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| Number | Title | Issue Date |
| 5254594 | Remedies for bone diseases Remedies for bone diseases comprising, as active ingredient, droloxifene or a salt thereof.... | 10/19/1993 |
| 5244668 | Low-melting moldable pharmaceutical excipient and dosage forms prepared therewith An excipient for a pharmaceutical compound which melts at body temperature but will not spontaneously deform at higher temperatures encountered in shipment and storage comprises: ______________________________________ Low MW Polyethylene glycol ... | 09/14/1993 |
| 5219548 | High affinity halogenated-tamoxifen derivatives and uses thereof Applicants describe the synthesis of fluorotamoxifen and iodotamoxifen analogs with the halogen atom positioned on the aliphatic chain of the tamoxifen molecule. The halogenated-tamoxifen derivatives possess superior binding affinities to estrogen recepto... | 06/15/1993 |
| 5139790 | Low-melting moldable pharmaceutical excipient and dosage forms prepared therewith An excipient for a pharmaceutical compound which melts at body temperature but will not spontaneously deform at higher temperatures encountered in shipment and storage comprises: ______________________________________ Low MW Polyethylene glycol ... | 08/18/1992 |
| 5130137 | Continuous delivery of luteinizing hormone releasing hormone compositions in combination with sex steroid delivery for use in treating benign ovarian secretory disorders This invention is directed to a delivery system and a method useful for the treatment of benign ovarian secretory disorders in female mammals by administering an LHRH composition. The method comprises administering during the entire follicular phase of th... | 07/14/1992 |
| 5102912 | Hydroxyoctadecadienic acid for the treatment of estrogen-dependent disease This invention describes the use of a hydroxyoctadecadienic acid, its acid oxidized to keto form or the ester derivatives of the acids, where the ester derivatives are low esters with 1 to 4 carbon atoms for the preparation of a pharmaceutical for treatme... | 04/07/1992 |
| 5047431 | 1,1,2-triphenylbut-1-ene derivatives Novel (E)-1-[4'-(2-alkylaminoethoxy)phenyl]-1- (3'-hydroxyphenyl)-2-phenylbut-1-enes of the general formula ##STR1## wherein R1 and R2 may be the same or different, provided that, when R1 and R2 are the sam... | 09/10/1991 |
| 4985248 | Pharmaceutical composition containing a safe extracts of fruits and vegetables for the treating and preventing of diabetes The new pharmaceutical composition and processes are provided for treating and preventing diabetes. The pharmaceutical composition is composed of three ingredients: Oleanolic acid, Saponins of Litchi and Kuguasu. The pharmaceutical composition is nontoxic.... | 01/15/1991 |
| 4894373 | Antiestrogens and their use in treatment of menopause and osteoporosis Disclosed is a method for treating menopausal symptoms and treating and preventing osteoporosis, wherein a true antiestrogen is administered and estrogen is not. This treatment is effective for female osteoporosis and can also be used to treat male osteop... | 01/16/1990 |
| 4870068 | Method of regulating fertility in swine using epostane The method of regulating fertility in swine which comprises administering to a pregnant sow near term an amount of epostane sufficient to induce parturition of live piglets on the following day is disclosed.... | 09/26/1989 |
| 4816258 | Transdermal contraceptive formulations A transdermal delivery system for the administering of ethinyl estradiol and levonorgestrel, in combination, utilizing a polymer matrix having the drug formulation along with a permeation enhancer dispersed throughout.... | 03/28/1989 |
| 4764382 | Device for controlled release drug delivery A device for the controlled release and delivery of a pharmacologically active agent, comprising a vinyl gel layer and a pharmacologically active agent uniformly dispersed in the layer in a pharmacologically effective amount, the vinyl layer comprising an... | 08/16/1988 |
| 4742082 | Solution of luprostiol and 1,2,-propanediol and methods of preparation and use A solution containing luprostial and 1,2-propanediol, characterized in that it contains luprostial in the form of its sodium salt in a solvent mixture comprising 50-90 percent by weight of 1,2-propanediol and 10-50 percent by weight of water, and has a pH... | 05/03/1988 |
| 4732904 | Antiestrogenic hydrazones Azido-, 4-nitro and 2,4-dinitrophenylhydrazones as well as 4,4'-dihydroxybenzophenone-hydrazone and other hydrazones are disclosed which have antiestrogenic activity useful in treating estrogen-requiring tumor cells. The described hydrazones bind to estro... | 03/22/1988 |
| 4618598 | Method of regulating hormone function or release A synthetic hormone complex comprising means for binding to the surface of a cell and means for altering second messenger mobilization by the cell. One form of the synthetic hormone complex functions as an antagonist with specific binding affinity for a c... | 10/21/1986 |
| 4372951 | Vaginal delivery for physiologic follicular-luteal steroid treatment A vaginal delivery system which provides an effective concurrent dosage of combined exogenous estrogenic active steroid and exogenous progestational active steroid during the corpus luteum phase of a follicular-luteal drug administration cycle to provide ... | 02/08/1983 |
| 4307086 | Branched chain and cycloaliphatic esters of the androstane and destrane series and pharmaceutical compositions containing same There are disclosed branched chain and cycloaliphatic esters of steroids having the formula: ##STR1## where R is H or CH3 ; R1 is H or CH3 ; R2 is H or CH3 ; R3 is H, OH, CH3 or ... | 12/22/1981 |
| 4272530 | Ɗ1,3,5(10) -Estratrienes Novel 11ଲ -substituted-Ɗ 1,3,5(10) -estratrienes of the formula ##STR1## wherein R1 is selected from the group consisting of optionally substituted unsaturated alkyl of 2 to 8 carbon atoms, optionally substituted ary... | 06/09/1981 |
| 4259325 | 1,3-Dibenzoic acid esters of 17-ethynyl-7-methyl-1,3,5(10)-estratriene-1,3,17ଲ-tri ol 1,3-Dibenzoic acid esters of 17-ethynyl-7-methyl-1,3,5(10)-estratriene-1,3,17ଲ-triol possess strong estrogenic and ovulation-inhibiting activities. As compared to the corresponding diacetic acid ester, these dibenzoic acid esters ... | 03/31/1981 |
| 4001229 | Alkanesulfonamido triphenylethylenes Triphenylethylenes having an N-(dialkylaminoalkyl)alkanesulfonamide substituent in the one of the phenyl rings may be prepared from similarly substituted benzophenones by reaction thereof with a benzyl Grignard reagent followed by dehydration of the resul... | 01/04/1977 |
| 3978048 | 17ଲ-SUBSTITUTED-ALLENE-BEARING STEROIDS Steroidal compounds of the invention bear a 17ଲ-oxygenated group and a 17-.PSI.-alkyl substituted allene group, e.g., 17-(penta-1'-2'-dienyl)-estra-4,9-dien-17ଲ-ol-3-one, and are prepared by a procedure, e.g., involving reacting ... | 08/31/1976 |
| 3939196 | Diarylcyclobutanes 1,3-bis(p-Hydroxyphenyl)cyclobutane and its monomethyl ether are estrogenic agents having antifertility action.... | 02/17/1976 |
| 3936491 | Adamantylene compounds Substituted diphenyl adamantylidene methanes. Examples of substituents on the para positions of the phenyl groups are propoxy and acetyloxy. The compounds have estrogenic activities.... | 02/03/1976 |
