Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 7329402 | Methods of imaging and treatment Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The... | 02/12/2008 |
| 7252845 | Synergistic compositions containing aromatic compounds and terpenoids present in Alpinia galanga Novel compositions of matter containing aromatic compounds and terpenoids which are present in and may preferably be derived from the plant Alpinia galanga (Zingiberaceae) show synergistic effects with respect to immunomodulation, and they significantly suppr... | 08/07/2007 |
| 7083572 | Therapeutic delivery systems Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Targeted therapeutic d... | 08/01/2006 |
| 7078015 | Ultrasound imaging and treatment Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly usefull for example, in ultrasonic imaging applications and in therapeutic dr... | 07/18/2006 |
| 6998107 | Composition comprising low density microspheres Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void having a volume that comprises at least about 75% of the total volume of the microspheres, and which contains a gas or the vapor of a... | 02/14/2006 |
| 6444700 | Product and method to reduce stress induced immune suppression In its broadest aspect, the present invention is directed to the discovery of immunonutritional products that are useful in reducing the immunological system suppression that results from stress. The stress may be in the form of physical exertion, mental ... | 09/03/2002 |
| 6337337 | Methods for treating disorders responsive to DHFR-inhibition A method for treating disorders responsive to DHFR inhibition is disclosed, wherein the disorders may include neoplastic diseases, rheumatoid arthritis, restenosis, multiple sclerosis, lupus, infections, and ectopic pregnancy. The inventive method compris... | 01/08/2002 |
| 6235796 | Use of fluorocarbons for the prevention of surgical adhesions Method for the prevention and inhibition of adhesion between tissues comprising the use of fluorocarbons are disclosed. The method provides for the introduction of a fluorocarbon into the surgical site of a mammalian body, such as a human, to minimize fri... | 05/22/2001 |
| 5859068 | Acceleration of tissue growth using fluorocarbon liquid A method for the acceleration of tissue growth using continuous fluorocarbon liquid-based positive pressure is disclosed, whereby significant increase in tissue growth is achieved.... | 01/12/1999 |
| 5824703 | Method of assisting normal breathing in a mammal having a lung disorder A method of assisting a mammal having a lung disorder to breathe ambient gas normally, i.e., without the assistance of a ventilator. The method includes providing an animal having a lung disorder, such as surfactant deficiency, stiff lung, or hyperinflate... | 10/20/1998 |
| 5684050 | Stable emulsions of highly fluorinated organic compounds Stable emulsions of highly fluorinated organic compounds for use as oxygen transport agents, "artificial bloods" or red blood cell substitutes and as contrast agents for biological imaging. The emulsions comprise a highly fluorinated organic compound, an ... | 11/04/1997 |
| 5674913 | Method for assisting normal breathing in a mammal having a lung disorder A method of assisting a mammal having a lung disorder to breathe ambient gas normally, i.e., without the assistance of a ventilator. The method includes providing an animal having a lung disorder, such as surfactant deficiency, stiff lung or hyperinflated... | 10/07/1997 |
| 5635539 | Stable emulsions of highly fluorinated organic compounds Stable emulsions of highly fluorinated organic compounds for use as oxygen transport agents, "artificial bloods" or red blood cell substitutes and as contrast agents for biological imaging. The emulsions comprise a highly fluorinated organic compound, an ... | 06/03/1997 |
| 5573757 | Viscoelastic compositions containing concentrated fluorinated compounds their method of preparation and their uses Compositions for topical application in gel form comprising a fluorocarbon or perfluorocarbon compound or mixtures thereof at a concentration of at least about 75% v/v, a minor quantity of a surface active agent and an aqueous phase. The compositions prov... | 11/12/1996 |
| 5565460 | Therapeutic purine agents for parkinson's disease The present invention relates to a therapeutic agent for Parkinson's disease containing as an active ingredient a polycyclic compound or a pharmaceutically acceptable salt thereof, the compound being represented by the following Formula (I): ##STR1##... | 10/15/1996 |
| 5374624 | Fluorocarbon blood substitute The present invention relates to fluorochemical blood substitutes used for preserving mammalian tissue having lysophosphatidyl compounds in non-toxic concentrations. More specifically, the invention relates to aqueous fluorochemical emulsions of a fluoroc... | 12/20/1994 |
| 5270345 | Non-bioaccumulable pesticides Novel pesticidal compositions, which are characterized by biodegradability and do not bioaccumulate to an unacceptable level in fats and tissues of animals, fowl and fish, containing active compounds and optionally a carrier suitable for administering sai... | 12/14/1993 |
| 5104900 | Naphthalene based snake repellant A new use for naphthalene comprising a snake repellant in the form of granules comprising 8% naphthalene, 32% sulfur and 60% montmorillonite. The compound is spread in a strip across an area where snakes are to be repelled and is effective against venomou... | 04/14/1992 |
| 5073383 | Inhibiting aggregation in fluorocarbon emulsions Aggregation of fluorocarbon emulsion particles, which occurs when the emulsion mixes with blood, is reduced by the addition of relatively large amounts of phosphate.... | 12/17/1991 |
| 5061484 | Perfluorochemical emulsion with stabilized vesicles A stable perfluorochemical emulsion is provided which comprises perfluorochemical particles in stabilized vesicles. The vesicles comprise a biocompatible polymer formed by coating the perfluorochemical particles with one or more phospholipid monomer(s) an... | 10/29/1991 |
