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| Number | Title | Issue Date |
| 7193084 | Polymorphic form of itraconazole The present invention provides a polymorphic form of itraconazole. ... | 03/20/2007 |
| 7112340 | Compositions of and method for preparing stable particles in a frozen aqueous matrix The present invention discloses a composition of a stable suspension of a poorly water soluble pharmaceutical agent or cosmetic in the form of particles of the pharmaceutical agent or cosmetic suspended in a frozen aqueous matrix and method for its preparation. The ... | 09/26/2006 |
| 7037528 | Microprecipitation method for preparing submicron suspensions The present invention provides a method for preparing submicron sized particles of an organic compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous, the process including the steps of: (i) dissolving... | 05/02/2006 |
| 6977085 | Method for preparing submicron suspensions with polymorph control The present invention provides a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous. The process includes the steps of: (i) d... | 12/20/2005 |
| 6951656 | Microprecipitation method for preparing submicron suspensions The present invention provides a method for preparing submicron sized particles of an organic compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous, the process including the steps of: (i) dissolving... | 10/04/2005 |
| 6787573 | Antiviral therapy The invention relates to the field of antiviral agents, and more specifically to antiviral therapy. The invention provides use of at least one compound or mixture of compounds of the general formula or a functional equiv... | 09/07/2004 |
| 6743419 | Method of reducing hair growth employing sulfhydryl active compounds A method of reducing the rate of mammalian hair growth includes topically applying a composition containing a sulfhydryl reactive compound to the skin. ... | 06/01/2004 |
| 6608061 | Bisaryl compound and medicament for cancer treatment comprising the same A medicament for treatment of cancer comprising a compound represented by the following general formula (I) or a physiologically acceptable salt thereof: Ar1 --S--R1 --S--Ar2 wherein R1 represents a nonmetal bridging... | 08/19/2003 |
| 6605641 | 20-HETE antagonists and agonists 20-HETE agonists and antagonists are disclosed along with therapeutic applications. In a preferable form of the invention, the 20-HETE agonists are selected from the group consisting of 21-hydroxyheneicosa-5(Z), 8(Z), 11(Z), 14(Z)-tetraenoic acid, 20-hydr... | 08/12/2003 |
| 6596769 | 20-Hete antagonists and agonists 20-HETE agonists and antagonists are disclosed along with therapeutic applications. In a preferable form of the invention, the 20-HETE agonists are selected from the group consisting of 21-hydroxyheneicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid, 20-hy... | 07/22/2003 |
| 6444709 | Heteroethylene compounds and pharmaceutical and cosmetic compositions containing same The invention relates to novel heteroethynylenic compounds having the general formula (I): ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, r... | 09/03/2002 |
| 6395781 | 20-HETE antagonists and agonists 20-HETE agonists and antagonists are disclosed along with therapeutic applications. In a preferable form of the invention, the 20-HETE agonists are selected from the group consisting of 21-hydroxyheneicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid, 20-hy... | 05/28/2002 |
| 6387959 | Antiviral therapy The invention relates to the field of antiviral agents, and more specifically to antiviral therapy. The invention provides use of at least one compound or mixture of compounds of the general formula ##STR1## or a functional equivalent or pharmaceutically ... | 05/14/2002 |
| 6239111 | In vivo method of improving survival rate of brain neurons The present invention discloses the use, in the manufacture of a preventive and therapeutic drug of a brain disease, of a compound represented by formula (1): [wherein R represents a hydrogen atom, an alkyl group, an alkenyl group, a substituted alkyl gro... | 05/29/2001 |
| 6106821 | Fly attractant compositions The invention relates to fly attractant compositions that comprise at least one volatile short chain carboxylic acid, at least one organic sulfide and at least one nitrogen heterocycle. In a preferred embodiment the composition additionally comprises at l... | 08/22/2000 |
| 6103753 | Intimal thickening inhibitory agent An intimal thickening inhibitory agent comprising, as an active ingredient, a compound represented by formula (1): ##STR1## wherein X represents an oxygen atom or a group of formula (2): ##STR2## wherein n represents an integer of from 0 to 2, R... | 08/15/2000 |
| 5981603 | Antiviral agents This invention relates to compounds, compositions, uses and methods for inhibiting viral and retroviral replication and for treating viral and retroviral infections via the administration of various compounds, including antioxidants, preferably compounds ... | 11/09/1999 |
| 5972993 | Composition and method for treating rosacea and sensitive skin with free radical scavengers A method for treating skin conditions, such as rosacea and sensitive skin, that manifest as a tendency towards flushing and blushing is provided. Also provided herein, are compositions for the treatment of rosacea and sensitive skin that are comprised of ... | 10/26/1999 |
| 5869506 | Fluoropropene compound, an insecticide containing the same and an intermediate for production thereof The present invention provides a fluoropropene compound represented by Formula I: ##STR1## wherein R1 represents a C1 -C10 alkyl group or other groups, Z represents an oxygen atom or other groups, R2, R | 02/09/1999 |
| 5840724 | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- o r This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical c... | 11/24/1998 |
