Did You Know...
...that after Parker Brothers executives turned down the game of Monopoly because it had "52 fundamental errors" (including taking too long to play), a copy of the game wound up in the home of the company president who stayed up until 1 a.m. to finish playing it? He was so impressed by the game that the next day he wrote to inventor Charles Darrow and offered to buy it!
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| Number | Title | Issue Date |
| 7420003 | Compounds and a novel process for their preparation The present invention is directed to a procedure for making an enantiomerically enriched compound containing a hydronaphthalene ring structure. The process involves reacting oxabenzonorbornadienes with nucleophiles using rhodium as a catalyst and in the presence of ... | 09/02/2008 |
| 7413738 | Releasable polymeric conjugates based on biodegradable linkers Activated polymeric bicine derivatives such as, as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed. ... | 08/19/2008 |
| 7307071 | RAF-MEK-ERK pathway inhibitors to treat cancer Materials and methods for treating certain cancers are described, preferably cancers that result from the up-regulation of the RAF-MEK-ERK pathway, and more preferably chronic myelogenous leukemia, and which cancer is preferably resistant to the inhibition of the Bc... | 12/11/2007 |
| 7276631 | Cyclopentylamine and cyclohexylamine derivatives as NK-1/SSRI antagonists The present disclosure relates to chemical compounds and their use in human therapy. A specific embodiment of the disclosure relates to compounds of Formula (I); or an isomer, a pharmaceutically acceptable salt or solvate thereof or a pharmaceutically acceptable for... | 10/02/2007 |
| 7250157 | Dermatological compositions and methods Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds,... | 07/31/2007 |
| 7135600 | Phenethanolamine derivatives for treatment of respiratory diseases The present invention relates to novel compounds of Formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases. ... | 11/14/2006 |
| 7122189 | Releasable polymeric conjugates based on aliphatic biodegradable linkers Activated polymeric bicine derivatives such as as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed. ... | 10/17/2006 |
| 7090831 | Pharmaceutical aerosol formulation The present invention relates to novel pharmaceutical aerosol formulations comprising: (A) salmeterol xinafoate in the form of particles coated by spray-drying with at least one surfactant in the absence of any other coating excipient, in suspension in (B) a liquefi... | 08/15/2006 |
| 7087229 | Releasable polymeric conjugates based on aliphatic biodegradable linkers Activated polymeric bicine derivatives such as, as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed. ... | 08/08/2006 |
| 7048925 | Acid-sensitive polyacetals and methods Polyacetals comprising a recurring units represented by a formula selected from the group consisting of formula (I) and (II): wherein A comprises at least one acetal group; B is selected from t... | 05/23/2006 |
| 7030162 | Treatment of migraine headache The invention is directed to pharmaceutical compositions useful in the treatment of migraine. The compositions contain metoclopramide and one or more NSAIDs in unit dosage form. By selecting NSAIDs that are non-acidic or segregating the metoclopramide and NSAID, the... | 04/18/2006 |
| 6955804 | Dermatological compositions and methods Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds,... | 10/18/2005 |
| 6933321 | Antiandrogenic biphenyls Biphenyl derivatives are disclosed for use in the treatment of androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, precocious puberty, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and premature male bal... | 08/23/2005 |
| 6933320 | Combination comprising combretastatin and anticancer agents An antitumor combination comprising a stilbene derivative and an anticancer compound selected from the group consisting of taxanes, alkylating agents, antimetabolites, vinca alkaloids, platinum compounds, epidophylloptoxins, and antibiotics as the active ingredients... | 08/23/2005 |
| 6890958 | Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications The present invention provides combinations of cardiovascular therapeutic compounds for the prophylaxis or treatment of cardiovascular disease including hypercholesterolemia, atherosclerosis, or hyperlipidemia. Combinations disclosed include a nicotinic acid derivat... | 05/10/2005 |
| 6878374 | Biodegradable polyacetals A polymer comprising recurring units represented by formula (I): wherein X is selected from the group consisting of C(O)OR1, C(O)SR1, C(O)NR1R2, and ... | 04/12/2005 |
| 6855341 | Anti-viral compositions and methods of making and using the anti-viral compositions Disclosed are anti-viral compositions containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients), and a pharmaceutical carrier. Also disclosed are methods of treating lesionous symptoms of a viral infection involvi... | 02/15/2005 |
| 6797728 | Use of intracellular calcium chelators to increase surfactant secretion in the lungs Pulmonary surfactant is required in order to reduce surface tension in the lungs so that less effort is needed to reinflate the lungs after exhalation. A number of diseases and conditions exist that disrupt the normal flow of surfactant secretion, resulting in respi... | 09/28/2004 |
| 6706290 | Methods for eradication of nanobacteria Nanobacteria contribute to pathological calcification in the human and animal body, including diseases such as kidney stones, salivary gland stones, dental pulp stones and atherosclerosis. The present invention provides methods for sterilizing articles contaminated ... | 03/16/2004 |
| 6641800 | Pressurized aerosol compositions comprising powdered medicament dispersed in hydrofluoroalkane Pressurized aerosol composition for administration by inhalation comprising a liquefied hydrofluoroalkane, a powdered medicament dispersed therein, and a suspending agent comprising a polymer soluble in the liquefied hydrofluoroalkane which is selected fr... | 11/04/2003 |
