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| Number | Title | Issue Date |
| 7358262 | Identification of genotype-selective anti-tumor agents The present invention relate to methods of identifying a genotype-selective agent. In certain embodiments, the invention relates to agents that are selectively toxic to engineered human tumorigenic cells. ... | 04/15/2008 |
| 7345174 | Cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof The present invention provides the compound having the formula: wherein each of R1 and R2 is, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino, piperidino, t-buty... | 03/18/2008 |
| 7329402 | Methods of imaging and treatment Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The... | 02/12/2008 |
| 7105151 | Oxygen delivery agents and uses for the same The present invention describes, inter alia, oxygen delivery agents or blood substitutes comprising a fluorinated gas and a stabilizing material, uses for the oxygen delivery agents or blood substitutes, and apparatus for making and delivering the oxygen delivery ag... | 09/12/2006 |
| 7097858 | Polyoxometalate materials, metal-containing materials, and methods of use thereof Polyoxometalate topical compositions for removing contaminants from an environment and methods of use thereof are disclosed. An embodiment of the polyoxometalate topical composition includes a topical carrier and at least one polyoxometalate, with the proviso that t... | 08/29/2006 |
| 7083572 | Therapeutic delivery systems Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Targeted therapeutic d... | 08/01/2006 |
| 7078015 | Ultrasound imaging and treatment Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly usefull for example, in ultrasonic imaging applications and in therapeutic dr... | 07/18/2006 |
| 7026360 | Pharmaceutical compositions containing compounds with activity for the enhancement of absorption of active ingredients The new pharmaceutical compositions contain, apart from one or more active ingredient(s), between 0.01 and 60% w/w of the compounds of formula I with n and m>18 and | 04/11/2006 |
| 6998107 | Composition comprising low density microspheres Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void having a volume that comprises at least about 75% of the total volume of the microspheres, and which contains a gas or the vapor of a... | 02/14/2006 |
| 6894079 | Method for reducing free-radical induced injury Disclosed are methods for reducing the injury to tissues, cells, microorganisms or lipids caused by free radicals. The method comprises exposing a composition comprising perfluorocarbon to the tissue, cell, microorganism or lipids in need of such a treatment. Perflu... | 05/17/2005 |
| 6878750 | Benzocycloheptenes, process for their production, pharmaceutical preparations that contain the latter as well as their use for the production of pharmaceutical agents This invention describes the new benzocycloheptenes of general formula I in which R1, R2 and SK have the meanings that are indicated in the description. The new ... | 04/12/2005 |
| 6749869 | Acidic aqueous chlorite teat dip providing shelf life, sanitizing capacity and tissue protection The mastitis control teat dip composition of the invention provides rapid initial kill, a useful highly pseudoplastic rheology, a barrier/film-forming capacity, a unique antimicrobial composition that is stable over an extended period of time, and unexpected long te... | 06/15/2004 |
| 6653354 | NMDA antagonist comprising xenon The present invention relates to the use of xenon as a neuroprotectant and/or as an inhibitor of synaptic plasticity. In a preferred aspect, the xenon acts as an NMDA antagonist. The present invention also provides a method of reducing the level of activa... | 11/25/2003 |
| 6653353 | Cosmetic and personal care compositions Cosmetic or personal care compositions comprise: a hair styling polymer having one or more groups selected from acidic functional groups, anionic groups derived from the acidic functional groups or a mixture of said groups; a partially or fully fluorinate... | 11/25/2003 |
| 6528545 | Preparations comprising a fluorocarbon or highly fluorinated compound and a lipophilic/fluorophilic organic compound, and their uses Fluorocarbon emulsions comprising a stabilizing, particle size controlling fluorophilic/hydrophilic compound which can have the formula RF1 --W--RH1 (I) wherein RF1 is a linear, branched or cyclic C... | 03/04/2003 |
| 6514963 | Methods for the inhibition of egg production in trematodes The present invention comprises methods and compositions for use in inhibiting egg production by parasitic trematode worms comprising administering to an individual in need thereof an effective amount of an agent which transiently inhibits the influx of c... | 02/04/2003 |
| 6495607 | Benzocycloheptenes, process for their production, pharmaceutical preparations that contain the latter as well as their use for the production of pharmaceutical agents Benzocycloheptenes of general formula I ##STR1## in which R1, R2 and Y have the meanings indicated herein, have antiestrogenic activity on and are suitable for the production of pharmaceutical agents, especially for prophylaxis and t... | 12/17/2002 |
| 6486212 | Semifluorinated alkanes and the use thereof The invention concerns semi-fluorinated alkanes of the general formulae RF RH or RF RH RF, RF being a linear or branched perfluoroalkyl group and RH being a linear or branched sa... | 11/26/2002 |
| 6472438 | Active topical skin protectants containing S-330 A topical skin protectant formulation containing a barrier cream and a reactive moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA's). The topical skin protectant offers a barr... | 10/29/2002 |
| 6472437 | Active topical skin protectants A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWAs). The topical skin protectant offers a barrie... | 10/29/2002 |
