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| Number | Title | Issue Date |
| 5314894 | (S)-(+)-hydroxychloroquine (S)-(+)-Hydroxychloroquine substantially free of (R)-(-)-hydroxychloroquine, or a pharmaceutically acceptable acid-addition salt thereof and a method of use thereof and a composition containing it for the treatment of malaria, lupus erythematosus or rheum... | 05/24/1994 |
| 5308837 | 5'-amine substituted adenosine analogs as immunosuppressants The present invention relates to a method of effecting immunosuppression in a patient in need thereof comprising administering to said patient an effective immunosuppressive amount of certain 5'-amine substituted adenosine analogs.... | 05/03/1994 |
| 5304549 | Amino acid derivatives Compounds of the formula ##STR1## wherein A is the group ##STR2## R1 is hydrogen, amino, protected amino, acylamino or lower alkyl optionally substituted by aryl, hydroxy, protected hydroxy, amino, protected amino, acylamino, mal... | 04/19/1994 |
| 5298494 | Monosaccharides having anti-proliferation and anti-inflammatory activity, compositions and uses thereof Derivatives of simple monosaccharides which exhibit anti-proliferative and/or anti-inflammatory activity and are useful for treating mammals having inflammatory disorders and/or autoimmune disorders. This invention also encompasses pharmaceutical composit... | 03/29/1994 |
| 5298521 | 1,5-diphenyl-3-pyrazolylalkyl-N-hydroxydithiocaramates, compositions and use 1,5-Diphenyl-3-pyrazolylalkyl-N-hydroxydithiocarbamates of the general formula: ##STR1## are disclosed to have anti-inflammatory activity in mammals.... | 03/29/1994 |
| 5281623 | Method for treating inflammation Provided are methods of treating inflammation, arthritis and muscular dystrophy and preventing ischemia-induced cell damage employing certain phenol and benzamide compounds.... | 01/25/1994 |
| 5278183 | Method for the treatment of autoimmune diseases A pharmaceutical composition for the treatment of autoimmune diseases comprising an effective amount of a compound of formula A--CH2 --O--CRR'--COOR"' (I) where A is the nucleus of 1-benzyl-indazol-3-yl, R and R', the same or... | 01/11/1994 |
| 5273742 | Biomedical water soluble hydrophilic polyurethane polymers and method of use thereof A method for treating a body condition comprising introducing an aqueous solution of a water soluble polyether polyurethane into said body condition.... | 12/28/1993 |
| 5266564 | Method for treating certain autoimmune diseases There is described the production of a pharmaceutical composition for the eatment of autoimmune diseases, whereby multiple sclerosis is excluded. As active materials, there are thereby used compounds of the general formula I ##STR1## in which R | 11/30/1993 |
| 5262161 | Stevia extract-containing medicine A medicine for skin diseases contains a fermented and condensed extract from the stems of Stevia Rebaudiana Bertoni as an active ingredient. The medicine is prepared by condensing and fermenting an extract from the ripened stems of Stevia Rebaudiana Berto... | 11/16/1993 |
| 5260328 | Phenyl-indenopurazol 3-oxo-propanamide derivatives useful in the treatment of rheumatoid arthritis Heteroaryl-3-oxo-propanenitrile derivatives of formula (I) ##STR1## wherein X represents an oxygen atom or a --CH(R4)--, --O--CH(R4)--, --S(O)n --CH(R4)--, --CH(R4)--O--, --CH(R4)--S(O... | 11/09/1993 |
| 5258403 | Metallo-organic salt compounds and pharmaceutical uses thereof The present invention provides pharmaceutical compositions for the treatment of tumor cells in a subject of for the treating of undesirable symptoms associated with the presence of free radicals. The compositions comprising a complex compound having the s... | 11/02/1993 |
| 5258371 | Method to reduce connective tissue destruction Provided is a method of treating humans or animals suffering from a condition or disease characterized by excessive collagen destruction, which comprises administering to said human or animal an effective amount of a 12a-deoxytetracycline represented by t... | 11/02/1993 |
| 5250442 | Method of treating rheumatoid arthritis using tetracycline A method of treating rheumatoid arthritis which includes first, taking a blood test to determine a rate of erythrocyte sedimentation and a rheumatoid factor, and then fasting for a 12-hour period prior to orally administering a 500 milligram dosage of tet... | 10/05/1993 |
