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| Number | Title | Issue Date |
| 8129360 | Utilization of phosphatidylserine in the treatment of attention deficit syndrome (ADHS) The invention concerns the use of phosphatidylserine (PS), lyso-phosphatidylserine or/and a physiologically acceptable salt thereof for the treatment of the attention deficit syndrome (ADHS) in small daily doses over a longer time period and in larger daily doses ov... | 03/06/2012 |
| 8084443 | Biological specimen collection and transport system and methods of use Disclosed are compositions for isolating populations of nucleic acids from biological, forensic, and environmental samples. Also disclosed are methods for using these compositions as one-step formulations for killing pathogens, inactivating nucleases, and releasing ... | 12/27/2011 |
| 8076315 | Pharmacological treatments for sleep disorders (apnoe) with prostanoid receptor antagonists This invention is directed to methods for preventing or ameliorating sleep-related breathing disorders. The method comprises administration to a patient in need thereof an effective dose of one or a combination of prostanoid receptor antagonists (eg. ramatroban, ife... | 12/13/2011 |
| 8044037 | Modified phosphocalcic compound, injectable composition containing same A phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of i... | 10/25/2011 |
| 7968529 | Use of sphingolipids for reducing high plasma cholesterol and high triacylglycerol levels The present invention is in the field of cholesterol and triglyceride-lowering methods and compositions. In particular, the present invention relates to the use of sphingolipids, more preferably phytosphingosine, sphingosine, sphinganine, ceramide, cerebroside and/o... | 06/28/2011 |
| 7858599 | Enhancement of urogenital function An exemplary method of treating a urologic symptom includes administering a daily dose of creatine to an individual wherein the daily dose of creatine lies in a range from about 0.35 mg to about 3.5 mg per kilogram body weight. Such an exemplary method may further i... | 12/28/2010 |
| 7713949 | Compositions and methods for enhancing paracellular permeability across epithelial and endothelial barriers Compositions and methods for enhancing paracellular permeability at an absorption site in a subject are disclosed. The method includes: (a) administering an effective amount of a phospholipase C inhibitor to a subject at a time in which enhanced paracellular permeab... | 05/11/2010 |
| 7709464 | Phosphatidyl oligoglycerols In order to form liposomes with a longer half-life in blood, use is made of defined compounds with the general formula (A) ... | 05/04/2010 |
| 7683043 | Creatine phosphate analog prodrugs, compositions and uses thereof Membrane permeable prodrugs of creatine phosphate analogs, pharmaceutical compositions comprising membrane permeable prodrugs of creatine phosphate analogs, and methods of treating diseases such as ischemia, heart failure, and neurodegenerative disorders comprising ... | 03/23/2010 |
| 7652001 | Pharmacologically active agents containing esterified phosphonates and methods for use thereof Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections, cell proliferation and bone metabolism. The compounds provided herein are alkyl esters of phosphonates. ... | 01/26/2010 |
| 7629332 | Nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents The present invention relates to a novel nitrophenyl mustard and nitrophenylaziridine alcohols, to their corresponding phosphates, to their use as targeted cytotoxic agents; as bioreductive drugs in hypoxic tumors, and to their use in cell ablation, including gene-d... | 12/08/2009 |
| 7625879 | Phosphohalohydrins, process for the production thereof and use thereof The invention provides compounds comprising at least one phosphohalohydrin group of the formula: where X is a halogen selected from among I, Br, Cl, R1 is selected from among —CH | 12/01/2009 |
| 7615543 | Treatment and prevention of tissue damage An agent for use in medicine, which agent comprises a plurality of ligands covalently co-linked so as to form a complex with a plurality of C-reactive protein (CRP) molecules in the presence thereof, wherein (i) at least two of the ligands are the same or different ... | 11/10/2009 |
| 7534776 | Process for preparing water-soluble phosphonooxymethyl derivatives of alcohol and phenol A process for making water-soluble phosphonooxymethyl ethers of hindered alcohol and phenol containing pharmaceuticals, such as camptothecin, propofol, etoposide, Vitamin E and Cyclosporin A. In particular, the process for preparing water-soluble phosphonooxymethyl ... | 05/19/2009 |
| 7521436 | Modified phosphocalcic compound, injectable composition containing same The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphos... | 04/21/2009 |
| 7462608 | Non nucleoside reverse transcriptase inhibitors Phosphorus-substituted imidazole compounds with anti-HIV properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit reverse transcriptase activity and are useful therapeutically for the inhibition of such enzymes,... | 12/09/2008 |
| 7459444 | Inhibitors of chymase The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated ... | 12/02/2008 |
| 7435408 | Porous particles comprising excipients for deep lung delivery Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm... | 10/14/2008 |
| 7432253 | Phosphoepoxides, method for making same and uses The invention provides compounds comprising at least one phosphoepoxide group of the formula: where R1 is selected from among —CH3 and —CH2—CH3. Cat+... | 10/07/2008 |
| 7417035 | Phospholipid derivatives of non-steroidal anti-inflammatory drugs Disclosed are compounds having non-steroidal anti-inflammatory drugs (NSAIDS) covalently linked to a phospholipid moiety via a bridging group. Also disclosed are a process for the synthesis of the compounds, pharmaceutical compositions comprising the compounds and t... | 08/26/2008 |
