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| Number | Title | Issue Date |
| 8129355 | Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex This invention relates to a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogeno... | 03/06/2012 |
| 8030359 | Polymer formulations of CETP inhibitors A pharmaceutical composition comprises (a) a CETP inhibiting compound, or a pharmaceutically acceptable salt thereof; (b) a concentration-enhancing polymer, and (c) optionally one or more surfactants; wherein the compound has the structure shown as Formula I below. ... | 10/04/2011 |
| 7375093 | Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex This invention relates to a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogeno... | 05/20/2008 |
| 7345096 | Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms The present invention relates to the use of compounds and composition of compounds that modulate norepinephrine levels for the prevention and treatment of vasomotor symptoms, such as hot flush, caused by, inter alia, thermoregulatory dysfunctions. ... | 03/18/2008 |
| 7332499 | Sulfonyl substituted n-(biarylmethyl) aminocyclopropanecarboxamides N-(Sulfonyloxybiarylmethyl) aminocyclopropanecarboxamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway. ... | 02/19/2008 |
| 7235237 | Methods of treating vascular diseases characterized by nitric oxide insufficiency The present invention provides methods of treating or preventing vascular diseases caused by nitric oxide (NO) insufficiency. The methods encompass administering a composition comprising an antioxidant, a compound to treat cardiovascular diseases, a nitrosated compo... | 06/26/2007 |
| 7202279 | Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders The present invention provides 4-substituted-2-azetidinone compounds, bicyclic 2-5-diketopiperazine compounds, and pharmaceutical compositions thereof that are potent, safe and effective neuroprotective agents. Due to their strong central nervous system (CNS) activi... | 04/10/2007 |
| 7160905 | Hydroxyethylene compounds with Asp2 inhibitory activity The present invention relates to novel hydroxyethylene compounds having Asp2 (β-secretase. BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevat... | 01/09/2007 |
| 6906059 | Pharmaceutical composition with protective action against oxidative/toxic substances, especially cardiotoxic substances The use of benzazepin-N-acetic acid derivatives which contain an oxo group in the a position to the nitrogen atom and are substituted in the 3 position by a 1-(carboxyalkyl)-cyclopentyl-carbonyl-amino radical, and of their salts and biolabile esters, for the prophyl... | 06/14/2005 |
| 6894078 | Alcohol based topical anesthetic formulation and method A method for applying a topical anesthetic to an area of skin comprising the steps of a) incorporating an anesthetic in a lipophilic base into a volatile solvent, to form a homogeneous solution; b) applying the homogeneous solution into the area of skin to be treate... | 05/17/2005 |
| 6828350 | Modulators of cysteine protease The present invention concerns novel mediators of the activity of picornavirus 3C protease and the modulation of the activity of other similar proteins. The modulators may be used in pharmaceutical compositions either for inhibition of 3C protease (for example in vi... | 12/07/2004 |
| 6774111 | Carbohydrate system and a method for providing nutrition to a diabetic The two carbohydrate mixture of this invention utilizes a source of fructose in combination with at least one readily digestible glucose polymer source. The addition of the fructose significantly decreases the glycemic response when compared to the digestible glucos... | 08/10/2004 |
| 6734202 | Fungicidal mixtures The invention relates to a novel fungicidal composition comprising a fungicidally acceptable carrier and/or surface active agent together with, and synergistically effective amounts of (a) at least one benzophenone of formula I | 05/11/2004 |
| 6689776 | Fungicidal combinations The invention relates to a method of combating phytopathogenic diseases on crop plants which comprises applying to the crop plants or the locus thereof being infested with said phytopathogenic disease an effective amount of a combination of a) a benzophen... | 02/10/2004 |
| 6599530 | Oral compacted composition comprising catechol derivatives The present invention relates to an oral compacted composition comprising entacapone, nitecapone, or a pharmaceutically acceptable salt thereof and croscarmellose sodium. The composition is premised on the discovery that croscarmellose sodium increases th... | 07/29/2003 |
| 6596774 | Synthesis, lipid peroxidation and cytotoxic evaluation of 10-substituted 1,5-dichloro-9(10H)-anthracenone derivatives The present invention is the synthesis of a series of 1,5-dichloro-9(10H)-anthracenones bearing O-linked and N-linked substituents in the 10-position. These compounds were evaluated for their ability to inhibit the growth of the human oral epidermoid carc... | 07/22/2003 |
| 6596064 | Biocidal-antifouling agents with low ecotoxicity index A use of tetralin derivatives as biocidal and antifouling agents for preventing and slowing the growth of algae, molds and microorganisms. In particular, the vitamin derivatives are constituted by salts of menadione bisulfite with the heterocyclic bases t... | 07/22/2003 |
| 6593347 | Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least o... | 07/15/2003 |
| 6548552 | Absorbent article, particularly a tampon having additives that reduce toxic shock syndrome toxin production An absorbent article, particularly a tampon having additives that reduce toxic shock syndrome toxin (TST-1) production is disclosed. The tampon has a combination of an effective amount of at least one oxygen inhibiting agent and an effective amount of at ... | 04/15/2003 |
| 6472429 | Fungicidal compositions A method of combating phytopathogenic diseases on crop plants includes applying to the crop plants or the locus thereof being infested with a phytopathogenic disease an effective amount of a combination of a) (E,E)--(methoxyimino)-2-[[[[1-[3(triflu... | 10/29/2002 |
| 6462044 | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions containing at least one nitrosated and/or nitrosylated phosphodiesterase inhibitor, and, optionally, one or more compounds that donat... | 10/08/2002 |
