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| Number | Title | Issue Date |
| 8084422 | Method of treating insulin resistance with a selective inhibitor of CB2 receptor activity The invention relates to the use of a selective inhibitor of CB2 receptor expression and/or for the manufacture of a medicament indented for the treatment and/or the prevention of obesity and obesity-related disorders. ... | 12/27/2011 |
| 8063011 | Prediction and prophylactic treatment of type 1 diabetes An in vitro method for predicting the onset of type 1 diabetes (T1 D) in a subject, comprises the steps of: (a) measuring the concentration of at least one amino acid, amino acid derivative or amino acid metabolite in a biological sample taken from the subject; (b) ... | 11/22/2011 |
| 7442720 | Compositions and methods for treating diabetes The subject invention provides compositions and methods for treating diabetes in patients. In a preferred embodiment, the invention provides compositions methods for treating diabetes and/or preventing or alleviating complications associated with diabetes. Specifica... | 10/28/2008 |
| 7435407 | Inhibition of olfactory neurosensory function to treat eating disorders and obesity The use of calcium channel blockers administered intra-nasally to inhibit olfactory sensory perception to treat eating disorders, including obesity, is described. Also described is a method of reducing food intake in a subject by administering a pharmaceutical compo... | 10/14/2008 |
| 7432069 | Biocompatible chemically crosslinked hydrogels for glucose sensing An hydrogel incorporating a biologically active component is provided that is useful as an interface material for transdermal sensing applications. Specifically, the hydrogel has a crosslinked gel structure and a biologically active component incorporated into the c... | 10/07/2008 |
| 7425332 | Treatment of autoimmune conditions with Copolymer 1 and related Copolymers The present invention is directed to polypeptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at l... | 09/16/2008 |
| 7422763 | Acid controlled induced viscosity fiber system and uses thereof The present invention relates generally to a method of blunting the postprandial glycemic response to a meal by feeding an acid controlled induced viscosity fiber system. The first component of the induced viscosity fiber system is anionic soluble fiber. The second ... | 09/09/2008 |
| 7419952 | Use of exendins and agonists thereof to treat diabetes Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that aff... | 09/02/2008 |
| 7416744 | Extracts, compounds and pharmaceutical compositions having anti-diabetic activity and their use The invention relates inter alia to pharmaceutical compositions containing an extract obtainable from a plant of the genus Trichocaulon or Hoodia having anti-diabetic activity; and to the use of such extracts and to compound (1) as herein defined and i... | 08/26/2008 |
| 7414044 | Use of targeted oxidative therapeutic formulation in treatment of type 2 diabetes A pharmaceutical formulation and its use. The pharmaceutical formulation contains peroxidic species or reaction products resulting from oxidation of an alkene, such as geraniol, by an oxygen-containing oxidizing agent, such as ozone; a penetrating solvent, such as d... | 08/19/2008 |
| 7405279 | Chimeric proteins for diagnosis and treatment of diabetes Novel chimeric fusion proteins comprising immunodominant epitopes of GAD and insulin are provided. Also provided are immunomodulatory methods for the use of such proteins for both the prevention and treatment of Type 1 diabetes mellitus. The chimeric fusion proteins... | 07/29/2008 |
| 7396659 | Inhibitors of nitric oxide synthase to treat type 1 diabetes A method for treating type 1 diabetes in a human in need of such treatment, comprising administering to the human a biologically effective amount of at least one inhibitor of inducible nitric oxide synthase or a pro-inflammatory cytokine, wherein the inhibitor is an... | 07/08/2008 |
| 7393875 | Methods and compounds for inhibiting amyloid deposits Methods and compositions which are useful in the treatment of amyloidosis. In particular, methods and compositions are provided for inhibiting, preventing and treating amyloid deposition, e.g., in pancreatic islets, wherein the amyloidotic deposits are islet amyloid... | 07/01/2008 |
