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| Number | Title | Issue Date |
| 7589128 | Process for preparation of amorphous form of a drug Provided is a process for preparation of amorphous form of an active pharmaceutical ingredient. ... | 09/15/2009 |
| 7563825 | Modulation of beta-catenin coactivator interactions to effect stem cell growth or differentiation Methods and agents are disclosed for modulating the interaction of β-catenin or γ-catenin with CBP or p300. Agents that increase the binding of CBP to β-catenin are associated with enhancing the β-catenin-related proliferation of adult stem cells, including hema... | 07/21/2009 |
| 7419814 | Mammalian sphingosine kinase type 2 isoforms, cloning, expression and methods of use thereof Methods for detecting agents or drugs which inhibit or promote an activity of sphingosine kinase type 2 isoform involving providing a recombinant DNA construct into a cell such that sphingosine kinase type 2 isoform is produced in the cell, adding at least one drug ... | 09/02/2008 |
| 7354956 | Composition containing a sapogenin and use thereof The present invention relates to a composition containing a sapogenin, and/or a sapogenin ester, and to the use of a sapogenin and/or a sapogenin ester to manufacture a composition that is suitable for topical application to the skin, and in a method wherein sapogen... | 04/08/2008 |
| 7335675 | Aqueous suspension formulation for foliar application fungicide The present invention provides an aqueous suspension formulation containing (RS)-N-[2-(1,3-dimethylbutyl)thiophene-3-yl]-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamide and having high rain resistance and stable residual effectiveness. A aqueous suspensi... | 02/26/2008 |
| 7320959 | Use of calmodulin kinase II inhibitors to treat myocardial dysfunction in structural heart disease The present invention provides a method for treating structural heart disease in a subject, comprising administering an effective amount of an inhibitor of CaMKII to the subject, whereby the administration of the inhibitor treats the structural heart disease in the ... | 01/22/2008 |
| 7291494 | Regulation of target protein activity through modifier proteins The present invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain has peptidase activity, e.g., isopeptidase activity. The present invention provides polypeptides and crystalline polypeptides containing the JAM domain an... | 11/06/2007 |
| 7279317 | Modulation of COP9 signalsome isopeptidase activity Methods for identifying agents that can increase or decrease the isopeptidase activity of a COP9 signalsome (CSN) are provided, as are agent identified using such screening assays. In addition, methods of ameliorating a pathologic condition such as a cancer or an au... | 10/09/2007 |
| 7261880 | Methods of treating Syndrome X with aliphatic polyamines The invention relates to a method for treating Syndrome X, or inhibiting the onset of symptoms of Syndrome X in a patient, and includes administering a therapeutically effective amount of a salt of at least one alkylated and cross-linked polymer, or a copolymer ther... | 08/28/2007 |
| 7256171 | Use of core 2 G1cNAc transferase inhibitors in treating inflammation This invention provides compounds and methods for treating inflammation. The compounds modulate the core 2 oligosaccharide-mediated binding of inflammatory cells, such as neutrophils, to endothelial cells and other myeloid cells. Significantly, the of the inv... | 08/14/2007 |
| 7232840 | Agents for combating plant pests The present invention relates to compositions for controlling plant pests containing the compound of formula (I) in a mixture with fungicidally active compounds, except for cyclopropylcarboxamide derivatives and ... | 06/19/2007 |
| 7211420 | Process for oxidizing terpenes A process for oxidizing a substrate which is an acyclic or cyclic terpene, or a cycloalkene; or a substituted derivative thereof, which process comprises oxidizing said compound with a mutant haem-containing enzyme, the mutant comprising the substitution of an amino... | 05/01/2007 |
| 7195903 | Methods for the treatment of thrombosis A fibrinolytically active metalloproteinase polypeptide (called “novel acting thrombolytic”) which is useful for blood clot lysis in vivo and methods and materials for its production by recombinant expression are described. ... | 03/27/2007 |
| 7192914 | Prevention of atherosclerosis and undesired blood clotting by reducing von Willebrand factor This invention provides methods and compositions for treating and preventing atherosclerosis other undesired blood clotting. The methods for treating and preventing atherosclerosis and related conditions involve administering to a mammal an agent that reduces activi... | 03/20/2007 |
| 7186443 | Systems and methods for dispensing an anti-traction, mobility denial material Systems and methods for dispensing an anti-traction, mobility denial material on a target surface. In various exemplary embodiments, a method of dispensing an anti-traction material on a target surface includes providing a polymer particle powder to a first section ... | 03/06/2007 |
| 7179627 | Cyclooxygenase variants and methods of use The invention relates to the isolation of novel cyclooxygenase type 1 (COX-1) variant enzymes. More specifically, the invention relates to the identification of cyclooxygenase transcripts harboring inton 1, or fragment thereof, of cyclooxygenase 1. The invention fur... | 02/20/2007 |
| 7141401 | COX1-interacting proteins and use thereof Protein complexes are provided comprising COX1 and one or more proteins selected from the group consisting of THR S14 and Opa1. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes and in treati... | 11/28/2006 |
| 7115641 | Antimicrobial oxazolidine/iodopropynyl-butyl carbamate composition containing less than 0.1wt% free formaldehyde This invention relates to a broad spectrum antimicrobial composition, effective against gram negative and gram positive bacteria and fungi, which comprises a synergistic composition comprising iodopropynyl butyl carbamate and a bicyclic hydroxymethyl oxazolidine con... | 10/03/2006 |
| 7101928 | Polymeric thickeners for oil-containing compositions Novel thickeners for oil-containing compositions are crystalline polymers, preferably side chain crystalline polymers, which (a) have a crystalline melting point, Tp, and an onset of melting temperature, To, such that Tp−To | 09/05/2006 |