| 6331543 | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions containing at least one nitrosated and/or nitrosylated phosphodiesterase inhibitor, and, optionally, one or more compounds that donat... | 12/18/2001 |
| 6323240 | 4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity 4-phenyl-4-oxo-butanoic acid derivatives for use in the treatment of the human or animal body by therepy; particularly as kynurenine-3-hydroxylase inhibitors, in the prevention and/or treatment of a neurodegenerative disease wherein the inhibition of such... | 11/27/2001 |
| 6297260 | Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least o... | 10/02/2001 |
| 6197825 | Azulenyl nitrone spin trapping agents, methods of making and using same The present invention relates to chromotropic nitrone spin trapping agents, methods of making these agents, compositions comprising same, and methods of their use. In particular, azulenyl nitrones of the present invention are effective agents for trapping... | 03/06/2001 |
| 6159988 | Arylcycloalkyl derivatives, their production and their use Compounds of formula I, ##STR1## and the physiologically tolerable salts thereof, wherein the substituents R1 -R4 have the meanings given in the specifications and show an activity against inflammatory conditions.... | 12/12/2000 |
| 6153648 | Iodopropargylamine compounds, and industrial antimicrobial and antifungal agents, algicides, and antifouling agents containing the same Iodopropargylamine compound of the general formula (1): ##STR1## wherein R1 and R2 each independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, or R1 and R2 combine with each o... | 11/28/2000 |
| 6150374 | Substituted cycloalkenes, process of preparing them and method of using them as pesticides The invention relates to novel substituted cycloalkenes of the formula (I), ##STR1## to a plurality of processes for their preparation, and to novel intermediates and a plurality of processes for their preparation.... | 11/21/2000 |
| 6127422 | Anti-viral method A method of inhibiting an envelope virus selected from the group consisting of influenza bovine diarrheal, hepatitis C and tick borne encephalitis virus that udergoes hemagglutinin-mediated fusion with a host cell is disclosed which comprises administerin... | 10/03/2000 |
| 6083988 | Azulenyl nitrone spin trapping agents, methods of making and using same The present invention relates to chromotropic nitrone spin trapping agents, methods of making these agents, compositions comprising same, and methods of their use. In particular, azulenyl nitrones of the present invention are effective agents for trapping... | 07/04/2000 |
| 6028114 | Use of aminothiolester derivatives in pharmaceutics Use of at least one aminothiol ester derivative for the preparation of a pharmaceutical composition intended to increase the inhibition of a character resistant to the induction of apoptosis of transformed cells, this character being due to the bc12 gene ... | 02/22/2000 |
| 6004958 | Compounds and methods for therapeutic intervention in preventing diabetic complications and procedures for assessing a diabetic's risk of developing complications and determining the efficacy of therapeutic intervention The present invention is based on the discovery of a metabolic pathway in which a specific kinase converts fructose-lysine into fructose-lysine-3-phosphate in an ATP dependent reaction. Fructose-lysine-3-phosphate (FL3P) is then broken down to form free ... | 12/21/1999 |
| 5990170 | Therapeutic use of mono and bicarboxylic acid amides active at the peripheral cannabinoid receptor The following description concerns a therapeutic method for the treatment of diseases connected with the modulation of the cannabinoid peripheral receptor, comprising administering amidic derivatives of mono and bicarboxylic acids with aminoalcohols or ar... | 11/23/1999 |
| 5866569 | Naphthalenedione nitric oxide synthase (NOS) inhibitors There are disclosed methods useful for the inhibition of inducible nitric oxide synthase by the adminstration of a compound of the formula I:. when R2 is H then R1 is selected from the group consisting of: 1) aryl,--NH--C0 -C | 02/02/1999 |
| 5861435 | Method for preventing settlement of aquatic fouling organisms A method for preventing settlement of aquatic fouling organisms on surface of an aquatic structure without environmental hazard is provided. The method is based upon absolutely novel concept to prevent the settlement by means of thick slime layer, i.e. bi... | 01/19/1999 |
| 5844004 | 10-substituted 1,8-dihydroxy-9 (10H) anthracenone pharmaceuticals Therapeutic compositions comprising 1,8-dihyroxy-9(10H) anthracenones substituted at position 10 thereof with phenylalkylidene or arylacyl blocking moieties, said compounds having substantial therapeutic activity and minimal inflammatory effect.... | 12/01/1998 |
| 5814664 | 3-alkylamino-2-hydroxy-4-hydroxymethyl-2-cyclopenten-1-one advanced glycosylation endproducts and methods of use therefor The present invention relates to advanced glycosylation endproducts, and particularly to the use of novel cyclopentenone aminoreductones, 3-alkylamino-2 -hydroxy-4-hydroxymethyl-2-cyclopenten-1-ones. Such AGEs can be used in various diagnostic and therape... | 09/29/1998 |
| 5739170 | Inhibitors of metazoan parasite proteases Compositions and methods are disclosed for treating a patient infected with a metazoan parasite by inhibiting the enzymatic action of the metazoan parasite protease, wherein there is employed at least one compound of formula I A--X--B wherein A is a subst... | 04/14/1998 |
| 5708030 | Substituted kynurenines and process for their preparation The present invention relates to the use in the treatment of cognitive disorders associated with the aging processes of the brain and perinatal brain disorders of compounds which act as inhibitors of the enzyme kynurenine aminotransferase (KAT).... | 01/13/1998 |
| 5677336 | Non-steroid androgen receptor antagonist compounds and methods Non-steroidal compounds which are high affinity, high specificity ligand antagonists for the androgen receptor are disclosed. Also disclosed are methods for employing the disclosed compounds for modulating processes mediated by the androgen receptor and f... | 10/14/1997 |