| 6623724 | Dermatological compositions and methods Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various... | 09/23/2003 |
| 6552088 | Biphenyl derivatives Biphenyl substituted amides with activity as antagonists of the neurokinin 1 (NK-1, substance P) receptor.... | 04/22/2003 |
| 6500416 | Pesticide There are described a flowable composition for controlling harmful insects and representatives of the order Acarina, comprising at least one pesticidally active compound, one or more signal substances selected from the group consisting of pheromones, kair... | 12/31/2002 |
| 6489366 | Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications The present invention provides combinations of cardiovascular therapeutic compounds for the prophylaxis or treatment of cardiovascular disease including hypercholesterolemia, atherosclerosis, or hyperlipidemia. Combinations disclosed include a nicotinic a... | 12/03/2002 |
| 6479551 | Treatment of migraine headache The invention is directed to pharmaceutical compositions useful in the treatment of migraine. The compositions contain metoclopramide and one or more NSAIDs in unit dosage form. By selecting NSAIDs that are non-acidic or segregating the metoclopramide and... | 11/12/2002 |
| 6462044 | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions containing at least one nitrosated and/or nitrosylated phosphodiesterase inhibitor, and, optionally, one or more compounds that donat... | 10/08/2002 |
| 6369115 | Stabilized powder formulations A dry powder formulation for treatment of pulmonary conditions, via inhalation, includes an effective amount of formoterol or a salt or solvate thereof, in a dry powder form, an effective amount of fluticasone, in a dry powder form, and an excipient. A me... | 04/09/2002 |
| 6331543 | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions containing at least one nitrosated and/or nitrosylated phosphodiesterase inhibitor, and, optionally, one or more compounds that donat... | 12/18/2001 |
| 6277829 | Process for preparing of aqueous formulation for opthalmic use The present invention describes a process for the preparation of aqueous formulations containing azithromycin for ophthalmic use, as well any formulations obtained by this process and their topical use in the ocular bacterial infections, more preferably i... | 08/21/2001 |
| 6274570 | Pesticidal compositions A liquid pesticidal composition, which is substantially free of water, comprising a hydrophobic pesticide or mixture of pesticides dissolved in an organic solvent and comprising as surfactants (a) a castor oil ethoxylate having 30-50 mol ethoxylate, (b) a... | 08/14/2001 |
| 6251942 | Compositions and methods for alleviating impaired mental function, memory loss and reducing recovery time in anaesthetized mammals Composition and methods of alleviating impaired mental function and memory loss in mammals and reducing the recovery time from anaesthesia in age mammals, comprising treating the mammal with a non-toxic, enhancing effective amount of a cell membrane perme... | 06/26/2001 |
| 6217887 | Leave-on antimicrobial compositions which provide improved immediate germ reduction The present invention relates to a leave-on antimicrobial composition comprising from about 0.001% to about 5% of an antimicrobial active; from about 0.5% to about 10% of an anionic surfactant; from about 0.1% to about 10% of a proton donating agent, wher... | 04/17/2001 |
| 6162805 | Use of an NK-1 receptor antagonist and an SSRI for treating obesity The present invention relates to the use of an NK-1 receptor antagonist and a selective serotonin reuptake inhibitor for the treatment or prevention of obesity.... | 12/19/2000 |
| 6159944 | Method for treating painful conditions of the anal region and compositions therefor Method and composition for treating painful conditions of the body, particularly the anal region. The compositions include a combination of nitroglycerin and sucralfate or a combination of nitroglycerin, lidocaine and sucralfate. The compositions may be i... | 12/12/2000 |
| 6106851 | Mild, rinse-off antimicrobial liquid cleansing compositions containing salicyclic acid The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.1% to about 5.0%, by weight of the cleansing composition, of an antimicrobial active; from about 6% to about 16%, by weight of the cleansing compositi... | 08/22/2000 |
| 6080790 | Tri-substituted phenyl derivatives and processes for their preparations Compounds of formula (1) ##STR1## are described wherein Y represents a halogen atom or a group --OR1, where R1 is an optionally substituted alkyl group; R2 represents an optionally substituted cycloalkyl or cycloalken... | 06/27/2000 |
| 6031007 | Pharmaceutical composition with anaesthetic effect The invention is directed to a novel pharmaceutical composition comprising one or more local anaesthetics in oil form, one or more surfactants, water and optionally a taste masking agent. The novel composition is advantageously used as a local anaesthetic... | 02/29/2000 |
| 6028093 | Fungicide compositions Fungicidal mixtures, comprising a) a carbamate of the formula I ##STR1## where T is CH or N, n is 0, 1 or 2 and R is halogen, C1 -C4 -alkyl or C1 -C4 -haloalkyl, it being possible for the radicals R to be ... | 02/22/2000 |
| 6004958 | Compounds and methods for therapeutic intervention in preventing diabetic complications and procedures for assessing a diabetic's risk of developing complications and determining the efficacy of therapeutic intervention The present invention is based on the discovery of a metabolic pathway in which a specific kinase converts fructose-lysine into fructose-lysine-3-phosphate in an ATP dependent reaction. Fructose-lysine-3-phosphate (FL3P) is then broken down to form free ... | 12/21/1999 |
| 5990170 | Therapeutic use of mono and bicarboxylic acid amides active at the peripheral cannabinoid receptor The following description concerns a therapeutic method for the treatment of diseases connected with the modulation of the cannabinoid peripheral receptor, comprising administering amidic derivatives of mono and bicarboxylic acids with aminoalcohols or ar... | 11/23/1999 |
