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| Number | Title | Issue Date |
| 8133882 | Quinolone derivative or pharmaceutically acceptable salt thereof Provided are quinolone derivatives having a lower alkyl or cycloalkyl at the 1-position; —N(R0)C(O)-lower alkylene-CO2R0, lower alkylene-CO2R0, lower alkenylene-CO2R0, —O-lower alkylene... | 03/13/2012 |
| 7423164 | Synthesis of ionic liquids Ionic compounds which are liquids at room temperature are formed by the method of mixing a neutral organic liqand with the salt of a metal cation and its conjugate anion. The liquids are hydrophobic, conductive and stable and have uses as solvents and in electrochem... | 09/09/2008 |
| 7338953 | Method of treating chronic fatigue syndrome Disclosed herein are methods of treating an individual suffering from, chronic fatigue syndrome. The methods generally include administration of a therapeutic amount of racemic reboxetine, or a pharmaceutically acceptable salt thereof, to the individual. ... | 03/04/2008 |
| 7282597 | Ascorbic acid derivatives and skin-whitening cosmetics It is an object to provide an L-ascorbic acid derivative which can keep the L-ascorbic acid stable to heat and light and thus has a long shelf life, which is high in permeability into the skin, which can be quickly hydrolyzed by phosphatase, an enzyme that is ubiqui... | 10/16/2007 |
| 7276503 | Method of treating chronic fatigue syndrome Disclosed herein are methods of treating an individual suffering from, chronic fatigue syndrome. The methods generally include administration of a therapeutic amount of optically pure (S,S) reboxetine, or a pharmaceutically acceptable salt thereof, to the individual... | 10/02/2007 |
| 7253680 | Amplifier system with current-mode servo feedback A system and method for compensating an amplifier apparatus for low frequency and/or DC components of an externally applied input signal as well as for any voltage offsets contributed by the amplifier circuitry. Band-limited servo feedback is applied to predetermine... | 08/07/2007 |
| 7241762 | Method of treating peripheral neuropathy Disclosed herein are methods of treating an individual suffering from peripheral neuropathy. The methods generally include administration of a therapeutic amount of racemic reboxetine, or a pharmaceutically acceptable salt thereof, to the individual. ... | 07/10/2007 |
| 7238679 | Heterocycles and uses thereof Compounds of the following formula are disclosed: wherein RB is a substituted or unsubstituted aryl or heteroaryl moiety; at least one of RU and RL is a phosphorus-containing moie... | 07/03/2007 |
| 7148210 | Method of treating bone metastasis The invention provides a drug combination for the treatment of diseases associated with bone metastasis. The combination provides adenosine or a derivative thereof, a bisphosphonate, and a targeting agent(s) to decrease the signs or symptoms associated with such dis... | 12/12/2006 |
| RE39264 | Pharmaceutical combination The invention relates to pharmaceutical compositions for topical administration comprising a topically acceptable antiviral substance and an antiinflammatory glucocorticoid in a pharmaceutically acceptable carrier. The pharmaceutical composition can be used in the p... | 09/05/2006 |
| 7078965 | Servo balancing among driver devices A method and apparatus for reducing imbalances among the outputs of a plurality of driver devices connected in a parallel configuration to drive a common load. One driver is designated as the master, and suitable servo circuitry is provided to each of the other slav... | 07/18/2006 |
| 7030103 | Sulfonamidomethyl phosphonate inhibitors of β-lactamase The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and... | 04/18/2006 |
| 7019139 | Quinolinones and uses thereof The invention relates to compounds of the general formula (and pharmaceutically acceptable derivatives thereof): in which RA, RB, RC, RD, R5, R7, R9... | 03/28/2006 |
| 7009054 | Quinolines and uses thereof This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use. ... | 03/07/2006 |
| 6713462 | Quinolinones and uses thereof The invention relates to compounds of the general formula (and pharmaceutically acceptable derivatives thereof): in which RA, RB, RC, RD, R5, R7, R9 | 03/30/2004 |
| 6706699 | Quinolines and uses thereof This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use. ... | 03/16/2004 |
| 6649605 | Treatment of tension-type headaches with NMDA receptor antagonists NMDA receptor antagonists, especially mirtazapine, can be used to treat tension-type headaches.... | 11/18/2003 |
| 6630135 | Use of sustained release antibiotic compositions in ophthalmic surgical procedures An improved method of sterilizing the field of surgery prior to an ophthalmic surgical procedure is described. The invention eliminates the need for painful and potentially traumatic injections of antibiotics by utilizing sustained release compositions wh... | 10/07/2003 |
| 6596709 | 6-sulphanoyl-3-quinolylphosphonic acid compounds The invention relates to a compound of formula (I): ##STR1## wherein: X represents chlorine or fluorine or CF3, R represents hydrogen or a group ##STR2## and methods for using the same.... | 07/22/2003 |
| 6498151 | Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. ##STR1## The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated d... | 12/24/2002 |
| 6486143 | 6-amino- or 6-hydrazino-sulphonyl-3-quinolynyl-phosphonic acid compounds The invention relates to a compound of formula (I): ##STR1## wherein: R1 represents halogen or a group CF3, R2 represents hydrogen or alkyl or cycloalkyl, R3 is as defined in the description, R4 and R5 | 11/26/2002 |
