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| Number | Title | Issue Date |
| 8138229 | Compositions and methods of delivery of pharmacological agents The present invention relates to a pharmaceutical composition comprising a pharmaceutical agent and a pharmaceutically acceptable carrier, which carrier comprises a protein, for example, human serum albumin and/or deferoxamine. He human serum albumin is present in a... | 03/20/2012 |
| 7348313 | Method for targeting cells involved in sclerotic and/or fibrotic diseases A compound includes a carrier molecule wherein the carrier molecule is linked to a further molecule, wherein the further molecule is at least one cyclic peptide in which the cyclic peptide portion thereof contains at least one sequence encoding a cell receptor recog... | 03/25/2008 |
| 7122191 | Microfluidized oil-in-water emulsions and vaccine compositions This invention provides submicron oil-in-water emulsions useful as a vaccine adjuvant for enhancing the immunogenicity of antigens. The present invention also provides vaccine compositions containing an antigen combined with such emulsions intrinsically or extrinsic... | 10/17/2006 |
| 7119124 | Pharmaceutical compositions containing plasma protein The invention is related to water-soluble products and pharmaceutical formulations in solid or liquid form mainly for parenteral use. They consist of or comprise a therapeutically active substance (having low aqueous solubility and a substantial binding affinity to ... | 10/10/2006 |
| 7078378 | Method of tissue repair II A substantially solid biomolecular solder for joining tissue comprising a partially denatured biomolecule. The solder can be formed into shapes to suit the needs of a user. The invention also relates to methods for joining tissue and methods for preparing the solder... | 07/18/2006 |
| 7070797 | Method of treating hematologic tumors and cancers Multiple myeloma and other hematologic tumors and/or malignancies can be treated by administration of a G1 and/or S phase drug, which is preferably β-lapachone, or a derivative or analog thereof, combined with a G2/M phase drug such as a taxane derivative, which is... | 07/04/2006 |
| 6974594 | Method of preparing biological materials and preparations produced using same Methods for preparing products containing moisture-sensitive materials, including biological materials such as proteins, peptides or live cells, comprising at least the steps: (i) providing a coating liquid comprising at least one active, a sugar polymer and a water... | 12/13/2005 |
| 6743826 | Pharmaceutical compositions containing plasma protein The invention is related to water-soluble products and pharmaceutical formulations in solid or liquid form mainly for parenteral use. They consist of or comprise a therapeutically active substance (having low aqueous solubility and a substantial binding affinity to ... | 06/01/2004 |
| 6706892 | Pulmonary delivery for bioconjugation Methods of and compositions for pulmonary delivery of therapeutic agents which are capable of forming covalent bonds with a site of interest or which have formed a covalent bond with a pulmonary solution protein are disclosed. Therapeutic agents useful in the invent... | 03/16/2004 |
| 6291532 | Use of N-aryl-2-hydroxyalkylamides for stimulating or inducing hair growth and/or arresting hair loss Methods and compositions for induction or stimulation of hair growth and retardation of hair loss are provided. Preferably, these compounds will include a perhalogenated alkyl radical having 1 to 4 carbon atoms.... | 09/18/2001 |
| 6284270 | Means for creating a mass having structural integrity The present invention relates to a means for creating a mass having structural integrity, including a rapidly disintegratable tablet for administration with or without the use of water. The present invention has a wide variety of different uses and applic... | 09/04/2001 |
| 6261603 | Skin cream Topical skin rejuvenation cream and lotion compositions for dry, damaged or aging skin comprising deionized water, mink oil, vitamin E, retinol acetate (vitamin A), ginseng, aloe vera, glycerin, lanolin (hydrous), gotu kola, soybean oil, fish liver oil, h... | 07/17/2001 |
| 6224905 | Biconvex rapidly disintegrating dosage forms A method for preparing solid rapidly disintegrating dosage forms shaped as biconvex tablets having symmetrical top and bottom surfaces and dosage forms obtainable thereby.... | 05/01/2001 |
| 6103269 | Solid bodies containing active substances and a structure consisting of hydrophilic macromolecules, plus a method of producing such bodies The invention relates to accurately meterable shaped articles, for example granules or pellets, containing hydrophilic macromolecules, active compounds and optionally further pharmaceutically acceptable structure-forming substances and auxiliaries, the ac... | 08/15/2000 |
