Did You Know...
...that to encourage use of his new invention, the shopping cart, market owner Sylvan Goldman hired fake shoppers to push the carts around his store in Oklahoma City? Seems his customers were reluctant to give up their hand-carried baskets.
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| Number | Title | Issue Date |
| 8063109 | Formulations for parenteral administration of (e)-2, 6-dialkoxystyryl 4-substituted benzylsulfones Formulations are provided for parenteral administration of (amino substituted (e)-2,6-dialkoxystyryl 4-substituted benzylsulfones and the sodium and potassium salts thereof for the prevention and/or treatment of conditions mediated by abnormal cell proliferation. Co... | 11/22/2011 |
| 7989502 | Intranasal delivery of modafinil Modafinil is selectively delivered to the brain, minimizing delivery to the blood, of a person in need thereof by administering to the person a therapeutically-effective dosage of modafinil, wherein the dosage is less than 1 mg, formulated in a lipid microemulsion (... | 08/02/2011 |
| 7595347 | Method for protecting normal cells from cytotoxicity of chemotherapeutic agents Pre-treatment with α,β unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone compound to a patient prior to anticancer chemotherapy with a mitotic ... | 09/29/2009 |
| 7468393 | Diarylsulfones as 5-HT2A antagonists Compounds of formula I: are potent and selective antagonists of the human 5-HT2A receptor, and hence useful in treatment of a variety of adverse conditions of the CNS. ... | 12/23/2008 |
| 7407648 | Merocyanine derivatives for cosmetic use The use is described of merocyanine derivatives of formula (1), wherein R1 and R2 are each independently of the other hydrogen; C1-C22alkyl; cyclo-C3C8alkyl; or unsubstituted or C1-C5 | 08/05/2008 |
| 7217740 | Diarylsulfones as 5-HT2A antagonists Compounds of formula I: are potent and selective antagonists of the human 5-HT2A receptor, and hence useful in treatment of a variety of adverse conditions of the CNS. ... | 05/15/2007 |
| 7183274 | Piperidine-2,6-diones heterocyclically substituted in the 3-position Piperidine-2,6-diones heterocyclically substituted in the 3-position corresponding to formula I Also the production and use of such compounds in pharmaceutical formulations and related methods of treatment. ... | 02/27/2007 |
| 7161031 | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula I: wherein: Ar, X, X1, g, R and R3 are as defined herein. ... | 01/09/2007 |
| 7056919 | Synergistic combination of fungicides to protect wood and wood-based products and wood treated by such combination as well as methods of making the same A wood treatment composition having a synergistic combination of fungicides which may include two or more compounds. These combinations are shown to be especially effective in providing resistance to decay, mold and mildew when wood is treated with these combination... | 06/06/2006 |
| 7056953 | (E)-styryl sulfone anticancer agents (E)-styryl benzylsulfones of formula I are useful as anticancer agents: wherein R1, R2, R3, and R4 are as defined herein. ... | 06/06/2006 |
| 7053123 | Substituted (e)-styryl benzylsulfones for treating proliferative disorders (E)-Styryl benzylsulfones useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula I: wherein: R1 is selected from the group consisting of halogen, C1–C6 alkoxy, nitro, phosphonato, amino, sulfamyl... | 05/30/2006 |
| 6833359 | Method for treating soil for the control of soil borne plant pathogens A method for reducing bacterial and fungal soil pathogens which comprises applying to a soil a chemically effective amount of a lignosulfonate, the amount preferably being between 0.05% and about 5% on a volume/weight basis. The method is effective in controlling a ... | 12/21/2004 |
| 6767926 | Method for protecting normal cells from cytotoxicity of chemotherapeutic agents Pre-treatment with α,β unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone compound to a patient prior to anticancer chemotherapy with a mitotic ... | 07/27/2004 |
| 6762207 | (E)-styryl sulfone anticancer agents (E)-styryl benzylsulfones of formula I are useful as anticancer agents: wherein R1, R2, R3, and R4 are independently selected from the group consisting of hydrogen, fluo... | 07/13/2004 |
| 6756409 | Phenoxyphenyl alkanesulphonates The invention relates to novel phenoxyphenyl alkanesulphonates, processes for their preparation, their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment of states of pain and neurodegenerative disorders. | 06/29/2004 |
| 6749869 | Acidic aqueous chlorite teat dip providing shelf life, sanitizing capacity and tissue protection The mastitis control teat dip composition of the invention provides rapid initial kill, a useful highly pseudoplastic rheology, a barrier/film-forming capacity, a unique antimicrobial composition that is stable over an extended period of time, and unexpected long te... | 06/15/2004 |
| 6699510 | Acidic aqueous chlorite teat dip with improved visual indicator stability, extended shelf life, sanitizing capacity and tissue protection The mastitis control teat dip composition having a visible indicator aspect of the invention provides a softening, soothing, smoothing, relaxing property, a rapid initial kill, a useful highly pseudoplastic rheology, a barrier/film-forming capacity, a uni... | 03/02/2004 |
| 6667346 | Method for protecting cells and tissues from ionizing radiation toxicity with , ଲ unsaturated aryl sulfones Pre-treatment with ,ଲ unsaturated aryl sulfones protects normal cells from the toxic side effects of ionizing radiation. Administration of a radioprotective ,ଲ unsaturated aryl sulfone compound to a patient prior to anticancer ra... | 12/23/2003 |
| 6656973 | (E)-4-carboxystyrl-4-chlorobenzyl sulfone and pharmaceutical compositions thereof Provided are the compound (E)-4-carboxystyryl-4-chlorobenzyl sulfone, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof.... | 12/02/2003 |
| 6642271 | Potentiating compounds This invention relates to novel compounds, capable of potentiating the efficacy of therapeutically active compounds, for example cytotoxic compounds used in the treatment of cancer. The novel compounds have been shown to increase the pharmacological activ... | 11/04/2003 |
