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| Number | Title | Issue Date |
| 7462647 | Pentalfluoroalkanesulfinyl naphthalenes and related estrogen receptor modulators The present invention provides a compound of the formula (I) wherein R is —H, or —C1-C4 alkyl; R1 is —H, —OH, —O(C1-C4 alkyl), —SO2(C1-C4 alkyl), or halo; X is —O... | 12/09/2008 |
| 7410655 | Anticancer agent An anticancer agent containing platinum preparation, humic substances, water and sodium chloride. Potassium tetrachloroplatinate is used as a platinum compound and lignohumic acid ammonium salts are used as humic substances taken in the following ratio of com... | 08/12/2008 |
| 7321002 | Chiral integrin modulators and methods of use thereof The invention provides enantiomers of ajoene and derivatives of Z(−)-ajoene. The derivative of Z(−)-ajoene are useful for modulating integrin-mediated functions, for treating disorders, diseases or conditions in which integrins play a role, and for treating tiss... | 01/22/2008 |
| 7291639 | Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) This invention provides methods of inhibiting plasminogen activator inhibitor-1 (PAI-1) in a mammal, utilizing compounds of the formula: wherein: A is C or N; B is O, S, N, or CH═CH; | 11/06/2007 |
| RE39866 | Nonpeptide insulin receptor agonists Modulation of the activity of the insulin receptor, enhancement of glucose uptake by cells, and other effects significant in the control and management of diabetes are accomplished using compounds of the formula wherein ... | 10/02/2007 |
| 7270834 | Pharmaceutical composition comprising dimethylsulfoxide and ozone A pharmaceutical composition to be externally applied as a topical preparation for treating several diseases, the composition comprising dimethylsulfoxide (DMSO) and ozone. A method for obtaining the composition by ozonizing DMSO and a method for treating diseases b... | 09/18/2007 |
| 7247655 | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2—CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy... | 07/24/2007 |
| 7235590 | Use of treosulfan and derivatives thereof for treating multiple sclerosis The invention relates to the use of treosulfan and/or derivatives thereof for producing a pharmaceutical composition used in the treatment of multiple sclerosis. ... | 06/26/2007 |
| 7214666 | Composition of orally administered nutritional supplements to repair articular cartilage Provided is a synergistic combination of nutritional supplements classified as Nutraceuticals and further combined with antioxidant vitamins and minerals that, when orally administered to mammals, provides optimal delivery of vital metabolic precursors necessary for... | 05/08/2007 |
| 7161031 | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula I: wherein: Ar, X, X1, g, R and R3 are as defined herein. ... | 01/09/2007 |
| 7153877 | Method and composition for preventing or reducing the symptoms of insulin resistance syndrome A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and administering to them an effective amount of a composition comprising niacin-bo... | 12/26/2006 |
| 7119110 | Method and composition for preventing or reducing the symptoms of insulin resistance syndrome A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and administering to them an effective amount of a composition comprising niacin-bo... | 10/10/2006 |
| 7081469 | Benzimidazole vascular damaging agents Vascular damaging agents composed of substituted 5(6)-substituted benzimidazole-2-carbamates are provided. These agents are useful in the preparation of medicaments for the treatment of diseases involving neovascularisation, particularly for the treatment of solid t... | 07/25/2006 |
| 7081467 | C2-disubstituted indan-1-ones and their derivatives, processes for their preparation and their use as pharmaceuticals The present invention is directed C2-disubstituted indan-1-ones of the Formula I, physiologically acceptable salts, and physiologically functional derivatives thereof, and pharmaceutical compositions comprising s... | 07/25/2006 |
| 7074829 | Antiestrogens, process for their production and their pharmaceutical use This invention relates to new antiestrogens of the general formula in which the substituents have the meanings that are explained in more detail in the description. The new compounds are a) pure antiestrogens o... | 07/11/2006 |
| 7053123 | Substituted (e)-styryl benzylsulfones for treating proliferative disorders (E)-Styryl benzylsulfones useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula I: wherein: R1 is selected from the group consisting of halogen, C1–C6 alkoxy, nitro, phosphonato, amino, sulfamyl... | 05/30/2006 |
| 7045663 | Chiral integrin modulators and methods of use thereof The invention provides enantiomers of ajoene and derivtives of Z(−)-ajoene. The derivative of Z(−)-ajoene are useful for modulating integrin-mediated functions, for treating disorders, diseases or conditions in which integrins play a role, and for treating tissu... | 05/16/2006 |
| 7045152 | Treating pulmonary disorders with gaseous agent causing repletion of GSNO Pulmonary disorders in which the GSNO pool or glutathione pool in the lung is depleted and where reactive oxygen species in lung are increased, are treated by delivering into the lung as a gas, agent causing repletion or increase of the GSNO pool or protection again... | 05/16/2006 |
| 7041677 | Use of monochloroflosequinan in the treatment of sexual dysfunction The present invention described the administration of halogenated flosequinan derivatives and the enantiomers of halogenated flosequinan derivatives for the treatment of sexual dysfunction (in males and females) and for the treatment of cardiovascular disease. ... | 05/09/2006 |
| 6998490 | Process for the preparation of organic compounds containing a sulfinyl or sulfonyl group A process for the oxidation of thioethers to sulfoxides or sulfones or for the oxidation of sulfoxides to sulfones by treatment of thioethers or sulfoxides with an oxidizing amount of ε-phthalimidoperhexanoic acid is particularly useful for the preparation of compo... | 02/14/2006 |