| 5902606 | Solid and liquid solutions of sparingly water-soluble medicinal substances Sparingly water-soluble active compounds, for example medicinal substances, are converted into the dissolved (molecularly disperse) state by dissolving them in a hydrophilic peptide having a molecular weight above 100 D, for example gelatin. The solubilit... | 05/11/1999 |
| 5888546 | Embolic material for endovascular occlusion of abnormal vasculature and method for using the same A multipurpose ointment (MPOc) in a semisolid-semiliquid form and a multipurpose particle (MPPc) in a solid soft particulate form are prepared by combining a matrix base in a aqueous solution with a liquid oil base and added modifiers and medications to f... | 03/30/1999 |
| 5876754 | Solid bodies containing active substances and a structure consisting of hydrophilic macromolecules, plus a method of producing such bodies The invention relates to accurately meterable shaped articles, for example granules or pellets, containing hydrophilic macromolecules, active compounds and optionally further pharmaceutically acceptable structure-forming substances and auxiliaries, the ac... | 03/02/1999 |
| 5849727 | Compositions and methods for altering the biodistribution of biological agents This invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic or bioactive agents. The methods and composition of the invention can be used with several therapeutic or bioactive agents and can achieve site-... | 12/15/1998 |
| 5788978 | Injectable pulsatile ivermectin composition An injectable ivermectin composition having a programmable release rate and providing multiple concentration peaks of active ivermectin to produce a sequence of ivermectin release pulses into the blood of cattle and horses. The composition comprises a sol... | 08/04/1998 |
| 5780060 | Microcapsules with a wall of crosslinked plant polyphenols and compositions containing them Microcapsules based on crosslinked plant polyphenols are described. These microcapsules are obtained by the interfacial crosslinking of plant polyphenols, particularly flavonoids. When incorporated in a composition such as a cosmetic, pharmaceutical, diet... | 07/14/1998 |
| 5767089 | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules Compositions and processes to alleviate oxygen toxicity are disclosed based on the use of nitroxides in association with physiologically compatible macromolecules. In particular, hemoglobin-based red cell substitutes are described featuring stable nitroxi... | 06/16/1998 |
| 5725804 | Non-crosslinked protein particles for therapeutic and diagnostic use Albumin particles in the nanometer and micrometer size range in an aqueous suspension are rendered stable against resolubilization without the aid of a crosslinking agent and without denaturation, by the incorporation of a stabilizing agent in the particl... | 03/10/1998 |
| 5714142 | Method and compositions for increasing the serum half-life of pharmacologically active agents by binding to transthyretin-selective ligands Compositions and methods are provided for increasing the serum half-life of a pharmacologically active agent. The novel compositions are covalent conjugates of the selected pharmacologically active agent and a transthyretin-binding ligand such as tetraiio... | 02/03/1998 |
| 5686429 | Method for providing nutrition to elderly patients The present invention provides a method for providing nutrition to elderly patients. Pursuant to the present invention, the enteral composition includes a protein source, a lipid source, and a carbohydrate source. Preferably, the protein source includes a... | 11/11/1997 |
| 5662935 | Process for preparing controlled release pharmaceutical forms and the forms thus obtained An improved process for preparing controlled release pharmaceutical forms comprises exposing a mixture comprising one or more excipients and one or more active ingredients compatible with each other and with said excipients to mechanical or electromechani... | 09/02/1997 |
| 5589468 | Method for providing nutrition to elderly patients The present invention provides a method for providing nutrition to elderly patients. Pursuant to the present invention, the enteral composition includes a protein source, a lipid source, and a carbohydrate source. Preferably, the protein source includes a... | 12/31/1996 |