| 6607737 | Topical composition comprising an activated, trans-structured cosmetic bonding agent The present invention relates to cosmetic compositions that comprise a safe and effective amount of a bonding agent comprising trans structure ##STR1## wherein X represents a cosmetic benefit agent, L represents an optional chemical linker between X and a... | 08/19/2003 |
| 6608061 | Bisaryl compound and medicament for cancer treatment comprising the same A medicament for treatment of cancer comprising a compound represented by the following general formula (I) or a physiologically acceptable salt thereof: Ar1 --S--R1 --S--Ar2 wherein R1 represents a nonmetal bridging... | 08/19/2003 |
| 6576675 | Z-styryl sulfone anticancer agents (Z)-styryl benzylsulfones of formula I are useful as anticancer agents: ##STR1## wherein R1 is selected from the group consisting of hydrogen, chloro and nitro; R2 is selected from the group consisting of hydrogen, lower alkyl, lower... | 06/10/2003 |
| 6552084 | Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders are disclosed.... | 04/22/2003 |
| 6548553 | Styryl sulfone anticancer agents Styryl sulfone compounds of the invention selectively inhibit proliferation of tumor cells, and induce apoptosis of tumor cells, while sparing normal cells. The compounds, which are useful in the treatment of cancer and other proliferative disorders, have... | 04/15/2003 |
| 6524624 | Two-part disinfecting systems and compositions and methods related thereto A two-part disinfecting systems, as well as disinfecting compositions and methods for making and using the same. The two-part disinfecting system contains a first part and a second part adapted to be mixed to yield an aqueous disinfecting composition, whe... | 02/25/2003 |
| 6444709 | Heteroethylene compounds and pharmaceutical and cosmetic compositions containing same The invention relates to novel heteroethynylenic compounds having the general formula (I): ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, r... | 09/03/2002 |
| 6436444 | Acidic aqueous chlorite teat dip providing shelf life sanitizing capacity and tissue protection The mastitis control teat dip composition of the invention provides rapid initial kill, a useful highly pseudoplastic rheology, a barrier/film-forming capacity, a unique antimicrobial composition that is stable over an extended period of time, and unexpec... | 08/20/2002 |
| 6414034 | Z-styryl sulfone treatment of proliferative diseases (Z)-styryl benzylsulfones of formula I are useful as anticancer agents: ##STR1## wherein R1 is selected from the group consisting of hydrogen, chloro and nitro; R2 is selected from the group consisting of hydrogen, lower alkyl, lower... | 07/02/2002 |
| 6391909 | Anandamide inhibitors as analgesic agents Disclosed is a method of inhibiting anandamide amidase in an individual or animal and novel inhibitors of anandamide amidase. The disclosed method can be used to reduce pain in an individual or animal suffering from pain, reducing nausea in an individual ... | 05/21/2002 |
| 6368608 | Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active polyaromatic propynyl compounds have the structural formula (I): ##STR1## in which X is one of the radicals: ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or ve... | 04/09/2002 |
| 6359013 | Styryl sulfone anticancer agents Styryl sulfone compounds of the invention selectively inhibit proliferation of tumor cells, and induce apoptosis of such tumor cells, while sparing normal cells. The compounds, which are useful in the treatment of cancer, have the formula II: ##STR1#... | 03/19/2002 |
| 6239111 | In vivo method of improving survival rate of brain neurons The present invention discloses the use, in the manufacture of a preventive and therapeutic drug of a brain disease, of a compound represented by formula (1): [wherein R represents a hydrogen atom, an alkyl group, an alkenyl group, a substituted alkyl gro... | 05/29/2001 |
| 6201027 | Substituted ଲ diketones and their use The invention relates to the compounds of formula I: ##STR1## wherein one of X1 and X2 is MeSO2 and the other one is hydrogen or halogen and X3 is hydrogen or halogen. These compounds have been found to be usefu... | 03/13/2001 |
| 6162445 | Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active polyaromatic propynyl compounds have the structural formula (I): in which X is one of the radicals: ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary,... | 12/19/2000 |
| 6153648 | Iodopropargylamine compounds, and industrial antimicrobial and antifungal agents, algicides, and antifouling agents containing the same Iodopropargylamine compound of the general formula (1): ##STR1## wherein R1 and R2 each independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, or R1 and R2 combine with each o... | 11/28/2000 |
| 6123966 | Stabilized two-part disinfecting system and compositions and methods related thereto A stabilized two-part disinfecting system comprising a first part and a second part adapted to be mixed to yield an aqueous disinfecting composition. The first part contains a non-esterifying acid and an alcohol-containing humectant or antifreeze, while t... | 09/26/2000 |
| 6103753 | Intimal thickening inhibitory agent An intimal thickening inhibitory agent comprising, as an active ingredient, a compound represented by formula (1): ##STR1## wherein X represents an oxygen atom or a group of formula (2): ##STR2## wherein n represents an integer of from 0 to 2, R... | 08/15/2000 |
| 6020382 | Method of treating diabetes and related disease states The instant invention is concerned with acetylphenols which are useful as antiobesity and antidiabetic compounds. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering or modulating triglyceride le... | 02/01/2000 |
| 5994410 | Therapeutic use of water-soluble fullerene derivatives A method of treating a free radical-related medical condition. The method includes the step of administering to a subject in need of such treatment an effective amount of a compound of the formula F(--X)m wherein F is a fullerene core; each X is ind... | 11/30/1999 |
