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| Number | Title | Issue Date |
| 7411044 | Polymerized hemoglobin solutions having reduced amounts of tetramer and method for preparing A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer t... | 08/12/2008 |
| 7357937 | Perfluorocarbon emulsions with non-fluorinated surfactants A stable FC emulsion is described. The FC emulsion of the present invention comprises a continuous FC immiscible hydrophilic liquid phase and a dispersed phase comprising FC suspended as droplets within the continuous phase. The emulsion further comprises an emulsif... | 04/15/2008 |
| 7297689 | Method for preparing peritoneal dialysate Carbonyl compounds generated and accumulated in the peritoneal dialysate can be inactivated or eliminated by a carbonyl compound-trapping agent such as aminoguanidine. Carbonyl compounds generated during sterilization and storage of the peritoneal dialysate can be e... | 11/20/2007 |
| 7291592 | Method for treating patients with massive blood loss Methods for treating a mammal suffering from massive blood loss comprising administering to the mammal a polymerized hemoglobin solution. ... | 11/06/2007 |
| 7135553 | Polymerized hemoglobin solutions having reduced amounts of tetramer and method for preparing A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer t... | 11/14/2006 |
| 7129329 | Heme proteins hemAT-Hs and hemAT-Bs and their use in medicine and microsensors The present invention provides an isolated archael and bacterial heme binding protein which reversibly binds oxygen with a low affinity. The heme binding protein may be utilized as a blood substitute. The invention also provides a method for controlled storage of ox... | 10/31/2006 |
| 7101846 | Methods and compositions for optimization of oxygen transport by cell-free systems Compositions, and methods of use thereof, for use as blood substitute products comprise aqueous mixtures of oxygen-carrying and non-oxygen carrying plasma expanders and methods for the use thereof. The oxygen-carrying component may consist of any hemoglobin-based ox... | 09/05/2006 |
| 6914127 | Acellular red blood cell substitute An acellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically acceptable carrier, its use and a process for preparing said acellula... | 07/05/2005 |
| 6911427 | No-modified hemoglobins and uses therefore S-nitrosohemoglobin (SNO-Hb) can be formed by reaction of Hb with S-nitrosothiol and by other methods described herein which do not result in oxidation of the heme Fe. Other methods can be used which are not specific only for thiol groups, but which nitrosate Hb mor... | 06/28/2005 |
| 6884773 | Modified hemoglobins, including nitrosylhemoglobins, and uses thereof Diseases which can be ameliorated by delivery of NO to tissues affected by the disease can be treated by administration of nitrosyl-heme-containing donors of NO, including nitrosylhemoglobin. Nitrosylhemoglobin can be made by the reaction of NO with hemoglobin under... | 04/26/2005 |
| 6855691 | Methods for producing and using S-nitrosohemoglobins Nitric oxide (NO) interacts with hemoglobin (Hb) at its metal centers, whereas S-nitrosothiols (RSNOs) can donate the NO group to β93 cysteine residues, thereby shielding the NO functionality from heme inactivation. S-nitrosylation of Hb is under the allosteric con... | 02/15/2005 |
| 6767544 | Methods for treating cardiovascular diseases with botulinum toxin The present invention provides for methods of treating cardiovascular diseases in a mammal. The methods include a step of administering an effective amount of a botulinum toxin directly to a blood vessel of a mammal thereby treating a cardiovascular disease. ... | 07/27/2004 |
| 6599878 | Superoxygenating blood substitutes based on hemoglobin and dihydropyidine compositions The present invention provides superoxygenating compositions that comprise hemoglobin and guanosine 3':5'-cyclic monophosphate (cyclic GMP) generating compounds, and methods for treatment of diseases or medical conditions which utilize the superoxygenatin... | 07/29/2003 |
| 6583113 | Nitrosated and nitrosylated heme proteins Nitrosylation of proteins and amino acid groups enables selective regulation of protein function, and also endows the proteins and amino acids with additional smooth muscle relaxant and platelet inhibitory capabilities. Thus, the invention relates to nove... | 06/24/2003 |
