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Class 514/825 - ARTHRITIS


Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter involving treatment of arthritis.
No. of patents: 678
Last issue date: 08/19/2008


                    17  
NumberTitleIssue Date
4076838Benzocycloheptene-2-acetic acids
This invention provides new compounds of formula I, ##STR1## wherein R1 is hydrogen or alkyl of 1 or 2 carbon atoms; R2 is hydrogen or halogen of atomic number from 9 to 35; A. I. each of R3 and R4 is hydrogen, or Ii...
02/28/1978
4073922Treatment of rheumatoid arthritis and related diseases
It is believed that rheumatoid arthritis and related collagen and auto-immune diseases are an infection and that various species of free-living (limax) amoebae are the aetiological agent of these diseases. It has been discovered that clotrimazole bis-phe...
02/14/1978
4074048Process for the preparation of 4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides
A novel process for preparing 4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides is disclosed. The process involves the base catalyzed rearrangement of a saccharinacetamide of structure I to give II, ##STR1## wherein R1 is hydrogen ...
02/14/1978
4071686Novel benzylidene amino-oxyalkyl carboxylic acids and carboxylic acid derivatives
Certain nuclear substituted benzylidene amino oxyalkyl carboxylic acids esters, amides and salts thereof have been found to have a strong anti-inflammatory activity and a potent analgetic activity. In addition, some of the compounds have an activity again...
01/31/1978
4064125Substituted amides having antiinflammatory activity
Compounds having the formula ##STR1## wherein R1 is alkyl, cycloalkyl or aryl; R2 is acyl; R3 is alkylamino or dialkylamino; A1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A
12/20/1977
4055595Substituted aryloxy-3,3,3-trifluoro-2-propionic acids, esters and salts thereof
Derivatives of 2-hydroxy-3,3,3-trifluoro-2-(alkyl or trifluoromethyl)propionic acid bearing a phenyl or naphthyl group linked to the 2-hydroxy group either directly or via an intermediate methylene group. The compounds reduce the concentrations of cholest...
10/25/1977
40534714-Thiazolidinone derivatives
Compounds having the formula ##STR1## wherein R1 is alkyl, cycloalkyl or aryl; R2 is alkylamino, dialkylamino or a nitrogen containing heterocyclic group; A1 is a saturated bond or an alkylene group having 1 to 4 carb...
10/11/1977
4053606Mercaptoalkylpyridine disulfides
Mercaptoalkylpyridines carrying an ethenyl or ethynyl substituent are prepared from known pyridine compounds, principally pyridoxine, by known chemical procedures, and are useful in the treatment of rheumatoid arthritis and related inflammatory diseases....
10/11/1977
4052412Benzo cycloheptathiophene carboxylic acid derivatives
This invention provides new compounds of formula I, ##STR1## wherein R1 is hydrogen, halogen of atomic number from 9 to 35 or lower alkyl, R2 is hydrogen or lower alkyl, each of R3 and R4 is hydrogen, or R3...
10/04/1977
4049700Ibuprofen p-hydroxyphenylurea ester
Ibuprofen p-hydroxyphenylurea ester having the formula II: ##STR1## was prepared from the free acid, ibuprofen [&#b1;2-(p-isobutylphenyl)propionic acid](I). The ester II above has the anti-inflammatory activity of the free acid, but in contradistinct...
09/20/1977
4049824Cetyl myristoleate
A method is described for immunizing against inflammatory rheumatoid arthritis in mammals and for immunizing against and relieving at least one of the symptoms of inflammatory rheumatoid arthritis in mammals....
09/20/1977
4049699Ibuprofen p-hydroxybenzaldehyde semicarbazone ester
Ibuprofen p-hydroxybenzaldehyde semicarbazone ester having the formula II: ##STR1## was prepared from the free acid, ibuprofen [&#b1;2-(p-isobutylphenyl)propionic acid] (I). The ester II above has the anti-inflammatory activity of the free acid, but ...
