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"The abolishment of pain in surgery is a chimera. It is absurd to go on seeking it...knife and pain are two words in surgery that must forever be associated in the consciousness of the patient."
Dr. Alfred Velpeau, French surgeon ; 1839
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| Number | Title | Issue Date |
| 8003706 | Enhanced production of blood clotting factors and fibrin fabric The blood collection, processing and transfer by separation of discrete components containing additional citrate (at least about trisodium citrate 9% w/v) in one or other of collection or processing bag provides for enhanced yield and purity of cryoprecipitate. Inhi... | 08/23/2011 |
| 7820722 | Permeation enhancers A pharmaceutical composition comprising a drug and a permeation enhancer that comprises a multi-carbon backbone having a functional group and also one or more side chains which have one or more carbon atoms and, optionally, one or more functional groups. ... | 10/26/2010 |
| 7422756 | Skin preparation The invention concerns a skin preparation for moistening human skin comprising a combination of a component A and a component B, wherein A includes at least two saturated C9-C31 fatty acids selected from the group consisting of iso- and anteiso... | 09/09/2008 |
| 7417159 | Conjugated linolenic acids and methods of preparation and purification and uses thereof This invention relates to a new conjugated linoleic acids, a process for preparation thereof and method of use. Thus this invention is concerned with the preparation and purification of conjugated linoleic acids from materials rich in alpha or gamma linoleic acids. ... | 08/26/2008 |
| 7411006 | Enhanced production of blood clotting factors and fibrin fabric The blood collection, processing and transfer by separation of discrete components containing additional citrate (at least about trisodium citrate 9% w/v) in one or other of collection or processing bag provides for enhanced yield and purity of cryoprecipitate. Inhi... | 08/12/2008 |
| 7388023 | Amino acids with affinity for the α2δ-protein Certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel are disclosed. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders. Also disclosed ar... | 06/17/2008 |
| 7378108 | Percutaneous absorption preparation of compound having angiotensin II antagonistic activity The present invention provides a percutaneous absorption preparation which comprises a compound having angiotensin II antagonistic activity and which allows the compound to permeate through the skin at a desirable rate for a prolonged period. ... | 05/27/2008 |
| 7374776 | Bone-filling composition for stimulating bone-forming and bone-consolidation comprising calcium sulfate and viscous biopolymers The present invention relates to a composition for bone-filling, more particularly, to a bone-filling composition for stimulating bone-formation and bone consolidation comprising calcium sulfate and viscous biopolymers. The composition of the present invention can e... | 05/20/2008 |
| 7361783 | (2S)-2-ethylphenylpropionic acid derivative The invention provides novel (2S)-2-ethylphenylpropanoic acid derivatives that bind to the receptor as ligands of human peroxisome proliferator-activated receptor (PPAR) α to activate and exhibit lipid-lowering effect, inhibitory effect on the arteriosclerosis, ant... | 04/22/2008 |
| 7326672 | Substantially enzyme free personal wash compositions comprising non-silicates with basal layer cationic charge The present invention relates to personal wash compositions comprising, non-silicate particles, wherein the basal layer(s) carries a net cationic charge. The use of these specific particles results in enhanced properties (e.g., enhanced foaming, hydrotroping) of the... | 02/05/2008 |
| 7309497 | Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients The invention relates to novel pharmaceutical compositions for the systemic administration of pharmacologically active ingredients. The invention relates in particular to an injectable pharmaceutical composition comprising (a) a pharmacologically active ingredient i... | 12/18/2007 |
| 7307078 | Polycyclic compounds which modulate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof Novel polycyclic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and also in the fields of cardio... | 12/11/2007 |
| 7297716 | Enhanced production of blood components, blood cells and plasma without freezing The blood collection, processing and transfer by separation of discrete components containing additional citrate (at least about trisodium citrate 2% w/v) in one or other of collection or processing bag provides for enhanced yield and purity of cryoprecipitate. Inhi... | 11/20/2007 |
| 7262158 | Cleansing compositions comprising a liquid silicone and ester mixture Cleansing compositions suitable for use in personal cleansing applications, and in particular make-up removal applications, which not only impart superior cleansing properties, but also which are relatively non-irritating and thus suitable for use by people having s... | 08/28/2007 |
| 7229642 | Amino acid modulated extended release dosage form Disclosed herein is a oral extended release dosage form comprising a plurality of granules of an effective amount of a pharmaceutically active compound, at least one amino acid, and an intragranular polymer in which the granule is dispersed within a hydrophilic extr... | 06/12/2007 |
| 7229630 | Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof The present invention provides compositions and stable liquid formulations comprising alpha adrenergic receptor antagonists and use thereof for increasing blood flow. In one embodiment, the stable liquid formulations of this invention are useful for reversing the ef... | 06/12/2007 |
| 7198801 | Formulations for transdermal or transmucosal application The present invention relates generally to formulations for transdermal or transmucosal administration of an active agent. The invention is a substantially malodorous-free and irritation free transdermal formulation which is substantially free of long chain fatty al... | 04/03/2007 |
| 7196059 | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith Pharmaceutical compositions that include insulin, an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component or a bile salt component without a fatty acid component are described. The insulin drug is covalently coupled to an oligomeric moi... | 03/27/2007 |
