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| Number | Title | Issue Date |
| 6075057 | Inhibition of carbohydrates metabolism by quinone compounds Optically pure enantiomers of avarol are obtained. The enantiomers of avarol are demonstrated to be highly effective inhibitors of -glucosidase and -mannosidase. Other enzymes assayed were not inhibited by these optically pure compounds. Inh... | 06/13/2000 |
| 6051588 | Nitroso esters of ଲ-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs A compound comprising a non-steroidal antiinflammatory agent to which is directly or indirectly linked an NO group, a pharmaceutical composition including the compounds and methods of treatment of pain and/or inflammation using the compounds and compositi... | 04/18/2000 |
| 6033649 | Light screening agents Photostable, cosmetic light-screening composition, comprising, in a cosmetically acceptable vehicle containing at least one fatty phase, about 0.1 to about 5%, in particular about 1 to about 3% by weight, of a dibenzoylmethane type UV-A screening agent an... | 03/07/2000 |
| 5990170 | Therapeutic use of mono and bicarboxylic acid amides active at the peripheral cannabinoid receptor The following description concerns a therapeutic method for the treatment of diseases connected with the modulation of the cannabinoid peripheral receptor, comprising administering amidic derivatives of mono and bicarboxylic acids with aminoalcohols or ar... | 11/23/1999 |
| 5985935 | Treatment and prophylaxis of diseases caused by parasites, or bacteria Aromatic compounds, or prodrugs thereof, which contain an alkylating site and which are capable of alkylating the thiol group in N-acetyl-L-cysteine, in particular bis-aromatic ,ଲ-unsaturated ketones, are used for the preparation of pharmaceu... | 11/16/1999 |
| 5929117 | Immunotherapeutic agents Cyano and carboxy derivatives of substituted styrenes are inhibitors of tumor necrosis factor , nuclear factor .kappa.B, and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory con... | 07/27/1999 |
| 5928629 | Photoprotective/cosmetic compositions comprising dibenzoylmethane/triazine/diphenylacrylate compounds Improvedly photostable, topically applicable cosmetic/dermatological sunscreen compositions well suited for enhanced photoprotection of human skin and/or hair against the damaging effects of UV-A and UV-B irradiation, particularly solar radiation, compris... | 07/27/1999 |
| 5925376 | Method for treating psoriasis using selected phosphorylase kinase inhibitor and additional compounds An improved method of treating psoriasis involves controlling the enhanced proliferation and terminal differentiation of psoriatic epidermis through the activity of epidermal phosphorylase kinase. In general, the method involves contacting psoriatic epide... | 07/20/1999 |
| 5891924 | Curcumin (diferuloylmethane) inhibition of NF.kappa.B activation The present invention provides a method of inhibiting the activation of the NF.kappa.B transcription factor in an animal in need of such treatment comprising the step of administering to said animal a pharmacologically effective dose of curcumin. Also pro... | 04/06/1999 |
| 5882634 | Compositions comprising a dibenzoylmethane derivative, a 1,3,5-triazine derivative and a dialkyl benzalmalonate, and methods of use therefor The present invention relates to novel cosmetic and/or dermatological compositions comprising, in a cosmetically and/or dermatologically acceptable support, i) a dibenzoylmethane derivative, in particular 4-tert-butyl-4'-methoxydibenzoylmethane, ii) at le... | 03/16/1999 |
| 5882632 | Compositions comprising a dibenzoylmethane derivative, a 1,3,5-triazine derivative and a silicon derivative containing a benzalmalonate function, and methods of use therefor The present invention relates to novel cosmetic and/or dermatological compositions comprising, in a cosmetically and/or dermatologically acceptable support, (i) a dibenzoylmethane derivative, in particular 4-tert-butyl-4'-methoxydibenzoylmethane, (ii) at ... | 03/16/1999 |
| 5882633 | Compositions comprising a dibenzoylmethane derivative, a 1,3,5-triazine derivative and an amide compound, and methods of use therefor The present invention relates to novel cosmetic and/or dermatological compositions comprising, in a cosmetically and/or dermatologically acceptable support, i) a dibenzoylmethane derivative, in particular 4-tert-butyl-4'-methoxydibenzoylmethane, ii) at le... | 03/16/1999 |