| 6468990 | Method of inhibiting binding of nerve growth factor to p75 NTR receptor The present invention relates to compositions which inhibit the binding of nerve growth factor to the p75NTR common neurotrophin receptor and methods of use thereof. In one embodiment, the compound which inhibits binding of nerve growth factor ... | 10/22/2002 |
| 6465444 | Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. ##STR1## The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated d... | 10/15/2002 |
| 6417177 | Chloroquine derivatives for the treatment of Parkinson's disease This invention provides compositions and methods for increasing cellular respiration of melanized catecholamine neurons, and methods for alleviating symptoms or stopping appearance and/or progression of symptoms of Parkinson's Disease, and methods for pre... | 07/09/2002 |
| 6410592 | Aminomethylcarboxylic acid derivatives The present invention relates to aminomethylcarboxylic acid derivatives general formula (I), wherein Z is (CH2)n, O, S, SO, SO2 or N--R5 ; n is 0, 1 or 2; X represents 1-3 substituents independently selected fro... | 06/25/2002 |
| 6395749 | Carboxamide compounds, methods, and compositions for inhibiting PARP activity The present invention provides carboxamine compounds, methods and compositions for inhibiting PARP activity.... | 05/28/2002 |
| 6337324 | Pharmaceutical combination The invention relates to pharmaceutical compositions for topical administration comprising a topically acceptable antiviral substance and an antiinflammatory glucocorticoid in a pharmaceutically acceptable carrier. The pharmaceutical composition can be us... | 01/08/2002 |
| 6322821 | Veterinary pharmaceutical composition A composition for preventing and treating milk fever in freshening cows, and a method of administering the composition. The basic composition is a mixture of water, calcium chloride, propylene glycol, B vitamins and minerals. The calcium content is lower ... | 11/27/2001 |
| 6228393 | Drug delivery via therapeutic hydrogels The present invention is directed to a vehicle for effecting drug delivery from a solid substrate. Hydrogels loaded with liposomal therapeutic agents such as antibiotics are covalently bonded to the surface of substrates such as in-dwelling medical device... | 05/08/2001 |
| 6200961 | Concentrates of organophosphorous insecticides A low volatile organic compound co-solvent system is disclosed for preparing emulsion concentrates of low melting organophosphorous insecticides wherein the bioefficacy of the insecticide active is significantly enhanced. The co-solvent system comprises a... | 03/13/2001 |
| 6130231 | Integrin receptor antagonists This invention relates to novel fused heterocycles which are useful as antagonists of the v 댣 and related integrin receptors, to pharmaceutical compositions containing such compounds, processes for preparing such compou... | 10/10/2000 |
| 6117885 | Biphenyl-substituted quinoline derivatives Compounds of the formula ##STR1## wherein X, R1, R2, R3, R4, R5, R6, A, B, D and E are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore... | 09/12/2000 |
| 6071895 | Polar-substituted hydrocarbons The present invention discloses the compounds of general formula (1) ##STR1## wherein R1, R2, R3 are optionally substituted carbonyl and amide derivatives which are useful as inhibitors of retroviral proteases, and ar... | 06/06/2000 |
| 6040299 | Cold storage stabilized organophosphorus insecticide formulation and method of making same There is disclosed a cold storage stabilized organophosphorus insecticide formulation. The formulation comprises a solid carrier and between approximately 2% and 40% by weight of the ultimate formulation of a nominally solid organophosphorus insecticide a... | 03/21/2000 |
| 6010711 | Methods, articles and compositions for the pharmacologic inhibition of bone resorption with phosphodiesterase inhibitors A class of active agents, and articles and compositions containing them and methods for treating human patients with them, which inhibit bone resorption of all types. This class of active agents comprises phosphodiester inhibiting compositions which inhib... | 01/04/2000 |
| 5990150 | Heterocyclic derivatives, method of production thereof and pharmaceutical use thereof Heterocyclic derivatives of the formula (I) ##STR1## wherein each symbol is as defined in the specification, pharmaceutically acceptable salts thereof and method of producing them. Pharmaceutical compositions containing the heterocyclic derivative or... | 11/23/1999 |
| 5985259 | Sustained release ophthalmic antibiotic compositions An improved method of sterilizing the field of surgery prior to an ophthalmic surgical procedure is described. The invention eliminates the need for painfull and potentially traumatic injections of antibiotics by utilizing sustained release compositions w... | 11/16/1999 |
| 5958464 | Veterinary pharmaceutical composition A composition for preventing and treating milk fever in freshening cows, and a method of administering the composition. The basic composition is a mixture of water, calcium chloride, propylene glycol, B vitamins and minerals. The calcium content is lower ... | 09/28/1999 |
| 5958905 | Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin Phosphoramidates and phosphinic amides and related compounds are provided. Also provided are methods that use the compounds for modulating the activity of the endothelin family of peptides are provided. In particular, compounds having formula: ##STR1... | 09/28/1999 |
| 5900410 | Monotherapy of peptic ulcers and gastritis The present invention is directed to compositions, methods and kits for treating areas of H. pylori infection in the GI tract. The active ingredient is an antibiotic-bisphosphonate adduct wherein the antibiotic is selected for its ability to eradicate H. ... | 05/04/1999 |
