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| Number | Title | Issue Date |
| 5026709 | Method for the preparation of a theophylline sustained release pharmaceutical composition and the composition prepared thereby A method for the preparation of a sustained release pharmaceutical composition comprising forming a fluidized ring of said particles and contacting said particles maintained suspended in said ring with a liquid composition containing a pharmaceutically ac... | 06/25/1991 |
| 5021460 | P-alkyl phenoxy alkanols for the treatment of allergic conditions p-Alkyl or cycloalkyl phenoxy alkanols and esters are provided having the structure: ##STR1## in which: R1 is an alkyl group having from one to six carbon atoms, preferably tertiary, and still more preferably tertiary-butul; or a biva... | 06/04/1991 |
| 5011845 | Cyclic diesters of 4-hydroxy-1,3-benzenedimethanol and compositions and methods employing such compounds Compounds of the formula ##STR1## wherein R5 represents C1 to C6 -alkyl or the group--(CH2)n --Z--(CH2)m --Ar wherein Z represents O, S or --CH2 --and Ar is pheny... | 04/30/1991 |
| 5011836 | Agents for the treatment of acute and chronic obstructive respiratory passage diseases A method for treating abstructive respiratory passage disorders which comprises the use of 5,11-dihydro-11-[[(1-methyl-4-piperidinyl)-amino]carbonyl]-6H-dibenz[b,e]a zepin-6-one; 5,11-dihydro-11-[(1-methyl-4-piperazinyl)acetyl]-6H-dibenz[b,e]azepin-6-... | 04/30/1991 |
| 5006556 | Dichloroaniline derivatives for the therapy or prophylaxysis of a disease associated with reversible airway obstruction The invention provides compounds of the general formula (I) ##STR1## wherein X represents a C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene chain and Y represents a bond, or a C1-4 alkylene, C2-4 al... | 04/09/1991 |
| 5002972 | Compound and composition of substituted hexenoic acid derivatives useful for treating thromboxane A2 mediated diseases Pharmaceutical compounds and compositions for injectable use in the treatment of thromboxane A2 mediating diseases, comprising a pharmaceutical carrier and a pharmacologically effective amount of a compound of the formula: ##STR1## wh... | 03/26/1991 |
| 5002967 | Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase The compounds of the present invention comprise substituted phenolic thioethers, sulfoxides, and disulfides that are specific inhibitors of 5-lipoxygenase and which, therefore, are useful in the treatment of local and systemic inflammation, allergy and hy... | 03/26/1991 |
| 5000936 | Methods for locally-treating allergic disorders with pharmaceutical preparations containing N-acetyl-aspartyl glutamic acid or its salts Pharmaceutical preparations with anti-allergic activity for local administration, which contains, a pharmaceutically acceptable salt of N-acetyl-(alpha, beta)-aspartyl glutamic acid in the form of ophthalmic preparations, nasal solutions, bronchial aeroso... | 03/19/1991 |
| 4999363 | Tricyclic compounds Novel tricyclic compound represented by formula ##STR1## possess a TXA2 biosynthesis inhibiting activity and/or a TXA2 receptor antagonizing activity, and are expected to have preventive and therapeutic effects on ischemic disea... | 03/12/1991 |
| 4997644 | Method of treating adult respiratory distress syndrome In accordance with the present invention, a method is provided for treating adult respiratory distress syndrome. The method comprises injecting an effective amount of a surface-active copolymer into an animal or human with adult respiratory distress syndr... | 03/05/1991 |
| 4992474 | Phenethanolamine derivatives Phenethanolamine derivatives are disclosed of formula ##STR1## wherein m is 2 to 8; n is 1 to 7 provided that m+n is 4 to 12; Ar is phenyl or phenyl substituted by one or two halogen atoms, alkyl or alkoxy groups or by an alkylenedioxy group; R1 | 02/12/1991 |
| 4988716 | Inhibitors of slow reacting substance of anaphylaxis Novel compounds and compositions which inhibit SRS-A in mammals are disclosed. Methods for preparing said compounds and compositions and methods for their use for treating allergic reactions, inflammation and for reducing the severity of myocardial infarc... | 01/29/1991 |
