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| Number | Title | Issue Date |
| 5196430 | Method of inhibiting the activity of leukocyte derived cytokines A family of compounds effective in inhibiting interleukin-1 (IL-1) activity, tumor necrosis factor (TNF) activity, and the activity of other leukocyte derived cytokines is comprised of 7-(oxoalkyl) 1,3-dialkyl xanthines of the formula ##STR1## i... | 03/23/1993 |
| 5194425 | MHC-mediated toxic conjugates useful in ameliorating autoimmunity The invention is directed to methods and materials useful in treating autoimmune diseases. The therapeutic agents are of the formula X1 MHC2 peptide or MHC2 peptide1 X wherein X represents a functional moiety se... | 03/16/1993 |
| 5189026 | Treatment of human diseases involving dysregulation or dysfunction of the nervous system A method of preventing, treating and/or controlling diseases caused by dysregulation and/or dysfunction of various portions of the nervous system which comprises administering to a patient, an effective amount of a compound of the avermectin family, e.g. ... | 02/23/1993 |
| 5182271 | Thioether, keto-ester and alkyl phospholipids useful in treating multiple sclerosis The invention discloses certain thioether, keto-ester and alkyl phospholipids which are useful in treating multiple sclerosis.... | 01/26/1993 |
| 5130297 | Conjugates useful in ameliorating autoimmunity MHC-II-peptide The invention is directed to methods and materials useful in treating autoimmune diseases. The therapeutic agents are of the formula X--MHC--peptide or MHC--peptide--X wherein X represents a functional moiety selected from a toxin and a labeling group; MH... | 07/14/1992 |
| 5114721 | Preparation of T-cell and T-cell membrane for use in prevention and treatment of autoimmune diseases Pharmaceutical preparations are provided for preventing or treating autoimmune diseases in which the active principle is activated T-lymphocyte cells, specific for the autoimmune disease to be treated, which cells have been treated by incubation with a ph... | 05/19/1992 |
| 5112810 | Method for treating multiple sclerosis A pharmaceutical composition containing serum thymic factor (FTS) and a method for using FTS containing compositions for treating a variety of immunodeficiencies and autoimmune diseases including multiple sclerosis, Guillain-Barre syndrome, inflammatory n... | 05/12/1992 |
| 5102883 | Pyrimidine biosynthesis inhibitors useful as immunosuppressive agents The pyrimidine biosynthesis inhibitors dichloroallyl lawsone, N-(phosphonoacetyl)-L-aspartic acid (PALA), pyrazofurin, and derivatives thereof, are useful as immunomodulatory and anti-inflammatory agents. Pharmaceutical formulations containing these compo... | 04/07/1992 |
| 5093317 | Treating disorders by application of insulin-like growth factor Method of enhancing the survival of neuronal cells, more preferably non-mitotic neuronal cells and/or cholinergic cells in a mammal, which cells are at risk of dying, which method includes administering to the mammal an effective amount of a functional de... | 03/03/1992 |
| 5064816 | Heterocyclic phospholipids useful in treating multiple sclerosis invention relates to heterocyclic phospholipids of formula III which are useful in treating multiple sclerosis: where R 2 is n-C14 -C20 alkyl; each R1, independently, is methyl or ethyl; Y is --O-- or --S--; n is an integ... | 11/12/1991 |
| 5055290 | Ciamexone as a selective immunosuppressant A method of selectively suppressing the excess immune reaction produced iatrogenically or autochthonously by administering 0.1 to 100 mg of ciamexone per kg of body weight.... | 10/08/1991 |
| 5051438 | Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof, compositions and use This invention relates to compounds of Formula I and the stereoisomers and pharmaceutically acceptable salts thereof ##STR1## wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl and m is 1 or 2; R1 is alkyl of 1 to 4 carbon atoms; R2 | 09/24/1991 |
| 5043355 | Use of L-carnitine derivatives in the therapeutical treatment of peripheral neuropathies The use is disclosed of compounds of general formula ##STR1## wherein: Y is methyl, and R is an unsubstituted or substituted alkyl group selected from methyl, or ethyl, and the pharmacologically acceptable salts thereof, for treating peripheral neuro... | 08/27/1991 |
| 5036102 | Method of treating autoimmune diseases comprising administration of psoralen dosage forms A method of treating leukocyte mediated autoimmune and skin diseases using psoralen reagent composition comprising sterile aqueous solutions suitable for extracorporeal administration to blood from a subject being treated by ultraviolet-A photophoresis.... | 07/30/1991 |
