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| Number | Title | Issue Date |
| 4291174 | 1-Hydroxymethyl-15-hydroxy-prosten-1-ol derivatives Prostaglandin analogs are disclosed that have the -chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C1 to C4 alkanoyl or optionally substituted benzoyl, the substituen... | 09/22/1981 |
| 4289707 | Nitrogen heterocycles 1,3,6-Trisubstituted piperazine-2,5-diones having biological properties related to those of the natural prostaglandins, their synthesis, compositions containing them, and their use in medicine.... | 09/15/1981 |
| 4284773 | 1,2,3,5-Tetrahydroimidazothienopyrimidin-2-ones A 1,2,3,5-tetrahydroimidazothienopyrimidin-2-one represented by the formula: ##STR1## wherein one of Z1, Z2 and Z3 is a sulfur atom and the remaining two of Z1, Z2 and Z3 represent CH,... | 08/18/1981 |
| 4283413 | Method for inhibiting aggregation of human thrombocytes New compounds and a process for making the same, for use in inhibiting aggregation in human blood and inhibiting the growth of tumors, said compounds being of the general formula: ##STR1## wherein R is hydrogen, alkanoyl, substituted alkanoyl, aralka... | 08/11/1981 |
| 4265898 | Imidazo[2,1-b]-[1,3,4]-thiadiazole compounds, composition and their medicinal use The present invention relates to certain new imidazo [2,1-b]-[1,3,4]-thiadiazole compounds, to the provision of pharmaceutical compositions containing said compounds and to the use of said compounds and compositions as antithrombotic agents and thrombolyt... | 05/05/1981 |
| 4262008 | 2,4-Disubstituted 5-oxo-5H-hexahydrofuro[3,2b]pyrroles A compound of formula (I): ##STR1## wherein: A is >CH-- and n is 1 to 6; or A is >C.dbd.CH-- and n is 0 to 5; or A is >CH--CH.dbd.CH and n is 0 to 4; and R1 is hydrogen or C1-6 alkyl; R2 is hydrogen or C1-4 alkyl; an... | 04/14/1981 |
| 4261896 | 1-Substituted-2-(substituted-imino)-1H-1,2-dihydrobenz[cd]indoles Novel 1-substituted-2-(substitutedimino)-1H-1,2-dihydrobenz[cd]indoles useful as inhibitors of platelet aggregation.... | 04/14/1981 |
| 4260806 | Carbocyclic thromboxane A2 analogues Stable biologically active thromboxane A2 analogues having the formula: ##STR1## wherein R1 is OR3, where R3 represents hydrogen or a pharmaceutically acceptable cation or lower alkyl group; or R1 | 04/07/1981 |
| 4260621 | 3-Amino-4-phenyl-6-piperidino-1H-pyrazolo[3,4-b]-pyridines and salts thereof Compounds of the formula ##STR1## wherein R1 is unsubstituted, mono-substituted or di-substituted piperidino, where the substituents are selected from the group consisting of methyl, hydroxymethyl, hydroxyl, phenyl and benzyl; R2 | 04/07/1981 |
| 4260779 | Oxothia compounds Oxothia compounds, especially 2-oxo-2,3-dihydro-benzo[b]thiophene compounds of the formula ##STR1## in which Ph represents an optionally substituted 1,2-phenylene radical, X represents oxygen or sulphur, R1 represents an organic radical bo... | 04/07/1981 |
| 4259336 | 4-Hydroxy-2H-[1]-benzothieno [2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxides and salts thereof Compounds of the formula ##STR1## wherein R1 is hydrogen, halogen or alkyl of 1 to 3 carbon atoms; R2 is hydrogen or alkyl of 1 to 3 carbon atoms; and R3 is aromatic hydrocarbyl of 6 to 10 carbon atoms or an aromatic ... | 03/31/1981 |
| 4258192 | N2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof N2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis in mammals.... | 03/24/1981 |
| 4258180 | C6-Modified cyclodextrin sulfate salts as complement inhibitors C6-Modified cyclodextrin sulfate salts useful as complement inhibitors.... | 03/24/1981 |
| 4258185 | Pyridazinone compounds Pyridazinone compounds of the formula: ##STR1## wherein A, B, R1, R2, R3, R4 and R5 are as defined hereinafter, and pharmaceutically acceptable acid addition salts thereof are disclosed. They are... | 03/24/1981 |