| 5807899 | Triphenylethylenes, process for their production, pharmaceutical preparations that contain these triphenylethylenes as well as their use for the production of pharmaceutical agents This invention describes the new triphenylethylenes of general formula I ##STR1## in which n means an integer from 1 to 10, R' means a sulfur-containing organic radical, R" means a hydrogen atom, an iodine atom or a hydroxy groups, E means a hydrogen atom, G m... | 09/15/1998 |
| 5679696 | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic-or heteroatom-containing linking group This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical c... | 10/21/1997 |
| 5665773 | Cloprostenol and fluprostenol analogues and their use to treat glaucoma and ocular hypertension Disclosed is the use of cloprostenol and fluprostenol analogues for the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic compositions comprising said compounds.... | 09/09/1997 |
| 5430062 | Stilbene derivatives as anticancer agents The present invention relates to stilbene derivatives which possess utility as anti-cancer agents. The compounds can be used to treat cancers which are susceptible to treatment therewith, and can be utilized in a method of treating such cancers. Pharmaceu... | 07/04/1995 |
| 5393776 | Tocotrienol analogs in the treatment of hypercholesterolemia and hyperlipidemia This invention relates to structurally novel acyclic tocotrienol analogs, which are useful for cholesterol/lipid lowering in cases of hypercholesterolemia and hyperlipidemia, and for atherosclerosis. Also provided are pharmaceutical compositions and a met... | 02/28/1995 |
| 5321046 | Hypocholesterolemic unsymmetrical dithiol ketals Disclosed herein are novel unsymmetrical dithiol ketals which are useful in the treatment or prevention of hypercholesterolemia, hyperlipoproteinemia, and atherosclerosis.... | 06/14/1994 |
| 5262441 | Aromatic compounds, their production processes and their compositions for the control of insect pests An aromatic compound of the formula: ##STR1## wherein R1 is a C3 -C8 alkyl group, a C3 -C8 alkoxy group, an alkoxyalkyl group having 3 to 8 carbon atoms, a C3 -C8 alkenyl gr... | 11/16/1993 |
| 5214070 | Diaryl ether cycloalkanes The invention concerns a diaryl ether cycloalkane of the formula I, or a pharmaceutically-acceptable salt thereof, ##STR1## wherein Ar1 is optionally substituted phenyl or naphthyl; X1 is oxy, thio, sulphinyl or sulphonyl; Ar | 05/25/1993 |
| 5214069 | Alcohol and ether derivatives The invention concerns a compound of the formula I, ##STR1## wherein Ar1 is optionally substituted phenyl or naphthyl; A1 is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene; Ar2 is optionally subs... | 05/25/1993 |
| 5183814 | Selective oestrogen therapy for perimenopausal or postmenopausal conditions The invention relates to a therapeutic product comprising an oestrogen and a pure antioestrogen for simultaneous, sequential or separate use in selective oestrogen therapy of perimenopausal or postmenopausal conditions; to a process for the manufacture of... | 02/02/1993 |
| 5087637 | Diarylacetylenes, the preparation and use thereof Diarylacetylenes of the formula I ##STR1## where R1 is hydrogen or C1 -C4 -alkyl, R2 and R3 are each hydrogen or, when R1 is hydrogen, together form a --C(CH3)2 -... | 02/11/1992 |
| 5084478 | Alkene, alkyne or cycloalkylene derivatives A compound of the formula ##STR1## wherein X has the formula --CR5 .dbd.CR6 --, --C.tbd.C-- or ##STR2## wherein ring A is phenyl, naphthyl or heterocyclic; wherein R1 is hydrogen, alkyl, alkanoyl or aroyl; wherei... | 01/28/1992 |
| 4940707 | Stilbene derivatives for treatment of skin disorders Compounds of the formula ##STR1## wherein R1 and R2 each independently are lower-alkyl; or together are alkylene with 3-5 C-atoms in a straight chain; one of the residues R3 and R4 is hydrogen and the other... | 07/10/1990 |
| 4853403 | 3-phenylthiomethylstyrene derivative, process for preparing the same, and antiallergic agent and tyrosinekinase inhibiting agent containing the same A 3-phenylthiomethylstyrene derivative having the general formula (1): ##STR1## or salt thereof with a base, when X is hydroxyl group, R1 is hydrogen atom or R2 is hydrogen atom, a process for preparing the 3-phenylthiomethylsty... | 08/01/1989 |
| 4845119 | Alkene, alkyne or cycloalkylene derivatives A compound of the formula ##STR1## wherein X has the formula --CR5 .dbd.CR6 --, --C.tbd.C-- or ##STR2## wherein ring A is phenyl, naphthyl or heterocyclic; wherein R1 is hydrogen, alkyl, alkanoyl or aroyl; wherei... | 07/04/1989 |
| 4845129 | Diaryl substituted cyclopentane and cyclopentene derivatives The invention discloses certain diaryl substituted cyclopentane and cyclopentene derivatives useful as PAF inhibitors, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using such compositions for inhibi... | 07/04/1989 |
| 4791123 | Insecticidal triffluormethyl alkane derivatives There are provided new alkane and alkoxyalkane derivatives of the general formula I ##STR1## in which R1, R2, R3, R4 and A have the meanings given in the description, processes for their preparation and ins... | 12/13/1988 |
| 4772633 | 6-pyridyl- and 6-phenyl-3-phenyl-1-hexenes and -1-hexynes, composition containing them, and insecticidal and acaricidal method of using them This invention relates to a novel compound represented by the following general formula (I), its production, and an insecticidal and acaricidal composition containing it as an active ingredient: ##STR1## wherein R1 and R2, which... | 09/20/1988 |
| 4732912 | Phenol derivatives A phenol derivative of the formula wherein NU is a defined bis-phenolic nucleus including a hydroxyphenyl-hydroxynaphthyl; hydroxyphenyl-hydroxyindanyl, hydroxyphenyl-hydroxybenzothienyl or di-hydroxyphenyl-ethylene or vinylene nucleus; wherein A is alkyl... | 03/22/1988 |
| 4686235 | Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as anti-inflammatory agents Substituted cinnamyl-2,3-dihydrobenzofurans and analogs were prepared from the nucleophlic substitution of a cinnamylhalide with a 2,3-dihydrobenzofuran anion or an analog thereof. These compounds were found to be potent topical anti-inflammatory agents.... | 08/11/1987 |