| 5849273 | Skin care and sunscreen composition containing dibenzoylmethane derivative, e.g., parsol.RTM. 1789, and C12, C16, C18 branched chain hydroxybenzoate and/or C12, C16 branched chain benzoate stabilizers/solubilizers A sunscreen composition containing a UV-A dibenzoylmethane derivative, such as 4-(1,1-dimethylethyl)-4'-methoxydibenzoylmethane (PARSOL.RTM. 1789), and a stabilizer/solubilizer for the dibenzoylmethane derivative having formula (I): ##STR1## The... | 12/15/1998 |
| 5840724 | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- o r This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical c... | 11/24/1998 |
| 5788954 | Hydrating skin care and sunscreen composition containing dibenzoylmethane derivative, E.G., parsol 1789, and C12, C16, C18 branched chain hydroxybenzoate and/or C12, C16, branched chain benzoate stabilizers/solubilizers A sunscreen composition containing a UV-A dibenzoylmethane derivative, such as 4-(1,1-dimethylethyl)-4'-methoxydibenzoylmethane (PARSOL.RTM. 1789), and a stabilizer/solubilizer for the dibenzoylmethane derivative having formula (I): ##STR1## whe... | 08/04/1998 |
| 5789413 | Alkylated styrenes as prodrugs to COX-2 inhibitors The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases c... | 08/04/1998 |
| 5783173 | Stable sunscreen composition containing dibenzoylmethane derivative, E. G., PARSOL 1789, and C12, C16, C18, branched chain hydroxybenzoate and/or C12, C16, branched chain benzoate stabilizers/solubilizers A sunscreen composition containing a UV-B dibenzoylmethane derivative, such as 4-(1,1-dimethylethyl)-4'-methoxydibenzoylmethane (PARSOL 1789), and a stabilizer/solubilizer for the dibenzoylmethane derivative selected from formula (I) and formula (II), and... | 07/21/1998 |
| 5725844 | Waterproof cosmetic or dermatological photoprotective preparations Water-resistant cosmetic or dermatological light protection formulations in the form of O/W emulsions or hydrodispersions, comprising one or more cosmetically or pharmaceutically acceptable hydrophobic inorganic pigments, these pigments being incorporated into... | 03/10/1998 |
| 5716995 | Anti-osteopathic composition An anti-osteopathic composition comprising as an active ingredient a compound represented by the following formula (I), (II) or (III): ##STR1## which is useful for therapeutic and prophylactic treatment of osteopathia such as osteoporosis and bone fr... | 02/10/1998 |
| 5679696 | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic-or heteroatom-containing linking group This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical c... | 10/21/1997 |
| 5593994 | Prostaglandin synthase inhibitors This invention relates to ortho substituted phenyl compounds as inhibitors of prostaglandin synthase, to pharmaceutical compositions comprising such compounds and to methods of using such compounds as antiinflammatory and antipyretic agents. The class of ... | 01/14/1997 |
| 5554608 | Inhibition of hair growth Mammalian hair growth is reduced by applying to the skin a composition including an inhibitor of protein kinase C.... | 09/10/1996 |
| 5545399 | Cosmetic composition A composition for topical application to the skin in order to promote the repair of photo-damaged or aged skin and/or to reduce or prevent damaging effects of ultra-violet light on skin and/or to lighten the skin comprising a hydrocalchone of general stru... | 08/13/1996 |
| 5401500 | Insect attractant compositions and methods for using same Described is a method of attracting Musca domestica L. (Diptera:Muscidae) using benzoin and/or dimethyl benzyl carbinyl acetate. The attractants taken alone or in combination find utility primarily as bait enhancers for acute toxins and/or trapping device... | 03/28/1995 |
| 5272178 | Compounds of cyclic phenolic thioethers which are useful in stimulating and inhibiting superoxide generation The present invention relates to compounds of the formula: ##STR1## wherein R1 and R2 are the same or different and independently represent tert-alkyl, phenyl, or hydrogen; R3 represents hydrogen or alkyl; X represent... | 12/21/1993 |
| 5140037 | Treatment of central nervous system disorders with imidazole angiotensin-II receptor antagonists Substituted imidazoles such as 2-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-5-(hydroxy methyl)imidazole and 2-butyl-4-chloro-1-[(2'-carboxybiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imi dazole and pharmaceutically acceptable salts there... | 08/18/1992 |
