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| Number | Title | Issue Date |
| 3978077 | Pyrazol-5-ones 1-Substituted pyrazol-5-ones of the formula ##SPC1## And pharmaceutically acceptable, nontoxic salts thereof, wherein R is hydrogen, amino, alkyl, alkenyl, phenyl or trifluoromethyl; R1 is hydrogen, alkyl, alkenyl, unsubstituted or substituted aryl or ... | 08/31/1976 |
| 3974165 | Hypotensive agents Optionally substituted 1-H-2,3,3a,4-Tetrahydro-2-oxopyrrolo[2,3-b]quinolines or the pharmaceutically acceptable salts thereof are compounds useful as blood platelet anti-aggregative and/or antihypertensive agents in mammals, including humans.... | 08/10/1976 |
| 3973026 | Inhibitor of blood plate aggregation There is prepared the compound N,N'-bis-(3-picolyl)-4-methoxy-isophthalamide. It is useful as an inhibitor of blood plate aggregation.... | 08/03/1976 |
| 3971789 | O-(4-Quinolylamino)benzamides The disclosure describes new 4-aminoquinoline derivatives of general formula ##SPC1## And their acid addition salts, where X is a halogen atom or a trifluoromethyl group, Z is a hydrogen atom or a defined substituent, R is group of the formula where ... | 07/27/1976 |
| 3968102 | S-substituted-2-thioadenosines S-Substituted-2-thioadenosines represented by the formula (I): ##SPC1## wherein R is as defined hereinafter, useful as a platelet aggregation inhibitor and a coronary vasodilator.... | 07/06/1976 |
| 3966938 | Treatment of thrombosis and the inhibition of blood platelet aggregation The invention concerns new 4a,10b-cis-substituted benzo-naphthyridines of the formula: ##SPC1## Wherein R1 is hydrogen, alkyl, alkoxy, alkylthio, fluorine, chlorine, bromine, nitro, trifluoromethyl, amino or acylamino, R2 is hydrogen... | 06/29/1976 |
| 3966917 | Platelet aggregation inhibitors Adenosine-5'-carboxamides which are effective as platelet aggregation inhibitors and represented by the formula ##SPC1## Wherein R is hydrogen, loweralkyl, lowercycloalkyl, loweralkenyl, or lowerhydroxyalkyl.... | 06/29/1976 |
| 3966792 | Prostaglandin compounds New prostaglandin analogues having therapeutic utility of the formula: ##SPC1## (wherein B is a grouping of the formula: ##SPC2## X is --CH2 CH2 -- or cis --CH=CH--, Y is trans --CH=CH-- or, when X is --CH2 CH2 ... | 06/29/1976 |
| 3965143 | 16-Oxygenated prostanoic acid derivatives 16-Oxygenated prostanoic acid derivatives, displaying valuable pharmacological properties, e.g. gastric anti-secretory, are produced by reaction of an (optionally 3-oxygenated)-5-oxocyclopent-1-enealkanoic/alkenoic acid or ester with the appropriate ... | 06/22/1976 |
| 3963701 | Substituted benzhydryl lactamimide derivatives Novel compounds useful as diuretic agents and anticoagulants are represented by the following formula ##SPC1## Wherein m is a positive whole integer of from 1 to 3; n is a positive whole integer of from 3 to 7; R and R1 may be the same or diffe... | 06/15/1976 |
| 3963716 | Novel 1-phthalazone derivative, a process for its preparation and a pharmaceutical composition containing it A pharmaceutically active phthalzone derivative of the following formula ##SPC1## Wherein each of R1 and R2 is a member selected from the group consiting of alkyl of from 1 to 3 carbon atoms; R3 is a member selected from t... | 06/15/1976 |
| 3962237 | 1 (H)-1,2,4-triazole derivatives This invention relates to compounds having the formula: ##SPC1## And the pharmaceutically acceptable acid addition salts thereof, wherein R represents a phenyl or substituted phenyl radical in which said substituent is halogen, lower alkyl, lower alkoxy, ... | 06/08/1976 |
| 3959263 | Prostaglandin intermediate Prostaglandin derivatives of the formula ##SPC1## In which R4, R5, R6 and R7 each are hydrogen or lower alkyl, X is hydroxy and Y is hydrogen or X and Y together are oxo, Z is CH2 CH2 or tr... | 05/25/1976 |
| 3957861 | Biphenylylpropionic acids and esters In accordance with this invention, there are disclosed compounds of the formula ##SPC1## Wherein X is selected from the group consisting of nitro and amino with the proviso that when y is hydrogen, X is nitro; Y is selected from the group consisting ... | 05/18/1976 |
| 3957814 | Pyrazol-5-ones 1-Substituted pyrazol-5-ones of the formula ##SPC1## And pharmaceutically acceptable, nontoxic salts thereof, wherein R is hydrogen, amino, alkyl, alkenyl, phenyl or trifluoromethyl; R1 is hydrogen, alkyl, alkenyl, unsubstituted or substituted aryl or ... | 05/18/1976 |
