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| Number | Title | Issue Date |
| 4036841 | Indolo[2,3]quinolizine derivatives Compounds of the formula ##STR1## wherein R1 stands for hydrogen or an acyl group, and R2 stands for an alkyl group are disclosed. A process for making the above compounds is also disclosed. The compounds are useful as vasodilatating... | 07/19/1977 |
| 4035372 | 4-{[4-(Diphenylmethyl)-1-piperidinyl]methyl}benzenamines 4-{[4-(Diphenylmethyl)-1-piperidinyl]methyl}benzenamines useful by reason of their vasodilating activity are disclosed.... | 07/12/1977 |
| 4035370 | Alkaloid esters Vasodilatory eburnamine-type alkaloid esters of the formula (I) ##STR1## and salts and quaternary derivatives thereof, wherein X~Y REPRESENTS A =CH=CH- or ##STR2## R represents a C1-6 alkoxycarbonyl group optionally substituted with ... | 07/12/1977 |
| 4033996 | 8-Aza-9-oxo(and dioxo)-thia-11,12-secoprostaglandins This invention relates to 8-aza-9-oxo(and dioxo)-thia-11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, for the prevention of thromb... | 07/05/1977 |
| 4029808 | Thienyl phenyl O-(aminoalkyl)-ketone oxime and furyl phenyl O-(aminoalkyl)-ketone oxime coronary vasodilators The invention relates to novel thienyl phenyl O-(aminoalkyl)-ketone oximes nd to novel furyl phenyl O-(aminoalkyl)-ketone oximes. These novel compounds exhibit a coronary vasodilatatory activity and may be used in the treatment of cardiopathies. The invention a... | 06/14/1977 |
| 4028365 | Benz[g]indolyl compounds A group of benz[g]indolyl compounds useful in the treatment of disorders and diseases of the cardiovascular system is described. These are piperidine compounds linked by the nitrogen atom to a substituted or unsubstituted benz[g]indolyl radical through th... | 06/07/1977 |
| 4024261 | Compositions and methods employing tetrahydroindolizine derivatives 1,4-Dihydropyridines bearing carbonyl functions in the 3- and 5-positions, being optionally substituted by lower alkyl in the 6-position, being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group, and being fus... | 05/17/1977 |
| 4022898 | 2-Amino-4-pyrimidyl-1,4-dihydropyridine derivatives 2-Amino-1,4-dihydropyridines bearing a carbonyl function in the 5-position and being optionally substituted by lower alkyl or phenyl in the 6-position, and the corresponding 2-amino-1,4,5,6,7,8-hexahydro-5-oxoquinolines, which derivatives are further... | 05/10/1977 |
| 4022776 | 5-[1-Hydroxy-2-(substituted-amino)]ethyl-8-hydroxycarbostyril derivatives 5-[Hydroxy-2-(substituted-amino)]ethyl-8-hydroxy-carbostyril derivatives represented by the formula (I) ##STR1## wherein R1 and R2, which may be the same or different, each represents a hydrogen atom, an alkyl group having 1 to ... | 05/10/1977 |
| 4021434 | Sodium ଲ-[2,6-dimethyl-3,5-bis(ethoxycarbonyl)-4-(3-nitrophenyl)-1,4-dihyd ropyridine-1-yl]ethyl sulfate Novel 1-substituted-1, 4-dihydropyridine derivatives, particularly diethyl 1-ethoxymethyl-4-(3-nitrophenyl)-2, 6-dimethyl-1, 4-dihydropyridine-3,5-dicarboxylate are provided. The novel derivatives have cerebral vascular dilator activity with low toxicity.... | 05/03/1977 |
| 4020178 | 1,4-Dihydropyridine esters used as coronary dilators and anti-hypertensives A new class of 1,4-dihydropyridines which are characterized by the presence of ester substitutes at positions 3 and 5 of the nucleus and by the presence of an alkoxyalkyl have particular application as coronary dilators, antifibrillators, anti-hypertensiv... | 04/26/1977 |
| 4016176 | Esters of 4-hydroxy-2,9-dioxatricyclo[4.3.1.03,7 ] decanes and processes for their production Compounds consisting of esters of 4-hydroxy-2,9-dioxatricyclo[4.3.1.03,7 ] decane having the formulae: ##STR1## in which formulae R1 is an alkyl radical having at most 4 carbon atoms, one of the radicals R2 and R... | 04/05/1977 |
| 4016154 | Novel derivative of N-(3,4,5-trimethoxy cinnamoyl) piperazine, its acid addition salts, its process of preparation and its therapeutic application A compound having the formula ##STR1## and its pharmacologically acceptable acid addition salts. The compound is prepared by condensing N-(3,4,5-trimethoxy cinnamoyl) piperazine with N-(2-pyrrolidinone) chloroacetamide. The compounds possess peripher... | 04/05/1977 |
