Class 514/700 - Polycyclo ring system

Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the compound contains a polycyclo
No. of patents: 37
Last issue date: 12/28/2010

Number	Title	Issue Date
7858666	IRE-1α inhibitors Compounds which directly inhibit IRE-1α activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in com...	12/28/2010
7432300	Gossypol co-crystals and the use thereof This invention relates to compositions comprising co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (...	10/07/2008
7342046	Gossypol co-crystals and the use thereof This invention relates to compositions comprising co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (...	03/11/2008
7101907	Topical administration of statins for treatment of bone disorders The topical administration of statins for the treatment of bone disorders is disclosed. ...	09/05/2006
7067524	Substituted phenyl naphthalenes as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, R4, R5, R...	06/27/2006
6946297	System for stabilizing samples A transport/preservation system has been found which provides safe, effective transport for patient specimens and bodily fluids, and functions as a preservative for biological reagents, therapeutics, and personal care products. The transport/preservative formulation...	09/20/2005
6914074	Substituted phenyl naphthalenes as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, R4, R5, R6, R7, R	07/05/2005
6794415	Biphenyl compounds and their use as oestrogenic agents A method of treating osteoporosis in warm-blooded animals comprising administering to warm-blooded animals in need thereof an effective amount to treat osteoporosis of a compound selected from the group consisting of a compound of the formula:	09/21/2004
6773727	Use of gossypol and related terpenes for control of urban and agricultural pests Low concentrations of gossypol and related phyllophage toxins from cotton improve the effectiveness of insecticidal agents against social insects, including cockroaches, and particularly termites and ants. Levels of gossypol and other cotton phyllophage toxins which...	08/10/2004
6608107	Methods and compositions to treat conditions associated with neovascularization This invention also provides a method to inhibit neovascularization in tissue by delivering to the cell or tissue an effective amount of gossypol, or a pharmaceutically acceptable salt, derivative or prodrug thereof. Also provided herein is a method for t...	08/19/2003
6593364	Triterpene derivatives and remedies for liver diseases A triterpene derivative useful for the treatment of hepatic disorders is disclosed. This compound comprises as an active ingredient a triterpene derivative represented by the following formula (I) or a salt thereof: ##STR1## wherein R1 represen...	07/15/2003
6368608	Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active polyaromatic propynyl compounds have the structural formula (I): ##STR1## in which X is one of the radicals: ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or ve...	04/09/2002
6313163	2,4-pentadienoic acid derivatives having retinoid-like biological activity Compounds of formula 1 ##STR1## wherein Z is selected from the group consisting of the radicals shown in Formula 2 and in Formula 3, ##STR2## Y is cyclopropyl optionally substituted with one or two R4 groups, the divalent Y radical being s...	11/06/2001
6201018	Triterpene derivatives and remedies for liver diseases A triterpene derivative useful for the treatment of hepatic disorders is disclosed. This compound comprises as an active ingredient a triterpene derivative represented by the following formula (IV) or a salt thereof: ##STR1## Y represents a single bond to...	03/13/2001
6162445	Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active polyaromatic propynyl compounds have the structural formula (I): in which X is one of the radicals: ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary,...	12/19/2000
6114397	Gossypol for the treatment of cancer A method for treating cancer in a human, which comprises administering to the human subject an anti-cancer effective amount of a compound selected from gossypol, gossypol acetic acid, gossypolone, metabolites thereof, or physiologically acceptable salts t...	09/05/2000
6080779	Compositions and methods for stimulating bone growth Compounds of the formula ##STR1## wherein X in each of formulas (1) and (2) represents a substituted or unsubstituted alkylene, alkenylene, or alkynylene linker of 2-6 C; Y represents one or more carbocyclic or heterocyclic rings; when two or more ri...	06/27/2000
5989976	Fabrication method for a field emission display emitter A fabrication method for a sharp tip emitter first includes a trench formed on a semiconductor substrate. Next, an isolating layer is deposited over the substrate by high-density plasma chemical vapor deposition (HDP CVD). A V-shaped groove is naturally f...	11/23/1999
5861385	Substituted triols Substituted triols are prepared by reducing appropriately substituted carboxylic esters. The substituted triols can be used as active substances in medicaments....	01/19/1999