| 5001119 | 16-substituted androstanes and 16-substituted androstenes Compounds of the formula: ##STR1## are useful as anti-cancer, anti-obesity, anti-diabetic, anti-coronary agents, anti-aging agents, anti-hypolipidemic agents and anti-autoimmune agents.... | 03/19/1991 |
| 4994466 | Method of treatment for multiple sclerosis A method of treating a patient suffering from multiple sclerosis comprising daily administration to such patient of from about 1 to about 100 mg of a pure narcotic antagonist, e.g., nalmefene or naltrexone. The antagonist may be administered in divided do... | 02/19/1991 |
| 4950687 | Diacetylrhein salts and their therapeutical use in the treatment of arthrosis A therapeutic treatment for the athrosis diseases comprising administering by intraarticular route from 1 to 5 ml of an aqueous solution containing from 10 to 50 mg of a diacetyl rhein salt having formula (I): ##STR1## wherein M represents an alkali ... | 08/21/1990 |
| 4898856 | Method for treating central nervous system diseases A method of treating humans suffering from central nervous system diseases, such as Alzheimer's disease, Parkinson's disease, senile dimentia. The treatment consists of inducing into the patient's blood stream at least one from the group consisting of: se... | 02/06/1990 |
| 4741902 | Compositions for treatment of neurological and related disorders The invention provides compositions of matter having pharmacological activity and which are useful in the treatment of the symptoms of neurological and other disorders, particularly those disorders which are caused by malfunction of the immune mechanism. ... | 05/03/1988 |
| 4657761 | Polyvalent non-specific immuno-stimulating vaccine and method A non-specific therapeutic polyvalent vaccine for subcutaneous injection containing a minimum combination of a PPD (tuberculin vaccine), a rabies vaccine, and snake venom vaccine and preferably including at least a DTP vaccine in addition and optimally a ... | 04/14/1987 |
| 4618601 | Medicaments based on zinc gluconate useful for the treatment of hyperprolactinaemias This invention relates to the use of zinc gluconate for making a medicament administered by the oral route and containing from 50 to 150 mg of zinc gluconate, said medicament being used for the treatment of hyperprolactinaemias.... | 10/21/1986 |
| 4454125 | Dry powder formulations having improved flow and compressibility characteristics, and method for the preparation thereof Dry, stable, self-lubricating formulations for use as pharmaceuticals or vitamin/mineral supplements, which do not require the inclusion of fillers, lubricants, binders and other conventional excipients, and which exhibit excellent free flowability and co... | 06/12/1984 |
| 4435407 | Certain substituted ଲ-oxo--carbamoylpyrrolepropionitriles ଲ-Oxo--(heterocyclic substituted carbamoyl)-ଲ-pyrrolyl-propionitriles are antiinflammatory and/or antiarthritic agents with immunomodulating properties. Their synthesis, pharmaceutical compositions thereof, and methods of treatment util... | 03/06/1984 |
| 4351841 | Pharmaceutical preparation and method of treatment 5-Methylisoxazole-4-carboxylic acid-(4-trifluoromethyl)-anilide and a process for its preparation is described. The compound has an antirheumatic, antiphlogistic, antipyretic and analgesic action, and can be used for the treatment of multiple sclerosis.... | 09/28/1982 |
| 4346103 | Treatment for arthritis and substances for use in such treatment The treatment of multiple sclerosis with 1,8-dialkyloxy-3 carboxy anthraquinone.... | 08/24/1982 |
| 4284786 | 5-Methylisoxazole-4-carboxylic-(4-trifluoromethyl)-anilide 5-Methylisoxazole-4-carboxylic acid-(4-trifluoromethyl)-anilide and a process for its preparation is described. The compound has an antirheumatic, antiphlogistic, antipyretic and analgesic action, and can be used for the treatment of multiple sclerosis.... | 08/18/1981 |
| 4200750 | 4-Substituted imidazo [1,2-a]quinoxalines A 4-substituted imidazo [1,2-a]quinoxaline of formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein R1 is bonded to a ring carbon through a carbon-to-carbon linkage and is an aliphatic, cycloaliphatic, substituted phenyl,... | 04/29/1980 |
| 4070464 | Method of treating autoimmune diseases 3,4-Dihydrospiro-2H-1,3-benzoxazines and pharmaceutical compositions thereof are useful in the treatment of autoimmune diseases.... | 01/24/1978 |
| 4058594 | Immuno-suppressive agents A method of providing an immuno-suppressive effect in the control or prophylaxis of neurological disorders, such as multiple sclerosis, and in organ and tissue transplants comprising administering a daily dosage of 5mg to 3g of γ-linolenic or dihomo-γ-l... | 11/15/1977 |