| 6992065 | Sustained release formulations A composition for sustained release comprises a carrier material containing a non-polymeric, non-water soluble liquid material having a viscosity of at least 5,000 cP at 37° C. that does not crytallize neat under ambient physiological conditions, a multivalent meta... | 01/31/2006 |
| 6992107 | Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy The present invention provides a compound of formula I; R22N—CH2COCH2—CH2CO—OR1 (I) wherein R1 represents (a) an optionally substituted branched C6-30 | 01/31/2006 |
| RE38915 | Nonpeptide insulin receptor agonists Modulation of the activity of the insulin receptor, enhancement of glucose uptake by cells, and other effects significant in the control and management of diabetes are accomplished using compounds of the formula wherein ... | 12/06/2005 |
| 6964776 | Compositions for the treatment of pigmentation disorders and methods for their manufacture The present invention addresses the problem of excessive discoloration in hydroquinone compositions of a neutral pH. Antioxidants in the hydroquinone phase and inorganic or amino acyl cationic salts of acidic ascorbyl esters, preferably sodium metabisulfite and magn... | 11/15/2005 |
| 6962689 | High viscosity embolizing compositions Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter deliver. ... | 11/08/2005 |
| 6919380 | Derivatives of C2-substituted indan-1-ol systems for the prophylaxis or treatment of obesity Derivatives of C2-substituted indan-1-ol compounds of formula I: its physiologically acceptable salts, and its physiologically functional derivatives for the prophylaxis or treatment of obesity are disclosed herein. Co... | 07/19/2005 |
| 6878750 | Benzocycloheptenes, process for their production, pharmaceutical preparations that contain the latter as well as their use for the production of pharmaceutical agents This invention describes the new benzocycloheptenes of general formula I in which R1, R2 and SK have the meanings that are indicated in the description. The new ... | 04/12/2005 |
| 6822120 | Sulfone liver X-receptor modulators The present invention is directed to selective LXR modulators, small molecule compounds corresponding to Formula I and is further directed to a process of treating a condition in a mammal that is modulated by LXR using a therapeutically effective dose of a compound ... | 11/23/2004 |
| 6814952 | Diagnostic imaging agent useful for selecting a therapy for cancerous bone metastasis A diagnostic imaging agent useful for selection of a therapy for cancerous bone metastasis is provided, which comprises 99mTc(V)-dimercaptosuccinic acid as an effective ingredient. The agent is administered to a patient, and a scintigram is taken. This is... | 11/09/2004 |
| 6812256 | Polysubstituted indan-1-ol systems for the prophylaxis or treatment of obesity Polysubstituted indan-1-ol compounds of formula I, its physiologically acceptable salts and physiologically functional derivatives are disclosed Compositions comprising the same, methods of preparation and methods for ... | 11/02/2004 |
| 6790463 | Uses of targeted oxidative therapeutic formulation in arteriosclerosis The use of a pharmaceutical formulation in treating coronary arteriosclerosis and a two-component pharmaceutical formulation. The pharmaceutical formulation contains peroxidic species or reaction products resulting from oxidation of an alkene, such as geraniol, by a... | 09/14/2004 |
| 6787573 | Antiviral therapy The invention relates to the field of antiviral agents, and more specifically to antiviral therapy. The invention provides use of at least one compound or mixture of compounds of the general formula or a functional equiv... | 09/07/2004 |
| 6749869 | Acidic aqueous chlorite teat dip providing shelf life, sanitizing capacity and tissue protection The mastitis control teat dip composition of the invention provides rapid initial kill, a useful highly pseudoplastic rheology, a barrier/film-forming capacity, a unique antimicrobial composition that is stable over an extended period of time, and unexpected long te... | 06/15/2004 |
| 6727279 | Arylsulphonamides and analogues The present invention relates to novel arylsulphonamides and analogues, to processes for their preparation and to their use for the prophylaxis and treatment of neurodegenerative disorders, in particular for the treatment of cerebral apoplexy, craniocerebral trauma,... | 04/27/2004 |
| 6699510 | Acidic aqueous chlorite teat dip with improved visual indicator stability, extended shelf life, sanitizing capacity and tissue protection The mastitis control teat dip composition having a visible indicator aspect of the invention provides a softening, soothing, smoothing, relaxing property, a rapid initial kill, a useful highly pseudoplastic rheology, a barrier/film-forming capacity, a uni... | 03/02/2004 |
| 6663874 | Composition to alleviate pain and topical method of applying same A composition for use by animals, including humans, to alleviate pain and/or inflammation around a painful joint, joint replacement surgery site, muscle, tendon, and/or ligament. A method to ameliorate pain and/or inflammation in or around a joint, muscle... | 12/16/2003 |
| 6620853 | Methods and compositions for prevention and treatment of restenosis with non-steroidal anti-inflammatory drugs Methods and compositions for the prevention and/or treatment of vascular restenosis, the methods comprising administering to individuals in need thereof, an effective amount of a non-steroidal anti-inflammatory drug alone or in combination with other conv... | 09/16/2003 |
| 6572873 | Generation of therapeutic microfoam Improved therapeutic sclerosing microfoams and methods and devices for making them are provided that have advantage in producing a consistent profile injectable foam with minimal input by the physician yet using high volume percentages of blood dispersibl... | 06/03/2003 |
| 6559181 | Antiestrogens, process for their protection and their pharmaceutical use This invention relates to new antiestrogens of the general formula ##STR1## in which the substituents have the meanings that are explained in more detail in the description. The new compounds are a) pure antiestrogens or b) antiestrogens with partial estr... | 05/06/2003 |
| 6531111 | High viscosity embolizing compositions Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery.... | 03/11/2003 |