| 7381713 | Treatment of cancer by reduction of intracellular energy and pyrimidines This invention provides a method for treating a cancer subject comprising administering to the subject a combination of ATP-depleting agents at concentrations which deplete the ATP level to at least 15% of normal in cancer cells, a pyrimidine antagonist, and an anti... | 06/03/2008 |
| 7354895 | Phosphinyloxy, oxime and carboxylic acid derivatives which are useful as carboxypeptidase U inhibitors The present invention relates to compounds of Formula I, and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and thus can be used in the preventio... | 04/08/2008 |
| 7351428 | Phosphatidyl oligoglycerols In order to form liposomes with a longer half-life in blood, use is made of defined formula (A) ... | 04/01/2008 |
| 7319095 | Use of GABAreceptor agonists The present invention relates to the use of GABAB receptor agonists for the treatment as well as the prevention of cough. ... | 01/15/2008 |
| 7304093 | Ketone compounds and compositions for cholesterol management and related uses The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a com... | 12/04/2007 |
| 7294619 | Lipid analogs for inhibiting the activity of hepatitis B antigen The invention relates to methods of treating viral infections, and in particular hepatitis B virus. The method comprises administering to a subject in need of such treatment an infection-controlling amount of a phospholipid or phospholipid derivative to inhibit the ... | 11/13/2007 |
| 7294621 | Lipid analogs for combating tumors The invention relates to methods of treating viral infections, and in particular hepatitis B virus. The method comprises administering to a subject in need of such treatment an infection-controlling amount of a phospholipid or phospholipid derivative to inhibit the ... | 11/13/2007 |
| 7294620 | Lipid analogs for inhibiting HIV-1 activity The invention relates to methods of treating viral infections, and in particular hepatitis B virus. The method comprises administering to a subject in need of such treatment an infection-controlling amount of a phospholipid or phospholipid derivative to inhibit the ... | 11/13/2007 |
| 7282514 | Reactive probes for two-photon fluorescent imaging and sensing Fluorescent dyes and probes are key components in multiphoton based fluorescence microscopy imaging of biological samples. In order to address the demand for better performing dyes for two-photon based imaging, a new series of reactive fluorophores tailored for mult... | 10/16/2007 |
| 7273604 | Anti-asthmatic combinations comprising surface active phospholipids Disclosed is a combination product for use in treating asthma and other respiratory conditions comprising a medicament comprising a surface active phospholipid composition in the form of a fine powder and an antiasthma drug. The product is arranged to be administere... | 09/25/2007 |
| 7259273 | Compositions containing lysophosphotidic acids which inhabit apoptosis and uses thereof The invention provides anti-apoptotic compositions containing lysophosphatidic acids and methods for making and using the compositions. Such compositions may also contain LPA potentiating agents, including proteins, lipid membrane structures and polymers such as pol... | 08/21/2007 |
| 7259184 | Ion channel modulating compounds and uses thereof Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatme... | 08/21/2007 |
| 7259154 | Pyrrolopyrimidines Compounds of the formula and N-oxides, prodrugs, acid bioisosteres, pharmaceutically acceptable salts or solvates of such compounds, or N-oxides, prodrugs, or acid bioisosteres of such salts or solvates, to compo... | 08/21/2007 |
| 7252706 | Inhibition of calcium and magnesium precipitation from wood preservatives A wood preservative that contains a copper salt complex and a precipitation inhibitor is provided. The wood preservative may contain copper carbonate, an alkanolamine such as monoethanolamine and precipitation inhibitor such as a phosphonate or ethylene diamine comp... | 08/07/2007 |
| 7247610 | Use of glutamate antagonists for the treatment of cancer Disclosed are methods for treating cancer by administering an inhibitor of the interaction of glutamate with the KA receptor complex. ... | 07/24/2007 |
| 7244718 | Water soluble prodrugs of hindered alcohols The present invention is directed to novel water-soluble prodrugs of aliphatic or aromatic hindered hydroxyl group containing pharmaceuticals. ... | 07/17/2007 |
| 7241459 | Polymers containing bioactive glass with antimicrobial effect The method of protecting a polymeric plastic from attack by bacteria and fungi includes providing bioactive glass particles having a mean particles size preferably less than 2 μm as an additive incorporated into the polymeric plastic. The bioactive glass particles ... | 07/10/2007 |
| 7229978 | Process for preparing water soluble phosphonooxymethyl derivatives of alcohol and phenol A process for making water-soluble phosphonooxymethyl ethers of hindered alcohol and phenol containing pharmaceuticals, such as camptothecin, propofol, etoposide, Vitamin E and Cyclosporin A. In particular, the process for preparing water-soluble phosphonooxymethyl ... | 06/12/2007 |
| 7205285 | Acyl phosphonate inhibitors of β-lactamases The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic β-lactamase inhibitors presently available, and which do not possess a β-lactam pharmacophore. These new inhibitors are fully synthetic... | 04/17/2007 |
| 7192618 | Antimicrobial composition for pre-harvest and post-harvest treatment of plants and animals An antimicrobial, anti-bacterial processing aid, food additive and food ingredient is provided to inhibit cellular growth of known pathogenic, indicator and spoilage organisms, such as salmonella, stahphylococcus, listeria, e coli, and the like. The antimicro... | 03/20/2007 |
