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| Number | Title | Issue Date |
| 5128324 | Transdermally applicable pharmaceutical preparations with sterolines and/or spiroketalines The invention relates to novel, transdermally applicable pharmaceutical preparations including sterolines or spiroketalines, a solvent selected from the group consisting of ethoxylated sterols and C12-C30 alcohols, and lipophilic ointment base. Methods of... | 07/07/1992 |
| 5128138 | Estradiol compositions and methods for topical application A mixture of estradiol or other estrogen and an uncrosslinked, water-insoluble vinylpyrrolidone copolymer provides a matrix which gradually releases the medicament upon application to the skin of a patient in the form of an ointment, gel or film. The poly... | 07/07/1992 |
| 5122540 | Method and composition for treating warts and throat soreness with DMSO and citric acid A solution of DMSO and a body reactive agent (such as citric acid) is provided, and is typically topically applied to the body, as to a wart or to the skin of the throat.... | 06/16/1992 |
| 5120716 | Percutaneous absorption promoting agent and dermatologic preparation containing the same A percutaneous absorption promoting agent comprising (A) at least one anionic surfactant and one or two or more of surfactants having a nitrogen atom in the molecule other than anionic surfactants, (B) one or two or more of anionic surfactants and one or ... | 06/09/1992 |
| 5118676 | Penetration enhancers for transdermal delivery of systemic agents This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals and into the blood stream in a transdermal device or formulation comprising topically ... | 06/02/1992 |
| 5112804 | Pharmaceutical composition and method of intranasal administration A composition and method for nasal administration of pharmaceuticals utilizes glycyrrhetinic acid as an absorption enhancer. The composition comprises an effective amount of the pharmaceutically active substance, glycyrrhetinic acid, in an amount effectiv... | 05/12/1992 |
| 5104656 | Percutaneous treatment with a high potency non-steroidal anti-inflammatory agent To prepare an analgesic, anti-inflammatory cream, ibuprofen-S is dissolved in the PEG-7-glycerylcocoate and propylene glycol by slightly warming the solution to about 40 degrees Centigrade. Fractionated coconut oil, di-isopropyladipate, stearic acid, cety... | 04/14/1992 |
| 5094857 | Treatment of acne or androgenetic alopecia by topical administration of ethisterone There is disclosed the use of ethisterone its nor analogs as well as their corresponding 17-esters formed with pharmaceutically acceptable carboxylic acids, for the reduction of lipids, in particular waxy solids in the sebaceous glands. Such removal facil... | 03/10/1992 |
| 5093334 | Dermal treatment of worm diseases in cats with praziquantel A method of treating a worm disease in a cat which comprises dermally applying to the cat 0.1-5 mg of praziquantel per kg of body weight.... | 03/03/1992 |
| 5091171 | Amphoteric compositions and polymeric forms of alpha hydroxyacids, and their therapeutic use Preventive as well as therapeutic treatment to alleviate cosmetic conditions and symptoms of dermatologic disorders with amphoteric compositions containing alpha hydroxyacids, alpha ketoacids, related compounds or polymeric forms of hydroxyacids is disclo... | 02/25/1992 |
| 5091182 | Dispensing units for ketorolac topical gel formlations A dispensing unit for a ketorolac topical gel formulation is disclosed, wherein the dispensing unit comprises a ketorolac topical gel formulation and a gas-impermeable multi-layered container wherein the container is comprised of a polyolefin inner layer ... | 02/25/1992 |
| 5087620 | Controlled dermal penetration enhancement using imidazoles Topical compositions are described which contain a vehicle which is free of lower alkanols, a pharmacologically active agent whose dermal penetration can be enhanced and a unique penetration control system. The control system contains an imidazole penetra... | 02/11/1992 |
| 5086077 | Endermic medicament with a gel base A novel endermic medicament having a consistency of a gel is proposed which is formulated, as a gel base, with non-ionic water-soluble cellulose ether, e.g., methyl cellulose and hydroxypropyl methyl cellulose, modified with a modification agent containin... | 02/04/1992 |
