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| Number | Title | Issue Date |
| 7408024 | Somatostatin antagonists The present invention is directed to a somatostatin antagonist according to formula (I): A1-cyclo {D-Cys-A2-D-Trp-A3-A4-Cys}-A5Y1, wherein A1 is an optionally substituted aromatic a-amino a... | 08/05/2008 |
| 7109166 | Sustained release formulation of a peptide This invention is directed to a sustained release composition comprised of Compound (A) having the formula or a pharmaceutically acceptable salt thereof, and a copolymer comprised of poly-(I)-lactic-glycolic-tart... | 09/19/2006 |
| 7074761 | Peptides and production and use thereof The peptides and precursors thereof, inclusive salts thereof, of the present invention are useful as a pharmaceutical composition, for example as therapeutic or prophylactic agents for hormone-producing tumors, acromegaly, gigantism, dementia, gastric ulcer and the ... | 07/11/2006 |
| 6914046 | NF-κB activation inhibitors, and their pharmaceutical uses Compounds inhibiting the activation of the nuclear factor κB (NF-κB) are used for the preparation of medications adapted for the treatment of malignant hemopathies and solid tumors, and for the prevention of the appearance or the treatment, of phenomena of resista... | 07/05/2005 |
| 6867181 | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides A method of spherifying a sustained release ionic conjugate which contains a free carboxyl group-containing polymer and a free amino group-containing drug which are ionically bonded to each other. ... | 03/15/2005 |
| 6630123 | Method to enhance tissue accumulation of radiolabeled compounds Administration of a radioisotopic compound by infusion over a period of time greater than two hours, preferably greater than twelve hours, greatly increases the maximum radioactivity that accumulates in the target cell. The efficacy of the administration ... | 10/07/2003 |
| 6521599 | Stable pharmaceutical formulation for intravenous or intramuscular administration of active peptide compounds A stable pharmaceutical formulation for intravenous or intramuscular administration of Octreotide, which is characterized in that the vehicle for injection of the peptide or pharmaceutically acceptable salts thereof contains glycine in concentrations rang... | 02/18/2003 |
| 6319512 | Implants for controlled release of pharmaceutically active principles and method for making same The present intention relates to an implant for the controlled release of at least one pharmaceutically active principle comprising a core containing at least one active principle and a sheath surrounding said core, wherein said sheath is composed of at l... | 11/20/2001 |
| 6221958 | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides Disclosed is a sustained release pharmaceutical composition. The composition includes a polyester containing a free COOH group ionically conjugated with a bioactive polypeptide comprising at least one effective ionogenic amine, wherein at least 50% by wei... | 04/24/2001 |
| 6171856 | Methods and compositions relating to no-mediated cytotoxicity The present invention relates to methods and compositions for the treatment of diabetes involving free radicals. In particular, the present invention is directed to the treatment or prophylactic intervention of diabetes. The present invention demonstrates... | 01/09/2001 |
| 6087337 | Method for treating benign and malignant proliferative skin disease A method of treating a mammal suffering from benign or malignant proliferative skin disease, e.g., melanoma or malignant skin metastases of melanoma, by topically administering to the mammal at the site of said diseased skin an effective amount of a somat... | 07/11/2000 |
| 6034175 | Salts of peptides with carboxy-terminated polyesters This invention relates to novel salts composed of a cation derived from a peptide containing at least one basic group and an anion derived from a carboxy-terminated polyester, processes for the manufacture of such salts, and the use of such salts in the m... | 03/07/2000 |
| 5976569 | Diketopiperazine-based delivery systems Compositions useful in the delivery of active agents are provided. These delivery compositions include (a) an active agent; and either (b)(1) a carrier of (i) at least one amino acid and (ii) at least one diketopiperazine or (b)(2) at least one mono-N-sub... | 11/02/1999 |
| 5889110 | Salts of peptides with carboxy-terminated polyesters This invention relates to novel salts composed of a cation derived from a peptide containing at least one basic group and an anion derived from a carboxy-terminated polyester, processes for the manufacture of such salts, and the use of such salts in the m... | 03/30/1999 |
| 5871711 | Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to peptide derivatives and analogs of somatostatin, and embod... | 02/16/1999 |
| 5863985 | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides Disclosed is a sustained release pharmaceutical composition. The composition includes a polyester containing a free COOH group ionically conjugated with a bioactive polypeptide comprising at least one effective ionogenic amine, wherein at least 50% by wei... | 01/26/1999 |
| 5843401 | Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to peptide derivatives and analogs of somatostatin, and embod... | 12/01/1998 |
| 5833942 | Technetium-99m labeled somatostatin-derived peptides for imaging and therapeutic uses This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to peptide derivatives and analogs of somatostatin, and embod... | 11/10/1998 |
| 5820845 | Somatostatin-derived peptides for imaging and therapeutic uses This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to peptide derivatives and analogs of somatostatin, and embod... | 10/13/1998 |
| 5817624 | Permeation enhancer compositions for increased absorption of therapeutic proteins through the colonic membrane The present invention is directed to a pharmaceutical formulation of a therapeutic polypeptide together with a permeation-enhancing mixture of sodium 3-nitrobenzoate and an oil to provide enhanced absorption of the polypeptide through the wall of the gast... | 10/06/1998 |