| 7390824 | Method for treating diabetes employing an aP2 inhibitor and combination A method is provided for treating diabetes and related diseases, especially Type II diabetes, employing an aP2 inhibitor or a combination of an aP2 inhibitor and another antidiabetic agent such as metformin, glyburide, troglitazone and/or insulin. ... | 06/24/2008 |
| 7384915 | Chimeric insulin-gad proteins for treating patients with type 1 diabetes or at risk of developing type 1 diabetes Novel chimeric fusion proteins comprising immunodominant epitopes of GAD and insulin are provided. Also provided are immunomodulatory methods for the use of such proteins for both the prevention and treatment of Type 1 diabetes mellitus. The chimeric fusion proteins... | 06/10/2008 |
| 7384630 | Chimeric pancreas Novel methods, tissues and compositions for increasing the pancreatic mass of a mammalian recipient including harvesting immature pancreatic tissue from a mammalian donor and transplanting said tissue into the peritoneal cavity of a mammalian recipient under conditi... | 06/10/2008 |
| 7378437 | Drugs for diabetes Use for the diabetes treatment of compounds or salts thereof, having the following general formula (I): A-(B)b0—(C)c0—NO2 wherein A contains the radical of a drug having an antiinflammatory or analgesic activity, B is a bivalent ... | 05/27/2008 |
| 7371871 | Inhibitors of glutaminyl cyclase The present invention relates to compounds that act as inhibitors of QC including those represented by the general formulae 1 to 9: and combinations thereof for the treatment of neuronal disorders, especially Alzheimer's di... | 05/13/2008 |
| 7368421 | Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis The present invention provides a new use of DP IV-inhibitors. The compounds of the present invention, and their corresponding pharmaceutically acceptable acid addition salt forms, are useful in treating conditions mediated by DP IV or DP IV-like enzymes, such as imm... | 05/06/2008 |
| 7368576 | Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents The present invention provides new uses of DPIV-inhibitors of the present invention, and their corresponding pharmaceutically acceptable acid addition salt forms, for treating conditions mediated by DPIV or DPIV-like enzymes, such as cancer and tumors. In a more pre... | 05/06/2008 |
| 7354953 | Time-release compositions for delivery of [CrO(carboxylate)(HO)] A time release composition is provided containing: a chromium complex having formula 3 [Cr3O(carboxylate)6(ligand)3]+ (3) wherein carboxylate is a C2-C5 alkyl car... | 04/08/2008 |
| 7341869 | Compositions and methods for treating diabetes The present invention provides an isolated population of cells containing an expressible nucleic acid encoding proinsulin containing a proinsulin cleavage site and a glucose-regulated expressible nucleic acid encoding a protease capable of cleaving the proinsulin cl... | 03/11/2008 |
| 7335645 | Effectors of dipeptidyl peptidase IV for topical use The invention relates to compounds for topically influencing the activity of dipeptidyl peptidase of the general formula wherein A is an amino acid having at least one f... | 02/26/2008 |
| 7319093 | Antidiabetic 2-substituted-5′-O-(1-Boranotriphosphate) adenosine derivatives 2-Substituted-5′-O-(1-boranotriphosphate)adenosine derivatives having at position 2 a radical R1 selected from the group consisting of H; halogen; O-hydrocarbyl; S-hydrocarbyl; NR3R4; and hydrocarbyl optionally substituted by halogen, CN, SCN, NO2, OR3, SR3 or NR3... | 01/15/2008 |
| 7312196 | Formulations for amylin agonist peptides The present invention is concerned with a pharmaceutical formulation comprising an amylin agonist and optionally a buffer, a tonicifier or stabilizer, and a preservative in a container, for example, a vial, prefilled cartridge, prefilled syringe or disposable pen. T... | 12/25/2007 |
| 7297689 | Method for preparing peritoneal dialysate Carbonyl compounds generated and accumulated in the peritoneal dialysate can be inactivated or eliminated by a carbonyl compound-trapping agent such as aminoguanidine. Carbonyl compounds generated during sterilization and storage of the peritoneal dialysate can be e... | 11/20/2007 |
| 7294618 | Glucopyranosyloxypyrazole derivatives and medicinal use thereof The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R1, R2 and R3 represent a hydrogen atom or a halogen atom; R4... | 11/13/2007 |