| 4975461 | P-aminophenols, derivatives thereof and method of use p-Aminophenols are provided having the structure ##STR1## wherein m is 0, 1 or 2; n is 0, 1, 2 or 3; R1 and R2 may be the same or different and are H, hydroxy or alkoxy; R3 is H, lower alkyl, alkanoyl or aroyl and R | 12/04/1990 |
| 4952564 | Antiallergic agent The present invention which is an antiallergic agent characterized by containing isoliquiritigenin as an effective component provides a novel antiallergic agent exhibiting a low toxicity and excellent antiallergic properties.... | 08/28/1990 |
| 4950674 | Arylalkylheterocyclic amines,N-substituted by aryloxyalkyl group in a method for allergy treatment A method of inhibiting Type 1 allergic responses in a living animal body with substituted heterocyclic amines is disclosed wherein the active agents are expressed generally by the formula which includes certain known and certain known compounds: ##ST... | 08/21/1990 |
| 4940712 | Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors 2-Amino and 2-thio-4-substituted-5-(hydroxy or alkoxy)-pyrimidines, which may be 6-substituted, and derivatives thereof are disclosed. The compounds are inhibitors of leukotriene synthesis and are, therefore, useful for the treatment of pulmonary, inflamm... | 07/10/1990 |
| 4933329 | Bis-S-alkylbenzene derivatives Novel bis-S-alkylbenzene derivatives capable of inhibiting lipoxygenase, inparticular, 5-lipoxygenase are disclosed. It is expected that the compounds, which are hardly metabolized in vivo, are highly useful in the treatment and/or prevention of various d... | 06/12/1990 |
| 4929605 | Pharmaceutical composition for piperidinoalkanol derivatives A pharamaceutical composition in solid unit dosage form comprising (a) a therapeutically effective amount of a piperidinoalkanol compound, or a pharmaceutically acceptable salt thereof, (b) pharmaceutically acceptable nonionic or cationic surfactant in an... | 05/29/1990 |
| 4923892 | Tricyclic aromatic compounds The present invention relates to compounds of formula I ##STR1## or a salt, ester or amide thereof; wherein R1 is --CH2 --CH2 --, CH2 --O-- or --O--CH2 --; R2 and R3 are the... | 05/08/1990 |
| 4921835 | Method of treating asthma The peptides of the formula ##STR1## together with their pharmacologically acceptable salts, which have been described as exhibiting analgesic, antidiarrhoeal and antitussive activity, are effective in reversing neuronally-mediated bronchoconstr... | 05/01/1990 |
| 4910208 | Method of inhibiting leukotriene biosynthesis by oral administration of p-aminophenols or derivatives thereof A method is provided for inhibiting leukotriene biosynthesis and thus treating asthma, psoriasis or inflammation by oral administration of p-aminophenols having the structure ##STR1## wherein m is 0 to 5; X is CH or N; R1 and R2... | 03/20/1990 |
| 4910204 | 2-amino-5-hydroxy-4-pyrimidones A compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen; R2 is (C1 -C15) alkyl, (C3 -C15)alkenyl, phenyl, substituted phenyl, (C7 | 03/20/1990 |
| 4908386 | Ethanolamine derivatives The present invention provides compounds of general formula (I) ##STR1## wherein Ar represents an unsubstituted or substituted phenyl gorup; R1 and R2 each represents a hydrogen atom or a C1-3 alkyl group; X represents a b... | 03/13/1990 |
| 4906658 | Fluoro-sulfones Compounds of Formula I ##STR1## the pharmaceutically acceptable salts, and the gamma-lactone form thereof are described. They are antagonists of leukotrienes and SRS-A.... | 03/06/1990 |
| 4874772 | Antiasthmatic agent An agent for treatment and prevention of asthma comprising 2-[2-phenyl-2-(2-pyridyl)]ethyl-2-imidazoline or a salt thereof as an active ingredient is disclosed.... | 10/17/1989 |
| 4867915 | 16-Substituted polyunsaturated hexadecanoic fatty acids Sixteen carbon atom carboxylic acids having 16-phenoxy or 16-phenylthio substituents, and 0, 1, or 4 triple bonds, methods of preparing them, and pharmaceutical preparations containing them. These compounds are useful as lipoxygenase inhibitors.... | 09/19/1989 |
| 4866051 | Micronised beclomethasone dipropionate monohydrate compositions and methods of use Beclomethasone dipropionate in the form of its micronised monohydrate substantially free from water other than water of crystallisation. Pharmaceutical compositions containing the compound are also described. The compositions may be in the form of powder ... | 09/12/1989 |