| 4256883 | Pyridoza prostacyclin analogues and N-oxides thereof Stable biologically active aromatic prostacyclin analogues of the formula ##STR1## wherein X represents ##STR2## and R represents hydrogen, a pharmaceutically acceptable cation or a pharmaceutically acceptable lower alkyl group, are useful in th... | 03/17/1981 |
| 4241215 | Prostane derivatives The disclosure relates to novel 4-cis-prostenoic acid derivatives, for example 16-(3-chlorophenoxy)-9,11,15-trihydroxy-17,18,19,20-tetranor -4-cis, 13-trans-prostadienoic acid, to chemical processes for their manufacture, to pharmaceutic... | 12/23/1980 |
| 4228180 | 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs New 7-oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs which have the general formula ##STR1## wherein R1 is hydrogen or lower alkyl; n is 0 to 4, m is 0 to 4 and x is 0 to 8, are useful as cardiovascular agents.... | 10/14/1980 |
| 4221805 | Method of inducing platelet antiaggregation activity Compositions useful for platelet antiaggregation activity are described, which contain as the active ingredient N-(2-chlorobenzyl)-pyrrolidine or a pharmacologically compatible salt thereof with an organic or an inorganic acid, and at least one pharmaceut... | 09/09/1980 |
| 4220603 | Pharmaceutically active (omega-aminoalkoxy)bibenzyls (Omega-aminoalkoxy)bibenzyls are prepared and found useful as pharmaceutical agents, particularly as inhibitors of platelet aggregation.... | 09/02/1980 |
| 4220795 | Cyclobutyl substituted derivatives of prostaglandin analogs Novel C15 cyclobutyl analogs or derivatives of prostaglandins of the E-, A- and F-classes are useful modifiers of smooth muscle activity. The compounds have valuable pharmacological properties such as platelet antiaggregating agents, gastric antisecretory... | 09/02/1980 |
| 4219668 | 4-Hydroxy,4-biphenylbutyric acid Compounds of metabolites of 3-(4-biphenylylcarbonyl)propionic acid useful as anti-inflammatory and anti-platelet aggregation agents.... | 08/26/1980 |
| 4216220 | Platelet aggregation inhibiting 2-oxyindoles, their compositions and method of use 2-Oxyindole derivatives represented by the following general formula: ##STR1## where R1 is selected from the group consisting of hydrogen, C1-4 alkyl, C2-4 alkenyl, benzyl and phenethyl; A is --CH.dbd.CH-- or ##STR2##... | 08/05/1980 |
| 4212979 | 2-Substituted benzisothiazolones A class of 2-substituted benzisothiazolones carrying a nitrogen-containing heterocyclic ring are effective in inhibiting platelet aggregation and are therefore of value in the prophylactic and therapeutic treatment of thrombotic diseases.... | 07/15/1980 |
| 4204068 | Nitrogen heterocycles Hydantoins and N-alkylhydantoins of formula (I) ##STR1## have biological properties related to those of naturally occurring prostaglandins and maybe used in medicine, for example in the treatment of thrombosis.... | 05/20/1980 |
| 4201863 | N2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof N2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis in mammals.... | 05/06/1980 |
| 4191694 | Prostaglandin-I2 derivatives Prostane derivatives of the formula ##STR1## wherein R1 is OR2 or NHR3 ; R2 is hydrogen, C1-10 alkyl, C4-10 cycloalkyl, C6-10 aryl, or a 5 or 6 membered heterocyclic ring having ... | 03/04/1980 |
| 4189579 | Aminoalkylthiopurines Novel aminoalkyl purine and pyrazolopyrimidine compounds useful in the inhibition of blood platelet aggregation in animals.... | 02/19/1980 |
