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| Number | Title | Issue Date |
| 6946457 | Methods of treating sickle cell disease This invention provides a method of treating a subject afflicted with sickle cell disease which comprises administering to the subject an amount of an antiviral agent effective to inhibit sickling of a cell in the subject, so as to thereby treat the subject afflicte... | 09/20/2005 |
| 6919374 | Viscosity modulating substance and use thereof It has now been found that N-L-alpha-aspartyl-L-phenylalanine 1-methyl ester (APM) lowers whole blood viscosity in patient, including those suffering from sickle cell disease and plasma cell dyscrasias. Upon in vivo APM treatment patients experienced a significant l... | 07/19/2005 |
| 6635631 | Iron compounds, compositions, methods of making the same and uses thereof The present invention is directed to complexes comprising iron in the ferric state and a hydroxypyrone. The present invention is also directed to methods of making such complexes and to the use of such complexes in the treatment and prevention of iron def... | 10/21/2003 |
| 6339080 | Iron compounds, compositions, methods of making the same and uses thereof The present invention is directed to complexes comprising iron in the ferric state and a hydroxypyrone. The present invention is also directed to methods of making such complexes and to the use of the complexes in the treatment and prevention of iron defi... | 01/15/2002 |
| 6087398 | Sickle cell anemia treatment The present invention provides a method of treating sickle cell anemia comprising the step of administering to an individual in need of said treatment a therapeutically acceptable dose of reducing agent. In yet another embodiment of the present invention,... | 07/11/2000 |
| 6083984 | Triglycerides and ethyl esters of phenylalkanoic acid and phenylalkenoic acid useful in the treatment of various disorders Two new forms of prodrug for phenylacetate, of even congeners of phenylalkanoic acid and phenylalkenoic acids, which are the phenylalkanoic or phenylalkenoic esters of glycerol, or the ethyl esters of phenylalkanoic acid or phenylalkenoic acids. These for... | 07/04/2000 |
| 6060510 | Triglycerides and ethyl esters of phenylalkanoic acid and phenylalkenoic acid useful in the treatment of various disorders Two new forms of prodrug for phenylacetate, of even congeners of phenylalkanoic acid and phenylalkenoic acids, which are the phenylalkanoic or phenylalkenoic esters of glycerol, or the ethyl esters of phenylalkanoic acid or phenylalkenoic acids. These for... | 05/09/2000 |
| 5968979 | Triglycerides and ethyl esters of phenylalkanoic acid and phenylalkenoic acid useful in treatment of various disorders Two new forms of prodrug for phenylacetate, of even congeners of phenylalkanoic acid and phenylalkenoic acids, which are the phenylalkanoic or phenylalkenoic esters of glycerol, or the ethyl esters of phenylalkanoic acid or phenylalkenoic acids. These for... | 10/19/1999 |
| 5919755 | Medical use of heme products The invention is to a method for stimulating the production of fetal hemoglobin in a mammal having a hemoglobinopathy, comprising administering heme or a derivative thereof.... | 07/06/1999 |
| 5885621 | Treatment of a hemoglobinopathy Disclosed are methods for treating a patient identified as having a hemoglobinopathy that is characterized by a reduced affinity of hemoglobin for oxygen. The methods involve providing gaseous nitric oxide and/or carbon monoxide for (i) inhalation by the ... | 03/23/1999 |
| 5846528 | Treating anemia using recombinant adeno-associated virus virions comprising an EPO DNA sequence The use of recombinant adeno-associated virus (AAV) virions for delivery of DNA molecules to muscle cells and tissue in the treatment of anemia is disclosed. The invention allows for the direct, in vivo injection of recombinant AAV virions into muscle tis... | 12/08/1998 |
| 5800819 | Piper guineense, pterocarpus osun, eugenia caryophyllata, and sorghum bicolor extracts for treating sickle cell disease A phytochemical composition for treating sickle cell disease is provided. The composition is a cold water extraction product of a mixture containing Piper guineenses seeds, Pterocarpus osum stem, Eugenia caryophyllum fruit, Sorghum bicolor leaves and pota... | 09/01/1998 |
