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| Number | Title | Issue Date |
| 4143131 | Removal of plutonium from hepatic tissue A method is provided for removing plutonium from hepatic tissues by introducing into the body and blood stream a solution of the complexing agent DTPA and an adjunct thereto. The adjunct material induces aberrations in the hepatic tissue cells and removes... | 03/06/1979 |
| 4140761 | Modification of hepatitis B virus infection in chronic carriers of hepatitis B surface antigen Interferon introduced parenterally in a human host or stimulated by an inducer (PICLC) for a period of greater than 21 days results in a major decrease in all markers of infectivity, such as DNA polymerase, and such markers remain at a depressed level dur... | 02/20/1979 |
| 4139637 | Quinone derivatives useful as medicaments The present invention relates to new chemical compounds which are useful in particular as medicaments. The compounds are derivatives of a quinone endowed with physiological and particularly vitamin activity and of a substituted hydrazine; they correspond ... | 02/13/1979 |
| 4132775 | Infectious bovine rhinotracheitis virus vaccine and method of preparing and using the same Pathogenic infectious bovine rhinotracheitis (IBR) virus may be modified by serial passages in non-bovine tissue cultures until it becomes non-pathogenic when applied to the intranasal passages of bovines. Such application will result in the induction of ... | 01/02/1979 |
| 4130641 | Induction of interferon production by modified nucleic acid complexes The present invention relates to the induction of interferon production in the cells of living organisms, including human beings. According to the invention, nucleic acid complexes, such as the polyriboinosinate and polycytidylate complex (rIn ... | 12/19/1978 |
| 4124702 | Polynucleotides active as inducers of interferon production in living animal cells Polynucleotides which are multistranded are active as inducers of interferon production in living animal cells. They may be: A. Synthetically complexed polymers of two homopolynucleotides. B. A nucleic acid released by phenol from a ribonucleic acid complex el... | 11/07/1978 |
| 4112120 | Methods and compositions for use in animal husbandry The disclosure relates to method for use in the husbandry of meat-producing domestic animals which comprises the oral administration to the animals of a p-benzoquinonedi-imide derivative, or a dihydro derivative or a salt thereof, and to compositions suit... | 09/05/1978 |
| 4079126 | Method of preparing a component consisting of sugar, lipid and protein derived from Pseudomonas aeruginosa which possess anti-tumor and interferon inducing properties This invention relates to a method of preparing original endotoxin protein of Pseudomonas aeruginosa. The invention relates more particularly to a method of preparing original endotoxin protein of Pseudomonas aeruginosa (hereunder abbreviated as OEP) by p... | 03/14/1978 |
| 4064137 | Penicillin and cephalosporin derivatives and process for preparing the same Novel penicillin and cephalosporin derivatives possessing interferon inducibility and represented by the formula ##STR1## wherein Y represents a hydrogen atom, a halogen atom a nitro group, an alkoxy group or an alkyl group; M represents a protective... | 12/20/1977 |
| 4058659 | 6,8-Disubstituted purine derivatives of 9-ଲ-D-ribofuranosyl 3',5'-cyclic phosphate Compounds of formula ##STR1## wherein X is --NR1 R2, --Cl, --Br or SR; Y is --X, --OH or --NH2 ; Z is hydrogen or --NH2 ; and R' is hydrogen or C1 -C18 acyl; R being hydrogen, aryl, ar... | 11/15/1977 |
| 4053582 | Attenuated fowl pox virus preparation for the treatment of infectious diseases, method for the manufacture thereof, and its use Preparation for the treatment of interferon-sensitive infectious diseases for use in human and veterinary medicine, characterized by the fact that it contains as active principle a fowl pox virus which has been attenuated by 420 to 800 cell culture passag... | 10/11/1977 |
| 4051260 | 2-Substituted-5-oxo-5H-dibenzo[a,d]cycloheptenes, and derivatives thereof, and methods and compositions for the use thereof 2-Substituted-5-oxo-5H-dibenzo[a,d]cycloheptenes represented by the following formula: ##STR1## where one of R2 and R3 is hydrogen, and the other is hydrogen, methyl, or ethyl, or together R2 and R3 are met... | 09/27/1977 |
| 4049794 | Treatment of infections in animals There is disclosed novel non-antigenic attenuated viruses which non-specifically stimulate the natural defense mechanism of a host organism with a detectable non-specific induction of interferon; to methods for their production and to their use for the pr... | 09/20/1977 |
| 4039656 | Production of attenuated viruses There is disclosed novel non-antigenic attenuated viruses which non-specifically stimulate the natural defense mechanism of a host organism with a detectable non-specific induction of interferon; to methods for their production and to their use for the pr... | 08/02/1977 |
| 4027021 | Interferon induction A method and therapeutic compositions for inducing interferon formation in vivo. To a host is administered an interferon inducer selected from the group consisting of A. 1,5-bis[(3-morpholinopropyl)amino]anthraquinone, B. 1-[(2-aminoethyl)amino]-5-[[1-(hydroxy... | 05/31/1977 |