| 7060476 | 27411, a novel human PGP synthase The present invention relates to a newly identified human PGP synthase. The invention also relates to polynucleotides encoding the PGP synthase. The invention further relates to methods using the PGP synthase polypeptides and polynucleotides as a target for diagnosi... | 06/13/2006 |
| 7048917 | Fat-binding polymers The present invention relates to a method for treating obesity, a method for reducing the absorption of dietary fat, and a method for treating hypertriglyceridemia in a patient and to particular polymers for use in the methods or in a manufacture of a medicament. Th... | 05/23/2006 |
| 7047317 | High performance network address processor system A high performance network address processor is provided comprising a longest prefix match lookup engine for receiving a request for data from a designated network destination address. An associated data engine is also provided to couple to the longest prefix match ... | 05/16/2006 |
| 7008920 | Medicinal composition The present invention provides a medicinal composition comprising (1) a pharmacologically active substance, (2) a drug absorbefacient and (3) a taurine compound or a polyamine. A taurine compound has an efect of suppressing or preventing damage of the intestinal muc... | 03/07/2006 |
| 7008903 | Pesticide The present invention provides a composition comprising synergistic amounts of a compound of the formula (I) wherein X, E, R, A and Z are as defined herein, and at least one fungicidal active compound as defined herein... | 03/07/2006 |
| 6964782 | Stable hydrogen peroxide compositions, products and methods of use Disclosed are several preferred embodiments of hydrogen peroxide which are packaged with ease of use and extended shelf-life in mind. The embodiments include foam, mist, gel, and disposable towelette forms of H2O2. Optional ingredients of topic... | 11/15/2005 |
| 6953682 | Nucleic acid sequences encoding adenylate kinase, phospholipid scramblase-like, DNA fragmentation factor-like, phosphatidylserine synthase-like, and atpase-like molecules and uses therefor The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the exp... | 10/11/2005 |
| 6949504 | Composition comprising at least one liquid fatty phase structured by at least one semi-crystalline polymer A composition comprising at least one liquid fatty phase structured by at least one semi-crystalline polymer having a low melting point and an organic structure, wherein said polymer is solid at ambient temperature, has a melting temperature of less than 50° C., an... | 09/27/2005 |
| 6939831 | Pestcide and/or plant growth regulating compositions The invention concerns pesticide and/or insecticide and/or plant growth regulating compositions comprising specific dendrimers, said compositions being, in particular, useable for agriculture and/or public health or domestic hygiene; the invention also concerns meth... | 09/06/2005 |
| 6936624 | Agents for preserving technical materials against insects The use of the compounds of the formula (I) as agents for preserving technical materials against insects. ... | 08/30/2005 |
| 6933128 | Cell-based assay for screening cox-2 inhibitors A cell-based assay is provided for screening substances for the capacity to inhibit COX-2 activity. The assay utilizes as a screening reagent a cell line which has been engineered to achieve constitutive or inducible expression of COX-2. In one embodiment, the cells... | 08/23/2005 |
| 6913899 | Polynucleotides encoding insect ethanolamine kinase and uses thereof The instant invention provides nucleic acid molecules encoding insect ethanolamine kinase, as well as ethanolamine kinase encoded thereby. The invention further provides methods of identifying agents that modulate a level of ethanolamine kinase mRNA, polypeptide, or... | 07/05/2005 |
| 6884768 | Medicinal compositions The present invention provides a medicinal composition comprising (1) a pharmacologically active substance, (2) a drug absorbefacient and (3) a taurine compound or a polyamine. A taurine compound has an efect of suppressing or preventing damage of the intestinal muc... | 04/26/2005 |
| 6867013 | Methods of screening for antagonists and agonists of polypeptides having kinase functions The invention is directed to purified and isolated human polypeptides having kinase function, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmente... | 03/15/2005 |
| 6849664 | Process for disposing biocide-containing cooling water The present invention relates to the use of deactivatable biocides in cooling water systems of industrial processes that require dissipation of heat. The present invention relates to methods of inhibiting growth and reproduction of microorganisms in the cooling wate... | 02/01/2005 |
| 6841579 | Diagnosis and treatment of AUR1 and/or AUR2 related disorders The present invention relates to AUR1 and/or AUR2 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of th... | 01/11/2005 |
| 6756410 | Induction of LDL receptor expression by extracellular-signal regulated kinase, ERK-1/2 Specific activation of the Raf-1/MEK/p42/44MAPK kinase cascade in HepG2 cells, independent of other “upstream” factors or cell growth regulation, leads to induction of LDL receptor transcription. The degree of p42/44MAPK activation determin... | 06/29/2004 |
| 6703230 | 47174, a novel human glycosyltransferase and uses thereof The invention provides isolated nucleic acids molecules, designated 47174 nucleic acid molecules, which encode novel glycosyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containin... | 03/09/2004 |
| 6673544 | Method for the light-controlled synthesis of biochips The present invention relates to a method for the photolithographic synthesis of biochips in which photolabile protective groups of the 2-(2-nitrophenyl)ethyl type are used, whereby the irradiation step that is common in the photolithographic chip synthes... | 01/06/2004 |
| 6613555 | 32142, 21481, 25964, 21686, novel human dehydrogenase molecules and uses therefor The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containi... | 09/02/2003 |
| 6566407 | Method for reducing oxalate A method for reducing oxalate levels in a patient that includes administering to the patient a therapeutically effective amount of non-absorbable amine polymers such as a polymer characterized by a repeat unit having the formula: ##STR1## and salts a... | 05/20/2003 |
