methods of treating cardiovascular diseases, dyslipidemia, dyslipoproteinemia, and hypertension with ether compounds The present invention relates to methods of treating cardiovascular diseases, dyslipidemia, dyslipoproteinemia, and hypertension comprising administering a composition comprising an ether compound.... | 01/14/2003 |
| 6503883 | Pharmaceutical preparations for the targeted treatment of crohn's disease and ulcerative colitis The invention relates to a pharmaceutical preparation, which contains an immunosuppressive active agent in dissolved form in a starch capsule, or hard or soft gelatin capsule which has been coated with one or several polymer films. The invention further r... | 01/07/2003 |
| 6500811 | Sulfonylaminophosphinic and sulfonylaminophosphonic acid derivatives, methods for their preparation and use Compounds of the formula I ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading enzymes is involved.... | 12/31/2002 |
| 6482808 | Use of reductive compounds for strengthening and improving the structure of materials containing keratin The composition for hardening, strengthening and restructuring keratin-containing materials and/or for increasing the volume of keratin-containing fibers, such as hair, contains from 0.3 to 50.0% by weight of one or more reductones, each having a --(HO)C.... | 11/19/2002 |
| 6479471 | NAALADase inhibitors The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit N-Acetylated -Linked Acidic Dipeptidase (NAALADase) enzym... | 11/12/2002 |
| 6458829 | Substituted γ-phenyl-Ɗ-lactones and analogs thereof and uses related thereto γ-Phenyl-substituted Ɗ-lactones and analogs thereof, including lactams, are disclosed. They may be formulated into pharmaceutical compositions, and/or used in the treatment or prevention of inflammation or other conditions or disease states.... | 10/01/2002 |
| 6436989 | Prodrugs of aspartyl protease inhibitors The present invention relates to prodrugs of a class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of prodrugs of HIV aspartyl protease inhibitors characterized by favorable aqueous solu... | 08/20/2002 |
| 6258801 | Fungicidal mixtures A fungicidal mixture, comprising a) a carbamate of the formula I, ##STR1## where T is CH or N, n is 0, 1 or 2 and R is halogen, C1 -C4 -alkyl or C1 -C4 -haloalkyl, and where the radicals R may be different if n... | 07/10/2001 |
| 6204245 | Treatment of narcolepsy with immunosuppressants The invention provides compositions and methods for treatment of narcolepsy or isolated cataplexy. Such methods entail administering a therapeutically effective regime of at least one immunosuppressive agent. The methods are particularly useful for prophy... | 03/20/2001 |
| 6200961 | Concentrates of organophosphorous insecticides A low volatile organic compound co-solvent system is disclosed for preparing emulsion concentrates of low melting organophosphorous insecticides wherein the bioefficacy of the insecticide active is significantly enhanced. The co-solvent system comprises a... | 03/13/2001 |
| 6136836 | Compositions for the systemic control of parasites of warm-blooded animals A composition and method for controlling warm-blooded animal parasites comprising 1-[3-chloro-4-(1,1,2-trifluoro-2-trifluoromethoxyethoxy)phenyl]-3-(2,6,dif luorobenzoyl)urea.... | 10/24/2000 |
| 6130211 | Phosphocholinate cardenolides Disclosed herein are cardenolides and related compounds covalently linked to phosphocholine moieties and pharmaceutical formulations comprising such compounds. Also disclosed herein are methods for treating hypertension, premenstrual syndrome (PMS), preec... | 10/10/2000 |
| 6124274 | Use of ascorbyl 2'-phosphates for stabilizing vitamin A and/or vitamin A derivatives in cosmetic and pharmaceutical preparations Ascorbyl 2'-phosphate is used for stabilizing vitamin A and/or vitamin A derivatives in cosmetic and pharmaceutical preparations.... | 09/26/2000 |
| 6054444 | Phosphonic acid derivatives The present invention relates to phosphonic acid derivatives that inhibit N-Acetylated -Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit... | 04/25/2000 |
| 6017903 | Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors The present invention relates to a method of treating a glutamate abnormality and a method of effecting a neuronal activity in an animal using a NAALADase inhibitor, and a pharmaceutical composition comprising an effective amount of a NAALADase inhibitor ... | 01/25/2000 |
| 6004946 | Treatment of global and focal ischemia using naaladase inhibitors The present invention includes compositions and methods of treatment for glutamate abnormalities and associated nervous tissue insult in a animal by inhibition of NAALADase enzyme. Compositions include glutamate-derived hydroxyphosphinyl derivative compou... | 12/21/1999 |
| 6001823 | Treatment or prophylaxis of diseases caused by pilus-forming bacteria Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infect... | 12/14/1999 |
| 5972349 | Synthesis of polyribosylribitol phosphate oligosaccharides Polyribosylribitol phosphate oligosaccharides are produced in a multistep process. The compound of the formula: ##STR1## wherein R1 is a first protecting group and R2 is a second protecting group, is coupled to a solid polyethyl... | 10/26/1999 |