| 4024241 | Nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid A nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid, poly-l-lysine and carboxymethylcellulose, and injectable preparations thereof in a pharmaceutically acceptable aqueous carrier such as saline solution. When administ... | 05/17/1977 |
| 4024222 | Nucleic acid complexes The present invention relates to the induction of interferon production in the cells of living organisms, including human beings. According to the invention, nucleic acid complexes, such as the polyriboinosinate and polycytidylate complex (rIn.rC.sub... | 05/17/1977 |
| 4021551 | 3,6-Bis-(heterocyclic aminoacyl-amino)-acridines and salts thereof Compounds of the formula ##STR1## wherein R1 is hydrogen or methyl, R2 and R3, together with each other and the nitrogen atom to which they are attached, form a saturated or unsaturated heterocyclic ring system which ... | 05/03/1977 |
| 4017359 | Production of non-antigenic attenuated viruses There is disclosed novel non-antigenic attenuated viruses which non-specifically stimulate the natural defense mechanism of a host organism with a detectable non-specific induction of interferon; to methods for their production and to their use for the pr... | 04/12/1977 |
| 3980776 | Composition containing double stranded RNA from basidiomycetes and method of use An inducer of interferon for the viral infection composed mainly of double stranded RNA is extracted and isolated from spore or mycelium of natural or cultivated basidiomycetes such as Cortinellus Shiitake.... | 09/14/1976 |
| 3975520 | Biologically active material Purified polyhedral virus particles capable of stimulating the production of interferon in animals are obtained from the fungal cells of the mold Aspergillus foetidus or Aspergillus niger or from the nutrient medium in which or on which said molds have be... | 08/17/1976 |
| 3966707 | Process for preparing double stranded RNA Virus particles capable of stimulating the production of interferon are isolated from fungal cells of the mould Aspergillus foetidus or Aspergillus niger or from the nutrient medium in which or on which Aspergillus foetidus or Aspergillus niger mould has ... | 06/29/1976 |
| 3957986 | Antiviral compositions containing bis-basic esters and amides of xanthene and xanthone Novel bis-basic esters and amides of xanthene and xanthone of the formula ##SPC1## Wherein: Z is oxygen or H2 ; each of R1 and R2 is hydrogen, (lower)-alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 ring carbon atoms, a... | 05/18/1976 |
| 3957989 | Antiviral compositions containing bis-basic ketones of xanthene and xanthen-9-one Novel bis-basic ketones of xanthene and xanthen-9-one have antiviral activity when administered orally and parenterally. The compounds are represented by the following formula: ##SPC1## Wherein Z is oxygen or H2 ; each A is a straight or branch... | 05/18/1976 |
| 3957988 | Antiviral compositions containing bis-basic ketones of thioxanthene The novel bis-basic ketones of thioxanthene have antiviral activity when administered orally and parenterally. These compounds are represented by the following formula: ##SPC1## Wherein A is a straight or branched alkylene chain having from 1 to about 6 ... | 05/18/1976 |
| 3956302 | Substituted pyrimidines For inducing interferon formation, compounds of the following formula: ##SPC1## Wherein X is a member selected from the group consisting of bromo and iodo and Y is ethyl when X is bromo; or Y is a member selected from the group consisting of ethyl, n-prop... | 05/11/1976 |
| 3948886 | 6-Substituted purine 3',5'-cyclic nucleotides Described herein are novel 6-alkylthio and 6-arylalkylthio purine 3',5' cyclic nucleotides variously exhibiting adenyl cyclase and (in animal studies) tumor inhibitory properties, interferon potentiation, antiviral activity, and the ability to activate ad... | 04/06/1976 |
| 3935185 | Polynucleotides of poly(5-hydroxycytidylic acids) Poly(5-hydroxycytidylic acids), produced by the enzymatic polymerization of 5-hydroxycytidylic acid, possess the ability to induce the production of interferon and, furthermore, exhibit anti-viral properties.... | 01/27/1976 |
| 3933893 | Derivatives of 9-phenanthrene Novel bis basic esters of 9-substituted phenanthrene and related 9-oxa and 9-aza derivatives thereof, their preparation and use for the prevention and inhibition of viral infections are disclosed.... | 01/20/1976 |
| 3932643 | Phenanthridines and phenanthridinones as antiviral agents Phenanthridines and phenanthridinones of the formulae ##SPC1## And the pharmaceutically-acceptable acid addition salts thereof wherein X is chloro, bromo, hydroxy, alkoxy having from 1 to 6 carbon atoms, amino, monoalkylamino, dialkylamino wherein each of... | 01/13/1976 |
| 3932456 | Bis-basic esters and amides of carbazole Novel bis-basic esters and amides of carbazole of the formula ##SPC1## Wherein: A. each of R1 and R2 is hydrogen, (lower)alkyl, cycloalkyl of 3 to 6 ring carbon atoms, alkenyl of 3 to 6 carbon atoms having the vinyl unsaturation in o... | 01/13/1976 |
| 3932617 | Interferon induction A method and therapeutic compositions for inducing interferon formation in vivo. To a host is administered an interferon inducer of the formula: ##SPC1## Wherein X is a member selected from the group consisting of bromo and iodo and Y is a member selected... | 01/13/1976 |
| 3931397 | Biologically active material This invention relates to antiviral substances, to a method for their preparation, and to pharmaceutical compositions comprising them.... | 01/06/1976 |