| 4016277 | 4-Quinoline and 4-isoquinoline derivatives of 2,6-diamino-1,4-dihydropyridine 2,6-Diamino-1,4-dihydropyridines bearing carbonyl functions in the 3- and 5-positions and being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The ... | 04/05/1977 |
| 4015002 | 1-Aryl-2-oxo-2,4,5,6,7,7a-hexahydro-indoles, salts, pharmaceutical compositions and methods of use This invention relates to 1-aryl-2-oxo-2,4,5,6,7,7a-hexahydro-indoles, and acid addition salts thereof. In particular, the compounds have (ଲ-aminoethoxy- or γ-amino-propoxy)-phenyl substituents, the amino groups in each case either being joined to ... | 03/29/1977 |
| 4015006 | 3(2H)-Isoquinolones therapeutic process New 2-substituted-3(2H)-isoquinolones and 2-substituted-3-alkoxyisoquinolines are disclosed. They are orally active hypotensives and peripheral vasodilators with an extended duration of action. Representative embodiments of this invention are 6,7-dim... | 03/29/1977 |
| 4012517 | Compositions and treatment Substituted thioxanthone and phenoxathiin compounds having bronchodilating properties, and their use in the treatment or prophylaxis of bronchoconstriction in mammals.... | 03/15/1977 |
| 4011319 | Pharmaceutical compositions and methods involving benzazepine derivatives Pharmaceutical compositions and a method of stimulating peripheral dopamine receptors by administering internally a nontoxic effective quantity of a benzazepine derivative to an animal. Renal vasodilator and diuretic methods are also disclosed.... | 03/08/1977 |
| 4011262 | 13,14-Dihydro-15-substituted-ω-pentanorprostaglandins of the two series The 15-substituted-ω-pentanorprostaglandins and various intermediates employed in their preparation. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins, but exhibit a greater tissu... | 03/08/1977 |
| 4009174 | Esters of substituted nicotinic acids Novel derivatives of nicotinic acid possessing vasomotor properties.... | 02/22/1977 |
| 4007189 | Pyrrolotriazolopyrimidine derivatives and process for the preparation thereof Pyrrolotriazolopyrimidine derivatives having the formula ##STR1## wherein R1 represents hydrogen atom or an alkyl group having from 1 to 4 carbon atoms and R2 represents an alkyl group having from 1 to 4 carbon atoms, a cycloalk... | 02/08/1977 |
| 4005095 | Substituted thienyl-acetic acid esters Substituted thienyl-acetic acid esters of the formula: ##STR1## in which R1 and R2 each, independently is H, CH3, C2 H5, C3 H7, OCH3, SCH3, Cl Br or NO... | 01/25/1977 |
| 4002762 | 2-Amino-3,4-dihydropyridines used to effect coronary vessel dilation and treat hypertension 3-Substituted 2-amino-3,4-dihydropyridine-3-carboxylic acid esters are produced by reacting 2-amino-1,4-dihydropyridine-3-carboxylic acid esters with an alkylating agent in the presence of an inert organic solvent at a temperature of from 20° C to 200° ... | 01/11/1977 |
| 4001252 | 2-Amino-3,4-dihydropyridines 2-Amino-3,4-dihydropyridine-3-carboxylic acid ester derivatives are produced by reacting 2-amino-1,4-dihydropyridine-3-carboxylic acid ester derivatives with an alkylating agent in the presence of an inert organic solvent at a temperature of from 20° to ... | 01/04/1977 |
| 4001238 | 1,3,4-Oxadiazole amides The 4-amino-6,7-dimethoxy-2-[4-(5-lower alkylthio-1,3,4-oxadiazole-2-carbonyl)-piperazin-1-yl]-quinazolines are potent antihypertensive drugs which have little or no -adrenergic blocking activity.... | 01/04/1977 |
| 4001259 | 3,6-Diamino-3,4-dihydro-2-pyridones 3,6-Diamino-3,4-dihydro-2-pyridones of the formula ##SPC1## Wherein R1 is straight or branched chain alkyl or alkenyl or said alkyl or alkenyl interrupted by 1 or 2 oxygen atoms; R2 is straight or branched chain alkyl; alkenyl; alkynyl; c... | 01/04/1977 |