| 5082863 | Pharmaceutical composition of florfenicol An injectable pharmaceutical composition for veterinary use is disclosed comprising Florfenicol, N-methyl-2-pyrrolidone, polyethylene glycol and a viscosity reducing agent. The composition is chemically and physically stable, exhibits constant blood level... | 01/21/1992 |
| 5082866 | Biodegradable absorption enhancers Biodegradable absorption enhancers, especially useful in pharmaceutical formulations, are compounds having the formula ##STR1## wherein R is hydrogen, C1 -C7 alkyl, benzyl or 4-hydroxybenzyl; n is a whole number from 4 to 18 inc... | 01/21/1992 |
| 5079008 | Transdermal monolith systems The invention relates to a monolith transdermal therapeutic system for the delivery of permeable drugs, especially formoterol, in the form of a matrix system comprising three layers: a) a backing layer which is impermeable to the components of the adhesiv... | 01/07/1992 |
| 5069909 | Transdermal administration of buprenorphine Method and laminated composite for administering buprenorphine transdermally to treat pain. The composite comprises an impermeable backing layer and a reservoir layer containing buprenorphine and optionally a permeation enhancer combined with a pressure-s... | 12/03/1991 |
| 5059628 | Medical composition for percutaneous administration A medical composition for external use comprising a proline ester represented by formula (I): ##STR1## wherein R1 and R2 are as defined in the specification, or a prolinol ester represented by formula (II): ##STR2## wh... | 10/22/1991 |
| 5059426 | Skin permeation enhancer compositions, and methods and transdermal systems associated therewith Skin permeation enhancer compositions are provided which increase the permeability of skin to transdermally administered pharmacologically active agents. The composition contains diethylene glycol monoethyl or monomethyl ether in addition to an ester comp... | 10/22/1991 |
| 5059603 | Method and composition for treating impotence A composition for treating impotence contains a vasodilator, a vasoconstrictor, and a penetration enhancing ingredient in a pharmaceutically acceptable carrier for topical application. The composition is applied topically to treat impotence.... | 10/22/1991 |
| 5059587 | Physiologically active peptide composition for nasal administration A nasal administration powder composition containing a physiologically active peptide as an active ingredient can be efficiently absorbed through nasal mucosa by the addition of a water-soluble organic acid as an absorption promoter. This composition may ... | 10/22/1991 |
| 5057497 | Oral method for the maintenance of healthy gingival tissues using TRF Absorption of Tissue Respiration Factor (TRF) into the gingival tissues is materially enhanced when it is formulated as a non-astringent hydrophilic pharmaceutical composition containing penetration promoting substances which are both hydrophilic and lipo... | 10/15/1991 |
| 5055456 | Anti-alopecia composition This invention is concerned with a composition of matter and method of applying same for use as hair grooming aid or preferably, to treat androgenetic alopecia comprising (a) an effective amount of a polysaccharide or mixtures thereof, polysaccharide deri... | 10/08/1991 |
| 5053227 | Skin permeation enhancer compositions, and methods and transdermal systems associated therewith Skin permeation enhancer compositions are provided which increase the permeability of skin to transdermally administered pharmacologically active agents. The composition contains diethylene glycol monoethyl or monomethyl ether in addition to an ester comp... | 10/01/1991 |
| 5045553 | Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter The present invention relates to a pharmaceutical composition for percutaneous drug absorption which comprises 5-isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and ethanol and/or an unsaturated higher fatty ac... | 09/03/1991 |
| 5043356 | Composition and method for rejuvenating skin using vitamin A propionate Topically applied compositions for the accelerated rejuvenation of skin and an associated method of skin care treatment are disclosed utilizing vitamin A propionate of the general formula ##STR1## in an aqueous based carrier at a concentration rangin... | 08/27/1991 |
| 5043441 | Compositions comprising 1-substituted azacycloalkanes This invention provides compositions comprising a physiologically-active agent and a compound having the structural formula ##STR1## wherein each X, Y and Z may represent oxygen, sulfur or two hydrogen atoms, provided however that, when Z represents ... | 08/27/1991 |