| 3957879 | Indane-1,3-dione derivatives The invention provides compounds of formula: ##SPC1## Wherein each of the groups R1 and R2, which may be the same or different, is a hydrogen atom or an alkyl group having 1 to 3 carbon atoms and R3 is a hydrogen or haloge... | 05/18/1976 |
| 3954835 | 4,5-Cis-didehydro-PGF1 compounds This invention is a group of 4,5-didehydro and 4,5,17,18-tetradehydro PG1 (prostaglandin-type) compounds, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of p... | 05/04/1976 |
| 3951949 | Sulfates of hydroxyethyl starch Sulfates of hydroxyethyl starch are useful as anti-inflammatory, anti-lipaemic, anti-arteriosclerosis, anti-ulcer or hypocholesterolic agents. They are manufactured by sulfation of hydroxyethyl starch.... | 04/20/1976 |
| 3952008 | Pyrazol-5-ones 1-Substituted pyrazole-5-ones of the formula ##SPC1## And pharmaceutically acceptable, nontoxic salts thereof, Wherein R is hydrogen or amino; R1 is hydrogen, alkyl, alkenyl, unsubstituted or substituted aryl or unsubstituted or substituted aralky; ... | 04/20/1976 |
| 3947582 | Phenylacetic acid compounds in treating abnormal platelet aggregation Pharmaceutical Compositions based on 4-(Benzoxazol-2-yl)phenylacetic acids, alcohols, esters, amides and their non-toxic pharmaceutically acceptable salts and method of treating abnormal platelet aggregation.... | 03/30/1976 |
| 3946029 | Indole derivatives 3-Indolyl pyridyl ketones of the general formula: ##SPC1## And pharmaceutically acceptable acid addition salts thereof wherein R1 represents A straight- or branched-chain saturated or unsaturated alkyl group having not more than 6 carbon atoms,... | 03/23/1976 |
| 3939268 | 2,4-Diamino substituted pyridol(3,2-d)pyrimidine as antithrombotic agents Pharmaceutical compositions containing as an active ingredient a compound of the formula ##SPC1## Wherein R1 and R2, which may be identical to or different from each other, are each morpholino, thiomorpholino, 1-oxido-thiomorpholino,... | 02/17/1976 |
| 3936439 | 2,6-Diaminonebularine derivatives Novel 2,6-diaminonebularine derivatives of the formula ##SPC1## Wherein R is a phenyl or cyclohexyl group which may be substituted with lower alkyl, lower alkoxy or halogen, and pharmaceutically acceptable salts thereof, exhibit excellent pharmacological ... | 02/03/1976 |
| 3935214 | 2-OR 3 KETO-3-OR-2-PHENYL-1,4-DISUBSTITUTED PIPERAZINES Novel 1,4-substituted phenyl piperazine compounds have a pronounced effect upon blood coagulation and are useful in the treatment of thrombotic diseases, especially of the arterial system. They are particularly used to inhibit thrombosis of the coronary o... | 01/27/1976 |
| 3935191 | Aminoalkyl ethers of 2,2'- and 3,3'-dihydroxybenzil Dialkylaminoalkyl ethers of 2,2'- and 3,3'-dihydroxybenzil are prepared by reacting the dithallium salt of 2,2'- or 3,3'-dihydroxybenzil with a dialkylaminoalkylchlorde. The products have antiarrhythmic activity.... | 01/27/1976 |
| 3935217 | Substituted pyrrolidinemethanols Substituted pyrrolidinemethanols of the formula: ##SPC1## Wherein R1 and R2 are each H or C1.sub.-4 alkyl; R3, R4 and R5 are each H, halogen, C1.sub.-4 alkyl or C1.sub.-4 | 01/27/1976 |
| 3933889 | 4,5-Cis-didehydro-PGF1.sub. analogs This invention is a group of 4,5-didehydro PG1 (prostaglandin-type) analogs having variable chain length, branching and fluoro substitution in the hydroxy-substituted side-chain, and processes for making them. These compounds are useful for a v... | 01/20/1976 |
| 3931155 | Process for preparing 2-azacycloalkylmethyl ketones A process for the preparation of 2-azacycloalkylmethyl ketones by chelating a methyl ketone with magnesium methyl carbonate and condensing the chelate with a 1-azacycloalkene in an atmosphere of carbon dioxide. The novel compounds described are useful ant... | 01/06/1976 |
| 3931289 | 3-Oxa phenyl-substituted PGE compounds This invention is a group of 3-oxa and 4-oxa phenyl-substituted PGE type, PGF type, PGA type and PGB type compounds, and processes for making those. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of ... | 01/06/1976 |
| 3931206 | Prostanoic acid derivatives Prostanoic acid derivatives having luteolytic activity are provided. A representative compound is 16-(6-chloropyrid-2-yloxy)-9.alpha., 11.alpha., 15-trihydroxy-17, 18, 19, 20-tetranor-5-cis, 13-trans-prostadienoic acid.... | 01/06/1976 |
| 3931279 | 5-Oxa prostaglandin F.sub.2.sub..alpha. analogs 5-Oxa prostaglandin-type compounds and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and woun... | 01/06/1976 |
