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| Number | Title | Issue Date |
| 7410947 | Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art... | 08/12/2008 |
| 7374774 | Electroprocessed material made by simultaneously electroprocessing a natural protein polymer and two synthetic polymers The invention is directed to novel compositions comprising an electroprocessed material and a substance, their formation and use. The electroprocessed material can, for example, be one or more natural materials, one or more synthetic materials, or a combination ther... | 05/20/2008 |
| 7358284 | Particulate acellular tissue matrix A method of processing an acellular tissue matrix to give a particulate acellular tissue matrix includes: cutting sheets of dry acellular tissue matrix into strips; cryofracturing the dry acellular tissue matrix strips at cryogenic temperatures; separating the resul... | 04/15/2008 |
| 7241740 | Peptides as solubilizing excipients for transforming growth factor beta proteins The present invention relates to compositions comprising excipients or solubilizing agents for proteins. The invention relates to the discovery that a peptide derived from the N-terminus extension of the T266 isoform of rhBMP-2 has properties that enhance the solubi... | 07/10/2007 |
| 7235527 | Protein and process for producing the same A protein consisting of the amino acid sequence in SEQ ID No: 1 derived from human MP52 and a homodimer protein thereof useful for treating cartilage and/or bone diseases and a process for its preparation. ... | 06/26/2007 |
| 7217691 | Methods of treatment of periodontal disease Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair. ... | 05/15/2007 |
| 7189263 | Biocompatible bone graft material Biocompatible bone graft material having a biocompatible, resorbable polymer and a biocompatible, resorbable inorganic material exhibiting macro, meso, and microporosities. ... | 03/13/2007 |
| 7129209 | Use of hydrophobic crosslinking agents to prepare crosslinked biomaterial compositions The present invention discloses novel crosslinked biomaterial compositions which are prepared using hydrophobic polymers as a crosslinking agent. Preferred hydrophobic polymers are those that contain two or more reactive succinimidyl groups, including disuccinimidyl... | 10/31/2006 |
| 7084082 | Collagen material and its production process The objective of the present invention is to provide a collagen material that possesses physical properties to an extent that allows suturing while still maintaining the biochemical properties inherently possessed by collagen, and retains its shape for a certain amo... | 08/01/2006 |
| 7041641 | Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art... | 05/09/2006 |
| 6962979 | Crosslinkable biomaterial compositions containing hydrophobic and hydrophilic crosslinking agents The present invention discloses novel crosslinked biomaterial compsotions which are prepared using hydrophobic polymers as a crosslinking agent. Preferred hydrophobic polymers are those that contain two or more reactive succinimidyl groups, including disuccinimidyl ... | 11/08/2005 |
| 6933326 | Particulate acellular tissue matrix A method of processing an acellular tissue matrix to give a particulate acellular tissue matrix includes: cutting sheets of dry acellular tissue matrix into strips; cryofracturing the dry acellular tissue matrix strips at cryogenic temperatures; separating the resul... | 08/23/2005 |
| 6821530 | Polymer composite compositions The invention relates to methods of treating mixtures containing polymeric materials, e.g., collagen, to form a polymer that intercalates into the polymeric material. The treatment provides greater tensile strength to the mixture, among other advantages. The polymer... | 11/23/2004 |
| 6797260 | Bleeding control and healing aid compositions and methods of use A composition is disclosed which has been shown to stop or control bleeding and seal open small blood vessels while accelerating the healing process of abraded oral “gum” and other “skin” (epithelial) tissues. The composition is preferably in the form of a p... | 09/28/2004 |
| 6752834 | Membrane for in guided tissue regeneration The invention provides a multi-layer membrane comprising a matrix layer predominantly of collagen II and having an open sponge-like texture, and at least one barrier layer having a close, relatively impermeable texture. Such a membrane is particularly suitable for u... | 06/22/2004 |
| 6710083 | Method of treating palmar and plantar fibromatosis A method of treating palmar and plantar fibromatosis is disclosed. The method includes administering to a patient of a therapeutically effective amount of a composition comprising 13-cis-retinoic acid. Preferably, the treatment method includes administering to a pat... | 03/23/2004 |
| 6679918 | Implantable putty material The present invention provides compositions for an implantable putty material for delivery of active compounds to a patient. More specifically, the present invention provides a material having a pH of between about 3 and 6 and possessing putty-like physic... | 01/20/2004 |
| 6652840 | Bleeding control and healing aid compositions and methods of use A composition is disclosed which has been shown to stop or control bleeding and seal open small blood vessels while accelerating the healing process of abraded oral "gum" and other "skin" (epithelial) tissues. The composition is preferably in the form of ... | 11/25/2003 |
| 6576249 | Bone putty and method A method for the preparation of bone gel and bone putty which comprises producing a viscous supernatant by dissolving demineralized bone matrix in water or a solution comprising water and at least one component normally found in human blood serum, at a te... | 06/10/2003 |
| 6548080 | Method for partially demineralized cortical bone constructs The invention is directed toward a sterile bone structure for application to a bone defect site to promote new bone growth at the site comprising a partially demineralized cortical bone structure, said bone structure comprising a cross sectional surface a... | 04/15/2003 |
| 6468514 | Method of preparing particularly skin-compatible cosmetic or dermatological cleansing preparations The use of one or more cosurfactants (surfactant B) in a mixture with one or more surfactants different from surfactant B (surfactant A) for reducing the binding of surfactant A to the surface of the skin.... | 10/22/2002 |