| 5750132 | Treatment of adverse effects associated with administration of extracellular hemoglobin The present invention relates to methods of lessening the severity and frequency of adverse effects associated with administration of extracellular hemoglobin comprising administration of a smooth muscle relaxant. Preferred smooth muscle relaxants are ter... | 05/12/1998 |
| 5669396 | Methods of detecting and treating vaso-occlusive crisis in sickle cell disease Methods are described for treating sickle cell disease, and in particular, detection and treatment of vaso-occlusive crisis in sickle cell disease. Antibodies are employed which bind competitively and suppress adhesion of sickle erythrocytes to autologous... | 09/23/1997 |
| 5585399 | Method of protecting cells and tissues by a triacylglycerol preparation The present invention relates to a method of using a preparation of triacylglycerol which contains unsaturated fatty acids having no more than two double bonds to preserve normal erythrocyte deformability, to improve microcirculation, to protect myocardiu... | 12/17/1996 |
| 5569675 | Methods of using carboxylic acid esters to increase fetal-hemoglobin levels This invention relates to novel methods of increasing the level of fetal hemoglobin (HbF) in a subject and methods of treating, preventing or ameliorating ଲ-globin or other HbF-related disorders by increasing the level of HbF in a subject in need of... | 10/29/1996 |
| 5447720 | Composition and method for treatment of hemoglobinopathies A composition and method of treatment of hemoglobinopathies, such as, for example, sickle cell disease and thalassemia, wherein an inventive extract used in such treatment is obtained from alfalfa and other certain plant materials, preferably using a hydr... | 09/05/1995 |
| 5439939 | Pharmaceutical compositions and methods using isobutyramide for treating betaglobin disorders This invention relates to treatment of betaglobin disorders, such as sickle-cell anemia and beta-thalassemia, by administering compositions of isobutyramide.... | 08/08/1995 |
| 5273992 | Method for reducing sickle erythrocyte dehydration and delaying the occurrence of erythrocyte sickling in-situ The present invention provides a chemical class of active compounds to be used as efficacious drugs in the treatment of sickle cell disease. The active compounds include imidazole derivatives, nitroimidazole derivatives, and triazole derivatives. These co... | 12/28/1993 |
| 5108754 | Orthomolecular method of treating sickle cell disease A method for preventing the sickling of sickle cells in a patient having sickle cell disease, the method which comprises administering to the patient a therapeutically effective amount of a compound having the formula: ##STR1## wherein X- | 04/28/1992 |
| 5025029 | Method for augmenting fetal hemoglobin A method is provided for inhibiting the γ to ଲ-globin switching in subjects afflicted with ଲ-globin disorders. The method is particularly adapted for ameliorating the clinical symptoms of sickle cell anemia by periodically introducing butyrat... | 06/18/1991 |
| 5006512 | Therapeutic usages of inhibitors for a potassium efflux channel The invention provides novel therapeutic usages of inhibitors of a potassium channel of the cells. Since the increase of the intracellular calcium concentration is known to trigger various reactions which destroy the cells, the prevention of calcium entry... | 04/09/1991 |
| 4904678 | Sickle cell anemia control Method of providing anti-sickling of red blood cells in sickle cell anemia patients without hemolyzing said cells, using thiocyanates alone, or together with Vitamin B6.... | 02/27/1990 |
| 4851404 | Method of treating hemoglobinopathy A therapeutic method of treatment of hemoglobinopathy by administration of a drug capable of blocking the Ca+2 channel in and out of muscle cells. Drugs known to possess this capability are 1,4-dihydropyridines, ଲ-phenethylamines, benzoth... | 07/25/1989 |
| 4835146 | Method of treating sickle cell anemia with danazol Treatment of sickle cell disease using danazol.... | 05/30/1989 |
| 4822821 | Method for augmenting fetal hemoglobin A method is provided for inhibiting the γ to ଲ-globin switching in subjects afflicted with ଲ-globin disorders. The method is particularly adapted for ameliorating the clinical symptoms of sickle cell anemia by periodically introducing into th... | 04/18/1989 |
| 4751244 | Compounds useful in treating sickle cell anemia The present invention is directed to compounds of the general formula I and pharmaceutically acceptable salts thereof: ##STR1## wherein: R1 =HO or HOOC(CH2)x CHR2 NH--; R2 =H, lower alkyl, benzyl or -... | 06/14/1988 |