| 5043162 | Hair growth promoter Compositions containing mixtures of lower alkyl nicotinate and histamine hydrochloride, particularly useful in promoting hair growth and revitalizing the hair and scalp by topical application.... | 08/27/1991 |
| 5041439 | Penetrating topical pharmaceutical compositions Topical pharmaceutical compositions containing a specific 6-amino-1,2-dihydro-1-hydroxy-2-iminopyrimidine component and a penetration-enhancing vehicle are disclosed. The vehicle comprises a binary combination of a C3 -C4 diol or C | 08/20/1991 |
| 5039527 | Hexamethylmelamine containing parenteral emulsions Improved hexamethylmelamine containing parenteral emulsions are prepared in the absence of organic solvents and containing low levels of biocompatible emulsifiers using ultrahigh energy Microfluidizer.RTM. processing equipment. The emulsions have oil phas... | 08/13/1991 |
| 5039513 | Photoprotection compositions and methods comprising sorbohydroxamic acid Disclosed are topical compositions comprising sorbohydroxamic acid with a radical scavenging compound which prevent damage to skin caused UV radiation. Also disclosed is a method for using these compositions topically, to prevent damage to skin caused by ... | 08/13/1991 |
| 5034386 | Methods for administration using 1-substituted azacycloalkanes This invention provides compositions comprising a physiologically-active agent and a compound having the structural formula ##STR1## wherein each X, Y and Z may represent oxygen, sulfur or two hydrogen atoms, provided however that, when Z represents ... | 07/23/1991 |
| 5032402 | 3-hydroxy-N-methylpyrrolidone and use as transdermal enhancer The novel compound, 3-hydroxy-N-methylpyrrolidone, is effective as a transdermal enhancer for the absorption of drugs through the skin of humans and animals. The 3-hydroxy-N-methylpyrrolidone is prepared from delta-butyrolactone which is converted to meth... | 07/16/1991 |
| 5032403 | Multilayer plaster The invention relates to a transdermal therapeutic system in the form of a multilayer plaster for the administration of active substances which are able to permeate, in the form of a matrix system containing at least three layers: (a) a covering layer whi... | 07/16/1991 |
| 5030442 | Non-crystalline minoxidil composition An aqueous, noncrystalline minoxidil composition for topical use which has significantly improved flux of the drug through human cadaver skin. The composition contains minoxidil complexed with an amphipathic compound, oleic acid and with pharmaceutically ... | 07/09/1991 |
| 5030629 | Compositions and method comprising heterocyclic compounds containing two heteroatoms as membrane penetration enhancers A method and compositions for enhancing absorption of topically administered physiologically active agents through the skin and mucous membranes of humans and animals in a transdermal device or formulation for local or systemic use, comprising a therapeut... | 07/09/1991 |
| 5026556 | Compositions for the transdermal delivery of pharmaceutical actives Compositions for the transdermal delivery of buprenorphine comprising a safe and effective amount of buprenorphine in a carrier comprising: (a) a polar solvent material selected from the group consisting of C3 -C4 diols, C3 -C | 06/25/1991 |
| 5023085 | Transdermal flux enhancers in combination with iontophoresis in topical administration of pharmaceuticals Transdermal flux enhancers such as oleic acid and 1-dodecylazacycloheptan-2-one are used in combination with iontophoresis in the topical administration of pharmaceutical agents.... | 06/11/1991 |
| 5019579 | Pharmaceutical compositions containing dextrorphan for intranasal application The object of the invention is a pharmaceutically acceptable composition suitable to achieve a systemic therapeutical response due to its antitussis action in warm-blooded animals, characterized in that it contains, per dosage unit: (I) an amount therapeu... | 05/28/1991 |
| 5019567 | Benzoyl peroxide--quaternary ammonium lipophilic salicylate based pharmaceutical and cosmetic compositions and their use especially in treatment of acne A pharmaceutical or cosmetic composition for topical application comprises, in a physiologically acceptable support, the combination of benzoyl peroxide and at least one quaternary ammonium lipophilic salicylate having general formula (I): ##STR1## ... | 05/28/1991 |
