...that after Walter Hunt patented the safety pin in 1849, he sold the rights to it for $400?
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| Number | Title | Issue Date |
| 4394381 | Method for the relief of pain There is disclosed an improved method for the relief in humans of pain which is susceptible to topical treatment comprising the topical application to the distressed areas of a person of an amount of an anesthetic composition effective to relieve said pai... | 07/19/1983 |
| 4393066 | Method for treatment of herpetic lesions The instant invention relates to a method for treating vesicular lesions comprising the topical application at the lesion site to a patient suffering from said lesions of an amount of folic acid effective for treating said lesions.... | 07/12/1983 |
| 4386076 | (E)-5-(2-Halogenovinyl)-arabinofuranosyluracil, process for preparation thereof, and uses thereof A novel compound, (E)-5-(2-halogenovinyl)-arabinofuranosyluracil; a process for producing the same comprising reacting 5-vinylarabinofuranosyluracil with a halogen; and use of the same as an anti-DNA virus agent, especially anti-herpes virus agent and ant... | 05/31/1983 |
| 4386081 | Phosphonoformic acid esters and pharmaceutical compositions containing same A pharmaceutical preparation containing as active ingredient a compound of the formula ##STR1## wherein R1 and R2 are the same or different, and each is selected from the group consisting of hydrogen, alkyl groups containing ... | 05/31/1983 |
| 4383990 | Antiviral agents, their preparation and use The compound of formula (I): ##STR1## wherein X is CFCl; and C1-6 alkanoyl esters and/or phosphate esters thereof, is active against herpes viruses.... | 05/17/1983 |
| 4355032 | 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent The compound 9-(1,3-dihydroxy-2-propoxymethyl)guanine and the pharmaceutically acceptable salts thereof are useful as antiviral agents.... | 10/19/1982 |
| 4352795 | 7-ଲ-D-Arabinofuranosyl-7H-pyrrolo[2,3-d]pyrimidine compounds and methods for their production Hydroxy, amino and sulfhydryl derivatives of 7-ଲ-D-arabinofuranosyl-7H-pyrrolo[2,3-d]pyrimidine, their corresponding esters and non-toxic pharmaceutically acceptable salts are produced by arabinofuranosylation of the requisite heterocycles with ... | 10/05/1982 |
| 4351847 | Antiviral alpha, alpha-dialkyl adamantylethylamines Warm-blooded animals are treated by administering to the animal a dosage, effective to prevent or to alleviate the symptoms of herpes virus, type II, of a compound of the formula I or its acid salt: ##STR1## wherein R1 and R2 ar... | 09/28/1982 |
| 4350707 | Inactivation of lipid containing viruses with butylated hydroxytoluene Inactivation of, and treatment of diseases caused by, lipid containing viruses, particularly herpes simplex virus, with butylated hydroxytoluene.... | 09/21/1982 |
| 4318926 | Method of curing or alleviating herpes infections and pharmaceutical compositions suitable therefor Method for the treatment of herpes infections by administering a compound of the formula ##STR1## in which alk represents alkylene containing 1 to 4 carbon atoms, R1 and R2 independently of each other, represent hydrogen, alkyl ... | 03/09/1982 |
| 4309989 | Topical application of medication by ultrasound with coupling agent A method of topically applying an effective medication in an emulsion coupling agent by ultrasound. More particularly, a method of treating a skin condition by applying a medication in an emulsion coupling agent and massaging it into the affected area wit... | 01/12/1982 |
| 4283421 | Anti-viral treatment Anti-viral treatment, particularly treatment of herpes by application to infected areas of tissues of a composition from combination of alcohol solution by p-amino benzoic acid with aqueous solution of n-alkyl dimethyl benzyl ammonium chlorides or bromide... | 08/11/1981 |
| 4248891 | 1-(1-Aminoalkyl)tricyclo[4,3,1,12,5 ]undecanes Compounds having the formula ##STR1## in which R is lower alkyl, and acid addition salts of said compounds. The compounds possess anti-RNA-viral activity and also an antiviral activity against herpes virus.... | 02/03/1981 |
| 4239761 | Basically substituted ureas and processes for the treatment of virus diseases The present invention is related to new basically substituted ureas having the general Formula I ##STR1## and the pharmaceutically acceptable acid addition salts thereof which produce an improved antiviral activity against DNS- and RNS-viruses. The ... | 12/16/1980 |
| 4237136 | Pharmaceutical compositions and methods of using thiadiazolo pyrimidinone compounds Substituted 7H-thiazolo- and 7H-thiadiazolo-pyrimidine-7-ones compounds and the drug composition containing same. The compounds are immunostimulants for mammals. A process of making these compounds and of using the drug composition.... | 12/02/1980 |
| 4230708 | Therapeutic application of (S) -or (RS)-9-(2, 3-dihydroxypropyl) adenine for use as antiviral agents The specification describes the use of S or RS 9-(2, 3-dihydroxypropyl) adenine either alone or in combination with ara-A for the treatment of virus diseases.... | 10/28/1980 |
| 4221794 | Method of imparting immunomodulating and antiviral activity Compounds of the formula ##STR1## where X is OH, NH2, SH, OR or SR (where R is alkyl of 1 to 4 carbon atoms or benzyl), R1 is H or alkyl of 1 to 8 carbon atoms, R2 is H or methyl, Y is the salt of an amine of the form... | 09/09/1980 |