| 6437005 | Active topical skin protectants using polymer coated metal alloys A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWAs). The topical skin protectant offers a barrie... | 08/20/2002 |
| 6420434 | Active topical skin protectants using polyoxometallates A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA's). The topical skin protectant offers a barri... | 07/16/2002 |
| 6417236 | Active topical skin protectants using hybrid organic polysilsesquioxane materials A topical skin protectant formulation containing a barrier cream and an active hybrid organic-inorganic polysilsesquioxane material for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA'... | 07/09/2002 |
| 6414039 | Active topical skin protectants containing polyoxometalates and/or coinage metal complexes A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA). The topical skin protectant offers a barrier... | 07/02/2002 |
| 6410603 | Active topical skin protectants using combinations of reactive nanoparticles and polyoxometalates or metal salts A topical skin protectant formulation containing a barrier cream and a active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWAs). The topical skin protectant offers a barrier... | 06/25/2002 |
| 6410604 | Active topical skin protectants containing OPAA enzymes and clecs A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA's). The topical skin protectant offers a barri... | 06/25/2002 |
| 6403653 | Active topical skin protectants using reactive nanoparticles A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA's). The topical skin protectant offers a barri... | 06/11/2002 |
| 6375962 | Barrier cream comprising hexamethylenetetramine or derivative thereof Skin protection agents such as topical compositions which can prevent the passage of toxic chemicals through the skin, such as barrier creams. Formulations may contain hexamethylene tetramine or derivatives or analogues thereof, which react with alkylatin... | 04/23/2002 |
| 6322800 | Emulsion and composition comprising a fluorohydrocarbon compound and a method for preparing such an emulsion and composition A fluorohydrocarbon compound of formula RF --C2 H4 --O--CO--RH, in which RF is a perfluorinated alkyl group and RH is an alkyl group, in and/or for the preparation of a stable emulsion cont... | 11/27/2001 |
| 6315756 | Tumescent solution Compositions of perfluorocarbons and methods of using these compositions for subcutaneous fat removal. A version of the composition also contains local anesthetic and/or vasoconstrictors. The composition is in association with a pharmacuetical carrier. Th... | 11/13/2001 |
| 6274633 | NMDA antagonist The present invention relates to the use of xenon as an NMDA antagonist. In particular, the invention relates to a method of treatment comprising modulating the activity of an NMDA receptor in a mammal, the method comprising modulating the activity of the... | 08/14/2001 |
| 6242472 | Methods for the pulmonary delivery of biological agents Methods of delivering a therapeutic or diagnostic agent in a perfluorochemical liquid carrier are provided. In preferred embodiments, the disclosed methods use compositions in the form of an emulsion or a dispersion for delivery of a biological agent to t... | 06/05/2001 |
| 6224885 | Barrier cream comprising hexamethylenetetramine or derivative thereof The present invention relates to protection agents, in particular to topical compositions such as barrier creams which can prevent the passage of toxic chemicals and chemical warfare agents through the skin. Formulations contain hexamethylene tetramine de... | 05/01/2001 |
| 6224851 | Use of a volatile polyfluorinated solvent as an antitransfer agent in cosmetic products The present invention provides a process for making transfer resistant make-up or sun-screen cosmetic compositions containing particles, which process includes introducing at least one volatile polyorganohalogen solvent, the halogen atom being fluorine, a... | 05/01/2001 |
| 6204296 | Patient oxygenation using stabilized fluorocarbon emulsions Storage stable fluorocarbon emulsions having a continuous aqueous phase and a discontinuous fluorocarbon phase, in which the fluorocarbon phase comprises a major amount of a first fluorocarbon or fluorocarbon mixture, and a minor amount of a second fluoro... | 03/20/2001 |
| 6136331 | Cosmetic preparations containing fluorinated oils A cosmetic containing fluorine-containing oil represented by the following formula do not inhibit the oil repellency of powder treated with a fluorine-containing compound, is excellent in affinity for the skin, and is inexpensive. ##STR1##... | 10/24/2000 |
| 6113919 | Preparations comprising a fluorocarbon or a highly fluorinated compound and a lipophilic/fluorophilic compound and their uses Fluorocarbon emulsions comprising a stabilizing, particle size controlling fluorophilic/hydrophilic compound which can have the formula RF1 --W--RH1 (I) wherein RF1 is a lin... | 09/05/2000 |
| 6008209 | Method of using vitamin D3 analogs with bis C-20 side chains This invention provides a method of treating or preventing neoplastic diseases. The method comprises adminstering to a host in need of such treatment or prevention an effective amount of a Vitamin D3 analog of the Formula I wherein: X is H... | 12/28/1999 |
| 5989918 | ADME analysis of mixtures A method for analyzing the ADME/PK properties of a mixture of compounds is (1) perfusing an animal or organ with a perfluorocarbon emulsion blood substitute, (2) administering the mixture of test compounds, (3) withdrawing an aliquot of the perfusate, (4)... | 11/23/1999 |
| 5955439 | Pharmaceutical aerosol containing at least one sugar This invention relates to aerosol formulations of use for the administration of medicaments by inhalation and in particular to a pharmaceutical aerosol formulation which comprises (a) particulate medicament; (b) at least one sugar; and (c) a fluorocarbon ... | 09/21/1999 |