5798354	Use of adamantyl-substituted polycyclic acetylene compounds in skin and hair treatment Novel pharmaceutically/cosmetically-active adamantyl-substituted polycyclic acetylene compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(f): ##STR2## and are useful for the treatment of a ...	08/25/1998
5716624	Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active polyaromatic propynyl compounds have the structural formula (1): ##STR1## in which X is one of the radicals: ##STR2## and are useful for the treatment of a wide variety of disease states, whether h...	02/10/1998
5696171	Contact lens disinfecting compositions and methods employing terpenes A disinfecting composition for contact lenses includes an effective disinfecting amount of a terpene or combination of terpenes....	12/09/1997
5593994	Prostaglandin synthase inhibitors This invention relates to ortho substituted phenyl compounds as inhibitors of prostaglandin synthase, to pharmaceutical compositions comprising such compounds and to methods of using such compounds as antiinflammatory and antipyretic agents. The class of ...	01/14/1997
5580857	Use of gibberellins for the treatment of prostatitis The use of active gibberellins for the preparation of a pharmaceutical composition for the treatment of prostatitis. The method results in a decrease in prostate mass....	12/03/1996
5476860	Diaromatic compounds derived from a salicylic unit and their use in human and veterinary medicine and in cosmetics Diaromatic compounds, characterized in that they correspond to the following general formula: ##STR1## in which: R1 is --CH3, --CH2 OH, --COR8 or --CH2 OCOR9, R8 is H, OH, -...	12/19/1995
5455265	Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors Process of treatment of mammals, including humans to treat diseases or conditions of the type which are normally treated with retinoid-like compounds is disclosed, with pharmaceutical compositions containing an active compound which is a selective agonist...	10/03/1995
5290817	Substituted 1-benzylindanes and their use as inhibitors of phospholipase A₂ The invention relates to benzylindane phospholipase A2 inhibitors, pharmaceutical compositions containing them, and methods of treating phospholipase A2 -mediated conditions in mammals by administration of a therapeutically effective...	03/01/1994
5260327	Methods for inhibiting the proliferation of brain and hepatic metastases by using lonidamine This invention provides methods for inhibiting the proliferation of brain or hepatic metastases, in vivo, by contacting the cells with lonidamine and radiation....	11/09/1993
5126371	Diarylacetylenes, their preparation and their use Novel diarylacetylenes of the formula I ##STR1## where A, R1, R2, R3, R4, R5 and R6 have the meanings stated in the description, are useful for the treatment of disorders....	06/30/1992
5112869	Substituted 1-phenylnaphthalenes This invention concerns compounds having the structure: ##STR1## wherein each of R2, R3, R4, R5, R6, R7, R2', R3', R4', and R5', is independently...	05/12/1992
5098895	Benzonaphthalene derivatives, a process for their preparation and their use in therapeutic and cosmetic compositions A benzonaphthalene compound has the formula ##STR1## wherein R1 represents ##STR2## or (ii) --CH2 OH; R6 represents ##STR3## or OR7 wherein R7 represents hydrogen, alkyl having 1-20 car...	03/24/1992
4983627	Novel 6-alkyl and 6.8-dialkylbicyclo(4.2.0)octane derivatives Compounds useful in treating or preventing gastrointestinal ulcers and in treating cardiovascular disorders such as thrombosis, hypertension and atherosclerosis are depicted in formulas (1), (2) and (3): ##STR1## wherein: A is --C.tbd.C--, trans --HC...	01/08/1991
4735966	Novel substituted (4.2.0)bicyclooctane derivatives with valuable therapeutic properties Compounds useful in treating cardiovascular disorders such as thrombosis, hypertension and atherosclerosis are depicted in formulas (1), (2) and (3): ##STR1## wherein: A is --C.tbd.C--, trans --HC.dbd.CH--, --CH2 CH2 -- or ...	04/05/1988
4456618	Naphthenic and heterocyclic retinoic acid analogues Naphthenic and heterocyclic retinoic acid analogues such as (E)-6-[2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethenyl]-2-naphthaldehyde, methyl 6-[2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethenyl]-2-naphthoate, 6-[2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethenyl]-2-nap...	06/26/1984
4297341	Spermicidal composition A water-soluble complex comprising polyvinylpyrrolidone and gossypol is an effective spermicide....	10/27/1981
4016289	Medicinal preparation for treatment of viral-etiology diseases A medicinal preparation for treatment of viral-etiology diseases contains the bisulphite compound of 2-fluorenonyl-glyoxal in combination with a pharmaceutical vehicle or unctuous base. A method of producing the bisulphite compound of 2-fluorenonyl-glyoxal, ...	04/05/1977
3958012	D 2-(6-Substituted-2-naphthyl)-propanals The d 2-(6-substituted-2-naphthyl)propanals of this invention are prepared by oxidizing the corresponding 2-(6-substituted-2-naphthyl)-1-propanols or by reducing d 2-(6-substituted-2-naphthyl)propionic acids, the 6-substituent being a methyl, ethyl, isopr...	05/18/1976

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Class 514/700 - Polycyclo ring system