| 6454787 | Collagen hemostatic foam A hemostatic device formed of collagen particles and methods for producing and using the hemostatic device to control bleeding are provided. The collagen particles of the hemostatic device have a hemostatic activity that is equivalent to the hemostatic ac... | 09/24/2002 |
| 6387391 | Bioresorbable polymeric clayey and sticky substance This invention provides a claycy and sticky substance as a new biomaterial that cannot be found in the current medical field, which is bioresorbable, shows tackiness, plasticity and shape holding ability at a temperature of approximately from 30 to 40° C... | 05/14/2002 |
| 6384012 | Use of isolated domains of type IV collagen to modify cell and tissue interactions The instant invention demonstrates that the 7S domain of type IV collagen disrupts cell aggregation and tissue development. Structural changes in mesoglea, inhibition of cell proliferation, and changes in cell differentiation patterns accompanies the bloc... | 05/07/2002 |
| 6372794 | Method for alleviating arthritis in mammals A method for alleviating arthritis in mammals by the oral administration of a pharmaceutical composition compound of native Type II collagen in helical form and sulfated polysaccharides found in mammalian cartilage, the Type II collagen and sulfated polys... | 04/16/2002 |
| 6344437 | Medicine drink food and feed having an action of strengthening bone The present invention is to provide a novel medicine, drink, food or feed having an action of strengthening bone. More specifically, the present invention is to provide a medicine, drink, food or feed combined with collagen, fraction containing collagen o... | 02/05/2002 |
| 6335007 | Collagen gel The present invention relates to a collagen gel, its production process, a medical material in which it is used or a kit for its production, wherein said collagen gel is obtained by crosslinking collagen with polyanion and carbodiimide.... | 01/01/2002 |
| 6333304 | Therapeutic compositions containing glucosamine, collagen and a bioflavanol for repair and maintenance of connective tissue A composition for treating arthroses in animals includes exogenous glucosamine, hydrolyzed collagen and a bioflavanol. Preferred glucosamines are glucosamine hydrochloride (HCI) and glucosamine sulfate. Preferred bioflavanols are those extracted from grap... | 12/25/2001 |
| 6284284 | Compositions and methods for production and use of an injectable naturally secreted extracellular matrix The present invention discloses compositions containing natural human extracellular matrices and methods for the use thereof. More particularly, the present invention provides compositions and methods for the repair of skin defects using natural human ext... | 09/04/2001 |
| 6180606 | Compositions with enhanced osteogenic potential, methods for making the same and uses thereof Osteogenic compositions, and methods for preparing same, which compositions comprise a porous or semi-porous matrix, an osteogenic factor and an agent such as growth factors, nutrient factors, drugs, calcium-containing compounds, blood products, large mol... | 01/30/2001 |
| 6180605 | Composition with enhanced osteogenic potential, method for making the same and therapeutic uses thereof The present invention provides improved osteogenic compositions having enhanced by the sorption of growth factors, of nutrient factors, or drugs onto or into the compositions. Compositions may consist of collagen and demineralized bone materials onto and ... | 01/30/2001 |
| 6071963 | Water dispersible compositions Novel, stable, cold water dispersible preparations of fat-soluble substances contain a microbially produced oil rich in arachidonic acid. These preparations are manufactured by preparing an aqueous emulsion of the microbially produced oil which has been s... | 06/06/2000 |
| 6034068 | Laminin 5 for periodontal treatment A trans-epithelial appliance or shaped article coated with laminin 5. Laminin 5 stimulates cell attachment and may be comprise an insoluble or soluble cell matrix. The appliance will be useful for reducing inflammation and/or infection at the site of entr... | 03/07/2000 |
| 6004926 | Body fat percent-lowering, body composition-improving food composition and a method for lowering the body fat percentage and improving the body composition A body fat percentage-lowering, body composition-improving food composition comprising 10-65 weight % of protein, 5-25 weight % of fat, and 15-70 weight % of carbohydrate, all on a dry weight basis, which composition is to be taken before, during, and/or ... | 12/21/1999 |
| 5972999 | Pharmaceutical compositions and methods for improving wrinkles and other skin conditions This application relates to a pharmaceutical composition for the prevention and treatment of skin conditions in a patient having a sugar compound that is converted to a glycosaminoglycan in the patient in an amount sufficient to thicken the skin, a primar... | 10/26/1999 |
| 5972908 | Collagen-based composition and process for preparing it This process for preparing a collagen-based composition, comprises grinding collagen fibers to a particle size of between 10 and 100 microns and mixing them with water in a sufficient quantity to give a gel.... | 10/26/1999 |
| 5962517 | Pharmaceutical compositions and methods for treating acne This invention relates to a pharmaceutical composition for the treatment of acne having an acne reduction component in an amount sufficient to reduce the redness and blemishes associated with acne. The invention also relates to pharmaceutical compositions... | 10/05/1999 |
| 5962025 | Method for treatment of systemic sclerosis and related fibrotic diseases The present invention is directed to a method and pharmaceutical formulations for the treatment of systemic sclerosis in mammals, by oral administration of collagen, including type I collagen, or biologically active peptide fragments thereof.... | 10/05/1999 |
| 5948766 | Use of tasteless, hydrolyzed collagen and agent containing the same Tasteless, hydrolyzed collagen from gelatin, gelatin or animal collagenic connective tissue having an average molecular weight of from 1 to 40 kD for the preparation of agents for the treatment of osteoporosis. It may be combined with conventional agents ... | 09/07/1999 |
| 5888522 | Tissue protective and regenerative compositions Methods are provided for preparing compositions suitable for protecting irritated or damaged skin from further oxidative and biochemical damage and thus permitting natural healing processes to progress, for accelerating the rate of healing of burns and su... | 03/30/1999 |