| 4001426 | Substituted benzofurans and benzothiophenes The compounds are benzoyl benzofurans and benzothiophenes having pharmacological activity, in particular, coronary vasodilator activity useful for the treatment of angina pectoris and intermediates for the preparation thereof.... | 01/04/1977 |
| 4000282 | 2-(3-Tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines Novel 2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines, their pharmaceutically their preparation are disclosed. These pyridines are vasodilators having anti-hypertensive activity of rapid onset and extended duration and reduced t... | 12/28/1976 |
| 3998953 | 1,3,7-Trisubstitued xanthine peripheral vasodilators Compounds of the formula ##STR1## wherein R is methyl or ethyl, R1 is methyl, ethyl or ##STR2## and R2 is methyl, ethyl, ##STR3## where Alk is alkyl of 1 to 4 carbon atoms, Q is ethyl, propyl, isopropyl or 2-hydroxy-pr... | 12/21/1976 |
| 3996234 | 1,4-Dihydropyridine carboxylic acid esters 1,4-DIHYDROPYRIDINE CARBOXYLIC ACID ESTERS OF THE FORMULA: ##STR1## or a pharmaceutically acceptable nontoxic salt thereof wherein R is hydrogen, straight- or branched-chain lower alkyl, lower alkenyl or lower alkynyl; R1 and R4 | 12/07/1976 |
| 3995041 | Derivatives of 2-substituted-hydroxyanilino-hexahydro-2H-benzo[]quinolizines 2-Substituted-hydroxyanilino-hexahydro-2H-benzo[]quinolizines of the structural formula, ##SPC1## In which R1 is a hydrogen atom or an alkanoyl group of 2 to 4 carbon atoms and each of substituents R2, R3, R4 | 11/30/1976 |
| 3994891 | Tetrahydroisoquinoline compounds Tetrahydroisoquinoline compounds represented by the formula: ##SPC1## In which X is a hydroxy group, Y is a hydroxy group or Y taken with X is --O--CH2 --O--, Z is hydrogen or a hydroxy group, R1 is hydrogen or an alkyl group of one to four ca... | 11/30/1976 |
| 3991057 | C-Piperazino-pyridine sulfonamides This invention relates to compounds of the formula: ##SPC1## Wherein R1 in the 3- or 5-position is preferably a substituted sulfonamido or a carboxamido group whereas R2 in the 2-, 4- or 6-position is preferably an alkyl- or hydroxya... | 11/09/1976 |
| 3989749 | 11,12-Secoprostaglandins This invention relates to 8,10-diaza-9-oxo(and thioxo)-11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, and for the prevention of ... | 11/02/1976 |
| 3987176 | Composition and use of 3,4-dihydropyridones as vasodilators and antihypertensive agents 3,4-Dihydropyridones of the formula ##SPC1## Wherein R1 is hydrogen, straight or branched chain alkyl, or --COOR' is a straight, branched or cyclic, saturated or unsaturated hydrocarbon or said hydrocarbon interrupted by 1 or 2 oxygen atoms; R | 10/19/1976 |
| 3985758 | 1,4-Dihydropyridine derivatives There are provided novel 1,4-dihydropyridine derivatives, particularly 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ଲ-(N-benzyl-N-methylamino)ethyl ester and 5-methyl ester. The 1,4-dihydropyridine derivatives are char... | 10/12/1976 |
| 3985886 | 2-Amino-4,5-dihydropyridine derivatives and process for their preparation 2-Amino-4,5-dihydropyridines-3,5-dicarboxylates substituted by lower alkoxy or lower alkylthio in the 6-position and optionally substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are antihypertensive agents an... | 10/12/1976 |
| 3985896 | Benzophenalenofurans The compounds are benzophenalenofurans having pharmacological activity, in particular, coronary vasodilator activity.... | 10/12/1976 |
| 3984558 | 1,3,5-Trisubstituted-1,2,4-triazole compounds used as bronchodilators Compounds useful in the treatment of asthma, the symptoms of allergy and in some instances in gout and hyperuricemia are described. The novel compounds are 1-substituted-1,2,4-triazoles being additionally substituted at the 3- and 5-positions with a pyrid... | 10/05/1976 |
| 3984413 | Phenoxyalkanecarboxylic acid esters of hydroxyalkyltheophyllines and method for their manufacture Phenoxyalkanecarboxylic acids are esterified with 7-(2-hydroxyethyl) theophylline or 7-(2,3-dihydroxypropyl) theophylline. The resulting esters have excellent antilipemic and anticholesterolemic properties as well as pronounced peripheral and vasodilative... | 10/05/1976 |