| 5571801 | Plasma expander and blood substitute An artificial plasma-like substance having at least one water soluble polysaccharide oncotic agent selected from the group consisting of high molecular weight hydroxyethyl starch, low molecular weight hydroxyethyl starch, dextran 40 and dextran 70, and al... | 11/05/1996 |
| 5518987 | Pesticide compositions for control of fungal disease in cultivated crops The present invention provides an effective method for controlling foliage and root fungus infection in cultivated crops. A fungicide composition in the form of an aqueous formulation which is applied to pre-harvest crops contains ingredients such as etri... | 05/21/1996 |
| 5518986 | Control of fungal disease in cultivated plants The present invention provides an effective method for controlling foliage and root fungus infection in cultivated crops. A fungicide composition in the form of an aqueous formulation which is applied to pre-harvest crops contains ingredients such as pent... | 05/21/1996 |
| 5487895 | Method for forming controlled release polymeric substrate A method for forming a controlled release polymeric substrate is provided by contacting a polymeric substrate with a liquid mixture containing a cross-linking agent at least partially soluble therein comprising water and an organic liquid, for a period of... | 01/30/1996 |
| 5432146 | Free-flowing bicarbonate fungicide compositions The present invention provides a fungicidal fertilizer composition which contains ingredients which are biocompatible for purposes of agricultural applications, and which are harmless to animals and humans. An invention fungicide composition in the form o... | 07/11/1995 |
| 5292362 | Tissue bonding and sealing composition and method of using the same Disclosed is a composition for bonding separated tissues together or for coating tissues or prosthetic materials including at least one natural or synthetic peptide and at least one support material which may be activated by energy and to methods of makin... | 03/08/1994 |
| 5254331 | Skin cream composition A skin cream composition of the present invention comprises: water, and emulsified and dispersed in the water: (1) a protein complex comprising serum proteins and hydrolyzed animal proteins; (2) a protein-amino acid-vitamin-nucleotide complex comprising p... | 10/19/1993 |
| 5209776 | Tissue bonding and sealing composition and method of using the same Disclosed is a composition for bonding separated tissues together or for coating tissues or prosthetic materials including at least one natural or synthetic peptide and at least one support material which may be activated by energy.... | 05/11/1993 |
| 5153174 | Polymer mixtures useful in skin care Binary polymer mixtures of albumin and glycosaminoglycan and ternary polymer mixtures of polyionic polypeptide and high molecular weight and highly charged polyanions are useful for managing skin including wrinkles or other irregularities. Aqueous composi... | 10/06/1992 |
| 5084276 | Quinolone carboxylic acid compositions with polymeric additive to reduce vein irritation Compositions and methods for treating bacterial infections are disclosed. Compositions of a quinolone carboxylic acid or a pharmaceutically acceptable salt or metal ion-acid complex thereof and a polymeric additive that reduces vein irritation upon infusi... | 01/28/1992 |
| 5079018 | Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs A readily dissolvable carrier material having sufficient rigidity for administration of drugs, nutrients, vitamins, biologically-active materials, foodstuffs and combinations thereof capable of rapid dissolution by saliva, bodily fluids or other liquid co... | 01/07/1992 |
| 5051406 | Pharmaceutical composition using albumin as a carrier and process for producing the same The pharmaceutical composition of the present invention is a pharmaceutical composition of high drug content containing 1-200 parts by weight of a drug having a protein binding property and 100 parts by weight of albumin. This pharmaceutical composition is pro... | 09/24/1991 |
| 5039540 | Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs A readily dissolvable carrier material having sufficient rigidity for administration of drugs, nutrients, vitamins, biologically-active materials, foodstuffs and combinations thereof capable of rapid dissolution by saliva, bodily fluids or other liquid co... | 08/13/1991 |
| 4914084 | Composition and method for introducing heme, hemoproteins, and/or heme-hemoprotein complexes into the body A liquid coacervate composition and a method of introducing heme, hemoproteins and/or heme-hemoprotein complexes into the body. The liquid composition, comprising an oxygen-carrying molecule containing iron and a two-phase aqueous coacervate system, can b... | 04/03/1990 |