| 5223257 | Topical composition for relieving aches and pains A composition comprising approximately equal proportions by volume of wintergreen oil, olive oil and/or oil of Eucalyptus and alcohol has an analgesic effect in treating aches and pains when rubbed or massaged on skin covering tissue from which such aches... | 06/29/1993 |
| 5209920 | Evaluative means for detecting inflammatory reactivity Inbred Lewis (LEW/N) female rats develop an arthritis in response to Group A streptococcal cell wall peptidoglycanpolysaccharide (SCW) which mimics human rheumatoid arthritis. Histocompatible Fischer (F344/N) rats, on the other hand, do not develop arthri... | 05/11/1993 |
| 5206223 | Method for inhibiting heparanase activity Heparanase activity in a patient may be inhibited by administering an effective heparanase-inhibiting amount of heparin or an effective chemically modified derivative of heparin which inhibits heparanase activity. Such derivatives are preferably N-desulfa... | 04/27/1993 |
| 5202159 | Preparation method of microdispersed tablet formulation of spray-dried sodium diclofenac enteric-coated microcapsules A preparation method of sodium diclofenac enteric-coated microcapsules by spray drying technique comprising the steps of (a) dissolving sodium diclofenac in an appropriate amount of distilled water; (b) adding an effective amount of excipients to the above sol... | 04/13/1993 |
| 5196430 | Method of inhibiting the activity of leukocyte derived cytokines A family of compounds effective in inhibiting interleukin-1 (IL-1) activity, tumor necrosis factor (TNF) activity, and the activity of other leukocyte derived cytokines is comprised of 7-(oxoalkyl) 1,3-dialkyl xanthines of the formula ##STR1## i... | 03/23/1993 |
| 5194446 | Compounds having one or more aminosulfaonyloxy radicals useful as pharmaceuticals Methods of treating chronic arthritis and osteoporosis which utilize both known and novel compounds which would fall under the general formula: (HO)p--A--[--OS(O)2 NR1 R2 ]z wherein A encompasses a wide range of values in... | 03/16/1993 |
| 5180735 | Cyclohexanol derivatives, production and use thereof The present invention relates to a compound of the formula: ##STR1## wherein A is halogen, N(O)mR1 R2, N.sym. R1 R2 R3 .multidot.X.crclbar., S(O)nR1 or S.sym. | 01/19/1993 |
| 5178873 | Essential fatty acid treatment A method of inhibiting phospholipase A2 in the control of inflammation, wherein delta-6,9,12,15-octadecatetraenoic acid (stearidonic acid) and/or delta-8,11,14,17-eicosatetraenoic acid is administered alone or in a pharmaceutically acceptable diluent or c... | 01/12/1993 |
| 5176918 | Topical medicament A topical medicament comprising a dilute aqueous solution of sodium bicarbonate and a transdermal carrier, preferably containing approximately equal proportions by weight of a 3 percent aqueous solution of sodium bicarbonate, and propylene glycol, the res... | 01/05/1993 |
| 5173499 | Compounds which inhibit complement and/or suppress immune activity The present invention is directed to compounds which suppress immune responses and/or selectively inhibit complement. These compounds contain an aromatic ring and are substituted dihydrobenzofurans, spirobenzofuran-2(3H)-cycloalkanes, and their open chain... | 12/22/1992 |
| 5164374 | Use of oligosaccharides for treatment of arthritis A method for the treatment of arthritis or a related autoimmune disease that exhibits immune complexes in serum or synovial fluid is provided which comprises exposure of the serum or synovial fluid to an oligosaccharide containing a structural component t... | 11/17/1992 |
| 5162361 | Method of treating diseases associated with elevated levels of interleukin 1 The present invention relates to a method of treating diseases associated with elevated levels of interleukin 1 (IL-1) including inflammatory diseases such as arthritis, skin hypersensitivity and endotoxemia. More specifically, the invention relates to a ... | 11/10/1992 |