| 6562872 | Emulsion of perfluoroorganic compounds for medical purposes, a process for the preparation thereof and methods for treating and preventing diseases with the use thereof An emulsion of perfluoroorganic compounds (PFOC) comprises a rapidly eliminable perfluorocarbon (PFC) and a slowly eliminable perfluorinated cyclic tertiary amine, perfluoro-N-4-(methylcyclohexyl)-piperidine and additionally comprises not less then three ... | 05/13/2003 |
| 6498141 | Method and apparatus for preparing an acellular red blood cell substitute A process is disclosed for the preparation of an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin. Also disclosed is an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin ... | 12/24/2002 |
| 6492103 | System for organ and tissue preservation and hypothermic blood substitution A unified solution system for organ and/or tissue preservation and/or hypothermic blood substitution can be used to prepare multiple solutions for use in various stages of organ procurement, preservation and transplantation and bloodless surgery procedure... | 12/10/2002 |
| 6432918 | Methods and compositions for optimization of oxygen transport by cell-free systems Compositions, and methods of use thereof, for use as blood substitute products comprise aqueous mixtures of oxygen-carrying and non-oxygen carrying plasma expanders and methods for the use thereof. The oxygen-carrying component may consist of any hemoglob... | 08/13/2002 |
| 6369118 | Biocompatible emulsifier A biocompatible emulsifier for forming stable emulsions is disclosed. The emulsifier is particularly useful for emulsions of biological fluids, such as artificial blood, and for emulsions as drug delivery vehicles.... | 04/09/2002 |
| 6251437 | Liquid/powder acid concentrate for dialysate and a method of making the same A hemodialysis acid concentrate which includes, before mixing, sodium chloride powder and sometimes dextrose powder as a powder component, and a liquid component which contains some or all of the following: potassium chloride, magnesium chloride, sodium c... | 06/26/2001 |
| 6204296 | Patient oxygenation using stabilized fluorocarbon emulsions Storage stable fluorocarbon emulsions having a continuous aqueous phase and a discontinuous fluorocarbon phase, in which the fluorocarbon phase comprises a major amount of a first fluorocarbon or fluorocarbon mixture, and a minor amount of a second fluoro... | 03/20/2001 |
| 6197745 | Methods for producing nitrosated hemoglobins and therapeutic uses therefor S-nitrosothiols (RSNOs) can donate the NO group to the cysteine residues of hemoglobin (Hb) without inactivating the heme. S-nitrosylation of Hb is under the allosteric control of oxygen and the oxidation state of heme. NO group release from S-n... | 03/06/2001 |
| 6187744 | Methods and compositions for regulating the intravascular flow and oxygenating activity of hemoglobin in a human or animal subject Methods for time-regulated prophylaxis or treatment of animals or humans for limited circulatory oxygen delivery induced by the inhibitory effects of a plasma-borne hemoglobin-based material on L-arginine.fwdarw.nitric oxide.fwdarw.cGMP pathways in the ar... | 02/13/2001 |
| 6117838 | Use of hemoglobin in the treatment of hypotension A method of treating a mammal suffering from hypotension by administering intermolecularly- or intramolecularly-crosslinked stroma-free hemoglobin to the mammal.... | 09/12/2000 |
| 6113919 | Preparations comprising a fluorocarbon or a highly fluorinated compound and a lipophilic/fluorophilic compound and their uses Fluorocarbon emulsions comprising a stabilizing, particle size controlling fluorophilic/hydrophilic compound which can have the formula RF1 --W--RH1 (I) wherein RF1 is a lin... | 09/05/2000 |
| 6090779 | Use of hemoglobin to treat septic shock Therapeutic treatment of septic shock comprises administering to an animal stroma-free hemoglobin, typically at a dose ranging from the least amount effective to increase perfusion, up to a dosage of about 2500 milligrams kilograms per of body weight.... | 07/18/2000 |
| 6054427 | Methods and compositions for optimization of oxygen transport by cell-free systems Compositions, and methods of use thereof, for use as blood substitute products comprise aqueous mixtures of oxygen-carrying and non-oxygen carrying plasma expanders and methods for the use thereof. The oxygen-carrying component may consist of any hemoglob... | 04/25/2000 |