| 7192598 | Wet-skin treatment compositions The invention provides wet skin treatment compositions for use during bathing. The compositions are activated by water and retained efficiently on skin. The compositions impart desirable benefits to skin, are perceived to absorb quickly on wet skin, and leave the sk... | 03/20/2007 |
| 7157097 | Penetration enhancing and irritation reducing systems This invention lies in the technology of transdermal and topical drug delivery. In particular, the present invention relates to enhancement of the penetration of transdermally or topically applied drugs and with the reduction of skin irritation that often accompanie... | 01/02/2007 |
| 7151196 | Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v... | 12/19/2006 |
| 7125869 | Polycyclic compounds which modulate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof Novel polycyclic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and also in the field... | 10/24/2006 |
| 7087642 | Inhibitors of IMPDH enzyme The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH e... | 08/08/2006 |
| 7074747 | Cleansing compositions Cleansing compositions suitable for use in personal cleansing applications, and in particular make-up removal applications, which not only impart superior cleansing properties, but also which are relatively non-irritating and thus suitable for use by people having s... | 07/11/2006 |
| 7067119 | Compounds and compositions for delivering active agents Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration and methods of preparation of the modified amino a... | 06/27/2006 |
| 7030082 | Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith Pharmaceutical compositions that include a drug and/or drug-oligomer conjugate, a fatty acid component and a bile salt component, or a bile salt component without a fatty acid component are described. The drug can be covalently coupled to an oligomeric moiety. The f... | 04/18/2006 |
| 7022335 | Suppository of retaining in lower region of rectum A suppository of retaining in a lower region of rectum, which contains a suppository base containing: (A) a fatty acid triglyceride, (B) one or more C14-18 fatty acid glycerides, and (C) a base ingredient for retaini... | 04/04/2006 |
| 6982079 | Compositions for treating hyperemia The present compositions advantageously treat hyperemia with substantially no added irritation to the eye. In one embodiment, the compositions include an ophthalmically acceptable carrier component, a vasoconstrictor component in an amount effective to treat hyperem... | 01/03/2006 |
| 6949529 | Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof The present invention provides therapeutic compositions containing lysophosphatidic acids, methods for making the compositions, and methods of use thereof. ... | 09/27/2005 |
| 6936275 | Amino acid modulated extended release dosage form Disclosed herein is a oral extended release dosage form comprising a plurality of granules of an effective amount of a pharmaceutically active compound, at least one amino acid, and an intragranular polymer in which the granule is dispersed within a hydrophilic extr... | 08/30/2005 |
| 6916851 | Skin care cosmetic methods of sebum control using carboxyalkylates of branched alcohols and/or alkoxylates thereof Cosmetic skin care methods of using and process of making carboxyalkylates of branched alcohols and/or alkoxylates thereof and process of making same. The compounds and compositions provide control of sebum secretion from sebocytes, improved oil control and improved... | 07/12/2005 |
| 6915038 | Optical corner coupler system and method An optical coupling system and method for transmitting optical signals around sharp bends or curves without the use of prisms, mirrors or other conventional reflecting elements. The coupling system includes a reflecting element having a curved outer reflecting surfa... | 07/05/2005 |
| 6911454 | Method for potentiating primary drugs in treating multidrug resistant disease The specification discloses a method for enhancing the inhibiting action of drugs against multidrug resistant cells, apparently by reversing or inhibiting the glycoprotein “pumps” associated with such cells. ... | 06/28/2005 |
| 6899896 | Hydrogel-driven layered drug dosage form A controlled release dosage form for sertraline has a core comprising a sertraline-containing composition and a water-swellable composition wherein the water-swellable composition is in a separate region within the core. A coating around the core is water-permeable,... | 05/31/2005 |
| 6887899 | Method for controlling house dust mites with a composition comprising phenylethyl propionate Pesticidal compositions for the control of dust mites containing one or more plant essential oils. In addition, the present invention is directed to a method for controlling dust mites by applying a pesticidally-effective amount of the above pesticidal compositions ... | 05/03/2005 |
| 6887906 | Compositions and methods for the delivery of oligonucleotides via the alimentary canal The present invention relates to compositions and methods which enhance the transport of nucleic acids, especially oligonucleotides at various sites in the alimentary canal of an animal. The methods and compositions enhance the transport of oligonucleotides across t... | 05/03/2005 |
| 6878389 | Azide method and composition for controlling deleterious organisms Disclosed is both a method and composition for controlling deleterious organisms, such as insects, nematodes and weeds by applying a compound comprised of a liquid medium comprising an azide and an azide stabilizer. The azide can be selected from the group consistin... | 04/12/2005 |
| 6867183 | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith Pharmaceutical compositions that include an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component are described. The insulin drug is covalently coupled to an oligomeric moiety. The fatty acid component and the bile salt component are pre... | 03/15/2005 |
| 6818224 | Use of gellable pharmaceutical compositions in periodontology A method is described for preparing a fluid pharmaceutical composition which allows the controlled release of at least one active substance. The method involves mixing a therapeutically effective amount of at least one active substance, from 3 to 55% by weight of ph... | 11/16/2004 |
| 6770625 | Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith Pharmaceutical compositions that include a drug-oligomer conjugate, a fatty acid component, and a bile salt component are described. The drug is covalently coupled to an oligomeric moiety. The fatty acid component and the bile salt component are present in a weight-... | 08/03/2004 |