| 5135940 | Leukotriene antagonists Compounds of the Formulae: ##STR1## are antagonists of leukotrienes of C4, D4 and E4, the slow reacting substance of anaphylaxis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cyt... | 08/04/1992 |
| 5109025 | Therapeutic agent for penal disorders 2',3,4,4'-tetrahydroxychalcone and pharmacologically acceptable salts thereof are used as a therapeutic agent for treatment of renal disorders, and have activity for treatment of renal disorders and also for treatment of renal disorders accompanied by dig... | 04/28/1992 |
| 5084478 | Alkene, alkyne or cycloalkylene derivatives A compound of the formula ##STR1## wherein X has the formula --CR5 .dbd.CR6 --, --C.tbd.C-- or ##STR2## wherein ring A is phenyl, naphthyl or heterocyclic; wherein R1 is hydrogen, alkyl, alkanoyl or aroyl; wherei... | 01/28/1992 |
| 5075339 | Benzylketone phospholipase A2 inhibitors The invention relates to benzylketone phospholipase A2 inhibitors, pharmaceutical compositions containing them, and methods of treating phospholipase A2 -mediated conditions in mammals by administration of a therapeutically effective... | 12/24/1991 |
| 5025036 | Catechol carboxylic acids The invention relates to catechol carboxylic acid derivatives of the formula ##STR1## wherein, R1 is ##STR2## acetyl, hydrogen, hydroxy or alkanoyloxy, R2 is ##STR3## hydroxy, hydrogen or alkanoyloxy, wherein R ... | 06/18/1991 |
| 4985464 | Drug compositions for local treatment of alopecia areata A drug composition for the local treatment of alopecia areata and other dermatological diseases is disclosed. The composition contains as an active ingredient an aliphatic, alkoxy or aryl substituted cyclopropenone. Diphenylcyclopropenone is a particularl... | 01/15/1991 |
| 4842859 | Pharmaceutical compositions for reducing hyperlipidemia and platelet-aggregation The new pharmaceutical compositions and processes are provided for reducing both hyperlipidemia and platelet-aggregation (PHP). The fine-PHP is composed of following ingredients: Scoparone or Aurapten, Curcumin, Ferulic Acid, Yejuhua-flavonoid and additive ing... | 06/27/1989 |
| 4829091 | Process for the preparation of ketones and novel insecticides produced therefrom An improved method for the decarbalkoxylation of alkylated ଲ-keto esters to obtain high yields of ketones. In accordane with the method, decarbalkoxylation of alkylated ଲ-keto esters is accomplished by heating the esters in the presence of dil... | 05/09/1989 |
| 4814340 | 1,4-diaryl alkane derivatives having insecticidal and acaricidal activity The present invention relates to novel aromatic alkane derivatives represented by the following general formula (I): ##STR1## wherein Ar stands for a substituted or unsubstituted phenyl or naphtyl group, R1 stands for a methyl, ethyl or is... | 03/21/1989 |
| 4791123 | Insecticidal triffluormethyl alkane derivatives There are provided new alkane and alkoxyalkane derivatives of the general formula I ##STR1## in which R1, R2, R3, R4 and A have the meanings given in the description, processes for their preparation and ins... | 12/13/1988 |
| 4649157 | Pharmaceutical compositions containing 5-phenyl-1,3-dioxoalkenyl compounds This invention relates to pharmaceutical compositions containing a class of 5-phenyl-1,3-dioxoalkenyl compounds useful as inhibitors of leukotriene biosynthesis and thus useful in the treatment of conditions associated with leukotrienes. This invention al... | 03/10/1987 |
| 4643994 | Novel organic trithio oxides and method for the preparation thereof This invention relates to novel organic trithio oxides of the formula: wherein R is selected from --CH2 CH.dbd.CH--, ##STR1## and (CH2)3 ; X is selected from ##STR2## X1 is selected from --S--S, ##STR3... | 02/17/1987 |
| 4613611 | Method of treating diabetes mellitus using arylglyoxals A method of treating diabetes mellitus using arylglyoxals which are known compounds.... | 09/23/1986 |
| 4609677 | Non-steroidal anti-inflammatory compounds and compositions thereof A non-steroidal anti-inflammatory composition comprising a therapeutically effective amount of active anti-inflammatory agent selected from the group consisting of 1-phenyl-1 cyclohexene, 4-phenylcyclohexanone, and mixtures thereof. The active agent may b... | 09/02/1986 |