| 6046161 | Use of hemoglobin in the treatment of cardiogenic shock A method for increasing perfusion in a mammal suffering from cardiogenic shock by administering a perfusion-increasing effective amount of intermolecularly- or intramolecularly-crosslinked stroma-free hemoglobin to the mammal.... | 04/04/2000 |
| 6022850 | Use of hemoglobin in the treatment of stroke A method for increasing perfusion in a mammal suffering from stroke by admninistering a perfusion-increasing effective amount of intermolecularly- or intramolecularly-crosslinked stroma-free hemoglobin to the mammal.... | 02/08/2000 |
| 6020308 | Methods for improving therapeutic effectiveness of treatment of vascularization disorders The present invention is directed to the use of an inhibitor of NO activity, such as a nitric oxide scavenger or an NO synthase inhibitor, as as an adjunct to treatment of inappropriate tissue vascularization disorders.... | 02/01/2000 |
| 5989918 | ADME analysis of mixtures A method for analyzing the ADME/PK properties of a mixture of compounds is (1) perfusing an animal or organ with a perfluorocarbon emulsion blood substitute, (2) administering the mixture of test compounds, (3) withdrawing an aliquot of the perfusate, (4)... | 11/23/1999 |
| 5985332 | Hemoglobins provided with ligands protecting the oxygen binding sites for use as artificial oxygen carriers for direct application in medicine and biology, and method for the preparation thereof Artificial oxygen carrier composed of native or modified hemoglobins for direct biological or medical use, in which the oxygen binding site of the hemoglobin is provided with a protective ligand, preferably carbon monoxide, which does not have to be remov... | 11/16/1999 |
| 5914352 | Methods for the use of stabilized fluorocarbon emulsions Storage stable fluorocarbon emulsions having a continuous aqueous phase and a discontinuous fluorocarbon phase, in which the fluorocarbon phase comprises a major amount of a first fluorocarbon or fluorocarbon mixture, and a minor amount of a second fluoro... | 06/22/1999 |
| 5904933 | Stable reverse and multiple fluorocarbon emulsions Stable reverse water-in-fluorocarbon emulsions and water-in-fluorocarbon-in-water multiple emulsions comprising the reverse fluorocarbon emulsions. The reverse emulsions comprise a continuous phase which is a highly fluorinated or perfluorinated compound,... | 05/18/1999 |
| 5869539 | Emulsions of perfluoro compounds as solvents for nitric oxide (NO) The present invention involves perfluoro compound emulsions including nitric oxide, their preparation and their use. These emulsions provide a new source of nitric oxide. Such nitric oxide-containing emulsions may be used for the administration of nitric ... | 02/09/1999 |
| 5846516 | Perfluoroalkylated amphiphilic phosphorus compounds: preparation and biomedical applications Perfluoroalkylated amphiphilic phosphorus compounds, corresponding to the formulae: ##STR1## wherein V is O or S; R1, R2 and R3 are H or substituted or unsubstituted perfluoroalkylated or hydrocarbon radicals; provide... | 12/08/1998 |
| 5846458 | Inhibition adsorption of proteins on the liposome surface Agents for inhibiting adsorption of proteins on the liposome surface and liposomes which are agglutination-free by binding said inhibiting agent on the surface are disclosed. The above-mentioned inhibiting agents comprise a hydrophobic moiety and a hydrop... | 12/08/1998 |
| 5817045 | Apparatus and method for enabling extracorporeal therapy of up to at least one half of a living patient's entire circulating blood supply during a continuous time interval The instant invention teaches an apparatus and a method for using an apparatus for extracorporeal therapeutic treatment of a changing volume of up to at least about half of the circulating blood of a living patient at one time. The apparatus includes firs... | 10/06/1998 |
| 5789376 | Transfusions with stabilized hemoglobin covalently bound to a nitroxide or polymers thereof Compositions and processes to alleviate oxygen toxicity are disclosed based on the addition of nitroxides to physiologically compatible macromolecules. In particular, hemoglobin-based red cell substitutes are described featuring stable nitroxide free radi... | 08/04/1998 |
| 5785950 | Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of making and using them This invention relates to compositions comprising highly fluorinated, chloro-substituted, non-cyclic organic compounds having 7 to 9 carbon atoms and to processes of making and using them. More particularly, this invention relates to emulsions comprising ... | 07/28/1998 |