| 5753618 | Somatostatin analogue composition and use in treating breast cancer The invention provides a pharmaceutical composition containing a somatostatin analogue, and its use in the treatment of breast cancer. The pharmaceutical composition preferably contains lactic acid in addition to the somatostatin analogue and is better to... | 05/19/1998 |
| 5693338 | Diketopiperazine-based delivery systems Compositions useful in the delivery of active agents are provided. These delivery compositions include (a) an active agent; and either (b)(1) a carrier of (i) at least one amino acid and (ii) at least one diketopiperazine or (b)(2) at least one mono-N-sub... | 12/02/1997 |
| 5672659 | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides A composition including a polyester containing one or more free COOH groups ionically conjugated with a bioactive polypeptide comprising at least one effective ionogenic amine, wherein the polyester contains a member selected from the group of L-lactic ac... | 09/30/1997 |
| 5500224 | Pharmaceutical compositions containing nanocapsules A pharmaceutical composition in the form of a colloidal suspension of nanocapsules, comprising an oily phase consisting essentially of an oil containing dissolved therein a surfactant and suspended therein a plurality of nanocapsules having a diameter of ... | 03/19/1996 |
| 5468726 | Treatment of neuropsychiatric disorders The administration of Somatostatin and growth hormone releasing factor at useful dosage levels alleviates the symptoms of various neuropsychiatric disorders. Growth hormone and neuropsychiatric responses to the administration of growth hormone releasing f... | 11/21/1995 |
| 5439688 | Process for preparing a pharmaceutical composition A pharmaceutical composition is prepared in the form of microparticles or of an implant comprising a biodegradable polymer selected from poly-1,4-butylene succinate, poly-2,3-butylene succinate, poly-1,4-butylene fumarate and poly-2,3-butylene succinate, ... | 08/08/1995 |
| 5389664 | Alleviating stomach ulcers in swine Alleviation of stomach ulcers in swine which are being administered exogenous somatotropin, by administering to the swine a benzimidazole compound selected from heterocyclylalkyl(sulfinyl or thio)benzimidazoles and [benzimidazolyl(sulfinyl or thio)alkyl]a... | 02/14/1995 |
| 5244882 | Porcine growth hormone analogs, and compositions An analog of porcine growth hormone, is disclosed which retains the diabetogenic, insulin-sparing and lipolytic properties of porcine growth hormone while being capable of improving growth in mammals.... | 09/14/1993 |
| 5225205 | Pharmaceutical composition in the form of microparticles A method for preparing a pharmaceutical composition in the form of microparticles, the composition thus obtained and its use for preparing injectable suspensions.... | 07/06/1993 |
| 5015626 | Porcine somatotropin to improve meat quality of pigs Muscle quality of pigs normally susceptible to porcine stress syndrome is improved by administering to the pigs in conjunction with their daily feed ration, a small amount of porcine somatotropin.... | 05/14/1991 |
| 5008244 | Method for increasing fertility in animals Somatotropin is administered to food producing animals in the finishing stage of growth to increase fertility by increasing embryonic survival and litter size during the reproductive stage of growth.... | 04/16/1991 |
| 4966889 | Treatment of inflammatory articular diseases The treatment of certain inflammatory articular diseases, e.g., rheumatoid arthritis, is carried out via the use of injectable compositions containing somatostatin.... | 10/30/1990 |
| 4904642 | Therapeutic somatostatin analogs An octapeptide of the formula: ##STR1## wherein each A1 and A2, independently, is H, C1-12 alkyl, C7-10 phenylalkyl, R1 CO (where R1 is C1-20 alkyl, C3-20 alkenyl... | 02/27/1990 |
| 4857505 | Sustained release compositions for parenteral administration and their use The invention relates to compositions comprising adducts of activated polysaccharides with biologically active growth hormones, somatomedins, growth factors and biologically active fragments. The invention also relates to a method for increasing and maint... | 08/15/1989 |
| 4853371 | Therapeutic somatostatin analogs An octapeptide of the formula: ##STR1## wherein each A1 and A2, independently, is H, C1-12 alkyl, C7-10 phenylalkyl, R1 CO (where R1 is C1-20 alkyl, C3-20 alkenyl... | 08/01/1989 |
| 4816438 | Insulin-selective somatostatin analogs Anglerfish somatostatin-28 has the formula: ##STR1## Anglerfish somatostation-28 is insulin-selective when administered in vivo and is useful for the treatment of insulinoma. The 14-residue C-terminal peptide may also be used.... | 03/28/1989 |
| 4798821 | Antihypertensive therapy for diabetics Process and compositions for lowering blood pressure in diabetic by employing a cyclopeptide compound is described.... | 01/17/1989 |
| 4748153 | Compounds having somatostatin-like activity useful as local anti-inflammatory agents Compounds having somatostatin-like activity have been found to be useful as local anti-inflammatory agents in the treatment of such conditions as, for example, psoriasis, eczema, seborrhea, and other localized inflammatory and allergic conditions. Particu... | 05/31/1988 |
| 4728638 | Somatostatine derivatives Somatostatine derivatives of the general formula ##STR1## wherein either (a) A is ##STR2## W is -CO-N(A4) or -N(A5)-CO- and Y1 and Y2 are H or together a bond or (b) A is H, alkyl, phenylalkyl or RCO a... | 03/01/1988 |
| 4703034 | Novel cyclic tetrapeptide There is disclosed a series of novel cyclic tetrapeptides related to somatostatin. The compounds have surprisingly been found to have the activity of increasing blood glucose when administered. The compounds are prepared using the solid phase or mixed anh... | 10/27/1987 |