09/20/1977
40468975-Mercaptopyridoxine alkanesulfonates and methods of use and pharmaceutical compositions
5-Mercaptopyridoxine C1-4 alkane sulfonates, particularly the ethane-1,2-disulfonate, is a superior pharmaceutically acceptable form of the previously preferred 5-mercaptopyridoxine hydrochloride and hydrobromide....
09/06/1977
4035509Methods and compositions for the use of 2-carboxy-5-oxo-5H-dibenzo[a,d]cycloheptenes, salts and esters thereof
2-Substituted-5-oxo-5H-dibenzo[a,d]cycloheptenes represented by the following formula: ##STR1## where R' is hydrogen, alkyl having 1 to 12 carbon atoms, or ##STR2## where n is an integer from 2 to 4, inclusive, and R4 and R5
07/12/1977
4024174Tranes-delta 2-prostaglandins
Trans-Ɗ2 -prostaglandin compounds are disclosed of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## R1 represents an alkyl group containing from 1 to 10 carbon atoms, or an alkyl group contain...
05/17/1977
4018764Ureylenebis methyl-phenylene-carbonyl-bis-dihydro-2-oxo-naphthoxazine disultonic acids
Ureylenebis[methyl-phenylene carbonyl]-bis-[dihydro-2-oxo-naphth-oxazine-disulfonic acids] and salts thereof useful as complement inhibitors....
04/19/1977
4010275Treatment of osteoarthritis
The treatment of Osteoarthritis by orally administering a pharmaceutical preparation containing a furanoside of the formula I ##STR1## wherein R1 is hydrogen or alkyl with up to 7 carbon atoms, and R3, R5 and R6
03/01/1977
40012709-Benzoyl-1,2,3,4-tetrahydrocarbazole
9-Benzoyl-3-hydroxymethyl-1,2,3,4-tetrahydrocarbazole and 9-benzoyl-3-(N-phenylcarbamoyloxymethyl)-1,2,3,4-tetrahydrocarbazole, having respectively antiinflammatory and antibacterial activities, and their preparation are described....
01/04/1977
3997559N-acetyl-L-hydroxy-proline zinc salt
Derivatives of L-hydroxyproline and their use in the treatment of inflammation and wound healing....
12/14/1976
3985779M-phenoxyphenyl propionic acid derivatives and preparation thereof
New meta-phenoxyphenyl propionic acid derivatives and pharmacologically acceptable salts thereof having excellent anti-inflammatory and analgesic activities with low toxicity are provided. The new compounds are adapted for therapeutical treatment of vario...
10/12/1976
3976674Aluminum salts of substituted phenylalkanoic acids
Novel Mono- and di-basic aluminum salts of 2-(3-phenoxyphenyl)-and 2-(3-phenylthiophenyl)alkanoic acids provide tasteless and practically water insoluble forms of said alkanoic acids, which have anti-inflammatory activity in mammals, for formulating pharm...
08/24/1976
3974188Process for producing cholestane type steroids
A process for producing cholestanyl phosphate or epicholestanyl phosphate or salts thereof in which the hydroxyl group at the three-position of cholestanol or epicholestanol is converted into the phosphoric ester by reaction with a phosphorylating agent i...
08/10/1976
3973022Quinolineacetic acid compositions
Compounds of the formula ##SPC1## Wherein Ar denotes an optionally substituted phenyl group or hetero-aromatic group with 5 or 6 ring members wherein the atom directly bonded to the quinoline ring is a carbon atom, R1 represents hydrogen, ...
08/03/1976
3971797S,S'-bis(pyridylmethyl)-carbonodithioates
S,S'-bis(pyridylmethyl)-carbonodithioates and derivatives thereof have utility in the treatment of rheumatoid arthritis. The compound useful in the method of treatment is prepared from known pyridine derivatives and, principally, from pyridoxine and relat...
