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| Number | Title | Issue Date |
| 7163694 | Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them Bioerodible poly(ortho esters) useful as orthopedic implants or vehicles for the sustained delivery of pharmaceutical, cosmetic and agricultural agents from dioxane-based di(ketene acetals). Block copolymers contain these bioerodible poly(ortho esters). These block ... | 01/16/2007 |
| 6749866 | Modulated release from biocompatible polymers The present invention relates to a composition for the modulated release of a biologically active agent. The composition comprises a biocompatible polymeric matrix, a biologically active agent which is dispersed within the polymeric matrix, and a metal cation compon... | 06/15/2004 |
| 6429195 | Aqueous prolonged release formulation Prolonged parenteral release into the circulatory system of a cow of a bioactive growth hormone releasing factor at desirably effective levels can be achieved using novel compositions in which the growth hormone releasing factor is present in an aqueous l... | 08/06/2002 |
| 6417237 | Macromolecular drug complexes and compositions containing the same Macromolecular drug complexes containing a drug, like human growth hormone, and a polymer having a plurality of acid moieties, like carboxyl moieties or phosphonic acid moieties, and compositions containing the same, are disclosed. Compositions, particula... | 07/09/2002 |
| 6368630 | Modulated release from biocompatible polymers The present invention relates to a composition for the modulated release of a biologically active agent. The composition comprises a biocompatible polymeric matrix, a biologically active agent which is dispersed within the polymeric matrix, and a metal ca... | 04/09/2002 |
| 6150330 | Aqueous prolonged release formulation Prolonged parenteral release into the circulatory system of a cow of a bioactive growth hormone releasing factor at desirably effective levels can be achieved using novel compositions in which the growth hormone releasing factor is present in an aqueous l... | 11/21/2000 |
| 5976569 | Diketopiperazine-based delivery systems Compositions useful in the delivery of active agents are provided. These delivery compositions include (a) an active agent; and either (b)(1) a carrier of (i) at least one amino acid and (ii) at least one diketopiperazine or (b)(2) at least one mono-N-sub... | 11/02/1999 |
| 5912015 | Modulated release from biocompatible polymers The present invention relates to a composition for the modulated release of a biologically active agent. The composition comprises a biocompatible polymeric matrix, a biologically active agent which is dispersed within the polymeric matrix, and a metal ca... | 06/15/1999 |
| 5874227 | Cyclic CRF antagonists Novel cyclic CRF antagonist peptides have the amino acid sequence: ##STR1## wherein Y is Ac, H, Ac-Thr or H-Thr; R30 is Glu or Cys; R32 is His or preferably a basic and/or aromatic D-amino acid such as D-His or D-Arg; R33 | 02/23/1999 |
| 5869081 | Progesterone vaginal ring for treatment of infertility The present invention relates to a method of administering progesterone to a normogonadal or a functionally agonadal human female undergoing an assisted reproduction technique. The invention further provides a method of hormone replacement for a human fem... | 02/09/1999 |
| 5656297 | Modulated release from biocompatible polymers The present invention relates to a composition for the modulated release of a biologically active agent. The composition comprises a biocompatible polymeric matrix, a biologically active agent which is dispersed within the polymeric matrix, and a metal ca... | 08/12/1997 |
| 5413797 | Controlled release ACTH containing microspheres ACTH polymeric controlled release systems are described wherein the ACTH retains good biological activity and is released over an extended period of time following administration by injection. In the preferred embodiment, the ACTH polymeric microspheres a... | 05/09/1995 |
| 5348729 | Evaluative means for detecting inflammatory reactivity The present invention is directed to a method for testing the susceptibility of a mammal to inflammatory diseases which comprises the steps of: administering to a mammal a compound selected from the group consisting of Type 1 mineralocorticoid receptor an... | 09/20/1994 |
| 5209920 | Evaluative means for detecting inflammatory reactivity Inbred Lewis (LEW/N) female rats develop an arthritis in response to Group A streptococcal cell wall peptidoglycanpolysaccharide (SCW) which mimics human rheumatoid arthritis. Histocompatible Fischer (F344/N) rats, on the other hand, do not develop arthri... | 05/11/1993 |
| 5132111 | CRF analog conjugates Agonists and antagonists of rCRF are disclosed that exhibit good binding affinity to CRF receptors. One exemplary agonist is: H-Ser-Gln-Glu-Pro-Pro-Ile-Ser- Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met- Ala-Arg-Ala-Glu-Gln-Glu-Ala-Glu-Gln-... | 07/21/1992 |
| 5114413 | Methods to make and use proteinaceous material present in kinin-free high molecular weight kininogen Disclosed herein are methods for using a proteinaceous material present in kinin free high molecular weight kininogen to treat surfaces to prevent or minimize adhesion by blood components and/or animal cells. For example, in medical applications, one can ... | 05/19/1992 |