| 4731381 | Method of treating a person for sickle cell anemia The present invention is directed to a method of treating a person for sickle cell anemia comprising administering to the person a therapeutically effective dosage of a compound of the general formula (I) and pharmaceutically acceptable salts thereof: ... | 03/15/1988 |
| 4704402 | Method of treating sickle cell anemia A method of treating a person for sickle cell anemia including administering to the person a therapeutically effective dosage of the compound ##STR1## wherein at least one R=Cl, BR, CH3 or OCH3 and each other R=H, R'=H or C... | 11/03/1987 |
| 4665058 | Compositions and method of treatment for sickle cell anemia The invention provides a new composition and method for the treatment of sickle cell anemia. The composition includes as an active ingredient an effective amount of the compound, phlorizin benzylazide: ##STR1## and an appropriate pharmaceutical excip... | 05/12/1987 |
| 4613616 | Polymeric iron chelators The present invention relates to polymeric iron chelators based upon hydroxamic acids having the general formula: ##STR1## wherein R is hydrogen or lower alkyl. The present compound is useful for the treatment of iron overload disorders particularly ... | 09/23/1986 |
| 4535183 | Pharmaceutical compounds, preparation, use and intermediates therefor and their preparation This invention is directed to novel ether compounds of formula (I) ##STR1## which are of value in medicine in the palliation of haemoglobinopathies, in particular sickle-cell anemia, and also in the palliation of pulmonary dyefunction, protection fro... | 08/13/1985 |
| 4385064 | Method for treating sickle cell anemia A method for the treatment of the acute pain crises of sickle cell anemia has been found which comprises the administration of the citrate or the oxalate salt of the 2-hexahydro-1H-azepin-1-yl)ethyl ester of -cyclohexyl-3-thiopheneacetic acid.... | 05/24/1983 |
| 4344958 | Method of inhibiting sickling of sickle erythrocytes using substituted-2-imidazolines Method for inhibiting the sickling of sickle erythrocytes in blood by contacting the sickle erythrocytes with a compound of the formula: ##STR1## or a pharmaceutically-acceptable salt thereof, wherein X represents sulfur, oxygen or imino; Rm | 08/17/1982 |
| 4343810 | Method of inhibiting sickling of sickle erythrocytes using 2-((haloanilino)methyl)-2-imidazolines Method for inhibiting the sickling of sickle erythrocytes in blood by contacting the sickle erythrocytes with a compound of the formula: ##STR1## or a pharmaceutically-acceptable salt thereof, wherein Ro represents chloro, bromo, fluoro or... | 08/10/1982 |
| 4343808 | Method of inhibiting sickling of sickle erythrocytes Method for inhibiting the sickling of sickle erythrocytes in blood by contacting the sickle erythrocytes with a compound of the formula: ##STR1## or a pharmaceutically-acceptable salt thereof wherein X represents sulfur, oxygen or imino; and Rm | 08/10/1982 |
| 4343809 | Method of inhibiting sickling of sickle erythrocytes employing 2-((halophenoxy)methyl)-2-imidazolines Method for inhibiting the sickling of sickle erythrocytes in blood by contacting the sickle erythrocytes with a compound of the formula: ##STR1## or a pharmaceutically-acceptable salt thereof, wherein Rm represents hydrogen or alkyl; and R... | 08/10/1982 |
| 4261980 | Method for prophylaxis and/or treatment of sickle cell disease Polypeptides which are useful in the prophylaxis and treatment of sickle cell disease are represented by the formula: ##STR1## wherein X is Val or Gln; Y is Pro or dehydroPro; Z is a residue of a basic amino acid with a side chain in the D-configurat... | 04/14/1981 |
| 4060630 | Ethylenediamine derivatives useful in treating sickle cell anemia Compounds of the following general formula are useful in the treatment of sickle cell anemia: ##STR1## WHEREIN EACH OF R and R1 is hydrogen, chlorine, fluorine, bromine, trifluoromethyl, hydroxy, a lower alkoxy group of from 1 to 4 carbon ... | 11/29/1977 |
| 4048325 | Low toxicity method of inhibiting sickling of sickle erythrocytes A low toxicity method of inhibiting sickling of sickle erythrocytes which comprises intermixing the erythrocytes with an effective anti-sickling amount of a water-soluble imidoester of the formula RC(=NH)OR' wherein R is an alkyl group of 1 - 8 carbon ato... | 09/13/1977 |