07/27/1976
39669423-Substituted-5-hydroxy(mercapto)alkylidene-rhodanine derivatives
3-Substituted-5-hydroxy(mercapto)alkylidene-rhodanine derivatives in which the 3-substituent is lower alkyl, cycloalkyl, alkenyl, phenyl, phenylalkyl, substituted phenyl or pyridylmethyl and having anti-arthritic activity are generally prepared from the a...
06/29/1976
39622573-Phenacylpiperidines
3-Phenacylpiperidines, useful as depressants, stimulants, and anti-inflammatory agents, are obtained by preparing, from a 3-halomethylpiperidine, a 3-piperidylmethylmagnesium halide which is condensed with a benzonitrile....
06/08/1976
39622612,3,4,5-Tetra hydro-5-oxo-1-benzothiepi N-4-carboxamide 1,1-dioxides
Compounds of the formula: ##SPC1## Are disclosed. In the above formula, R1 is aryl such as benzene or a heterocycle such as pyridine, isoxazole, or thiazole. The aryl or heterocyclic group R1 is substituted or unsubstituted. R2
06/08/1976
3962438Anti-arthritic 1H-pyrimido-(5,4,3-kl)phenothiazine-1,3(2H)-diones and 1-thiones
1H-Pyrimido[5,4,3-kl]phenothiazine-1,3(2H)-diones are prepared from the corresponding 1-thione-3-one compounds by methylation followed by acid hydrolysis. The 1,3-dione products and 1-thione-3-one intermediates are useful as anti-arthritic agents....
06/08/1976
39563255-Heterocyclic-1,2,3,6-tetrahydro-4(5H) pyrimidinone
The compounds of this invention are 5-heterocyclic-1,2,3,6-tetrahydro-4(5H)-pyrimidinethiones which have pharmacological activity, in particular gastric acid secretion inhibitory activity, and 5-heterocyclic-1,2,3,6-tetrahydro-4(5H)-pyrimidinones which ...
05/11/1976
39460366,11-Dihydro-11-oxo-dibenzo[b,e]thiepine-2-acetic acids
The present invention provides compounds of formula I, ##SPC1## wherein R1 is hydrogen, fluorine, chlorine, bromine, hydroxyl, lower alkyl, lower alkoxy, amino or lower acylamino, and R2 is hydrogen or lower alkyl, Useful as antiphlogisti...
03/23/1976
3936467Hydroxyalkylenimino-phenyl-acetic acids
New ଱-(cyclic tert. aminophenyl)-aliphatic acids, e.g. those of the formula ##SPC1## R1 = h or alkyl R2 = h, alk(en)yl, cycloalk(en)- yl or cycloalk(en)yl-alkyl A = hydroxylated lower alkylene And functional derivatives thereof, are...
02/03/1976
3933840Azole derivatives
Azole derivatives of the formula ##SPC1## Wherein R1 is free or esterified carboxyl or other functionally modified carboxyl group, R2 and R3 each are aryl; A is Cn H2n in which n is an integer from 1 ...
01/20/1976
3933789Extraction of sterolins from plant material
A method of obtaining a sterolin-rich product useful in the treatment of geriatric complaints such as benign hypertrophy of the prostate, comprising pulping a plant product containing sterolin, boiling the pulp in water, filtering the material thus obtain...
01/20/1976
393246311-Deoxy-13-dihydro-prostaglandin-9-ketals
This disclosure describes novel 11-deoxy-13,14-dihydro-prostaglandin-9-ketals useful as bronchodilators and as gastric acid secretion inhibitors....
01/13/1976
39324983-Indenyl-γ-(ketobutyric)-acid compounds
New substituted indene acids and non-toxic pharmaceutically acceptable amides, esters and salts derived therefrom. The substituted indene acids disclosed herein have anti-inflammatory, anti-pyretic and analgesic activity. Also included herein are methods ...
01/13/1976
3931207Tetramic acid analogs of pulvinic acid
Tetramic acid analogs of pulvinic acid having anti-arthritic activity are prepared by treatment of the corresponding tetramic acid lactones with an alkali metal lower alkoxide....
01/06/1976
                    17  
 
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