| 7291594 | GLP-1 derivative and preparation thereof absorbable via mucous membrane A GLP-1 derivative is provided including an amino acid sequence of GLP-1 (7-35) having deletion, substitution and/or addition of one or more amino acids and having Waa-(Xaa)n-Yaa (in which Waa is Arg or Lys, Xaa is Arg or Lys, n is an integer of 0 to 14, and Yaa is ... | 11/06/2007 |
| 7288254 | Use of immunotoxins to induce immune tolerance to pancreatic islet transplantation The invention provides a method of treating diabetes in a subject, comprising administering to the diabetic subject an immunotoxin, thereby reducing the subject's T-cell population, and administering to the subject pancreatic islet cells from a donor. The immune tol... | 10/30/2007 |
| 7279457 | Rapid acting drug delivery compositions Drug formulations for systemic drug delivery with improved stability and rapid onset of action are described herein. The formulations may be administered via buccal administration, sublingual administration, pulmonary delivery, nasal administration, subcutaneous adm... | 10/09/2007 |
| 7276258 | Herbal extract and compound lupinoside and its analogues as anti-diabetic type II drugs from plant Pueraria tuberosa The present invention relates to a method of preventing and/or treating diabetes type 2, also, it relates to a method of augmenting Glut4 phosphorylation and Glut4 translocation to a target cell membrane to enhance insulin signal in a signal transduction pathway; fu... | 10/02/2007 |
| RE39866 | Nonpeptide insulin receptor agonists Modulation of the activity of the insulin receptor, enhancement of glucose uptake by cells, and other effects significant in the control and management of diabetes are accomplished using compounds of the formula wherein ... | 10/02/2007 |
| 7271153 | Nitrogenous heterocyclic derivatives, medicinal compositions containing the same, medicinal uses thereof, and intermediates therefor The present invention provides nitrogen-containing heterocyclic derivatives represented by the general formula: wherein X1 and X3 independently represent N or CH; X2 represents N ... | 09/18/2007 |
| 7264813 | Therapeutic uses of powder A method for treating a disease selected from diabetes mellitus and atherosclerosis, and a method for reducing triglycerides and/or increasing HDL cholesterol levels in the plasma of a subject. The method comprises administrating. to a subject an effective amount of... | 09/04/2007 |
| 7247616 | Pyrazole derivatives and diabetic medicine containing them The present invention provides pyrazole-O-glycoside derivatives represented by the following formulae, used as a diabetic medicine ... | 07/24/2007 |
| 7229965 | Use of growth hormone in low dose The invention relates to treatment of patients in need of increasing insulin sensitivity by administration of growth hormone or analogues thereof, preferably human growth hormone, in a low dose and the use of growth hormone or analogues thereof, preferably human gro... | 06/12/2007 |
| 7229964 | Insulin derivatives The present invention relates to insulin derivatives in which a lipophilic group having from 12 to 40 carbon atoms is attached to the α-amino group of the N-terminal amino acid in the B-chain or to the carboxy group of the C-terminal amino acid in the B-chain have ... | 06/12/2007 |
| 7226990 | Extendin derivatives The present invention relates to novel derivatives of exendin-4 or exendin-4 fragments, wherein the derivatives have a lipophilic substituent attached, optionally via a spacer, to an amino acid residue, which is not the N-terminal or C-terminal amino acid residue of... | 06/05/2007 |
| 7214778 | Glycoprotein with antidiabetic, antihypertensive, antiobesity and antihyperlipidemic effects from , and a method for preparing same A glycoprotein extracted from the fruiting body of Grifola frondosa is demonstrated to have antidiabetic, antihypertensive, antiobesity and antihyperlipidemic effects, and has great potential as an active component for pharmaceuticals, dietary supplements or ... | 05/08/2007 |
| 7211557 | Use of GLP-1 analogs and derivatives administered peripherally in regulation of obesity This invention relates the use of glucagon-like peptides such as GLP-1, a GLP-1 analog, or a GLP-1 derivative in methods and compositions for reducing body weight. ... | 05/01/2007 |
