Bizarre Patents
Nicotine Containing Dental Floss
Keep away cavities and cancer at the same time.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8067395 | Inhibitors of tyrosine kinases and uses thereof Disclosed herein are compounds that inhibit the activity of particular tyrosine kinases. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed,... | 11/29/2011 |
| 7998946 | Regulators of the hedgehog pathway, compositions and uses related thereto The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway,... | 08/16/2011 |
| 7989434 | Heterocyclic self-immolative linkers and conjugates The present invention provides heterocyclic linker compounds useful for linking drug moieties to ligands. The compounds also include drug-ligand conjugates comprising a ligand capable of targeting a selected cell population, and a drug connected to the ligand by a h... | 08/02/2011 |
| 7807659 | Caspase inhibitors and uses thereof The present invention relates to novel classes of compounds of formula I which are caspase and TNF-alpha inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this inventio... | 10/05/2010 |
| 7772215 | Water detection composition and water detection indicator A novel water detection composition for use in place of blue gel and a water detection indicator. The water detection composition comprises, as active components, a porphyrin complex, and at least one inorganic acid salt of a metal selected from a group consisting o... | 08/10/2010 |
| 7749983 | Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and ... | 07/06/2010 |
| 7625880 | Inhibitors of tyrosine kinases and uses thereof Disclosed herein are compounds that inhibit the activity of particular tyrosine kinases. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed,... | 12/01/2009 |
| 7427636 | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds The invention is related to phosphorus substituted IMPDH inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such comp... | 09/23/2008 |
| 7410956 | Caspase inhibitor prodrugs The present invention relates to compounds of formula I which are prodrugs of caspase inhibitors and pharmaceutically acceptable salts thereof. This invention further relates to the release of caspase inhibitors from these compounds through selective bond cleavage. ... | 08/12/2008 |
| 7348318 | α-Amino-N-(diaminophosphinyl)lactam derivatives There are disclosed a novel α-amino-N-(diaminophosphinyl)lactam derivative represented by general formula (1): wherein, for example, A is a hydrogen atom or a substituent such as a lower alkyl group or the like; W, X, Y an... | 03/25/2008 |
| 7345082 | Phosphinic acids The present invention relates to phosphinic acid derivatives of formula I wherein R1, R2, R3 and R4 are described hereinabove. These compounds can be used in the treatment or prev... | 03/18/2008 |
| 7335649 | Thrombopoietin mimetics Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comp... | 02/26/2008 |
| 7332481 | Thrombopoietin mimetics Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comp... | 02/19/2008 |
| 7319096 | Thyroid hormone receptor antagonists for cardiac and metabolic disorders II This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac and metabolic disorders, such as cardiac arrhythmias, thyrotoxicosis, subclinical hyperthyrodism... | 01/15/2008 |
| 7314874 | Benzamides and related inhibitors of factor Xa Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and c... | 01/01/2008 |
| 7312241 | Diphenylethylene compounds and uses thereof The present invention relates to Diphenylethylene Compounds and compositions comprising a Diphenylethylene Compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering to a subject in need thereof... | 12/25/2007 |
| 7291639 | Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) This invention provides methods of inhibiting plasminogen activator inhibitor-1 (PAI-1) in a mammal, utilizing compounds of the formula: wherein: A is C or N; B is O, S, N, or CH═CH; | 11/06/2007 |
| 7285565 | Benzamides and related inhibitors of factor Xa Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders. ... | 10/23/2007 |
| 7259262 | Arylazole derivatives, their manufacture and use as pharmaceutical agents There are presented compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms thereof, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments cont... | 08/21/2007 |
| 7253180 | Pre-organized tricyclic integrase inhibitor compounds Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed. A1 and A2 are moieties forming a five, six, or... | 08/07/2007 |
| 7235543 | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each of the substituen... | 06/26/2007 |
| 7235574 | Pentafluorosulfanyl compounds The present invention provides the compounds of formula I-A their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds,... | 06/26/2007 |
| 7223746 | Omega cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists The invention relates to the use of derivatives of E-type prostaglandins as EP2 agonists, in general, and, in particular as ocular hypotensives. The PGE derivatives used in accordance with the invention are represented by the following formula I: | 05/29/2007 |
| 7214701 | Active substance combinations having insecticidal and acaricdal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) ... | 05/08/2007 |
| 7208486 | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each of the substituen... | 04/24/2007 |
| 7199162 | Use of treosulfan for patient conditioning before bone marrow or blood stem cell transplantation The invention relates to the use of treosulfan as a conditioning agent before allogenic transplantation of bone marrow or haematopoietic stem cells, whereby treosulfan is administered, either as single effective agent, or in combination with other chemotherapetic ag... | 04/03/2007 |
| 7199113 | Pharmaceutically active compounds and methods of use thereof The invention includes pharmaceutically active compounds and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for treatment or prophylaxis of undesired thromb... | 04/03/2007 |
| 7192944 | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each of the substituen... | 03/20/2007 |
| 7160870 | Thrombopoietin mimetics Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comp... | 01/09/2007 |
| 7148210 | Method of treating bone metastasis The invention provides a drug combination for the treatment of diseases associated with bone metastasis. The combination provides adenosine or a derivative thereof, a bisphosphonate, and a targeting agent(s) to decrease the signs or symptoms associated with such dis... | 12/12/2006 |
| 7138520 | Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same In part, the present invention is directed to coordination complexes comprising a therapeutic agent. In one aspect, the subject compositions comprise a platinum metal center and a covalently attached therapeutic agent. ... | 11/21/2006 |
| 7122677 | NK1 antagonists A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5... | 10/17/2006 |
| 7109172 | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease The present invention relates to compounds of formula I or formula Ia or pharmaceutically acceptable salts thereof, that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3–NS4A protease. As such, they act by interfering with the l... | 09/19/2006 |
| 7101907 | Topical administration of statins for treatment of bone disorders The topical administration of statins for the treatment of bone disorders is disclosed. ... | 09/05/2006 |
| 7098196 | Regulators of the hedgehog pathway, compositions and uses related thereto The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway,... | 08/29/2006 |
| 7084126 | Methods and compositions for enhancing cellular function through protection of tissue components Methods and composisions for enhancing cellular function through protection of a tissue components such receptors, proteins, lipids, nucleic acids, carbohydrates, hormones, vitamins, and cofactors, by administering pyrophosphate analogs or related compounds. ... | 08/01/2006 |
| 7081436 | Paste formulation for seed treatment of plants Disclosed herein is a composition comprising a seed treatment formulation and an organosilicone additive of the formula: wherein: X is a number from 0 to 30; Y ... | 07/25/2006 |
| 7060290 | Phosphocholine linked prodrug derivatives Disclosed are compounds of general formula (I) that function as prodrugs, thereby increasing bioavailabilities of the linked therapeutic agents, wherein the LINKER is (i) substituted or unsubstituted alkyl, (ii) substituted or unsubstituted alkenyl, (iii) substitute... | 06/13/2006 |
| 7049335 | 3-azabicyclo[3.1.0]hexane derivatives The subject invention provides a compound of the formula I, wherein X, Q, n, R1, R2, R3, R4, R5, R6, R7, R8, R9, ... | 05/23/2006 |
| 7045116 | Treatment of osteomyelitis with radiopharmaceuticals This invention relates to medical uses of radiopharmaceuticals. Specifically, the present invention relates to the use of radiopharmaceuticals to treat osteomyelitis. The present invention provides improved system and methods of for the direct delivery of radiopharm... | 05/16/2006 |