| 4853381 | Ethanolamine compounds The invention provides compounds of the general formula (I) ##STR1## wherein Ar represents a phenyl group optionally substituted by one or more substituents selected from halogen atoms, or the groups C1-6 alkyl, C1-6 alkoxy, nit... | 08/01/1989 |
| 4845122 | Anti-allergy treatment using 2-(substituted amino)-4,5-dihydro-4-oxo-3-furancarboxylic acids and derivatives thereof As an anti-allergic treatment for warm-blooded animals, therapeutic amounts of a compound having the formula I (including acid salts thereof) or II are administered: ##STR1## where; R is OR4 or NHR5 in which R4 is hyd... | 07/04/1989 |
| 4837203 | Pharmacologically active compounds and use The peptides of the formula wherein X is hydrogen or an amidino group and X2 is D-S-methylmethionyl or D-arginyl, together with their pharmacologically acceptable salts, which have been described as exhibiting analgesic, antidiarrhoeal and anti... | 06/06/1989 |
| 4833126 | Pharmacologically active compounds and use The peptides of the formula ##STR1## together with their pharmacologically acceptable salts, which have been described as exhibiting analgesic, antidiarrhoeal and antitussive activity, are effective in reversing neuronally-mediated bronchoconstr... | 05/23/1989 |
| 4822611 | Oral hyposensitization in the treatment of allergies A method of treating allergies whereby hyposensitization to allergens to which the patient has been found to be sensitive by skin testing and history is induced by sequentially scheduled oral administration of titrated amounts of allergenic extracts in a ... | 04/18/1989 |
| 4810713 | Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment A method of treating allergy with substituted heterocyclic amines is disclosed wherein the active agents are expressed generally by the formula which includes certain known and certain novel compounds: ##STR1## wherein p is zero, one or two; m is one... | 03/07/1989 |
| 4806525 | Formulation comprising gelatin and glycine for treating the dryness of skin A formulation comprised of soft gelatin and glycine in a proportion of about 3:1 to 2:1 by weight, to which can be added mineral oligoelements and vitamins, which, when administered orally, exerts in a relatively short time a moisturizing activity on skin... | 02/21/1989 |
| 4804678 | Method for treating allergic conditions There is described a pharmaceutical composition comprising liposomes and sodium cromoglycate. There is also described an aqueous suspension comprising sodium cromoglycate partitioned between a free aqueous phase and a liposome phase. There is further desc... | 02/14/1989 |
| 4780476 | Azoniaspironortropanol esters as asthma therapeutics and broncholytics The present invention is concerned with the use of azoniaspironortropanol esters of the general formula: ##STR1## wherein R signifies one of the following radicals: (a) an alkylene radical of the general formula: ##STR2## in which R3 | 10/25/1988 |
| 4778816 | Anti-asthmatic composition and process for preparing the same 5-(3-n-Butyloxalylaminophenyl) tetrazole having an excellent SRS-A release-inhibiting effect is used as an effective component for an anti-asthmatic agent, and a pharmaceutical preparation obtained by mixing the tetrazole with a specific dispersant such a... | 10/18/1988 |
| 4778673 | Additive-containing paints There have been prepared paints containing as additives known pharmaceutical products, having such a therapeutic or prophylactic action as to neutralize or prevent the irritating effect of the volatile components of the paints on the respiratory and conju... | 10/18/1988 |
| 4774226 | Pharmaceutical preparation for the prophylactic treatment of allergies and process for the preparation of said pharmaceutical preparation A pharmaceutical preparation for the prophylactic treatment of allergies which contains as active ingredient an extract of pollen which contains nor more than 5% by weight, referred to the dry weight of the extract of pollen, of proteins having a high mol... | 09/27/1988 |
| 4758594 | Inhibitors of slow reacting substance of anaphylaxis Novel compounds and compositions which inhibit SRS-A in mammals are disclosed. Methods for preparing said compounds and compositions and methods for their use for treating allergic reactions, inflammation and for reducing the severity of myocardial infarc... | 07/19/1988 |