| 4186136 | Novel benzothienyl amino (propyl and butyl) ketones, a method of preparation thereof and their application to therapeutics Compounds having the formula ##STR1## wherein R1 and R2 are alkyl having one to 4 carbon atoms, allyl or ##STR2## is pyrrolidino, piperidino, perhydroazepino or morpholino, RX is an inorganic acid, organic acid or an a... | 01/29/1980 |
| 4182887 | 3-Amino-4-phenyl-1H-pyrazolo[3,4-b]pyridines and salts thereof Compounds of the formula ##STR1## wherein R1 is mono- or di-substituted amino, where the substituents are selected from the group consisting of alkyl of 1 to 6 carbon atoms, cyclohexyl, allyl and benzyl; unsubstituted, mono-substituted or ... | 01/08/1980 |
| 4182897 | Amino- or guanidino-phenylpropionic acid derivatives Amino- or guanidino-phenylpropionic ester derivatives represented by the formula: ##STR1## wherein R is --NH2 or ##STR2## R1 is hydrogen or a lower alkyl group, and R2 is an unsubstituted or a lower-alkyl-, ... | 01/08/1980 |
| 4181670 | Phenyl 5Z,8Z,11Z,14Z-eicosatetraenoate and congeners Preparation and use of platelet aggregation inhibiting and antisecretory phenyl 5Z,8Z,11Z,14Z-eicosatetraenoate and congeners are disclosed.... | 01/01/1980 |
| 4177344 | Anhydro-sugars The invention relates to novel 1,6-anhydro-ଲ-D-hexopyranose derivatives of the formula I ##STR1## in which R2 is hydrogen, methyl or aromatic acyl, R3 and R4 are alkyl, alkenyl or aralkyl and one of the radicals... | 12/04/1979 |
| 4174448 | Process for the preparation of thienopyridine derivatives This invention relates to a process for the preparation of compounds having the general formula: ##STR1## in which: R1 represents a hydrogen atom, an optionaly substituted alkyl, aryl or aralkyl radical; R2 and R3 are... | 11/13/1979 |
| 4169948 | Pyrazolopyrimidines Novel aminoalkyl purine and pyrazolopyrimidine compounds useful in the inhibition of blood platelet aggregation in animals.... | 10/02/1979 |
| 4168377 | Process of preparing mixed heparin salts Mixed or simple heparin salt having a reduced amount of a selected metal ion alone or with another metal ion in a mixed heparin. A heparin salt having a reduced sodium content being essentially sodium free and having a selectively high calcium or other se... | 09/18/1979 |
| 4167566 | Antithrombotic 2-prenyl-3-oxo-5,6-diaryl-as-triazenes The invention relates to compounds of the formula ##STR1## in which R and R' are identical or different and may be a hydrogen, an alkyl, a dialkylamino, an alkoxy, a halogen, or a hydroxy. These compounds are useful as drugs in the control of thrombo... | 09/11/1979 |
| 4163852 | Process for the preparation of tetrahydro-thieno[3,2-c]- and [2,3-c]pyridine derivatives This invention relates to a process for the preparation of tetrahydro-thieno[3,2-c]pyridine derivatives of the formula ##STR1## AND THEIR ISOMERIC TETRAHYDRO-THIENO[2,3-C]PYRIDINE DERIVATIVES IN WHICH R1 represents hydrogen, a lower alkyl ... | 08/07/1979 |
| 4158667 | 6-Keto PGF analogs Prostaglandin (PG1) derivatives having (1) a 6-keto feature, for example ##STR1## or (2) a 9-deoxy-6,9-epoxy feature together with a 5-halo or 6-hydroxy feature, for example ##STR2## said derivatives having pharmacological activi... | 06/19/1979 |
| 4156729 | 1,2-Benzisothiazolin-3-ones 6-Substituted-1,2-benzisothiazolin-3-ones carrying an aminoalkyl group in the 2-position and being optionally substituted in the 4- and/or 5-position are antithrombotic agents. The compounds, of which 2-(2-diethylaminoethyl)-4,5-dimethyl-1,2-benzisothiazo... | 05/29/1979 |
| 4149007 | C14 Phenyl-substituted derivatives of prostaglandin analogues Analogues of prostaglandins A, E and F in which a phenyl moiety is attached to the C14 carbon atom are disclosed. Also disclosed are methods of preparing the analogues and starting materials. The compounds have the structural formula: ##ST... | 04/10/1979 |