| 4917930 | Perfluoro compound dispersions containing reduced amounts of surfactant and process of preparation Compositions having enhanced gas and drug transporting capability, are prepared by providing a perfluoro compound dispersed in an aqueous medium with a surfactant to form an aqueous initial dispersion, concentrating the perfluoro compound phase of the dis... | 04/17/1990 |
| 4895876 | Concentrated stable fluorochemical aqueous emulsions containing triglycerides A stable concentrated aqueous emulsion of perfluorochemical, a phospholipid and a triglyceride of fatty acids has been demonstrated which has enhanced stability, diminished particle size and heightened tolerance by biological systems. The emulsion has uti... | 01/23/1990 |
| 4889525 | Sensitization of hypoxic tumor cells and control of growth thereof Method of sensitizing hypoxic tumor cells to radiotherapy and chemotherapy by contacting the cells or the vasculature thereof with an aqueous dispersion of an oxygen carrying perfluoro compound and a dispersant for the compound, and sensitizing chemothera... | 12/26/1989 |
| 4879062 | Preparation of a gel having gas transporting capability An inert, water-immiscible inert organic liquid having gas transport properties, water and a suitable emulsifying agent are formed into a stable gel by emulsifying a mixture of the same, concentrating the emulsion to form a gel phase and a liquid phase an... | 11/07/1989 |
| 4866096 | Stable fluorochemical aqueous emulsions A stable aqueous emulsion of perfluorochemical, a phospholipid and a triglyceride of fatty acids has been demonstrated which has enhanced stability, diminished particle size and heightened tolerance by biological systems. The emulsion has utility as an ox... | 09/12/1989 |
| 4569943 | Physiologically active substance P-23924, its production and use The compound of the formula: ##STR1## wherein R1 is hydrogen, methyl or hydroxymethyl, R2 is hydrogen or methoxy, R3 is hydroxy or methoxy, and R4 is hydrogen or a group ##STR2## is novel, and the... | 02/11/1986 |
| 4497829 | Process for preparing perfluorochemical emulsion artificial blood Particles of perfluoro compound with a lipid coating are emulsified by sonification in aqueous medium, wherein the proportion of perfluoro compound in the emulsion is preferably about 30-75% (w/v) and the proportion of lipid is preferably about 7-9% (w/v)... | 02/05/1985 |
| 4490351 | Methods of treating disorders of an eye with liquid perfluorocarbons Liquid perfluorocarbons and substituted derivatives thereof are used as fluid substitutes for the vitreous or the aqueous of the eye. These liquids are also used to transparentize the cornea or lens when either becomes opacifed due to degeneration or cata... | 12/25/1984 |
| 4452818 | Extraocular method of treating the eye with liquid perfluorocarbons Extraocular ophthalmic preparations useful as therapeutic, lubricating or protective agents are disclosed. Liquid perfluorocarbons and substituted derivatives are the active components of the ophthalmic preparations. The neat perfluorocarbon liquids are n... | 06/05/1984 |
| 4443480 | Artificial blood and other gas transport agents Gas transport agents such as artificial blood containing a perfluorocyclocarbon and an amine oxide are disclosed. These compositions have been found to provide transparent emulsions or solutions for use in oxygen transport, particularly in animals. Large ... | 04/17/1984 |
| 4397870 | Process for prolonging retention of emulsion particles in the bloodstream The retention of coated particles previously infused into the bloodstream of animals may be prolonged by one or more injections of coating substance. For example, the retention of an artificial blood composition comprising emulsified lecithin-coated perfl... | 08/09/1983 |
| 4395393 | Artificial blood emulsifiers An artificial blood composition comprises a perfluoro chemical, physiological saline and a polyoxybutylene-polyoxyethylene block copolymer. The block copolymer provides stable emulsions.... | 07/26/1983 |
| 4366169 | Use of perfluorocarbons as wound treatment Victims suffering certain types of wounds are treated by contacting the wound with a substantially fluorinated carbon material or a mono- or di-brominated derivative thereof containing molecular oxygen.... | 12/28/1982 |
| 4201791 | Pesticide powders, their use and preparation An at least partially water insoluble powder containing a pesticide in admixture with an inert diluent wherein the pesticide is incorporated within the powder during its formation. The powder can be manufactured by directly admixing the pesticide, i.e., a... | 05/06/1980 |
| 4105798 | Perfluoro polycyclic compounds for use as synthetic blood and perfusion media Novel emulsions of non-aromatizable perfluorinated compounds are useful as blood substitutes or as perfusion materials for the storage of organs such as kidneys prior to transplant. The compounds employed are polycyclic compounds and emulsions prepared fr... | 08/08/1978 |
| 4053632 | Compounds of spiro-amine type and methods for their use Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof; processes for their preparation; intermediates useful for their preparation; pharmaceutical preparations containing at least one of these compounds; and the use the... | 10/11/1977 |
| 3992532 | Flowable pesticide formulations Disclosed herein are flowable pesticide formulations comprising; 40-60% by weight of the total formulation of a liquid water-insoluble toxicant or mixture of toxicants, 1-25% weight of the total formulation of a hydrocarbon oil from the group consisting e... | 11/16/1976 |
| 3962439 | Oxygen-transferable emulsion Oxygen-transferable perfluorocarbon compounds having 9 to 11 carbon atoms such as perfluorodecalin, perfluoro(C3-5 -alkylcyclohexanes), perfluoro(C4-6 -alkyl tetrahydropyrans), perfluoro(C5-7 -alkyltetrahydrofurans), perfl... | 06/08/1976 |