| 5155096 | Method for potentiation of a therapeutic agent The invention relates to a method for potentiation of a therapeutic agent, the method comprising the steps of administering an effective dose of insulin to induce to hypoglycemia; administering a pre-determined dose of a therapeutic agent; and administeri... | 10/13/1992 |
| 5135934 | 3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents Dihydrobenz[c]acridine carboxylic acid derivatives are provided which are useful for the treatment and/or prevention of organ transplantation rejection, graft versus host disease, autoimmune diseases, psoriasis and chronic inflammatory diseases.... | 08/04/1992 |
| 5135952 | Antiinflammatory and/or antiallergic methods The present invention relates to a useful antiinflammatory and/or antiallergic composition comprising a compound of the formula: ##STR1## (wherein the R's are same or different and each means a hydrogen atom or lower alkyl group) or a pharmaceuticall... | 08/04/1992 |
| 5130297 | Conjugates useful in ameliorating autoimmunity MHC-II-peptide The invention is directed to methods and materials useful in treating autoimmune diseases. The therapeutic agents are of the formula X--MHC--peptide or MHC--peptide--X wherein X represents a functional moiety selected from a toxin and a labeling group; MH... | 07/14/1992 |
| 5130485 | N-hydroxy-N-(3-(2-substituted phenyl)prop-2-enyl)ureas and thioureas useful as 5-lipoxygenase inhibiting agents This invention relates to N-hydroxy-N-[3-(2-substituted phenyl)prop-2-enyl]ureas and thioureas, formulations containing those compounds, and methods of using such compounds as 5-lipoxygenase inhibiting agents.... | 07/14/1992 |
| 5128339 | Proteolytic enzyme inhibition method 4-R4 -R5 -2-Saccharinylmethyl aryl carboxylates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R4 -R5 -2-halomethylsaccharin with an arylcarboxylic acid in the presence of an aci... | 07/07/1992 |
| 5124334 | Benzylalcohol phospholipase A2 inhibitors The invention relates to benylalcohol phospholipase A2 inhibitors, pharmaceutical compositions containing them, and methods of treating phospholipase A2 -mediated conditions in mammals by administration of a therapeutically effective... | 06/23/1992 |
| 5120835 | Saccharide derivatives of protocatechualdehyde Novel saccharide derivatives of protocatechualdehyde represented by the general formula (I): ##STR1## wherein R1 represents a hydrogen atom or a benzoyl group, and R2 represents an alkyl group. The method for preparing thereof a... | 06/09/1992 |
| 5114721 | Preparation of T-cell and T-cell membrane for use in prevention and treatment of autoimmune diseases Pharmaceutical preparations are provided for preventing or treating autoimmune diseases in which the active principle is activated T-lymphocyte cells, specific for the autoimmune disease to be treated, which cells have been treated by incubation with a ph... | 05/19/1992 |
| 5110831 | Vinylogous hydroxamic acids and derivatives thereof as 5-lipoxygenase inhibitors The present invention relates to vinylogous hydroxamic acids, processes for their manufacture, pharmaceutical preparations containing them, and their use in the treatment of various disorders.... | 05/05/1992 |
| 5109010 | Dibenzofuranyl substituted 1,5-dihydro-4-(N-methylhydroxylamino)-2H-pyrrol-2-ones Novel cyclic vinylogous N-hydroxy-N-methylureas are useful in the treatment of leukotriene mediated conditions such as asthma and rheumatoid arthritis.... | 04/28/1992 |
| 5091522 | Retinoic esters of D-desosamine, process for their preparation and their use in human or veterinary medicine and in cosmetic compositions Retinoic esters of D-desosamine have the formula ##STR1## wherein the ##STR2## radical is (all trans) retinoyl, (13 cis) retinoyl or etretinoyl, and R2 represents linear or branched alkyl having 1-24 carbon atoms; and the ... | 02/25/1992 |
| 5087637 | Diarylacetylenes, the preparation and use thereof Diarylacetylenes of the formula I ##STR1## where R1 is hydrogen or C1 -C4 -alkyl, R2 and R3 are each hydrogen or, when R1 is hydrogen, together form a --C(CH3)2 -... | 02/11/1992 |
| 5079001 | Liquid oral formulation of diclofenac The invention relates to an aqueous oral pharmaceutical preparation of diclofenac which can be used for treating pain and inflammatory processes, and to the preparation of a preparation of this type.... | 01/07/1992 |