| 5109111 | CRF antagonists Several known members of the corticotropin releasing factor (CRF) family have been synthesized and tested, including human and rat CRF which have the formula: H-Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His- Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-A... | 04/28/1992 |
| 5049547 | Composition for stimulating integumental melanocytes A pharmaceutically active composition comprising a pharmaceutically acceptable carrier and one or more alpha-MSH or analogues thereof for use in the stimulation of integumental melanocytes in vertebrates in order to bring about the production of melanin i... | 09/17/1991 |
| 5043321 | Adrenocorticotropin release inhibiting factor A method for alleviating stress induced immunosuppression is accomplished by application of low doses of ANF[1-28] or other ANF analogs having intact N-terminal sequences. Atrial natriuretic factors (ANFs) with intact N-terminal sequences are shown to be ... | 08/27/1991 |
| 4918055 | Method of stimulating melanocytes by topical application of analogs of alpha-MSH, and compositions for use in same A method for stimulating integumental melanocytes by the topical application of alpha-MSH analogs, and compositions comprising said analogs for use in the method are described.... | 04/17/1990 |
| 4866038 | Method of stimulating integumental melanocytes by topical application of analogs of alpha-msh A method for stimulating integumental melanocytes by the topical application of alpha-MSH analogs, and compositions comprising said analogs for use in the method are described.... | 09/12/1989 |
| 4762820 | Therapeutic treatment for congestive heart failure A novel therapeutic method for treating human and animal subjects afflicted with congestive heart failure is provided by administering effective dosages of a selective antagonist for arginine vasopressin to the subject. The antagonist is an effective and ... | 08/09/1988 |
| 4594239 | Method for neutralizing offensive chemicals A technique is described for neutralizing unishiol. The technique involves contacting urushiol with a chlorine-containing compound in a liquid medium. In one embodiment the chlorine-containing compound is sodium or calcium hypochlorite in an aqueous solut... | 06/10/1986 |
| 4415558 | CRF And analogs CRF (Corticotropin Releasing Factor) has the formula: H-Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-L eu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu- Leu-Asp-Ile-Ala-NH2. Analogs have been synthe... | 11/15/1983 |
| 4377573 | Method of control of gastrointestinal bleeding Norepinephrine has been found as useful in a method of treatment to control gastrointestinal bleeding when injected directly into the portal blood supply by direct injection into either the peritoneal cavity or the gastrointestine i.e. intragastrically. A... | 03/22/1983 |
| 4167562 | Method and composition for treating arteriosclerosis New compositions and their method of use for treating cardiovascular diseases primarily due to arteriosclerosis and atherosclerosis. These new compositions are prepared from a base Ringers injection to which is added a B-complex, hydrochloric acid, sodium... | 09/11/1979 |
| 4130514 | Synthesis of peptides Peptides having adrenocorticotropic hormone activity and resin peptides useful in preparation of such peptides, particularly such peptides having asparagine at the carboxyl end thereof and more particularly such peptides having from 19 to 25 amino acids i... | 12/19/1978 |
| 4112073 | Medicinal composition comprising adrenal cortical hormone and thyroid stimulating hormone releasing hormone A medicinal composition comprising both adrenal cortical hormone and thyroid stimulating hormone releasing hormone has such excellent properties as increasing the therapeutic effects and suppressing side effects of the adrenal cortical hormone.... | 09/05/1978 |
| 4089821 | Synthesis of peptide amides Peptide amides having biological activity and resin peptide amides useful in the preparation of peptides having biological activity, particularly such peptides containing the structure ##STR1## in which R is divinylbenzene crosslinked polystyrene and... | 05/16/1978 |
| 4071510 | Peptides having a high adrenocorticotropic effect and a method of producing the same The invention concerns peptides having the general formula X--Glu--His--Phe--Arg--Trp--Gly--Lys--Pro--Val--Gly--Lys--Lys--Y--NH2 wherein X represents alkyloxy carbonyl, aryl alkyloxy carbonyl or D-Ser-Met, and Y represents a residue of n diamin... | 01/31/1978 |
| 4018753 | Polypeptides with ACTH-like activities A polypeptide of the formula: wherein X1 is -aminoisobutyric acid, ଲ-alanine, L-serine, glycine, D-serine, D-alanine, γ-aminobutyric acid or sarcosine residue; X2 is L-methionine, L-norleucine, L-isoleucine or L-norvali... | 04/19/1977 |
| 3954975 | Salts of ACTH-peptides and processes for their manufacture Pharmaceutical preparations containing acid addition salts of ACTH-peptides with saturated or unsaturated fatty acids of chain length 12-36 carbon atoms.... | 05/04/1976 |