| 4171373 | Ethynylbenzene compounds and derivatives thereof to treat pain, fever and inflammation The method of treating patients by administering an effective amount of a mercapto, lower acyl thio or lower alkyl thio substituted ethynylbenzene compound, and the pharmaceutical preparation thereof.... | 10/16/1979 |
| 4158056 | Antiviral method 5'-Deoxy-5'-(1,4-diamino-4-carboxybutyl)adenosine, also known as Sinefungin and as antibiotic A-9145, is employed in a method for treating and controlling viral infections, for example, Herpes simplex and Pseudorabies infections in man and animals.... | 06/12/1979 |
| 4153695 | Substituted 2,3-dihydro imidazo[1,2-c]pyrimidines Di-substituted 2,3-dihydroimidazo[1,2-c]pyrimidines, useful as anti-viral agents.... | 05/08/1979 |
| 4133893 | Topical treatment of skin diseases A topical preparation for the treatment of skin diseases such as acne vulgaris, acne rosacea, psoriasis and herpes simplex which comprises 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane and a pharmaceutically acceptable carrier or diluent.... | 01/09/1979 |
| 4133959 | Aryloxyalkyl diketones Aryloxyalkyl diketones, useful as anti-viral agents, are prepared from an aryloxyalkyl halide and an alkali metal enolate salt of a diketone or keto-ester, or from a haloalkyl-diketone and an alkali metal salt of a phenol.... | 01/09/1979 |
| 4069382 | 9-(5-O-Acyl-ଲ-D-arabinofuranosyl)adenine compounds 9-(5-O-Acyl-ଲ-D-arabinofuranosyl)adenine compounds and their production by reacting 9-(ଲ-D-arabinofuranosyl)adenine with a reactive derivative of an alkanoic acid. The compounds are useful as antiviral agents. The compounds are water-soluble a... | 01/17/1978 |
| 4056673 | Phosphonoacetic acid derivatives of nucleosides Phosphonoacetic acid derivatives of purine and pyrimidine nucleosides are novel antiviral and/or antineoplastic agents.... | 11/01/1977 |
| 4055717 | 9-(3-O-Acyl-ଲ-D-arabinofuranosyl)adenine compounds, 9-(2,3-di-O-acyl-ଲ-D-arabinofuranosyl)-adenine compounds, and method for their production 9-(3-O-Acyl-ଲ-D-arabinofuranosyl)adenine compounds, 9-(2,3-di-O-acyl-ଲ-D-arabinofuranosyl)adenine compounds, and their production by reacting in each case the corresponding 5-silyl ether derivative with a tetraalkylammonium fluoride. The compo... | 10/25/1977 |
| 4053600 | Tricyclic 1,2,4-triazolo-quinazolines The invention discloses 5-substituted-1,2,4-triazolo[4,3-c]quinazolines and 1,2,4-triazolo[1,5-c]quinazolines having pharmacological activity in animals and useful, for example, as hypotensive and anti-inflammatory agents. The compounds may be prepared, f... | 10/11/1977 |
| 4049798 | Method for the treatment of Herpes Simplex A method for the treatment of Herpes Simplex comprising administration of a mixture comprising (a) Vitamin C and (b) Vitamin P.... | 09/20/1977 |
| 4048432 | 9-(3,5-Di-O-acyl-ଲ-D-arabinofuranosyl)adenine compounds and method for their production 9-(3,5-Di-O-acyl-ଲ-D-arabinofuranosyl)adenine compounds and their production by reacting in each case a 9-(5-O-tri-substituted-silyl-2,3-di-O-acyl-ଲ-D-arabinofuranosyl)adeni ne compound with a tetraalkylammonium fluoride. The compounds are usef... | 09/13/1977 |
| 4027025 | 8-Azapurine derivatives 9-Hydroxyethoxymethyl (and related) derivatives of 2-amino-6-substituted-8-azapurines have been found to have potent anti-viral activities. Novel compounds and their pharmaceutically acceptable salts, pharmaceutical formulations containing the compounds o... | 05/31/1977 |
| 4008240 | Xanthene and thioxanthene derivatives Novel 2,7-bis basic alkanol derivatives of xanthene and thioxanthene, their preparation and use for the prevention and inhibition of viral infections are disclosed.... | 02/15/1977 |
| 3988314 | Compound U-50,228, derivatives thereof, and processes for preparation New antiviral agent U-50,228 and derivatives thereof, produced by the controlled fermentation of the known microorganism Streptomyces platensis var. clarensis var nova, NRRL 8035. This antiviral agent and its derivatives are active against DNA-viruses, fo... | 10/26/1976 |
| 3974186 | Bis-basic ethers of 2,6- and 2,7-dihydroxyanthraquinones Disclosed are novel compounds and pharmaceutical formulations having antiviral activity. The disclosed compounds have the formula ##SPC1## Wherein one R2 is a hydrogen atom and the other R2 is the radical ##SPC2## A is a straight cha... | 08/10/1976 |
| 3956277 | Purine sugar derivatives This invention relates to purine sugar derivatives which are useful as suppressors of the immune response and as antiviral agents, and to methods of preparation thereof.... | 05/11/1976 |
| 3946021 | Bis-basic ketones of carbazole The novel bis-basic ketones of carbazole of the present invention have antiviral activity when administered orally and parenterally. These compounds are represented by the following formula: ##SPC1## Wherein Z is hydrogen or lower alkyl having from 1 to 4... | 03/23/1976 |
| 3932424 | Bis-basic ethers of carbazole The novel bis-basic ethers of carbazole of the present invention have useful antiviral properties. These new compounds are represented by the formula ##SPC1## Wherein Z is hydrogen or lower alkyl having from 1 to 4 carbon atoms; and each X is ##... | 01/13/1976 |